Background: Thyroid dysfunction plays an important role in the pathology of diabetes-associated cognitive dysfunction (DACD). However, thyroid hormone (TH) signaling and action changes in DACD brains remain unknown. This study evaluated the alternations in TH signaling and action in the brains of DACD mice and explored the beneficial effects of levothyroxine (L-T4) treatment.Methods: KK-Ay mice, serving as a spontaneous type 2 diabetes mellitus model, underwent intragastric administration of 10 ng/g and 20 ng/g of L-T4 solution or normal saline for 8 weeks. Age-matched C57BL/6J mice were used as normal controls. Cognitive and memory functions were examined through the open field and Morris water maze tests. Hippocampal TH signaling and pathogenic status were evaluated. The potential signaling pathways involved in the neuroprotective action of L-T4 were investigated through RNA sequencing and further verified through quantitative real-time PCR (qPCR), Western blotting (WB), immunofluorescence (IF), and fluorescent multiplex immunohistochemistry (mIHC) in vivo and vitro.Results: The expressions of hippocampal TH transporters (Mct8 and Oatp1c1), Dio2, and TH receptor were upregulated, whereas Dio3 as well as the TH-positive regulated genes MBP, Enpp2, and Klf9 were downregulated in DACD mice. Exogenous L-T4 partially alleviated cognitive and memory dysfunction and restored hippocampal neuronal activity by optimizing TH signaling. RNA sequencing provided insights into the role of type I interferon (IFN-I) signaling and necroptosis on the amelioration of hippocampal damage after L-T4 treatment. WB and qPCR further confirmed that the levels of key proteins for IFN-I signaling and necroptosis (p-STAT1, p-STAT2, IRF9, ZBP1, p-RIP3, and p-MLKL) were increased, but largely returned after L-T4 administration in vivo and T3 treatment in vitro. IF and mIHC revealed that IRF9 and p-MLKL colocalized in neurons, but not in astrocytes or microglia, of the hippocampus in DACD mice. The diabetes mellitus group had an increased number of IRF9+ p-MLKL+ NeuN+ cells, which decreased after L-T4 treatment. The elevated IFN-I signaling-mediated necroptosis in HT22 cells was also decreased by T3.Conclusion: We demonstrated abnormal hippocampal TH signaling and action in DACD. Promoting TH action with exogenous L-T4 ameliorated hippocampal impairment through inhibiting IFN-I signaling-induced necroptosis.

目的 利用国家数据库描述人群碘营养与常见甲状腺疾病的变化趋势,分析全民食盐加碘与疾病的关联,探讨补碘的时间滞后效应,为碘缺乏病的防治提供科学依据.方法 结节性甲状腺肿、甲状腺机能亢进症和甲状腺良性肿瘤的出院人数来自国家卫生主管部门发布的《统计年鉴》;人群补碘水平根据全国碘盐监测和碘缺乏病监测提供的数据计算;儿童尿碘水平来自碘缺乏病监测,采用Eviews10.0软件中的多项式分布滞后模型(PDL)分析碘对甲状腺疾病的时间滞后效应.结果 人群补碘水平逐年下降,但仍在142.55μg/(天?人)水平,它与儿童尿碘中位数相关(r=0.93,P＜0.05).结节性甲肿、甲亢和良性甲瘤出院率呈上升趋势,2018年结节性甲肿出院率比2013年增长11倍,甲亢增加6.6倍.PDL模型分析结果显示补碘水平对结节性甲肿和甲亢的出院率存在滞后效应且有统计学意义,分别是5年或7年,且仍为负效应关系.结论 在碘适宜环境中,从碘盐中获取的碘营养可能不是结节性甲肿、甲亢和甲状腺良性肿瘤患者人数上升的危险因素,而可能是保护因素.

目的 探讨和分析妊娠期亚临床甲状腺功能减退症(SCH)的妇女在10年后甲状腺功能的结局.方法 对241例妊娠期妇女进行前瞻性随访,随访时间为产后10年,以促甲状腺激素(TSH)、游离甲状腺激素(FT4)和抗甲状腺过氧化物酶抗体(TPOAb)为实验室诊断指标,分别采用阎氏妊娠期特异参考值范围和成人实验室标准诊断.结果 妊娠期和10年后随访妇女的SCH患病率分别为18.3％和10.4％(P＜0.05).妊娠期SCH妇女中,10年后有36.4％仍为SCH.妊娠期甲状腺功能正常的妇女中,10年后有4.6％发展为SCH,1.5％发展为甲减,TPOAb阳性占比分别为22.2％和66.7％.对比10年后甲功诊断,阎氏标准的准确度、灵敏度、特异度、假阳性率分别为84.2％、60.0％、87.7％、12.3％.Kappa值为0.38(P＜0.05).10年后随访妇女与妊娠早、中、晚期妇女的TSH和FT4均存在相关性(P＜0.05).结论 妊娠期SCH妇女在10年后仍有很大比例存在SCH,TPOAb阳性可能是产后甲功减退的危险因素,采用妊娠期参考值可能会提高诊断的准确度,建议妊娠期SCH妇女产后复查.

目的 应用自动化碘分析仪可能是解决监测工作量大,对县级技术人员要求高的选择之一,为此,选择基层技术人员,通过观察他们操作DAT-560所实现的精密度和结果可靠性水平,说明全自动碘分析仪的实用性和可靠性.方法 由县级技术人员操作全自动碘元素分析仪(DAT-560),完成设备可操作性试验、方法特性试验,包括工作曲线试验、精密度试验和准确度实验.结果 DAT-560检测0～300μg/L范围内尿碘,工作曲线方程r=-0.9997;精密度实验中相对标准偏差为1.37％～ 2.78％;不同浓度标准物质平均加标回收率在99.1％～101.9％之间,不同浓度尿样稀释后按稀释倍数还原后测定值与原来定值的相对偏差在2.36％～4.26％之间;30份现场尿样的测定结果与卫生行业标准方法测定值比较,差异无统计学意义(P＞0.05),3人测同一样本,差异无统计学意义(P＞0.05).结论 DAT-560用于县一级疾控尿碘监测有着良好适用性、高可靠性与精确度.

Objective:Placental iodide transport is necessary for maintaining an adequate iodide supply to the developing fetus. We hypothesized that compounds from the placental barrier can compensate for decreases in maternal iodine intake and normalize fetal iodine levels. Methods:Pregnant rats administered different amounts of iodine (1.24, 2.5, 5, or 10 mu g/day) were evaluated on gestational day (gd) 16 and 20. The iodine levels in maternal blood, amniotic fluid (AF), and placental tissue were estimated using As-Ce catalytic spectrophotometry. The protein and/or messenger RNA (mRNA) levels of sodium iodide symporter (NIS), pendrin, alpha-smooth muscle actin (alpha-SMA), and CD31 in the placental labyrinth, trophoblast cells isolated using laser capture microdissection (LCM), and/or fetomaternal thyroid were detected using immunoblotting, real-time polymerase chain reaction, and/or immunohistochemistry. Results:When iodine intake was reduced, iodine levels in maternal blood gradually decreased; however, placental iodine levels were not significantly different between groups on gd16 and gd20. Minimal changes were observed in AF iodine levels on gd16, and a mild decreasing trend was observed (iodine dose, 10 to 1.24 mu g/day) on gd20. NIS protein, which was linearly distributed along the basolateral membrane of maternal-fetal thyroid follicles, gradually increased with decreasing iodine levels. Regarding iodine deficiency in the placental labyrinth on gd16 and gd20, pendrin and glycosylated NIS proteins were significantly upregulated in a dose-dependent manner. However, the mRNA levels were unchanged. Furthermore, the conversion of NIS protein from the nonglycosylated to the glycosylated form increased. In trophoblast cells isolated using LCM,PDSmRNA levels increased in the 1.24-mu g/day group on gd16 but notNISmRNA levels. There was a smaller alpha-SMA(+)area in the labyrinth zone on gd16 and gd20; however, the proportional CD31(+)area increased on gd16 and reduced on gd20 with decreased iodine levels. Conclusions:All mechanisms upregulating the expression of iodine transporters and changes in villous stroma and microvessel area in the placental labyrinth can promote iodide transfer from mother to fetus in iodine deficiency, especially before the onset of fetal thyroid function. Compensatory NIS protein regulation in the placenta against decreased iodine intake mainly occurs during translation and glycosylation modification after translation. Pendrin may be more important than NIS in the mediation of placental iodide transport.

In response to the recent interest in potassium iodate iodized (KIO 3) salt safety, we reviewed the background of KIO 3 in replacing of potassium iodine (KI) as salt fortificator and its effect in prevention and control of iodine deficiency disorders (IDD) or endemic goiter, the decision-making changes of fortificator of iodized salt in China, the research and progress of toxicology, and whether IO 3- exits in urine without decomposition or not. Our inclusions are: it is believed that the decision of the international organizations and agencies of national and local governments about the safety of KIO 3 in iodized salt is supported by adequate and scientific evidents. When it comes to the safety of KIO 3 added in iodized salt, it must be based on the trace amount of KIO 3 in salt which is limited while intaking. Reductive substances in food, cooking heating or reduction system of human body might quickly reduce trace IO 3- to I -, therefore, IO 3- might not be found in fresh urine.

Iodine is an essential element in the synthesis of thyroid hormones. The normal brain development of children depends on thyroid hormone, and the critical period is in the first three years of life. Iodine deficiency is the most influential and preventable factor that is known to cause brain neurodevelopmental disorders in children. Therefore, research on the relationship between iodine nutrition and thyroid function of pregnant women and brain development of offspring has always been a hot spot in the research and prevention of iodine deficiency disorders. However, there has been no clear conclusion on the influence and extent of thyroid dysfunction such as hidden iodine deficiency in pregnant women (urinary iodine is 100-150 μg/L), subclinical hypothyroidism and hypothyroidism on the brain development of offspring. This article reviews the research in this field, the related research on the effects of iodine deficiency, iodine supplementation and iodine overdose on children's brain development, and introduces the preventive and therapeutic effects of iodine and thyroxine supplementation during pregnancy.

Objective To investigate the expression of MCT8,DCX,SHH and ARC/ARG3. 1 in brain neurons of neonatal rats exposed to thyroid dysfunction in uterus.Methods Wistar pregnant rats were randomly divided into control group and experimental groups in which rats were drunk water with 1, 3, or 5 ppm propylthiouracil

目的 阿克苏地区曾是严重碘缺乏病流行地区,持续评估人群碘营养状况非常必要.方法 根据《全国碘缺乏病监测方案(新修订)》,在阿克苏地区所辖区8县1(市),采集8 ～ 10岁在校儿童和孕妇尿碘,对儿童做B超检查甲状腺肿,并收集居民户食用盐样,采取的尿样和居民户盐样分别采用WS/T 107.1-2016和GB/T13025.7检测.结果 居民户合格碘盐食用率为97.2％,儿童甲状腺肿大率1.3％,儿童尿碘中位数为217.0 μg/L;孕妇尿碘中位数为217.0 μg/L.结论 总体上儿童和孕妇碘营养适宜,没有碘缺乏病流行,阿克苏地区碘缺乏病处于持续消除状态.

目的 针对甲状腺功能正常的抑郁症患者,比较不同促甲状腺素(TSH)水平时患者的抑郁情况,探索正常甲状腺功能对抑郁症的影响.方法 选取在天津市精神卫生中心住院治疗的甲状腺功能正常的符合《国际疾病分类(第10版)》(ICD-10)诊断标准的抑郁症患者77人,根据TSH水平是否大于中位数,将患者分为TSH低值组(n=51)和高值组(n=26).采用汉密尔顿抑郁量表17项版(HAMD-17)评定患者抑郁情况,比较两组的抑郁状态.结果 TSH低值组自杀、胃肠道症状和疑病项目评分均高于TSH高值组,差异均有统计学意义(t=-1.11、2.42、2.32,P均<0.05).结论 甲状腺功能正常的抑郁症患者,TSH水平越低,抑郁情绪越明显.

Objective To understand the awareness level of iodine deficiency (ID) impairments and the attitude on edible iodized salt,and its consumption among doctors and nurses in cities,in order to provide scientific evidence for health education on iodine deficient disorders (IDD) in the future.Methods The questionnaire was self-designed,and spread through the web page of Wenjuanxing,an online server company,from May 6 to June 6,2017.At the end of the survey,a total of 481 valid questionnaires were reclaimed,in which ratio of gender was female 63.8％ (307/481),male 36.2％ (174/481).The data were analyzed by SPSS 22.0,including logistic regression analysis with backward according to the statistical significant level of P ＜ 0.05.Results Among doctors and nurses,90.4％ (435/481) knew ID impairments;72.8％ (350/481) answered intelligent disability as the most serious problem of ID;55.5％ (267/481)misunderstood that the areas in which they lived were not ID areas,although all cities surveyed were ID areas;41.0％ (197/481) of doctors and nurses misunderstood that coastal residents did not need to consume iodized salt.About the evaluation of iodine nutrition status of current population,15.6％ (75/481) of respondents judged as iodine excess.About consuming edible salt,76.3％ (367/481) selected iodized,9.6％ (46/481)non-iodized,and 14.1％ (68/481) both iodized and non-iodized.The results of logistic regression analysis showed the factors that prevents health care workers from choosing iodized salt were:"living in coastal areas","think him or her as iodine adequate","know that iodine deficiency can affect the development of children but still adhere to the consumption of non-iodized salt";the factors that promoted the choice of iodized salt for medical staff were "insist on buying iodized salt,and do not choose non-iodized salt",and 75.8％ (238/314)of them knew that intelligent disability as the most serious problem of ID.Conclusions Most doctors and nurses have high level of knowledge on ID and its control.But lack of information,as well as misunderstanding of "coastal areas iodine adequate" and worry about "excess iodine causes thyroid diseases and cancer",which would hinder the active consumption of iodized salt.Health education for them should be conducted through professional ways,stressing on the threaten of ID environment,sharing the information about national and local progress on control of IDD and iodized salt safety,and clarifying the relationship between iodine salt or iodine and thyroid cancer and nodules.

Iodine is an essential element for the thyroid hormone (TH) synthesis. It is well known that TH is involved in the regulation of genes related to fetus brain and neural development during pregnancy. The roles of TH in brain and neural development will even last to 3 years after birth. Fetal TH in the first and second trimesters originally comes from the free thyroxine (FT4) of pregnant women. Fetus in the last trimesters can produce TH which depends on the iodine supplements from pregnant women. The studies from the iodine-deficient areas showed that the iodine deficiency resulted in the brain impairment, and that the severity of brain impairment was related to the severity of iodine deficiency, such as endemic cretinism, subclinical endemic cretinism and intelligence impairments. The risks of TH deficiency and fetus brain impairment were increased even in those pregnant women with the latent iodine deficiency. The iodine replacement therapy in the iodine-deficient areas(iodized salt or iodized oil, etc.) can effectively prevent from offspring intelligence impairments. Excessive iodine intake usually happened in the areas with excessive iodine in drinking water. Studies of human being and animal suggested that the fetus developing brain can tolerate the excessive iodine in a certain extent. However, pregnant women should avoid the exposure to excessive iodine environment for long term. The test of 24 hours urinary iodine is available method for the evaluation of individual iodine nutrition. The iodized salt is a safe, effective and convenient supplement of iodine nutrition for those pregnant women with iodine deficiency. The adviced iodine intake is 200-500μg/d for pregnant women.

目的 评估实施免费碘盐供应以来新疆阿克苏地区人群碘营养状况.方法 按《全国碘缺乏病监测方案(修订稿)》的抽样要求,在阿克苏地区所属的9个县市中抽取45个乡(镇)开展碘盐监测,采集居民户食用盐盐样;抽取其中27个乡(镇)小学的8～10岁在校学生(每个年龄30人,男女各半),采集1次性随意尿样测定尿碘,B超检查甲状腺肿大情况,采用中国联合型瑞文测试实施团体测验评估智商(IQ);在抽取小学附近,抽取孕妇20名,采集1次性随意尿样测定尿碘.两个人群均进行碘缺乏病防治知识知晓率调查.盐碘测定采用直接滴定法,其他强化食用盐采用仲裁法(GB/T 13025.7-2012);尿碘测定采用过硫酸铵消化-砷铈催化分光光度法.结果 共采集居民家中盐样2700份,盐碘含量平均值为(26.95±5.10)mg/kg,碘盐覆盖率为98.56％(2 661/2700),合格碘盐食用率为98.00％(2 646/2 700).共采集8～10岁学生尿样2 159份,尿碘中位数为235.50μg/L;甲状腺B超检查8～ 10岁学生2 179人,肿大率为1.51％(33/2 179);IQ测定8～ 10岁学生2 098人,平均得分为88.03±17.14.共采集孕妇尿样1 047份,尿碘中位数为213.50μg/L.学生和孕妇碘缺乏病防治知识平均知晓率分别是98.82％(751/760)、99.23％(258/260).结论 阿克苏地区贫困人群实施免费碘盐供应后,儿童和孕妇的碘营养状况良好,人群防治意识明显提高,免费碘盐供应在贫困地区的碘缺乏病防治中发挥了重要的作用.

为了探讨营养性铁缺乏对妊娠期妇女甲状腺功能的影响,2008至2009年在新疆阿克苏地区调查妊娠期妇女,测定尿碘、铁蛋白、TSH 、TT3、TT4、FT3、FT4和血红蛋白水平.共调查妊娠期妇女639例,尿碘中位数为198.59 μg/L,其中孕早、中、晚期铁缺乏组(ID组)、缺铁性贫血组(IDA组)、正常对照组的尿碘中位数均大于150 μg/L,组间无显著差异(P＞0.05).单纯铁蛋白＜15μg/L者占44.2％ (250/565),缺铁性贫血者占17.5％ (99/565).随着妊娠的发展,孕妇血红蛋白和铁蛋白逐渐下降,孕早、中、晚期差异有统计学意义(P＜0.05).孕中、晚期的铁营养水平与甲状腺功能相关检测指标组间有统计学意义,其中孕中期血清FT4水平在IDA组明显高于ID组和正常对照组(P＜0.05),孕晚期IDA组FT4水平高于ID组和正常对照组,且与ID组比较差异有统计学意义(P＜0.05),IDA组FT3/FT4水平与ID组和对照组比较呈下降的趋势,且与ID组比较差异有统计学意义(P＜0.05),而在孕早期的铁营养水平与甲状腺功能各个检测指标组间差异无明显的统计学意义.相关分析发现,孕早、晚期血红蛋白水平与甲状腺功能指标存在一定的相关性(P＜0.05).当孕妇碘缺乏被完全纠正后,铁缺乏仍然可能会影响甲状腺功能.

目的:对比首发精神分裂症患者,与精神分裂症超高危人群的神经认知功能特点及相关因素.方法:分别纳入30例首次发作未接受过系统治疗的精神分裂症患者(患者组)、30例来自一级亲属中的超高危人群-精神病风险综合征者(超高危组),以及30例健康志愿者(对照组)作为被试对象,采用连线测验(TMTA)、精神分裂症简易认知评估:符号编码、霍普金斯词语学习测验修订版(HVLT-R)、简易视觉记忆测验-修订版(BVMT-R)、Stroop色词测验持续操作测验(CPT)、威斯康星卡片分类测验(WCST)对注意力、学习和记忆、信息处理速度以及执行功能4个领域进行全面评定.结果:与正常对照组相比,首发精神分裂症患者在认知功能注意能力/警觉性、学习与工作记忆、信息处理速度及执行功能4个领域的差异有统计学意义(P＜0.05),而超高危组则在除空间记忆(BVMT-R)和信息处理速度中的TMTA测验外的其它方面均与对照组存在差异(P＜0.05),差异小于患者组.认知功能指标中仅CPT与病程呈负相关(P＜0.05),WCST持续错误数与PANSS得分呈正相关(P＜0.05).结论:精神分裂症高危人群存在相对广泛的认知功能损害,但轻于首发精神分裂症患者,认知功能缺陷可能是精神分裂症的素质指标之一.

目的 观察哺乳期妇女口服400 mg及200 mg碘油丸后妇女及其婴儿的碘营养状况.方法 在新疆阿克苏地区两个村选择81名近半年未服用过碘油丸的哺乳期妇女,分别一次性口服400 mg或200 mg碘油丸,服药前采集妇女及其婴儿一次性随意尿样,在服药后第1至9个月每月采集妇女一次性随意尿样,第1、3、6个月每月采集婴儿一次性随意尿样,采用砷铈催化分光光度法测定尿碘.结果 在干预后的9个月中,两组妇女尿碘中位数均高于干预前,差异有统计学意义(P＜0.05).除第3个月外,其他时间两组妇女尿碘中位数均为400 mg组高于200 mg组,两组之间在第7、9月差异有统计学意义(P＜0.05).干预后两组婴儿尿碘中位数均高于干预前,差异有统计学意义(P＜0.05).400 mg组婴儿尿碘中位数始终高于200 mg组,两组间仅第1个月差异有统计学意义(P＜0.05).结论 两种剂量碘油丸均可提高哺乳期妇女及婴幼儿碘营养水平;400 mg碘油丸效果持续时间更长;在妇女日常食用碘盐的情况下,200 mg碘油丸对母子更加安全.

目的 了解新疆南疆地区碘缺乏病防治现状,掌握病情变化,评估防治效果.方法 选择新疆南疆缺碘较为严重的和田地区洛浦县和克州地区阿克陶县的农村,选择8～ 10岁学龄儿童和育龄期妇女作为调查对象.采取现况调查与追溯历史资料调查相结合的方法,将专家分成克汀病临床诊断组、学校碘缺乏病调查组和入户碘缺乏病调查组,分别开展工作.对当地县疾控中心和乡医院经病例搜索出的疑似克汀病儿童(≤10岁)进行诊断.每个乡选择1所小学,调查100名8～ 10岁儿童,用B超法测定其甲状腺体积,测查智商,采集尿样检测尿碘含量.每个乡调查30名20 ～ 50岁育龄妇女,用触诊法检查甲状腺大小,采集尿样测定尿碘含量,用半定量法检测其家中盐样,并送实验室定量测定盐碘含量.每个乡采集水样测定水碘含量.结果 ①在洛浦县、阿克陶县未发现新发克汀病儿童;②洛浦县和阿克陶县8～ 10岁儿童尿碘中位数分别是201.6、174.2μg/L;B超法检查儿童甲状腺肿大率分别为0.5％(1/200)和3.5％(7/200);③洛浦县和阿克陶县8～ 10岁儿童平均智商分别是91.9和87.7;④洛浦县和阿克陶县20～50岁育龄期妇女尿碘中位数分别为163.9、192.3μg/L;⑤洛浦县和阿克陶县居民户碘盐覆盖率分别为96.7％和95.1％,居民合格碘盐食用率分别为91.7％(55/60)和85.2％(52/61),盐碘均数分别为25.9、24.8 mg/kg;⑥洛浦县和阿克陶县居民户饮用水含碘量最大值分别为3.27、3.60 μg/L.结论 新疆南疆地区8～ 10岁儿童和育龄妇女碘缺乏病病情已得到有效控制,碘缺乏病防治效果显著.

Objective: To investigate the predictors of drive for thinness and body dissatisfaction in female students from a medical college in Tianjin.Methods: A total of 181 female students took part in the study.They completed the Drive For Thinness of EDI,the Body Dissatisfaction of EDI,BMI-based Silhouette Matching Test(BMI-SMT) and the Sensitive interpersonal relationship of SCL-90.Results: While the weight satisfaction,the deviation of perception and the deviation of expectation for individual were found to be forecasters of drive for thinness,the weight satisfaction,the deviation of perception were found to be predictors of body dissatisfaction.For those in the group of normal Body Mass Index,the deviation of perception,the deviation of expectation of one's own body were significantly higher than those in the group of underweight;the body-esteem and weight satisfaction were significantly lower,their body dissatisfaction and drive for thinness were significantly greater.Conclusion: For female college students,the cognitive distortion,the unreasonable expectation of one's own body and the low weight satisfaction are important factors to influence their drive for thinness;and their own unreasonable expectations and the low weight satisfaction are important predictors of body dissatisfaction.

目的 评估新疆阿克苏地区自2007年实施应急补碘措施2年后孕妇及哺乳期妇女碘营养现状,为碘缺乏病防治工作提供依据.方法 2008-2009年间在拜城和乌什两县碘缺乏病区抽样调查了869名孕妇(占同期孕妇的73.4%)及302名哺乳期妇女,采集其一次随意尿样,并入户采集盐样和饮用水样.盐碘的测定采用直接滴定法,尿碘和水碘测定采用过硫酸铵消化-砷铈催化分光光度测定法.结果 两县水碘中位数为2.24 μg/L,范围为1.12～4.81μg/L.合格碘盐食用率为98.4%.拜城和乌什县孕妇尿碘中位数分别为164.66、187.02 μg/L,其中察尔齐、大桥和托克逊乡孕妇分别为125.54、144.15和77.60μg/L.拜城和乌什县哺乳期妇女尿碘中位数分别为299.84、271.37μg/L.随着妊娠的发展,孕妇尿碘水平逐渐下降,但差别无统计学意义.结论 两县孕妇和哺乳期妇女的碘营养得到明显改善,目前的应急措施尚需维持,但同时要加强监测.

Objective To conduct the iodine nutrition status of the lactating women and infants in Wushi and Baicheng County of Akesu region.Methods With the method of multiple stagecluster sampling,251 urine samples of lactating women and 216 urine samples of infants were tested in Baicheng county and Wushi county.Ammonium persulfate digestible-arsenic-cerium catalyzed spectro photometry was used to detect single random urine of the lactating women and infants in those villages.Amount of iodine in edible salt were tested by using direct titration method.Results A total of 251 urine samples of lactating women and 216 urine samples of infants were tested.As a result,the median urinary iodine of lactating women was 245.88 μg/L,the samples with iodine 150 μg/L were accounting for 23.35%.The median urinary iodine of infants was 195.58 μg/L,the samples with iodine 150 μg/L were accounting for 35.1%.The median urinary iodine of lactating women in the Baicheng and Wushi county were 256.60 μg/L and 229.86 μg/L.The median urinary iodine of infants in the Baicheng and Wushi county were 205.47 μg/L and 167.86 μg/L.The median salt iodine of lactating women and infants in the Baicheng and Wushi county were 34.46 mg/kg,reached the national recommended standard(20～50 mg/kg).Conclusion A portion of the lactating women and the infants has insufficient iodine nutrition in this region.Effective and targeted measures to supplement the iodine should be taken promptly in light of the local conditions to prevent mental retardation caused by iodine deficiency.