Objective To observe the impacts of deanxit combined with liuweianxiao capsule on dyspepsia and life quality of the patients with functional dyspepsia(FD).Methods 158 cases of FD were randomized into two groups.Liuweianxiao capsule was administered orally,3 capsules,3times/d in control group(79 cases).On the basis of the therapy as control group,the anxiolytic and antidepressant,deanxit was administered orally,1 tablet,once per day in treatment group(79 cases).The duration of treatment was 8 weeks in two groups.Life quality scale(questionnaire of life quality index,QL-INDEX)and dyspepsia scale were used to evaluate the patients before treatment,4 weeks and 8 weeks after treatment separately.Results The score of dyspepsia in 4 weeks and 8 weeks after treatment:the persistent duration of symptom in treatment was lower than that in control group(P0.01).The life quality score:the score in treatment group was higher than that in control group(P0.01).Conclusion Deanxit combined with liuweianxiao capsule improve apparently in dyspepsia and life quality in the patients with functional dyspepsia.

Objective To study the cost-effectiveness and quality of life on different treatment protocols for patients with peptic ulcer. Methods 165 patients of helicobacter pylori positive peptic ulcer were divided into three groups randomly, Group A: 55 cases ( Omeprazole Capsules + Amoxycillin Capsules + Furazolidone Tablets). Group B: 55 cases (Esomeprazole + Amoxycillin Capsules + Clarithromycin Tablets). Group C:55 cases (Bismuth Postassium Citrate Capsules + Amoxycillin Capsules + Metronidazole Tablets). The treatment course of each group was four weeks. We studied the HP eradication and response rate of ulcer, evaluated three treatment protocols by cost-effectiveness analysis of pharmacoeconomics and appraised patients' quality of life through QLICD-PU before and after three 、six months treatment separately. Results The cost-effectiveness comparison of three groups indicated that the comparative difference of Group A and B had no statistical significance, but the two groups had one more unit of curative effect than Group C. The cost of Group B was obviously less than that of Group A. While Group C compared with Group A and B, the difference had obvious statistical significance ( P ＜ 0. 05 ). The comparison of life quality score of three group indicated that difference of Group A and B had no statistical significance, while Group C compared with Group A and B, the difference had obvious statistical significance ( P ＜ 0. 05 ). Conclusion The comparison of cost-effectiveness and quality of life of three group showed that the treatment protocol of Group B had best curative effect. It is cost-effective and can improve patients' life quality.

目的 寻找一种简便且费用较低的幽门螺杆菌临床菌株的分离培养方法,以提高幽门螺杆菌临床菌株的培养阳性率.方法 将284例胃黏膜标本采用盲涂法接种于含10%绵羊血的哥伦比亚选择性培养基上,并对其中的40例胃黏膜标本采用二氧化碳培养箱法(5%～10%CO2)和有机玻璃罐中充入混合气体法(5%02、10%CO2、85%N2)进行对照培养,培养3～7天后,把分离培养成功的幽门螺杆菌临床菌株经革兰染色及生化反应鉴定后,保存于-80℃冰箱.结果 有机玻璃罐中充入混合气体法优于二氧化碳培养箱法.结论 有机玻璃罐中充入混合气体法更适合于幽门螺杆菌临床菌株的分离培养,且幽门螺杆菌临床菌株的培养阳性率与入选病人的性别、年龄无关.

[Objective]To analyze the HP's drug resistance rate of 5 major antibiotics and inquire into the economic effect of the different treatment plans for peptic ulcer relevant to Hp in Lvliang,Shanxi province.[Methods]Samples of gastric mucosa were segregated and cultured in diagnosis of Hp clinical strain.The 104 successful samples were given the susceptibility test by paper disk method to 5 major antibiotics.According to the result of susceptibility test,135 positive samples of Hp culture were selected and devided into three groups at random:45samples of A group(Omeprazole + Amoxil+ Furaltadone);45 samples of B group(Astravenbca +Amoxil+Clarithromycin);45 samples of C group(Colloidal bismuth subcitrate + Amoxil + Arilin).The course of treatment on 3 groups were all 4 weeks.The eradicating rate of Hp and coalescence rate of peptic ulcer were observed.Pharmacoeconomics'cost-effect analysis was used to evaluate the three kinds of treatments.[Results]The positive rate of Hp culture was 36.6%.The drug resisitance rate of Arilin was 75.3%;Clarithromycin 7.4%;Amoxil 7.4%;Levofloxacin 12.4%;Furaltadone 8.6%.The eradicating rate of Hp:A group was 91.12%,B group 93.33%,C group 51.12%.The coalescence rate of ulcer:A group was 93.34%,B group 95.56%,C group 42.23%.The cost effect analysis,the increasing cost-effect analysis(△C/△E)and rearising rate of ulcer in 1 year indicate B group was the best scheme for peptic ulcer relevant to Hp.[Conclusion ]Bacterial culture,susceptibility tests,and pharmacoeconomics are very important in optimizing treatment plans,guiding rational drug usage and increasing economic efficiency.

目的 探讨不同治疗方案对Hp相关性消化性溃疡治疗的经济效果.方法 选取162例Hp阳性的消化性溃疡患者,其中胃溃疡65例,十二指肠球部溃疡97例.随机分成三组:A组54例(奥美拉唑胶囊+阿莫西林胶囊+呋喃唑酮片);B组54例(埃索美拉唑片+阿莫西林胶囊+克拉霉素片);C组54例(枸橼酸铋钾胶囊+阿莫西林胶囊+甲硝唑片).三组疗程均为4周.观察Hp根除率及溃疡总有效率,并运用药物经济学的成本-效果分析法对Hp相关性消化性溃疡的3种治疗方案进行分析评价.结果 Hp根除率A、B、C组分别为92.59%、90.74%、48.15%;溃疡总有效率A、B、C组分别为94.44%、90.74%、40.74%.A、B、C组Hp根除率的成本与效果比分别为14.92、12.74、12.95,溃疡总有效率的成本与效果比分别为14.63、12.74、15.31.A、B、C组Hp根除率的增量成本与效果比分别为17.06、12.50、0,溃疡总有效率的增量成本与效果比分别为14.12、10.65、0,故Hp相关性消化性溃疡患者采用B组治疗方案最佳.结论 药物经济学在优化治疗方案、指导合理用药及提高经济效益方面具有重要作用.

目的探讨多塞平配合心理支持治疗功能性消化不良的临床疗效。方法将门诊168例功能性消化不良患者随机分成治疗组和对照组,分别予以莫沙必利、雷尼替丁治疗。治疗组加用多塞平(doxepin)及心理支持治疗。结果治疗4周后统计结果,治疗组显效45.2%,有效39.3%,总有效率84.5%,治疗组与对照组的疗效有显著差异,P<0.01。结论多塞平及心理支持治疗与莫沙必利联合使用可显著提高功能性消化不良的临床疗效,值得推广。