Three novel pyran derivatives (1-3) were synthesized and characterized via IR, 1H NMR, HRMS, and single crystal X-ray crystallography. The anti-osteosarcoma activities of the three compounds were investigated against three human osteoma sarcomatosum cells (MG-63, U-2 OS, and HOS) by MTT assay. The results showed that compared with compounds 1 and 2, compound 3 exerted rather potent activities against the three cell lines.

目的 探讨颅脑外伤患者早期血清超敏C反应蛋白(hs-CRP)与伤后抑郁的相关性分析.方法 选取2012年4月至2015年4月我院收治的185例颅脑外伤患者为研究对象,检测所有患者入院时、入院12h、入院24h的血清hs-CRP水平,记录患者相关临床资料,按照伤后是否出现抑郁将患者分为抑郁组(n=48例)和非抑郁组(n=137例),比较两组患者相关临床资料的差异.结果 185例颅脑损伤患者中出现伤后抑郁的有48例(发病率25.9％);抑郁组中患者入院时格拉斯哥昏迷评分(GCS)低于非抑郁组(P＜0.05)、低氧血症的比例高于非抑郁组(P＜0.05);抑郁组中患者入院12h、24h的血清hs-CRP水平高于非抑郁组(P＜0.05);回归分析提示入院12h的血清hs-CRP(OR=1.887,P＜0.05)、和24h的血清hs-CRP (OR=1.452,P＜0.05)是颅脑损伤患者中出现伤后抑郁的独立危险因素.结论 血清hs-CRP与颅脑外伤后抑郁的发生具有一定的相关性,早期检测血清hs-CRP水平对于评估伤后抑郁的发生具有一定的临床意义.

OBJECTIVE To summarize the complications and the early clinical effect of less invasive stabilization system and the femoral condylar support plates in the treatment of AO type C distal femoral fractures. METHODS From September 2007 to February 2012, 46 patients with AO type C distal femoral fractures were retrospectively studied. Of all patients 25 were treated with less invasive stabilization system including 14 males and 11 females with a mean age of (56.3±4.2) years old; according to AO classification, there were 14 cases of C1, 8 cases of C2 and 3 cases of C3 with a mean hospital stay of (15.6±1.7) days. While 21 cases were treated with femoral condylar support plates fixation including 12 males and 9 females with a mean age of (53.8±5.1) years old;there were 13 cases of C1, 6 cases of C2 and 2 cases of C3 with a mean hospital stay of (17.8±2.2) days. Comparative analysis was performed from the operation related index,postoperative complications and Evanich score of the knee joint function between the two groups at follow-up. RESULTS All 46 patients were followed up from 13 to 38 months with a mean time of 19.6 months after surgery. Complications included 1 case with infection,3 cases with internal fixation failure, 1 case with nonunion and 1 case with activity limitation of the affected knee. The differences in the incision length, blood loss, fracture healing time were significant between two groups (P<0.05), while there was no significant difference in the duration of operations, hospital stays and the incidence of postoperative complications between two groups (P>0.05). The statistical significance was also found in the Evanich score at last follow-up between two groups (P<0.05). CONCLUSION Patients with less invasive stabilization system fixation had the characteristics of less trauma, shorter fracture healing time and better functional recovery. Less invasive stabilization system had became one of the ideal internal fixations in the treatment of AO type C distal femoral fractures.

Objective To summarize complications and early clinical effect of less invasive stabilization system and the femoral condylar support plates in treatment of AO type C distal femoral fractures. Methods We reviewed 46 patients who had internal fixation of AO type C distal femoral fractures. Of all 46 patients, 25 were with less invasive stabilization sys-tem and 21 were with femoral condylar support plates fixation. Comparative analysis was performed using intraoperative in-dex, postoperative complications and the Evanich score at follow-up. Results All 46 patients were followed up with a mean time of 19.6 months after surgery. The difference in incision length, blood loss, fracture healing time was significant between the 2 groups(P<0.05)but not in the duration of operations and hospital stays(P>0.05). The statistical signifi-cance was also found in the total incidence of postoperative complications and the Evanich score at the last follow-up(P<0.05). Conclusion Patients with less invasive stabilization system fixation had the characteristics of less trauma, shorter fracture healing time, less postoperative complications and better functional recovery compared with femoral condylar sup-port plates. Less invasive stabilization system had became an ideal internal fixation in treatment of AO type C distal femoral fractures.

Objective To summarize the outcome and complications of minimally invasive proximal humerus internal loc-king system( PHILOS)and the nonoperative treatment for pediatric subtrochanteric femur fractures. Methods A total of 24 children with subtrochanteric femur fractures treated with proximal humerus internal locking system and nonoperative treatment between Febrary 2005 and Febrary 2011 were identified. We retrospectively compared 15 children treated with minimally inva-sive proximal humerus internal locking system to 9 children treated nonoperatively. Comparative analysis was performed from the length of hospitalization,time to radiographic union,time to full weightbearing,outcome scores and postoperative complica-tions. Results All 24 patients were followed up for a mean time of 31. 5 months after surgery. The difference in the length of hospitalization,time to radiographic union and time to full weightbearing was significant for the 2 groups(P<0. 05). Outcome scores were significantly better in the proximal humerus internal locking system group(P<0. 05)and the overall complication rate was lower compared with nonoperative group(P<0. 05). Conclusion Our results indicate that minimally invasive proxi-mal humerus internal locking system of pediatric subtrochanteric femur fractures is associated with better outcome scores and a lower overall complication rate when compared with nonoperative group. Minimally invasive proximal humerus internal locking system had became one of the ideal treatment of pediatric subtrochanteric femur fractures.

目的 探讨Maisonneuve骨折的特点,提高临床认识,减少漏诊,同时给予正确的修复内侧结构,恢复踝关节功能.方法 患者外踝均采用钢板固定,内侧结构均给予固定,6例采用松质骨螺钉固定,3例采用锚钉固定,2例采用克氏针固定；下胫腓联合均采用单枚螺钉经或不经钢板孔固定.结果 该组11例,按照美国足踝骨科协会(American Orthopedic Foot&Ankle SocietyAOFAS)推荐的足踝评分系统评分恢复优5例,良4例,可2例.结论 要认识Maisonneuve骨折是踝关节骨折Lauge-Hansen分型中旋前-外旋型Ⅲ度骨折,AO分型中C型骨折,是较少见的一种骨折类型,减少漏诊的发生,并予可靠的固定,尤其是内侧结构,才能降低该病的致残率。

<正>笔者医院自2005年以来通过手术治疗髋臼骨折23例,取得良好效果,现报道如下。资料与方法1一般资料本组23例,采用经腹直肌外缘入路,5例加用Kocher-Langenbeck入路。男性16例,女性7例,年龄23～56岁,平均37.5岁。致伤原因:车祸伤14例,坠落伤9例。骨折按Letournel分类:前壁骨折7例,前柱骨折10例,后柱骨折1例,双柱骨折3例,T形骨折2例。合并伤:髋关节中心性脱位3例,失血性休克2例,脊柱骨折2例,四肢骨折3

<正>2009年1月至2010年3月我科采用小切口椎板开窗髓核摘除术治疗腰椎间盘突出症患者38例,取得了良好效果,现报道如下。资料与方法1一般资料本组纳入标准:①确诊为腰椎间盘突出症的患者;②MRI示椎间盘突出压迫马尾或神经根,临床症状典

目的 探讨经伤椎椎弓根置钉后路钉棒系统内固定联合对侧椎弓根椎体内植骨在胸腰椎骨折中的疗效.方法 采用经伤椎单侧椎弓根椎体植骨,对侧椎弓根及上下椎体行后路钉棒系统内固定治疗胸腰椎骨折43 例,术前、术后及随访时行X线片检查,观察椎体高度及矫正Cobb角有无丢失,以及内固定物有无断裂、松动情况发生.结果 全部病例获得随访,无内固定物松动、断裂发生,术前、术后远期椎体高度丢失率、矫正Cobb 角丢失度方面比较,差异有统计学意义(P<0.05).结论 胸腰椎骨折经伤椎椎弓根椎体植骨联合伤椎置钉内固定后,可恢复伤椎椎体高度,重建脊柱的稳定性,防止术后远期椎体高度和矫正Cobb 角的再丢失以及内固定的松动、断裂.

目的:探讨腓骨闭合复位内固定方法治疗踝关节骨折疗效分析。方法:将98例踝关节骨折患者随机分为观察组和对照组,观察组45例,对照组53例。对照组采用腓骨常规切开复位内固定术治疗,观察组采用腓骨闭合复位内固定术治疗。结果:根据Baird-Jackson踝关节评分标准评价,观察组优38例,良5例,及格1例,差1例,对照组分别为39、5、4、5例。两组相比有显著性差异。结论腓骨闭合复位内固定方法治疗踝关节骨折具有损伤小,固定可靠、安全,骨折愈合率高的优点。