目的:探讨双乌痹痛胶囊治疗类风湿性关节炎的临床效果.方法:将2018年12月至2019年12月在石家庄市第三医院诊断为类风湿性关节炎的患者120例,随机分为观察组60例和对照组60例.观察组口服双乌痹痛胶囊,对照组口服雷公藤多甙片,两组疗程均为12周.观察用药前后临床症状、体征、病情变化,实验室指标等项目的变化.评估2组临床疗效及不良反应.结果:经过3个疗程治疗后,两组类风湿性关节炎患者临床症状均明显好转,其中观察组总有效率为93.33％,高于对照组的83.33％(x2=4.615,P=0.032),在治疗过程中两组患者均未出现导致停药的严重不良反应.结论:双乌痹痛胶囊治疗类风湿性关节炎临床疗效明显,可减轻患者的痛苦和经济负担.

Objective To observe the clinical effect of the integrated Chinese western therapy in treating acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods A total of 110 cases of patients with acute exacerbation of COPD were enrolled from June 2015 to May 2016 in Department of Internal Medicine of Lingshou County Hospital of Integrated Traditional Chinese Medicine and Western Medicine,which were divided into control group and observation group according to different treatment methods,55 cases in each group.Control group was treated with conventional western medicine,observation group was treated with traditional Chinese medicine on the basis of control group,both groups were treated for 2 weeks.The clinical effect and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than control group(P<0.05).There were no serious adverse events happened between the two groups.Conclusion Integrated Chinese western therapy have an obviously clinical effect in treating acute exacerbation of COPD,and with good safety.

目的 考察注射用盐酸溴己新雾化溶媒的用量以及与磷酸肌酸钠、果糖二磷酸钠注射液配伍禁忌.方法 应用2 ml、3 ml、5 ml、10 ml的0.9%氯化钠注射、注射用磷酸肌酸钠1 g、果糖二磷酸钠注射液5 g分别与4 mg盐酸溴己新进行混合试验,观察混合溶液的性状变化.结果 少于10 ml氯化钠注射液,均不能将溴己新完全溶解.注射用盐酸溴己新与磷酸肌酸钠、果糖二磷酸钠注射液混合后溶液浑浊.结论 注射用盐酸溴己新雾化时不宜采用较小剂量的0.9%氯化钠注射,4 mg本品溶媒用量至少为10 ml.注射用盐酸溴己新与磷酸肌酸钠、果糖二磷酸钠注射液存在配伍禁忌.

目的 探讨依达拉奉联合银杏达莫治疗急性心肌梗死的临床疗效.方法 选取灵寿县中西医结合医院2016年收治的急性脑梗死患者130例,随机分为观察组和对照组,各65例.入院后患者均给予常规药物治疗,观察组患者给予依达拉奉联合银杏达莫治疗,对照组患者给予依达拉奉治疗,两组患者的疗程均为2周.比较两组患者的临床疗效及神经功能改善情况,并密切关注患者不良反应发生情况.结果 观察组患者治疗总有效率高于对照组(P<0.05).治疗前,两组患者神经功能缺损情况比较,差异无统计学意义(P>0.05);观察组患者药物治疗2周后的神经功能缺损情况显著改善,且改善情况优于对照组(P<0.05).观察组患者不良反应发生率低于对照组(P<0.05).结论 在常规药物治疗的基础上,对急性脑梗死患者采用依达拉奉联合银杏达莫治疗是一种可行、有效、经济的治疗方法,临床疗效确切,可有效改善患者的神经功能,且安全性高.

目的:总结麻醉药品和第一类精神药品(简称麻精药品)处方登记和处方编号的工作方法,并评价处方登记和处方编号对麻精药品管理工作规范性的改进作用.方法:按照麻醉精神药品操作规范进行处方审核、登记与编号,采用随机数字表法抽查在实施麻醉精神药品处方规范化登记与编号前后各一个月的麻精药品处方共335张,逐张审核处方规范性.结果:操作规范实施后的处方规范率有明显提高,差异具有统计学意义(P=0.013).结论:严格监督落实处方登记和处方编号工作,可以提高麻精药品管理工作水平.

Objective To observe the effects of traditional Chinese medicine which supplements Qi and activates blood circulation on the treatment of the X-ray radiotherapy-induced lung injury.Methods Eighty-four patients who were given three-dimensional conformal radiotherapy were randomized into treatment group and control group.The patients in treatment group were given traditional Chinese medicine, which supplements Qi and activates blood circulation, while the patients in control group were given antibiotics and hormone instead.Results The outcome of treatment group was better than that of control.The response rates were 88.6％ and 60.0％, respectively (x2 = 9.16, P ＜ 0.05) .Compared with the patients in control group, the clinical manifestations and pulmonary CT reflected better response in the patients of the treatment group(x2 =12.22,P ＜ 0.05) .Conclusion The traditional Chinese medicine, which supplements Qi and activates blood circulation,has a good therapeutical effect on radiation pneumonitis and protective role for radiation-induced pulmonary fibrosis.

Objective To study the chronic toxicity of Yiqihuoxue recipe in mice to provide necessary theretical basis for its clinical application.Methods 120 healthy mice were randomly divided into low dose group(78 g/kg),medium dose group(156 g/kg),high dose group(312 g/kg) and control group(0.9% sodium chloride injection),with 30 in each.The major conditions in all the groups before treatment and during the 1st,2nd and 3rd month of treatment and 2 weeks after drug discontinuance were observed.Hematology and biochemistry indicators were detected,and the tissues of liver,kidney and stomach were observed by pathology 3 months after administration and 2 weeks after drug discontinuance.Results During administration,there was no significant difference in major conditions between groups with different dosages of Yiqi Huoxue recipe and control group.Before treatment and during the 1st,2nd and 3rd month of treatment and 2 weeks after drug discontinuance there was no significant difference in body weight between groups with different dosages of Yiqihuoxue recipe and control groups(P0.05).3 months after administration and 2 weeks after drug discontinuance,hematology and biochemistry indicators in all the groups showed no significant difference(P0.05).Pathology result showed that the tissues of heart,liver,spleen,lung,kidney,stomach,small intestine and gonads were normal.Conclusion The Yiqihuoxue recipe can be administered orally on a long-term basis with no toxic effect.