Objective:To explore the efficacy of Wuling Capsules in the treatment of insomnia patients. Methods:The clinical data of 72 patients with insomnia diagnosed and treated in our hospital from January 2021 to December 2021 were retrospectively analyzed，and they were divided into an observation group and a control group according to different treatment methods，with 36 cases in each group. Among them，the control group was given estazolam tablets，and the observation group was given Wuling capsules，both groups were treated continuously for 4 weeks. The sleep conditions，clinical efficacy and adverse reactions were compared between the two groups.Results:After treatment，the sleep status self-rating scale (SRSS) score of the observation group was lower than that of the control group，and the difference was statistically significant (P<0.05). The incidence of reaction (5.56%) was lower than that of the control group (22.22%)，and the difference was statistically significant (P<0.05). Conclusion:The application of Wuling Capsules in the treatment of patients with insomnia can obtain exact curative effect，can effectively improve their sleep quality，and has high safety.

Objective：To study the clinical effect of Ziwan Zhike Huatan Decoction on acute and chronic bronchitis．Methods：The clinical data of 80 patients with acute and chronic bronchitis admitted to our hospital from January 2021 to December 2021 were retrospectively analyzed．According to different treatment methods，they were divided into a treatment group of 40 cases and a control group of 40 cases．The control group was treated with ambroxol tablets，and the treatment group was treated with Ziwan Zhike Huatan Decoction．Both groups were treated for 2 weeks．The therapeutic effect，TCM symptom score and serum C-reactive protein（CRP）level before and after treatment，and the incidence of adverse reactions were observed and compared between the two groups．Results：The total effective rate of the treatment group［92．50%（37/40）］was higher than that of the control group［75．00%（30/40）］，the difference was statistically significant（P ＜ 0．05）；Compared with before treatment，the TCM symptom scores and serum CRP levels of the two groups were decreased at the end of the two weeks of treatment，and the treatment group was lower than the control group，the difference was statistically significant（P＜0．05）；There was no significant difference in the incidence of adverse reactions between the treatment group［10．00%（4/40）］and the control group［5．00%（2/40）］（P ＞ 0．05）．Conclusion：Ziwan Zhike Huatan Decoction has a definite clinical effect in the treatment of acute and chronic bronchitis．It can promote the relief of symptoms such as cough and expectoration，reduce the level of serum CRP，and reduce the inflammatory response of the body．It has few adverse reactions and high safety．It is worthy of widespread clinical promotion and application．

目的 观察镇肝熄风汤加减方治疗急性缺血性脑卒中的临床疗效.方法 将76例急性缺血性脑卒中患者随机分为对照组和观察组各38例.对照组患者给予西药常规治疗;观察组患者在对照组基础上给予镇肝熄风汤加减方口服治疗.观察治疗前后神经功能缺损程度NIHSS评分变化,检测血管内皮功能指标变化.结果 观察组临床总有效率为92.11％,明显高于对照组的73.68％(P<0.05);观察组患者的NIHSS评分、血清中vWF、ET-1显著降低,eNOS水平显著升高(P<0.05).结论 镇肝熄风汤加减方利于修复急性缺血性脑卒中患者的神经功能损伤,推断可能是通过改善血管内皮功能实现的.

目的 探究在丙戊酸钠的基础上给予拉莫三嗪治疗脑卒中引起的癫痫的临床疗效.方法 对象为就诊于本院在2016年1月-2017年12月的68例脑卒中继发性癫痫患者,随机分为两组各34例.观察组采用丙戊酸钠加拉莫三嗪治疗,对照组仅以丙戊酸钠治疗.两组患者在接受治疗前后的每年癫痫发作频率及平均持续时间、接受治疗第12个月时丙戊酸钠用量,并记录服药期间不良反应的发生率.结果 观察组治疗后癫痫发作频率、持续时间、接受治疗第12个月时丙戊酸钠用量均明显少于对照组,表明具有统计学意义(P＜0.05).两组患者不良反应发生率无明显差剐,无统计学意义(P＞0.05).结论 两药联合能有效减少癫痫的发作频率和持续时间,减少丙戊酸钠的用量,且未明显增加不良反应,为患者带来受益,值得在临床上进一步研究乃至推广.

目的:研究芪参脑脉通胶囊对慢性脑供血不足患者血栓前状态的干预及血管内皮保护作用.方法:将260例慢性脑供血不足证属气血亏虚、痰瘀阻络型患者随机分为治疗组和对照组(实际研究治疗组128例、对照组127例),治疗组在基本治疗的基础上给予芪参脑脉通胶囊口服,两组疗程为2月,检测治疗前后血栓前状态标志物FIB、t-PA、PAI-l水平及血管内皮功能指标FMD、vWF、ADMA、VE-Ca水平,并进行统计学处理.结果:治疗组治疗后血栓前状态标志物FIB、t-PA、PAI-l水平及血管内皮功能指标FMD、vWF、ADMA、VE-Ca水平等改善程度均显著优于于对照组(P ＜0.05;P ＜0.01).结论:芪参脑脉通胶囊能有效干预气血亏虚、痰瘀阻络型慢性脑供血不足患者血栓前状态,并有效保护其血管内功能.

目的 观察自拟消栓通络经验汤剂辨治短暂性脑缺血发作(气虚血瘀证)的临床效果.方法 将120例患者按随机数字表法分为对照组和治疗组各60例,对照组患者给予硫酸氢氯吡格雷片联合阿司匹林治疗,治疗组患者在对照组基础上联合给予自拟消栓通络经验汤剂内服治疗,两组均连续治疗2周.比较两组临床疗效、治疗前后中医证候积分、凝血功能指标变化、血液流变学指标及平均血流速度变化.结果 治疗组的总有效率91.67％,显著高于对照组的76.67％ (P＜ 0.05);治疗组治理后中医证候积分明显低于对照组(P＜0.05);治疗组患者的凝血功能各指标改善优于对照组患者,PT、APTT水平治疗前后及组间差异无统计学意义(P＞0.05),PLT水平显著低于治疗前及对照组(P＜0.05);治疗组患者血液流变改善优于对照组(P＜0.05);治疗组患者的平均血流速度改善优于于对照组(P＜0.05).结论 自拟消栓通络经验汤剂辨治(气虚血瘀证)短暂性脑缺血发作疗效确切,其机制可能与改善脑部血液循环及血流速度、抗血小板作用密切相关,值得临床深入研究探讨.

Objective To observe the clinical effect of Qishen Tongluo decoction(QTD)for treatment of ischemic stroke.Methods One hundred and sixty patients with qi deficiency,blood stasis and wet stagnation syndrome were divided into two groups:Control group treated by routine treatment,treatment group treated by QTD and routine treatment for 14 days.The clinical curative effect,the efficacy of traditional Chinese medicine(TCM)and the nerve function (The NIHSS score and Barthel index)were observed,and the data were statistical y analyzed.Results After 14 days,the clinical curative effect,the efficacy of TCM and the nerve function in treat-ment group was significantly higher than that in control group of before and after treatment(P<0.05 or P<0.01).Conclusion The early use of QTD in ischemic stroke can improve the clinical effect,recovery of nerve function and symptoms of the neurologic impair-ment and activities of daily living ability.

目的 研究自拟参芪通络汤对缺血性中风患者脑保护机制.方法 将236例气虚血瘀兼水湿停滞型缺血性中风患者随机分为治疗组和对照组(治疗组116例、对照组117例).对照组予临床基础治疗,治疗组在基础治疗的基础上给予自拟参芪通络汤口服,总疗程为14 d,检查两组治疗前及治疗后血可溶性肿瘤坏死因子相关凋亡诱导配体(sTRAI)、骨保护素(OPG)、血浆超敏C反应蛋白(hs-CRP)、血清过氧化物歧化酶(SOD)、丙二醛(MDA),治疗前及治疗后2d、7d、14d血清基质金属蛋白酶-9等,并进行统计学处理.结果 治疗组治疗后血sTRAI、OPG、hs-CRP、SOD、MDA改善明显高于对照组(P＜0.01),治疗后2d、7d、14 d血MMP-9改善程度也显著优于对照组(P＜0.01).结论 自拟芪参通络汤治疗缺血性中风,能够多途径、多靶点的进行脑保护.

目的 观察自拟参芪通络汤对缺血性中风患者血管内皮功能的影响.方法 将162例气虚血瘀兼水湿停滞证缺血性中风患者随机分为治疗组79例和对照组78例,对照组采用西医常规治疗,治疗组在此基础上给予自拟参芪通络汤口服,两组疗程均为14d.结果 治疗组治疗后内皮细胞依赖性舒张功能(FMD)及血管性假血友病因子(vWF)、非对称性二甲基精氨酸(ADMA)、内皮细胞钙黏蛋白(VE-Ca)等水平改善较对照组更加明显(P＜0.05).结论 自拟芪参通络汤治疗缺血性中风,能够有效保护患者的血管内皮功能.

目的:观察通心络胶囊治疗不稳定性心绞痛的疗效。方法:我院不稳定性心绞痛98例患者随机分为两组,对照组常规治疗,治疗组加用通心络胶囊,分析两组心绞痛发作次数、心电图改善及心血管事件发生情况。结果:两组均无死亡病例,两组比较心电图总有效率、心绞痛发作次数差异有统计学意义(P<0.05)。治疗3个月后,治疗组复发5例(7.4%),对照组复发8例(26.7%),差异有统计学意义(P<0.05)。且均无明显副作用。结论:通心络胶囊可以有效缓解心绞痛症状,减少发作次数及发作时间,且副作用小,疗效确切。

目的:观察导痰汤治疗椎基底动脉供血不足的临床疗效。方法:选择106例椎基底动脉供血不足的患者,随机分为2组,均给予肠溶阿司匹林、尼莫地平作为基础治疗后,将其中54例给予导痰汤治疗(治疗组),52例给予培他啶治疗(对照组)。观察治疗前后患者主要临床症状及经颅多普勒超声(TCD)的变化及痰热症状。结果:导痰汤明显改善椎基底动脉供血不足患者的临床症状和TCD的流速异常及患者的痰热症状。结论:导痰汤对痰热型眩晕症的椎基底动脉供血不足患者具有良好的治疗效果。

声带息肉是耳鼻喉科的常见病,治疗方法通常利用间接喉镜、直达喉镜或全麻支撑喉镜手术摘除,患者痛苦大,手术方式相对复杂.自1999年9月至2003年10月,笔者利用电子胃镜下微创术治疗声带息肉256例,术后口服金嗓散结丸,取得了满意效果.现报告如下.