OBJECTIVE:To observe the effects of electroacupuncture (EA) on the body weight, disease progression and the expression of heat shock protein 70 (HSP70) in lumbar spinal cord of amyotrophic lateral sclerosis (ALS) mice, so as to explore the mechanism of EA on treating ALS. METHODS:Eighteen ALS transgenic SOD1G93A mice were randomly divided into model, EA and medication groups, with 6 mice in each group, and six C57BL/6J mice were used as the normal group. Mice in the EA group received EA at "Quchi"(LI11)-"Hegu"(LI4), "Zusanli"(ST36)- "Sanyinjiao"(SP6), 30 min/time, 5 times/week, for 8 weeks.Mice in the medication group were given riluzole solution (7.6 mg·kg-1·d-1) by gavage for 8 weeks. The body weight of the mice was recorded and the motor function of the hind limbs was evaluated by the neurological function scoring stan-dard of the ALS Therapeutic Development Institute. The expression of HSP70 in lumbar spinal cord was detected by Western blot and immunohistochemistry, respectively. RESULTS:Compared with the normal group, the body weight and the expression of HSP70 in the model group decreased significantly (P<0.05), while no significant difference in the body weight was found among other groups(P>0.05). After intervention and in comparison with the model group, the disease onset time and paralysis time of the EA group and the medication group were significantly delayed (P<0.05, P<0.01), the expression of HSP70 in the EA group and the medicine group was significantly increased (P<0.05, P<0.01).But there was no significant difference in the survival time among all groups(P＞0.05). The disease onset time of the EA group was shorter than that in the medication group (P<0.05). CONCLUSION:EA can increase the expression of HSP70 in lumbar spinal cord, thereby delaying the progression of ALS.

The aim of the present study was to investigate the effect of a Traditional Chinese Herbal Medicine (TCHM), named Jinwei Tang on histone deacetylase 2 (HDAC2) and its role in the regulation of corticosteroid resistance in a rat model of chronic obstructive pulmonary disease (COPD). Male Wistar rats were divided into five groups (each n=10): COPD group, established by the intratracheal instillation of lipopolysaccharide and passive smoke exposure, and control, budesonide, theophylline + budesonide and Jinwei Tang + budesonide groups. Lung function was measured, lung tissue histopathology was examined and HDAC2 expression in the lung was assessed by immunohistochemistry. In addition, protein levels of interleukin-8 (IL-8), tumor necrosis factor (TNF)-α and HDAC2 in lung homogenate were quantified by ELISA. The rat COPD model exhibited alterations of the ratio of forced expiratory volume in 0.2 sec (FEV0.2) to the forced vital capacity, FEV0.2, dynamic compliance and airway resistance. HDAC2 expression was markedly reduced in the lung tissue of the COPD group compared with the control group, and treatment with Jinwei Tang + budesonide or theophylline + budesonide resulted in significant attenuation of the reduction of HDAC2 expression in the lungs (P<0.05). However, treatment with budesonide alone did not significantly alter HDAC2 expression. In the Jinwei Tang + budesonide and theophylline + budesonide groups, IL-8 and TNF-α expression was significantly decreased (P<0.05) and the HDAC2 level increased (P<0.05) compared with that in the COPD group. In conclusion, Jinwei Tang modulates airway inflammation and may enhance the anti-inflammatory effect of glucocorticoid through the upregulation of HADC2 expression in a rat model of COPD.

唐启盛教授在精神疾病的治疗上具有丰富的经验,擅长心身同调、肝肾同治,尤其在焦虑障碍、抑郁障碍的治疗上独具心得.唐教授治疗焦虑障碍由辨病人手,根据肝郁化火的核心病机,分肝郁化火证、肾虚肝旺证、肝胆湿热证对证治疗.唐教授认为,王清任《医林改错》中所记载“灯笼病”与焦虑障碍的瘀血内阻证临床特征十分符合,临床从疏肝清热、活血化瘀角度治疗,疗效显著.

现代心理学所研究的心理现象是指人的心理过程和人格。心理过程包括认知过程、情感过程、意志过程，认知过程主要包括感觉、知觉、记忆、思维、想象。根据对历代中医文献的研究分析：感知活动的中枢为心神，心是认知客观事物的处所；“心有所忆谓之意”，把心所接受的外界信息保留下来成为记忆，即脾意；“因志而存变谓之思，因思而远慕谓之虑”，其中的思、虑即与思维、想象相符合；中医的“七情学说”与情感过程相符合；“意之所存谓之志”，志与意志过程相符合。

Objective: To evaluate the effectiveness and safety of Chinese herbal medicine (CHM) versus fluoxetine on depression.Design: A systematic review of randomized controlled trials (RCTs).Methods: RCT with two parallel groups that compared CHM and fluoxetine on treatment of depression with reported decreased Hamilton Depression Scale (HAMD) and adverse events during treatment were included after searching through six electric-databases. The methodological quality of RCTs was assessed according to the Cochrane risk of bias tool. Meta-analysis was conducted using RevMan 5.3 software with pooled mean difference (MD) or risk ratio (RR) and their 95% confidence interval (Cl) if no significant heterogeneity was detected. A SOF table was generated using GRADEPro software to evaluate the overall quality of the evidence.Results: Twenty-six trials with 3294 participants were included in the review. Most of them had high risk of bias during conducting and reporting. The results achieved weak evidence which showed CHM had similar effect to fluoxetine (20 mg/day) on relieving depression according to HAMD assessment (for primary depression: MD 0.08, 95%CI -0.98-0.82; for secondary depression: MD = -0.36, 95%CI -1.55-0.83), but fewer incidences of adverse events than the drug (for primary depression: RR=0.31, 95%CI 0.17-0.59; for post-stroke depression: RR=0.04, 95%CI 0.00-0.25). No serious adverse event was found in neither CHM nor fluoxetine group.Conclusions: Due to the poor quality of included trials and the potential publication bias of this review, no confirmed conclusion could be draw to evaluate the effectiveness and safety of CHM for depression compared with fluoxetine. (C) 2015 Elsevier Ltd. All rights reserved.

目的 研究广泛性焦虑症相关失眠辨证分型之间的多导睡眠图(PSG)表现的差异性,为PSG在情志病方面的临床应用提供理论依据.方法 运用双盲法,由2名副主任医师对符合纳入标准的患者进行中医辨证分型,应用多功能睡眠监测系统,各组患者在不服用安眠药物的情况下,进行睡眠监测,记录相关指标,然后打印PSG诊断报告,最后采用SPSS 16.0统计软件包进行统计分析.结果 肝郁化火组、心脾两虚组睡眠总时间显著缩短,睡眠潜伏期显著延长,慢波睡眠(SWS)时间与比例及快速眼动睡眠(REM)时间显著减少,觉醒次数显著增加,睡眠效率显著下降,与正常组比较,差异有统计意义(P＜0.05);肝郁化火组睡眠潜伏期显著延长,与心脾两虚组比较,差异有统计意义(P＜0.05);心脾两虚组SWS时间及比例显著低于肝郁化火组,差异有统计意义(P＜0.05).结论 广泛性焦虑症相关失眠在睡眠结构、睡眠进程及睡眠维持方面均有异常表现,实证(肝郁化火)与虚证(心脾两虚)之间的PSG也具有各自的特点,再次证实PSG检测对广泛性焦虑症相关失眠的重要意义.

Objective: To study the relationship between the degree of insomnia with their personality characteristics and quality of life. Methods: The scale of Pittsburgh sleep quality index(PSQI), world health organization quality of life BREF(WHOQOL-BREF), Eysenck personality questionnaire(EPQ) for insomnia patients were assessed using statistical means to analyze the intrinsic link. Results: 120 cases were observed in patients with insomnia, PSQI total score mean was(10.200±2.992), which was positively correlated with the total score of quality of life and psychological, physiological, and social relations, and so on. Insomnia crowd who had tendency to introversion-mood swings and outgoing-mood swings were more than that of normal population. Conclusion: The quality of sleep can af ect an individual's physical health, psychological state and social relations harmonious or not, and anxiety, tension, irritability personality can induce and aggravate insomnia.

This study investigated the metabolic change in brain of depression-like rats and the intervention effects of Yinao Jieyu recipe.Twenty rats were randomly allocated into normal group,depression group,fluoxetine group and Yinao Jieyu recipe group,with five rats in each group.The animals in the normal group were raised regularly.The animals in the other three groups were subjected to chronic unpredictable mild stress(CUMS) for 21 days.After the CUMS treatment,the animals in the depression group received saline treatment by gastrogavage for 6 weeks,and those in the fluoxetine group and Yinao Jieyu recipe group received fluoxetine and Jieyu recipe treatments,respectively,by gastrogavage for 6 weeks.In vivo 1H MRS was performed to measure the changes of N-acetyl aspartate(NAA),choline(Cho) and creatine(Cr) levels in the left prefrontal cortex and hippocampus.Compared to the normal group,the depression group and the fluoxetine group showed significantly decreased NAA/Cr ratio in the hippocampus and frontal cortex.The Yinao Jieyu recipe group showed significantly higher NAA/Cr ratio in the hippocampus and prefrontal cortex relative to the depression group.The hippocampal Cho/Cr ratio in the depression group was found increased(P0.05),while that in the Yinao Jieyu recipe group decreased(P0.01),compared to the normal group.The prefrontal Cho/Cr ration in the depression group and fluoxetine group showed significant increases relative to the normal.The prefrontal Cho/Cr ratios in the Yinao Jieyu recipe group and fluoxetine group were significantly lower than that in the depression group.In conclusion,the Yinao Jieyu recipe appeared to have apparent anti-depression effects in rats subjected to CUMS.

目的:观察安神定志丸治疗抑郁症心胆气虚型的临床疗效.方法:将60例抑郁症心胆气虚型患者采用随机数字表法分为治疗组30例,给予安神定志汤剂;对照组30例给予氟西汀治疗,疗程为6周.在治疗1,2,4,6周时,对两组的汉密顿(HAMD)减分疗效、中医证候疗效进行对比观察.结果:两组在治疗1周时的HAMD减分率,其差异具有统计学意义(P<0.01),而在治疗2,4,6周时HAMD减分率差异无统计学意义;两组间中医证候疗效在各时间点比较,其差异具有统计学意义(P<0.01),安神定志汤剂对抑郁症心胆气虚型中医证候疗效明显优于氟西汀.结论:安神定志汤剂治疗抑郁症心胆气虚型具有良好的临床疗效.

BACKGROUND Wet cupping is a traditional Chinese medicine therapy commonly used in treating herpes zoster in China, and clinical studies have shown that wet cupping may have beneficial effect on herpes zoster compared with Western medication. METHODS We included randomized controlled trials (RCTs) on wet cupping for herpes zoster. We searched PubMed, the Cochrane Library (Issue 3, 2008), China Network Knowledge Infrastructure (CNKI), Chinese Scientific Journals Fulltext Database VIP, and Wan Fang Database. All searches ended in February 2009. Two authors extracted data and assessed the trials' quality independently. RevMan 5.0.18 software (The Cochrane Collaboration, The Nordic Cochrane Centre, Copenhagen, Denmark) was used for data analysis with effect estimate presented as relative risk (RR) and mean difference (MD) with a 95% confidence interval (CI). RESULTS Eight RCTs involving 651 patients were included, and the methodological quality of trials was generally fair in terms of randomization, blinding, and intention-to-treat analysis. Meta-analyses showed wet cupping was superior to medication in the number of cured patients (RR 2.49, 95% CI 1.91 to 3.24, P < .00001), the number of patients with improved symptoms (RR 1.15, 95% CI 1.05 to 1.26, P = .003), and reducing the incidence rate of postherpetic neuralgia (RR 0.06, 95% CI 0.02 to 0.25, P = .0001). Wet cupping plus medication was significantly better than medication alone on number of cured patients (RR 1.93, 95% CI 1.23 to 3.04, P = .005) but demonstrated no difference in symptom improvement (RR 1.00, 95% CI 0.92 to 1.08, P = .98). There were no serious adverse effects related to wet cupping therapy in the included trials. CONCLUSION Wet cupping appears to be effective in the treatment of herpes zoster. However, further large, rigorously designed

Objective To research clinical curative effects of Yinaojieyu Recipe on depression with syndrome of kidney deficiency and liver-qi stagnation.Methods Sixty subjects were randomly divided into two groups,Yinaojieyu group and Fluoxetine group,with 30 cases in each group. Patients in the Yinaojieyu group were treated with Yinaojieyu Recipe and in the Fluoxetine group with Fluoxetine for six weeks. Hamilton rating scale for depression(HAMD) and TCM syndrome manifestations were used to evaluate curative effect on the 2nd,4th and 6th weeks.Results With the time of therapy going,HAMD curative effect increased in both groups and was more obvious in Yinaojieyu group,but there was not a significant difference between two groups (P0.05).TCM syndrome curative effects also increased in both groups and was more significant in Yinaojieyu group,and there was a significant difference between two groups(P0.01).Conclusion Yinaojieyu Recipe has better clinical curative effects in treating depression with syndrome of kidney deficiency and liver-qi stagnation.

Objective To observe the symptomatic improvement by Jieyu Prescription for patients with depression of kidney deficiency and liver-qi stagnation. Methods Sixty subjects were randomly divided into two groups: Yinao Jieyu group and Fluoxetine group,30 cases in each group. Yinao Jieyu group was treated with Jieyu Prescription and Fluoxetine group with Fluoxetine for six weeks. TCM symptoms were observed on 2nd,4th and 6th weeks of treatment. Results Curative effects of Jieyu Prescription on deficiency of sexuality and frequent sigh were better than those of Fluoxetine on the 2nd,4th and 6th week,P 0.05 or 0.01; curative effects on pain in the waist and back were better than those of Fluoxetine on the 2nd and 4th weeks,P 0.01,and had no significant difference between the two groups on the 6th week,P 0.05; curative effect on swelling and pain in the flank was better than that of Fluoxetine on the 2nd week,P 0.01,and had no significant difference between the two groups on the 4th and 6th weeks,P 0.05; curative effect on inattention had no significant difference between the two groups on the 2nd and 4th weeks,P 0.05,and was better than that of Fluoxetine on the 6th week,P 0.01; curative effect on melancholy,boredom and listlessness had no significant difference between the two groups,P 0.05. Conclusion Jieyu Prescription is effective in improving symptoms in patients with depression of kidney deficiency and liver-qi stagnation.