A new Gd(III) coordination polymer, namely [Gd(bpt)(H2O)(DMF)]n·3n(H2O) (1, H3bpt = biphenyl-3,4′,5-tricarboxylic acid, DMF = N,N-dimethylformamide), has been successfully synthesized under solvothermal conditions. In the structure of 1, the dinuclear [Gd2(COO)4] building subunits are connected by the bpt3− ligands into a 3D framework with (3,6)-connected flu-3,6-C2/c topology. Moreover, the catalytic performances of 1 and 1′ (desolvated sample) towards the cyanosilylation of benzaldehyde and its derivatives have been tested under mild conditions. The catalytic activity of 1′ is higher than that of compound 1, indicating that more open metal sites in coordination polymer is beneficial to the cyanosilylation reaction. In addition, in vitro anticancer activities of compounds 1 and 1′ (desolvated sample) on four human gastric cancer cells (MGC-803, SGC-790, MKN45 and AGS) were further determined.

Purpose Dioscin has been proven to have anti-cancer, anti-inflammatory, and anti-infection roles. However, the role of Dioscin in inflammatory bowel disease (IBD) and its related mechanisms is unclear and needs further study. Methods The colitis model in mice was established. After Dioscin (20, 40, or 80 mg/kg) treatment, the colon length was measured by a ruler. Histopathology, inflammatory cytokines, gut permeability, tight junction proteins, macrophage infiltration, macrophage polarization, and miR-125a-5p level were detected by hematoxylin-eosin staining, enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction (qRT-PCR), FITC-dextran, Western blot, and flow cytometry. In vitro experiments, after RAW264.7 cells induced by lipopolysaccharide (LPS)/interleukin-4 (IL-4), were treated with Dioscin and miR-125a-5p inhibitor, miR-125a-5p level, cell vitality, inflammatory cytokines, and M1/M2 marker genes were measured by qRT-PCR and MTT assay. Results Dioscin (20, 40, or 80 mg/kg) relieved DSS-triggered colitis and restrained the serum and colon of pro-inflammatory cytokines expression. Meanwhile, different concentrations' Dioscin weakened M1 macrophage polarization but facilitated tight junction protein expressions, M2 macrophage polarization, and miR-125a-5p level in colitic mice. Moreover, miR-125a-5p inhibitor reversed the modulation of Dioscin on miR-125a-5p expression, cell vitality, and inflammatory cytokines in lipopolysaccharide (LPS)-induced RAW264.7 cells. We further discovered that Dioscin restrained M1 marker gene (CD16) expression while intensifying M2 marker genes (CD206 and Arginase-1) expressions in vitro, which was reversed by miR-125a-5p inhibitor. Conclusion Dioscin modulated macrophage polarization by increasing miR-125a-5p, thereby improving the intestinal epithelial barrier function and reducing IBD.

BACKGROUND Ulcerative colitis (UC) is usually diagnosed through histopathology, enteroscopy, clinical symptoms, and physical findings; however, it is difficult to accurately evaluate disease severity. AIM To investigate the value of endoscopic ultrasonography (EUS) in the evaluation of the severity and prognosis of UC. METHODS Patients with UC who were seen in our hospital from March 2019 to December 2020 were eligible, and disease severity was evaluated according to the modified Truelove and Witts and Mayo scores. We performed EUS, calculated the UC endoscopic index of severity (UCEIS) and EUS-UC scores, and administered appropriate treatment. The UCEIS and EUS-UC scores of patients were assessed in relation to disease severity, and the correlations between UCEIS and EUS-UC scores and disease severity was also analyzed. The UCEIS and EUS-UC scores before and after treatment were also compared. RESULTS A total of 79 patients were included in this study. According to the Mayo Index, 23, 32, and 24 patients had mild, moderate and severe UC, respectively. The UCEIS and EUS-UC scores were higher in moderate cases (4.98 +/- 1.04 and 5.01 +/- 0.99, respectively) than in mild cases (1.56 +/- 0.82 and 1.64 +/- 0.91, respectively, P < 0.05). Furthermore, the UCEIS and EUS-UC scores (7.31 +/- 1.10 and 7.59 +/- 1.02, respectively) were higher in severe cases than in moderate cases (P < 0.05). According to the modified Truelove and Witts scores, 21, 36, and 22 patients were classified as having mild, moderate and severe disease, respectively. The UCEIS and EUS-UC scores were significantly higher in moderate disease (4.79 +/- 1.11 and 4.96 +/- 1.23, respectively) than in mild disease (1.71 +/- 0.78 and 1.69 +/- 0.88, respectively, P < 0.05). Additionally, the UCEIS and EUS-UC scores in severe disease (7.68 +/- 1.22 and 7.81 +/- 0.90, respectively) were significantly higher than in moderate disease (P < 0.05). The UCEIS and EUS-UC scores were significantly and positively correlated with disease severity according to the modified Truelove and Witts score and Mayo score (P < 0.05). The UCEIS and EUS-UC scores after 2 mo of treatment (3.88 +/- 0.95 and 4.01 +/- 1.14, respectively) and after 6 mo of treatment (1.59 +/- 0.63 and 1.64 +/- 0.59, respectively) were lower than the respective scores before treatment (5.93 +/- 1.79 and 6.04 +/- 2.01) (P < 0.05). CONCLUSION EUS can clarify the status of UC and accurately evaluate the treatment response, providing an objective basis for formulation and adjustment of the treatment plan. (c) The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article previously published in Volume 17 Issue 10 of this journal in October 2018 has been retracted in line with the guidelines from the Committee on Publication Ethics (COPE, http://publicationethics.org/resources/guidelines).

内镜检查是消化内科检查及治疗的常用手段,但患者易出现烦躁以及紧张等情绪,因此为了提高检查安全性,无痛内镜检查得到广泛应用[1].虽然无痛内镜检查可以有效减少患者紧张情绪,但是老年高血压患者因为麻醉药物使用较易出现心脏以及呼吸抑制[2].个性化宣教可以为患者提供有效心理支持,帮助患者及家属了解检查相关知识以及相关注意事项,减轻患者相关负性情绪[3].本研究在老年高血压患者无痛内镜检查围术期护理中采用个性化宣教,以寻求合理、安全、有效的老年高血压无痛内镜检查围术期护理方式.

The chemokine (C-X-C motif) ligand (CXCL) family plays an important role in inflammation. In order to understand the role of CXC chemokine family in carcinogenesis, this study explored a group of early gastric cancer (GC) patients, and assessed the level of CXC chemokine ligand (CXCL) in blood samples of patients representing systemic circulation and tumor microenvironment, detected the expression of CXC chemokine receptor (CXCR) in tumor tissues, and measured tumor infiltrating immune cell subsets. 69 patients with GC were included in a single center prospective study and were followed up for 6 years. The level of CXCL1-14 was determined by ELISA and the concentration gradient of chemokine was calculated. Western blot was used to detect the expression of CXCR1, CXCR2, CXCR3, and CXCR4 in tumor tissue. CXCL1-14 expression was inhibited by siRNA in HGC27 cells and then the migration ability of HGC27 cells was detected by cell scratch test. The results of this study showed that the chemokine concentrations of CXCL1, CXCL2, CXCL5, CXCL8, CXCL11, and CXCL13 in peripheral blood and tumor drainage blood of patients without recurrence after treatment were significantly lower than those before treatment. The concentrations of CXCL1, CXCL2, CXCL4, CXCL5, CXCL7, CXCL8, CXCL9, CXCL10, CXCL12, CXCL13, and CXCL14 in peripheral blood and tumor drainage blood were significantly higher than those in patients without recurrence. Patients with low expression of CXCR1 and CXCR3 had lower AFP (alpha fetoprotein), smaller tumor volume, and lower TNM tumor stage. Patients with lower expression of CXCR2 and CXCR4 had higher AFP (alpha fetoprotein) level, larger tumor volume, and higher TNM tumor stage. After down-regulation of CXCLs expression, the migration ability of most cell lines was significantly inhibited. This study suggests that CXCL chemokine family plays an important role in the pathogenesis of GC and can be used as a marker for the development of GC.

目的 探究经颈静脉肝内门体分流术(TIPS)联合部分性脾栓塞术(PSE)对肝硬化伴脾亢患者外周血细胞水平、免疫球蛋白、血氨及安全性的影响.方法 选择74例肝硬化患者,依据治疗方法分为观察组(n=37)和对照组(n=37),对照组仅行TIPS治疗,观察组行TIPS与PSE联合治疗.分析比较两组外周血细胞水平、免疫球蛋白、血氨及不良反应的变化.结果 术后7 d及30 d,观察组外周血细胞血小板(PLT)、白细胞(WBC)水平明显高于术前及对照组(t分别=6.25、4.25、6.30、4.63、7.34、4.71、6.25、4.69,P均<0.05);术后30 d,观察组IgA、IgG及IgM水平明显高于术前及对照组(t分别=3.78、3.14、3.94、3.23、3.84、3.20,P均<0.05).术后30 d,两组血氨水平明显高于术前(t分别=6.42、5.07,P均<0.05),两组间血氨水平比较,差异无统计学意义(t=0.90,P>0.05).两组轻微并发症及严重并发症的比较,差异均无统计学意义(χ2分别=0.35、0.56,P均>0.05).结论 TIPS与PSE联合治疗可改善肝硬化伴脾亢患者外周血细胞水平,减轻患者免疫抑制作用,不增加患者术后并发症风险.

Objective To evaluate the clinical efficacy of transjugular intrahepatic portosystem shunt (TIPS) and gastric coronary vein embolization (GCVE) in the treatment of patients with cirrhosis,portal hypertension and upper gastrointestinal bleeding.Methods From Jan 2014 to May 2017 72 patients were enrolled and divided into the TIPS group (36 cases,receiving TIPS) and TIPS + E group (36 cases,byTIPS+GCVE).Results Portal vein diameter (1.21 ±0.08)cm vs.(1.26 ±0.09)cm,portal pressure (23.9 ± 2.1) cmH2O vs.(25.1 ± 2.2) cmH2O and congestion index (0.06 ± 0.03) cm/s vs.(0.08 ±0.03) after 1 month of treatment in TIPS + E group was significantly lower than the TIPS group,and the portal vein velocity was significantly higher than that of the TIPS group (42 ± 6) cm/s vs.(38 ± 7) cm/s,t =2.491,2.367,2.828,t =2.343,all P ＜ 0.05.The Child-Pugh score in the TIPS + E group was significantly lower than that in the TIPS group (7.9 ± 1.4) vs.8.6 ± 1.6,t =2.074,P =0.042).There was no statisticall different difference in postoperative hepatic encephalopathy in the two groups (17％ vs.11％,x2 =0.465,P =0.496).The one-year rebleeding rates in the TIPS group and the TIPS + E group were 14％ and 3％,respectively.The risk of rebleeding in the TIPS + E group was significantly lower than that in the TIPS group (HR =0.218,P =0.041).The one-year access obstruction rates in the TIPS group and the TIPS + E group were 17％ and 14％,respectively.(P =0.679).The all-cause mortality rates of the TIPS group and the TIPS + E group were 8％ and 3％,respectively,showing no statistically (P =0.299).Conclusions TIPS + GCVE therapy in the treatment of portal hypertensive upper gastrointestinal bleeding effectively reduces the risk of rebleeding.

Purpose: To investigate the effect of bifidobacteria on intestinal injury and flora in a mouse model of ulcerative colitis (UC). Methods: Mouse model of UC was produced using dextran sulphate sodium (DSS). The mice were divided into seven groups, viz, reference group, MRS-L medium-negative control group, mesalamine-positive control group, high dose bifidobacteria (MIMBb75) group, middle dose MIMBb75 group and low dose MIMBb75 group. Normal mice were used as control. All mice were sacrificed at day 7 of treatment, and colon length, hemoglobin concentration and intestinal flora were determined. Results: Bifidobacteria inhibited UC-induced decreases in mice hemoglobin and UC-induced colon shortening. In addition, it augmented the diversity of intestinal flora and increased the number of bacteroides and Clostridium leptum. Conclusion: Bifidobacteria plays a therapeutic role in UC via regulation of intestinal micro flora.

Purpose: To investigate the role of bone marrow kinase in chromosome X (BMX) in colorectal cancer (CRC) cell resistance to ABC294640 treatment. Methods: HCT-116R, LS174T and WiDr cells were transfected with either BMX-specific siRNA or scrambled siRNA, and then BMX mRNA and protein expressions were detected by quantitative polymerase chain reaction (qPCR) and western blotting, respectively. The cells were treated with ABC294640 and cell viability evaluated using cell counting and colony formation assays. Apoptosis was determined by detecting caspase 3/7 activity. To evaluate tumor growth of HCT-116R cells, a xenograft model was utilized to measure tumor size. Results: Pharmacological inhibition of sphingosine kinase type 2 (SK2) with ABC294640 significantly decreased cell viability (p < 0.001) when compared with control group. SK2 inhibition also remarkably induced apoptosis in HCT-116 CRC cells in a dose-dependent manner (p < 0.01 and p < 0.001). However, no significant effects were observed in HCT-116R, LS174T, or WiDr cells following ABC294640 treatment. BMX mRNA and protein expression increased in ABC294640-resistant cell lines. In addition, silencing BMX expression with siRNA potentiated ABC294640-induced inhibition of tumor growth in CRC cells in vitro and in vivo. Conclusion: ABC294640-induced BMX upregulation impedes the antitumor effect of ABC294640 in CRC cells. Therefore, these results may provide a novel therapeutic strategy for CRC using a combination of ABC294640 treatment and BMX blockade.

[Objective]To explore the clinical efficacy of etiasa combined mesalazine suppository in the treatment of ulcerative proctitis patients and its effect on cell factor and coagulation function.[Methods]98 cases of ulcerative proctitis patients were selected from our hospital during the period from March 2016 to March 2017,randomly divided into observation group and control group(n=49 in each).The control group was treated with mesalazine suppository,and the observation group was treated with etiasa combined mesalazine suppository.The two groups were treated for 4 weeks.The therapeutic effect,the main symptom scores,the changes of cytokines and coagulation function indexes before and after treatment were compared between two groups.[Results]The total effective rate of the observation group(93.88 ％)was higher than that of the control group(75.51％)(P＜0.05).Abdominal pain,diarrhea and tenesmus score decreased in two groups after treatment (observation group:t =22.1175,19.5513,26.4094,control group:t =9.4541,12.0130,13.1201,P＜0.05);abdominal pain,diarrhea and tenesmus score of the observation group after the treatment was lower than that of the control group(t=22.6722,17.9396,19.3115,P＜0.05).The two groups after treatment of serum IL-4 increased IL-6 and TNF-α levels decreased(the observation group:t=11.8961,27.3087,29.7986,the control group:t =5.8183,16.7994,13.1329,P＜0.05);the observation group after treatment,serum IL-4 was higher than the control group and the IL-6 and TNF-α levels were lower than the control group (t =7.2642,13.0384,18.4502,P＜0.05).D-D and PLT levels decreased in two groups after treatment(observation group:t=19.2078,20.1096,control group:t=6.5099,9.6857,P＜0.05);D-D and PLT levels after treatment were lower than those of the control group(t=8.4034,13.3176,P＜0.05).[Conclusion]Etiasa combined mesalazine suppository in the treatment of ulcerative proctitis patients has obvious clinical curative effect,and can improve patients with micro inflammatory state and coagulation function,with important research value.

The solvothermal reactions of barium nitrate and 4,4',4 "-(1,3,5-triazine-2,4,6-triyl) tribenzoic acid (H(3)TATB) in a mixed solvent of N, N-Dimethyl formamide (DMF) and H2O at 120 degrees C leads to the formation of a new Ba(II)-based coordination polymer Ba(HTATB)(H2O)](DMF) 2 (1) based on the ligand as a C-3 symmetric 3-connected organic node and the Ba2+ ion as 5-connected node. The efficient encapsulation of an anticancer drug 5-fluorouracil (5-Fu) on the desolvated 1 (1a) has been studied by grand canonical Monte Carlo (GCMC) simulation. In addition, the MTT assay method was assessed the ability of this drug delivery system on liver cancer HepG2 cells as well as the cytotoxicity of the carrier, which show that this drug loaded system exhibits very high biocompatibility and, hence, is promising as intracellular drug delivery carriers.

Objective To investigate the changes of D-dimer (D-D) and von Willebrand factor (vWF) levels in patients with gastric cancer and their correlation with tumor pathological features. Methods A total of 70 cases of gastric cancer patients were selected as the observation group, another 70 healthy people were selected as the control group, and the levels of D-D and vWF between the two groups and among different tumor pathological characteristics were compared, and the correlation of the D-D and vWF levels with tumor pathological features was analyzed. Results The levels of D-D and vWF in the observation group were significantly higher than those in the control group, and significantly increased with the increase of TNM stage, the depth of invasion and the occurrence of metastasis, the levels of D-D and vWF, with the differences statistically significant(P<0.05). D-D and vWF levels were positively correlated with TNM stage, depth of invasion and metastasis(P<0.05) ; D-D level was negatively correlated with the degree of differentiation(P<0.05) ; there were no correlation between D-D level and pathological type(P>0.05), and there was no correlation of the vWF level with the degree of differentiation and pathological type(P>0.05) ; and there was a positive correlation between the D-D level and the vWF level(P<0.05). Conclusion The levels of D-D and vWF in patients with gastric cancer significantly increased, monitoring D-D and vWF levels has a great value in the diagnosis and progression of gastric cancer.

Chemokine (C-X-C motif) ligand (CXCL) is a class of secreted growth factor that signals through a G-protein coupled receptor. CXCL protein family members play important roles in inflammation and aberrant expression is associated with growth and progression of certain tumors. To explore the expression pattern and action mechanism of CXCL1 and CXCL8 in development of gastric carcinoma (GC), 72 cases of GC and para-carcinoma tissue specimens were used for experimental study, and qPCR was used for analysis on the expression of CXCL1 and CXCL8 in GC specimens. For in vitro culture of GC cell HGC27, knockout of CXCL1 and CXCL8 genes for GC cell HGC27 was performed through RNA interference, proliferation of HGC27 cells was tested by MTT, apoptosis of HGC27 cells was tested by flow cytometry, and the influence of CXCL1 and CXCL8 on HGC27 cell migration was tested by transwell. CXCL1 and CXCL8 expression level in HGC27 cells was analyzed by Western blotting. Co-immunoprecipitation (co-IP) was used for identifying interaction of CXCL1 and CXCL8 with CXCR2 in GC cells. The results show that both CXCL1 and CXCL8 expression were significantly up-regulated. Relevant clinical data showed that low expression of CXCL1 and CXCL8 significantly correlated with features for poor prognosis of GC, including serum alpha-fetoprotein (AFP) level, tumor size, and TNM staging. Down-regulation of CXCL1 and CXCL8 may up-regulate expression of each other and thus silencing expression of CXCL1 and CXCL8 may significantly inhibit proliferation and migration capabilities of HGC27 cells, and induce the apoptosis. Downregulated CXCL1 and CXCL8 expression in GC cells may significantly intensify interaction of one another and with CXCR2. The above results indicate that CXCL1 and CXCL8 participate in GC proliferation, apoptosis, and migration processes through specific binding with CXCR2 by a synergistic effect.

目的 探讨不同Child-Pugh分级肝硬化患者血小板参数与凝血指标的变化特征.方法 选取肝硬化患者98例,根据Child-Pugh分级标准分为A级、B级、C级3组,选取健康志愿者35例作为对照组,检测各组血小板参数及凝血指标水平.结果 不同Child-Pugh分级肝硬化患者的PLT、PCT均低于对照组,PDW、MPV均高于对照组;PLT、PCT随着Child-Pugh分级水平的升高而降低,PDW、MPV随着Child-Pugh分级水平的升高而升高,上述差异均有统计学意义(P＜0.05).不同Child-Pugh分级肝硬化患者的PT、APTT、TT均比对照组延长,Fib均比对照组降低;PT、AOTT、TT随着Child-Pugh分级水平的升高而延长,Fib随着Child-Pugh分级水平的升高而降低,上述差异均有统计学意义(P＜0.05).结论 肝硬化患者均有血小板参数及凝血指标的异常改变,且与肝功能Child-Pugh分级密切相关.

[目的]探讨英夫利西单抗治疗小肠克罗恩病患者临床疗效观察及对患者黏膜愈合和血清实验指标影响.[方法]选自我院于2014年3月～2017年3月收治的小肠克罗恩病患者94例,按照随机表法分为观察组47例与对照组47例.对照组口服硫唑嘌呤片,观察组在对照组基础上结合注射用英夫利西单抗.2组均以8周为1个周期,疗程均为4个周期.比较2组治疗疗效,治疗前后CDEIS评分、主观症状评分、CDAI评分、血清实验指标变化和黏膜愈合情况.[结果]观察组总有效率(82.98％)高于对照组(59.57％)(P＜0.05).2组治疗后CDEIS评分、主观症状评分及CDAI评分降低(观察组:t＝23.7080、22.5599、22.7149,对照组:t=15.5055、10.0715、13.2485,P＜0.05);观察组治疗后CDEIS评分、主观症状评分及CDAI评分高于对照组(t＝10.8065、13.9072、10.0482,P＜0.05).2组治疗后CRP和ESR降低而TLB和ALB增加(观察组:t=30.0790、21.4127、19.8374、22.7012,对照组:t=24.7104、8.6120、12.9603、12.9035,P＜0.05);观察组治疗后CRP和ESR低于对照组而TLB和ALB高于对照组(t=21.7920、11.5971、7.8347、13.0521,P＜0.05).观察组黏膜愈合率(51.06％)高于对照组(29.79％)(P＜0.05).[结论]英夫利西单抗治疗小肠克罗恩病患者临床疗效明显,可改善患者黏膜愈合,增加TLB和ALB及降低CRP和ESR,具有重要研究意义.

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目的 研究富含亮氨酸的α-2糖蛋白1(Leucine rich alpha-2 glycoprotein 1,LRG1)在结直肠癌患者血清的表达,探讨其临床意义.方法 共纳入65例结直肠癌患者、55例结直肠良性肿瘤患者、50例健康志愿者;分别采用酶联免疫吸附法(Enzyme linked immunosorbent assay,ELISA 法)检测血清LRG1水平,然后对三组患者血清中LRG1和CEA表达水平、结直肠癌血清LRG1与临床肿瘤分期的关系进行统计分析.结果 与结直肠良性肿瘤组及健康查体组相比,结直肠癌组血清中LRG1和 CEA水平明显偏高(P<0.01),结直肠良性肿瘤组和正常对照组比较差异无统计学意义(P>0.05);结直肠癌肿瘤分期与患者血清LRG1水平相关,Ⅲ、Ⅳ期恶性肿瘤患者血清LRG1水平明显高于Ⅰ、Ⅱ期恶性肿瘤患者,差异有统计学意义(P<0.01);联合检测与单独检测LRG1相比,差异有统计学意义(Z=2.763,P<0.01);与单独检测相比,联合检测准确率更高,差异有统计学意义(Z=3.034,P<0.01);LRG1与CEA差异有统计学意义(Z=0.752,P<0.05).结论 LRG1可作为结直肠癌诊断潜在的生物学标记.

The mechanism underlying the metastasis of gastric cancer (GC) cells remains elusive. REG3A is considered an oncogene in various cancers, but in GC its role is unclear. Here, we report that the expression of REG3A was significantly increased in the tumor tissues of patients with GC compared with the matched normal tissues. Knockdown of REG3A induced by specific small interfering RNA (siRNA) significantly repressed the proliferation of GC cells for 24 h or 48 h. Moreover, knockdown of REG3A significantly suppressed the migration, invasion, and adhesion of GC cells in vitro. Furthermore, knockdown of REG3A reduced the phosphorylation of JAK2 and STAT3, and altered the messenger RNA (mRNA) and protein expression levels of E-cadherin, Snail, RhoC, MTA1, MMP-2, and MMP-9. Taken together, REG3A is overexpressed in GC and promotes the proliferation, migration, invasion, and adhesion of GC cells by regulating the JAK2/STAT3 signal pathway. REG3A may be a potential therapeutic target for GC.

目的 对肝硬化门脉高压患者经颈静脉肝内门体分流术(TIPS)手术前后体质测量指标、糖代谢和肝肾功能变化情况进行研究,探讨TIPS术对肝硬化门脉高压症患者代谢的影响.方法 选择2014年1 1月-2015年10月温州医科大学附属第一医院乙型肝炎肝硬化门脉高压性TIPS手术治疗患者56例作为研究对象,比较肝硬化门脉高压患者TIPS手术前后体质测量指标、糖代谢和肝肾功能变化情况.结果 肝硬化门脉高压患者TIPS手术后1个月及6个月时的体重高于术前和术后7 d(P ＜0.05);肝硬化门脉高压患者TIPS术后7d、1个月及6个月时干重高于术前(P＜0.05).肝硬化门脉高压患者TIPS术后7d、术后1个月和术后6个月空腹胰岛素水平明显低于术前(P＜0.05).肝硬化门脉高压患者TIPS手术后7d谷丙转氨酶和谷草转氨酶高于手术前(P＜0.05),术后1个月和术后6个月谷丙转氨酶和谷草转氨酶均低于手术前(P＜0.05),术后1个月和术后6个月谷丙转氨酶和谷草转氨酶低于术后7 d(P ＜0.05).术后7d白蛋白和术前比较差异无统计学意义(P＞0.05),术后1个月和术后6个月白蛋白高于术前(P＜0.05).肝硬化门脉高压患者TIPS术后7d、术后1个月和术后6个月尿素低于术前(P＜0.05).结论 TIPS术治疗门脉高压症肝硬化能够增加患者体重和干重,改善肝功能,改善胰岛素抵抗和尿素代谢.