目的 分析补肾益髓方防治恶性肿瘤化疗后血小板减少症的临床效果.方法 收集2014年1月至2015年1月既往化疗≥2次、符合诊断标准及本研究纳入标准、需要再次进行化疗的住院患者.采用完全随机方法随机分为治疗组和对照组,每组35例.对照组以标准化疗方案进行单纯化疗治疗,治疗组在单纯化疗治疗基础上,于化疗前1 d开始加以补肾益髓方中药汤剂口服21 d.以2组PLT及MPV指标、不同时间中医临床症状积分、KPS评分、不良反应发生率为依据.结果 治疗组治疗前PLT水平与对照组差异无统计学意义(P>0.05);2组治疗后14 d、21 d PLT水平均高于治疗前(P<0.05);治疗组治疗后14 d、21 d PLT水平均高于对照组(P<0.05);治疗组治疗前中医证候积分与对照组差异无统计学意义(P<0.05);治疗组、对照组治疗后14 d、21 d中医证候积分均低于治疗前(P<0.05);治疗组及对照组治疗后21 d中医证候积分均低于治疗后14 d(P<0.05);治疗组治疗后14 d、21 d中医证候积分均低于对照组(P<0.05);治疗组治疗后总有效率高于对照组(P<0.05);2组患者均无严重肝肾功能损害;治疗组不良反应总发生率低于对照组(P<0.05).结论 中药补肾益髓方对防治接受化疗的恶性肿瘤患者血小板减少症能够发挥良好临床效果,安全性也较好,值得进一步研究和大力推广.

目的:探讨小金胶囊联合左甲状腺素钠片治疗桥本氏甲状腺炎的临床研究.方法:选取2017年8月—2019年1月收治的桥本氏甲状腺炎患者106例,按照数字表法将其随机分为两组,对照组应用左甲状腺素钠片治疗,研究组应用小金胶囊联合左甲状腺素钠片治疗,对两组患者临床疗效、甲状腺功能及炎症反应等指标进行分析.结果:研究组的临床治愈比例高于对照组(50.9％vs 18.7％);研究组的T3(2.2±0.5)nmol/L、T4(124.2±17.8)nmol/L、FT3(4.3±0.7)pmol/L及FT4(14.4±2.9)pmol/L与对照组无明显差异(P>0.05),研究组的TSH(1.8±0.2)μIU/L低于对照组(P<0.05);研究组甲状腺抗体水平TG-Ab(253.4±12.8)IU/mL、TPO-Ab(241.3±12.8)IU/mL均低于对照组(P<0.05);研究组IL-8(0.4±0.2)ng/mL、IL-17(7.4±2.1)pg/mL及APN(5.9±1.1)μg/mL低于对照组(P<0.05),研究组的IL-10(91.8±12.6)pg/mL高于对照组(P<0.05);研究组不良反应(22.64％)与对照组(24.53％)无明显差异(P>0.05).结论:采用小金胶囊联合左甲状腺素钠片治疗桥本氏甲状腺炎患者,能有效改善患者甲状腺抗体水平,调节自身炎症因子平衡,具有较高的安全性,可以在临床中进行进一步推广.

目的 分析儿童咳嗽变异性哮喘(cough variant asthma,CVA)误诊的相关原因,以降低误诊率,提高儿童CVA的临床诊治水平.方法 回顾性分析2015年8月—2019年6月我院收治的86例CVA患儿中8例误诊患儿的临床资料.结果 本组误诊率为9.30％.8例中3例因咳嗽38～52 d入院,2例因慢性反复发作性咳嗽3、6个月入院,2例因反复刺激性咳嗽3～5个月、加重5～7 d入院,1例因反复咳嗽1月余入院,误诊为支原体肺炎3例,支气管炎及慢性咽炎各2例,百日咳1例,误诊时间为2～6(3.46±0.42)d.本组经支气管舒张及激发试验、肺功能检查、皮肤变应原试验,并结合病史、临床表现确诊为CVA.确诊后予支气管扩张剂、β2受体激动剂、糖皮质激素、抗组胺药物等治疗后病情好转出院,出院后均随访半年,均未再发.结论 CVA临床表现不典型,接诊医生诊断思维狭隘,易引起误诊.临床医生应加强对CVA的认识,详细询问病史,综合分析病情,及时行针对性医技检查,可减少或避免误诊的发生.

目的:研究纳米穴位贴敷联合超声脉冲电导治疗肺癌疼痛的临床效果.方法:选择本院于2019年1月-2020年1月期间收治60例肺癌疼痛患者作为本次研究对象,按照患者入院接受治疗的先后顺序,将患者分为对照组和观察组,每组各有30例患者,对照组内采用口服右酮洛芬片的方法进行治疗,观察组内采用纳米穴位贴敷联合超声脉冲电导方法进行治疗,对比两组患者的临床治疗效果.结果:观察组内患者的治疗效果显著由于对照组内患者的治疗效果,两组比较有显著差异(P<0.05).结论:为肺癌疼痛患者采用纳米穴位贴敷联合超声脉冲电导进行治疗,疗效显著,临床应用价值明显,应在临床广泛推广应用.

目的 探讨小金胶囊联合左甲状腺素钠治疗高碘地区桥本甲状腺炎伴结节的效果及对甲状腺抗体与甲状腺功能的影响.方法 选取2018年1月至2019年3月河北省黄骅市人民医院收治的桥本甲状腺炎伴结节患者104例,按随机数字表法分为对照组与研究组,各52例.对照组应用左甲状腺素钠,研究组在此基础上联合应用小金胶囊.比较两组临床治疗有效率;治疗前后两组甲状腺相关抗体指标水平差异及变化;治疗前后两组甲状腺功能:游离三碘甲腺原氨酸、游离甲状腺素及促甲状腺激素水平差异及变化;两组治疗的安全性.结果 研究组有效率为94.2％,显著高于对照组的80.8％(P<0.05).治疗后研究组抗甲状腺球蛋白抗体水平、甲状腺过氧化物酶抗体水平显著低于对照组(P<0.05).治疗后研究组与对照组游离三碘甲腺原氨酸水平及游离甲状腺素水平差异无显著性(P>0.05),研究组促甲状腺激素水平显著低于对照组(P<0.05).两组患者未出现严重的4级不良反应及并发症,差异无显著性(P>0.05).结论 左甲状腺素钠联合小金胶囊治疗桥本甲状腺炎伴结节,可显著提高患者的临床治疗有效率,改善甲状腺功能及甲状腺抗体功能,且不会增加患者发生相关不良反应的风险.

目的:研究超声电导辅助镇痛在癌痛规范化治疗的应用效果.方法:选择我院2019年1月-2020年1月期间收治的80例癌痛患者作为本次研究对象,按照随机分组的方法将80例患者分为观察组与对照组两组,每组各40例,为对照组内患者采用常规疗法进行治疗,为观察组内患者在常规治疗的基础上,采用超声电导作为辅助疗法进行治疗,对比两组患者不良反应或副作用的发生率.结果:观察组内患者不良反应的发生率明显低于对照组,两组比较有显著差异(P<0.05).结论:在常规治疗的基础上,为癌痛患者采用超声电导作为辅助疗法,能够有效的提高癌痛疾病的临床治疗效果,提升临床治疗的安全性,降低不良反应的发生率,临床应用价值显著,应在临床中广泛推广应用.

目的 分析反复呼吸道感染患儿体内的微炎性反应水平与外周血T淋巴细胞亚群的相关性.方法选择2017年2月—2019年6月诊断为反复呼吸道感染的患儿120例作为感染组,同期门诊体检正常儿童120例为对照组.检测2组的外周血T淋巴细胞亚群指标,并检测血清超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、IL-17、转化生长因子-β1(TGF-β1)、降钙素原(PCT)水平和中性粒细胞/淋巴细胞比例(NLR).分析Treg T淋巴细胞比例和Th17/Treg比值与NLR、hs-CRP、IL-6、TGF-β1的相关性,并分析Th1/Th2、Th17/Treg、Treg T淋巴细胞比例对反复呼吸道感染的诊断效能.结果与对照组比较,感染组的外周血CD4+T淋巴细胞比例、CD4+/CD8+、Th1/Th2、Th17/Treg比值降低,血清hs-CRP、NLR、IL-6、TGF-β1水平升高,IL-17水平降低(P<0.05).2组血清PCT水平比较差异无统计学意义(P>0.05).Treg T淋巴细胞比例与NLR、hs-CRP、IL-6、TGF-β1呈直线正相关(P<0.05),Th17/Treg比值与NLR、hs-CRP、IL-6、TGF-β1呈直线负相关(P<0.05).以Th1/Th2≤7.65为截断值,其诊断灵敏度为78.46％,特异性为83.42％.以Th17/Treg≤0.43为截断值,其诊断灵敏度为81.24％,特异性为88.70％.以Treg T淋巴细胞比例≥32.28％为截断值,其诊断灵敏度为84.35％,特异性为87.92％.结论反复呼吸道感染患儿体内存在免疫炎性反应失衡.Treg T淋巴细胞比例、Th17/Treg比值与血清炎性因子水平存在相关性.外周血Th1/Th2、Th17/Treg、Treg T淋巴细胞比例对反复呼吸道感染具有一定诊断价值.

目的:观察鳖甲化坚汤联合化疗治疗晚期胃癌对血清肿瘤标志物水平的影响研究.方法:选择医院2015年1月～2017年1月收治胃癌晚期患者120例,按随机数表法分为两组.对照组采用常规西药化疗方案治疗,三周为1个疗程,治疗6个疗程;观察组在对照组基础上服用鳖甲化坚汤,1剂/天,治疗4周后停药1周,总治疗时间为18周.统计两组患者疗效,检测两组患者糖链抗原(CA19-9、CA72-4)、癌胚抗原(CEA)水平,检测两组患者免疫功能,采用癌症患者生命质量核心量表(QLQ-C30)评估两组患者生活质量.结果:观察组治疗有效率(87.69％)明显高于对照组(70.91％),差异有统计学意义(P＜0.05);治疗后,观察组CEA、CA19-9、CA72-4水平均低于对照组,差异有统计学意义(P＜0.05);治疗后,观察组CD3+、CD4+均高于对照组,CD8+低于对照组,差异有统计学意义(P＜0.05);治疗后,观察组躯体功能、角色功能、情绪功能、社会功能及总体健康评分均高于对照组,差异有统计学意义(P＜0.05).结论:鳖甲化坚汤联合化疗治疗晚期胃癌可有效降低血清肿瘤标志物水平.

目的 探讨小金胶囊联合左甲状腺素钠片治疗桥本甲状腺炎伴结节的临床效果.方法 随机抽取河北省黄骅市人民医院2013年5月至2016年12月收治的124例桥本甲状腺炎伴结节患者,采用随机数字表法分为研究组和对照组各62例.对照组患者给予左甲状腺素钠片治疗,研究组患者给予小金胶囊联合左甲状腺素钠片治疗,观察两组患者治疗效果、治疗前后甲状腺激素水平、治疗前后甲状腺体积、治疗不良反应等,进行统计分析.结果 两组患者治疗前后甲状腺激素水平无显著性差异(P>0.05),两组间比较,无显著性差异(P>0.05).研究组治疗有效率为90.32％,对照组为54.84％,有显著性差异(χ2=4.644,P=0.031).两组患者治疗后甲状腺体积均恢复,与治疗前比较,差异均有显著性(研究组t=8.582,P<0.001;对照组t=3.033,P=0.003),两组治疗后甲状腺体积差异有显著性(t=4.037,P<0.001).两组治疗后均未出现明显不良反应.结论 小金胶囊联合左甲状腺素钠片治疗桥本甲状腺炎伴结节患者对甲状腺功能影响较小,治疗安全有效,值得临床应用.

目的 研究三伏贴联合黄芪穴位注射的方法治疗小儿反复呼吸道感染,探讨其相关炎性机制与反复呼吸道感染发病的关系,并评价其临床疗效.方法 反复性呼吸道感染的小儿患者160例分为对照组和研究组,每组80例,对照组给予常规西医对症治疗,研究组在对照组的基础上给予三伏贴(头伏、中伏及末伏中选取1 d进行贴敷,穴位选取肺腧、肾腧、脾腧、定喘、大椎以及膻中穴,时间选取三伏中的任一天进行)联合黄芪穴位注射于双侧足三里穴处进行,5 d为1疗程,治疗期为3个疗程,每个疗程结束后中间休息1 d,并于治疗前后分别检测2组患者的血清免疫球蛋白(IgG、IgM、IgA、C3)、中性粒细胞/淋巴细胞比例(NLR)、白介素-6(IL-6)、白介素-10(IL-10)、白介素-17(IL-17)、转化生长因子(TGF-β1)水平,并对2组患者治疗后的临床疗效进行对比分析.结果 治疗前2组患者的IgG、IgM、IgA、C3、NLR、IL-6、IL-10、IL-17、TGF-β1比较差异无统计学意义(P>0.05);治疗后2组患者的IL-6、IL-10、NLR及TGF-β1水平较前下降,IL-17水平较前上升,且研究组明显优于对照组,差异有统计学意义(P<0.05),外周血浆免疫球蛋白IgG、IgM、IgA、C3水平轻度下降,差异无统计学意义(P>0.05).研究组临床疗效明显优于对照组(P<0.05).结论 炎性反应广泛参与小儿反复呼吸道感染的发生发展中,三伏贴联合黄芪穴位注射可有效的下调患儿体内的炎性反应,对于小儿反复呼吸道感染的临床疗效显著.

目的:探讨经超声脉冲理疗仪穴位导入高乌甲素治疗癌痛的临床观察中的应用.方法:选择2015年1至2018年1月在我院就诊的84例中晚期肿瘤患者,随即分2组,对照组患者接受常规干预:口服奥施康定,在爆发痛时肌注盐酸哌替啶;观察组患者在上述常规治疗的基础上,联合超声理疗仪进行理疗并在穴位中注射高乌甲素注射液和利多卡因注射液.观察两组患者在滴定完成后10 d后的镇痛疗效和VAS评分,10d内接受盐酸哌替啶肌注的平均次数和满意度,患者癌痛治疗相关副作用的发生情况.结果:观察组患者的显效例数为23例,显效率为54.8％,较对照组明显提高(P<0.05);观察组总有效例数为35例,总有效率为83.3％,较对照组明显提高(P<0.05).治疗前两组患者的VAS评分未见明显差异(P>0.05);治疗后1d,观察组VAS评分较对照组明显降低(P<0.05);治疗后10d,观察组VAS评分较对照组明显降低(P<0.05).两组患者在治疗后1d和治疗后10d的VAS评分较治疗前均明显降低(P<0.05).观察组10d哌替啶肌肉注射的平均次数为1.6±1.0次,对照组平均次数为2.5±1.1次,观察组平均次数明显低于对照组(P<0.05).观察组满意例数为37例,站88.1％,较对照组满意例数26例,占61.9％,满意度明显升高(P<0.05),发现观察组不良反应发生的总例数为19例,占45.2％,较对照组29例,占69.0％,明显降低(P<0.05).结论:在常规癌痛干预中,联合穴位注射和超声辅助,能够改善镇痛的疗效和减少疼痛评分,减少哌替啶的肌注次数和不良反应的发生,提高患者满意度.

目的:探讨反复呼吸道感染患儿体内免疫功能与炎性反应机制及护理研究.方法:选择2014年10月至2017年10月诊断反复呼吸道感染患者160例作为观察组,取同期门诊正常小儿60例作为对照组,采用流式细胞仪分析2组患者外周血T淋巴细胞亚群:CD3+、CD4+、CD4+CD25+、CD4+/CD8+、NK细胞比例变化,双抗体夹心电化学发光法检测血清降钙素原(PCT),免疫比浊法检测血清C反应蛋白,全血细胞计数计算中性粒细胞/淋巴细胞比例(NLR),酶联免疫吸附法检测血清白介素-6、白介素-10、转化生长因子(TGF-β1)水平.采用Pearson相关分析IL-6与NLR、CRP之间相关性.结果:观察组与对照组比较,患儿外周血T淋巴细胞亚群CD3+[(39.83±5.73)％比(50.57±6.32)％,t=2.680]、CD4+[(33.79±4.21)％比(40.78±3.27)％,t=2.548]、CD4+/CD8+ [(0.98±0.24)比(1.23±2.38),t=2.543]、NK细胞[(19.83±3.26)％比(23.45±4.27)％,t=2.765]水平下降,CD4+ CD25+[(26.87±4.29)％比(19.82±5.32)％,t=2.903]水平升高,2组比较差异有统计学意义 (P＜0.05).血清CRP[(21.89±3.58)mg/L比(11.23±3.87)mg/L,t=2.902]、NLR[(5.43±0.32)比(3.90±0.45),t=2.451]、IL-6[(26.89±7.62)U/L比(12.37±5.62)U/L,t=3.091]水平升高,IL-10[(24.80±3.21)U/L比(35.80±5.42)U/L,t=3.084]、TGF-β1[(43.89±5.17)pg/ml比(56.57±6.90)pg/ml,t=2.654]水平下降,2组比较差异有统计学意义(P＜0.05).2组患者血清PCT水平差异无统计学意义(P＞0.05).CD4+ CD25+比例与NLR、CRP呈正相关(r=0.881;0.783,P＜0.05).结论:反复呼吸道感染患者存在机体免疫调节功能紊乱与炎性应激反应加剧,主要表现为抑制性免疫T淋巴细胞比例上调与血清炎性细胞因子水平升高.二者之间存在一定相关,应重视对其免疫调节治疗及护理.

[Objective]To investigate the effects of analgesia and quality of life in patients with cancer pain through acupoint introduction of lappaconitone by ultrasonic pulse therapy instrument . [MethodslA total of 98 patients with advanced stage tumors admitted to our hospital were divided into two groups. Patients (n = 48) in the control group received standardized treatment for cancer pain,and patients (n = 50) in the observation group were treated with ultrasound-guided analgesia on the basis of routine treatment. Both groups received continuous treatment for 7 days . Analgesic effect and quality of life between the two groups were compared.[Results]After treatment, the NRS scores (number rating scale) of the two groups were lower than those before treatment(P <0.05),and the NRS scores in the observation group were significantly lower than in the control group (P <0.05) . The total effective rate of pain relief in the observation group was 90.00％ (45/50), which was significantly higher than that in the control group 68.75％ (33/48, P < 0.05). Before treatment , there was no significant difference in life quality measurement scale (WHOQOL-BREF scores) between the two groups (P>0.05) . After treatment, both groups had higher scores in terms of subjective feeling of health condition, quality of life, physiological,psychological, environmental and social relations (P <0.05) . Compared to the control group, the scores of subjective feeling of health condition,physiological and psychological status in the observation group was better (P <0.05) . There was no significant difference in subjective feeling of life quality, environmental and social relations between the two groups (P >0.05).[Conclusion]The introduction of lappaconitone by ultrasonic pulse therapy can significantly reduce the pain level of cancer patient and improve the pain relief rate and quality of life in patients with cancer pain

Objective To observe the effects of Xiaojin capsule combined with left thyroxine sodium tablets on thyroid antibody of patients with hashimoto's thyroiditis. Methods A total of 124 patients with hashimoto's thyroiditis who were treated in our hospital from May 2013 to December 2016 were randomly divided into study group ( n=62) and control group (n=62). The patients in study group were treated by Xiaojin capsule combined with left thyroxine sodium tablets, however,the patients in control group were treated by left thyroxine sodium tablets only. After treatment the therapeutic effects,the changes of levels of TG-Ab and TPOAb, thyroid nodule volume,TCM symptom scores were observed and compard between two groups. Results After the treatment,the levels of TG-Ab and TPOAb,thyroid nodules volume,TCM symptom scores were significantly decreased,as compared with those before treatment (P <0. 05). Moreover there were significant differences in decrease degree of antibodies, TCM symptom scores after treatment between two groups,however, there were no significant differences in the changes of thyroid nodule volume after treatment between two groups (P>0. 05). Conclusion Xiaojin capsule combined with left thyroxine sodium tablets on thyroid antibody can significantly improve the symptoms and signs of patients with hashimoto's thyroiditis,which can also obviously reduce the levels of thyroid autoantibodies,with safety and reliablity,therefor, which is worthy of clinical popularization.

Objective:.To study the therapeutic effect of Jiawei Sini Powder on diarrhea-predominant irritable bowel syndrome (IBS) by comparing traditional Chinese medicine mnd western medicine,and to provide references for the treatment of irritable bowel syndrome.Methods:From October 2014 to October 2016,80 cases of diarrhea predominant irritable bowel syndrome were treated in our hospital,and they were divided into two groups:40 cases in controlled group and 40 cases in treatment group.According to the different clinical treatment methods,patients were randomly divided into treatment group (using dialectical treatment) and controlled group (using conventional treatment).Results:The treatment group of 40 patients,of which 21 patients were cured,the total number of 52.5％;treatment markedly in 12 patients,accounting for 30.0％ of the total number of cases;effective treatment of patients in 3 cases,7.5％ of the total number;treatment ineffective patients in 4 cases,10.0％ of the total number of cases.The controlled group of 40 patients,of which 12 patients were cured,accounting for 30％ of the total number of cases;10 cases of markedly effective treatment,accounting for 25.0％ of the total number of cases;9 cases of effective treatment,the number of 22.5％,9 cases of ineffective treatment of patients,accounting for 22.5％ of the total number of cases,the difference was statistically significant.After treatment,the scores of TCM syndromes of the two groups were all reduced in different degrees,the treatment group was much more than the controlled group,the difference was significant (P ＜ 0.05).After treatment,the IBS symptom scores (P ＜ 0.05).After the treatment,the patients were followed up for one month after the treatment,and the integral table of the TCM syndrome and the score of the score of the TCM syndromes were collected.The scores of the treatment group were significantly lower than those of the controlled group.More than 10 points were judged as relapse (P ＜0.05).The quality of life of the patients included mental status,emotional status,energy intensity,sleep status,daily social behavior (P ＜ 0.05).The relapse rate of the treatment group was 7.5％,significantly lower than the controlled group which was 20.0％.The diet was normal,the work was normal and the daily movement of 8 projects,the treatment group in the above 8 projects were higher than the controlled group,the difference was statistically significant.Conclusion:Whether the patients ' condition improve,the recurrence rate or the quality of life of patients with dialectical Chinese medicine treatment group is better than Western medicine to get a better effect.

Objective:To observe the effect of Jiawei Sini San (加味四逆散, JWSNS) on diarrhea type of irritable bowel syndrome.Methods:The 120 patients with irritable bowel syndrome were randomly divided into treatment group and control group,60 cases in each.The treatment group was given JWSNS,while the control group was treated with pinaverium bromide,treatment for 6 weeks.Before and after treatment,the main symptom scores,IBS-QOL scale scores and therapeutic effect were evaluated.Results:After treatment,the main clinical symptoms scores in treatment group and control group decreased,the difference was statistically significant (P＜0.05),the scores of treatment group were lower than the control group,the difference was statistically significant (P＜0.05);the IBS-QOL scores and the total scores of the treatment group and the control group were improved,the difference was statistically significant (P＜0.05);and the treatment group after treatment of integral health concerns and the total score were higher than the control group,the difference was statistically significant (P＜0.05).Compared with the control group,the treatment group had higher total effective rate,and the difference was statistically significant (P＜0.05).After treatment,the treatment group and the control group of serum IL-1β and IL-8 level was lower than that before treatment,the difference was statistically significant (P＜0.05);serum IL-1β and IL-8 level of treatment group was lowcr than the treatment group,the difference was statistically significant (P＜0.05).Conclusion:JWSNS has a significant clinical effect in the treatment of diarrhea predominant irritable bowel syndrome (liver stagnation and spleen deficiency type).

Objective:To investigate the clinical effect of modified Sini San combined with acupuncture in the treatment of liver-stomach disharmony.Methods:97 cases of pregnant vomiting patients with the pattern of liver-stomach disharmony were randomly divided into the observation group (49 cases) and the control group (48 cases).The observation group was treated with modified Sini San combined with acupuncture, and the control group was treated with Sini San alone.The clinical efficacy after medication, the TCM syndrome integral, and serum levels of β-HCG before and after medication were compared between the two groups.Results:The clinical effective rate of the observation group was 97.96%, which was higher than 83.33% of the control group, the difference was significant(P<0.05).There was no significant differences in terms of β-HCG level and TCM syndrome integral betwe the two groups before medication(P>0.05);after medication, the TCM syndrome integral and serum β-HCG levels of the observation group {(7.21± 0.84), (210 168±9 420.25)Mlu/ml} improved more than those in the control group {(13.15±0.67), (201 535±9 625.06) Mlu/ml}, in which there was a statistical significance(P<0.05).Conclusion:The modified Sini San combined with acupuncture has a good clinical effect for pregnant vomiting with liver-stomach disharmony, it can obviously improve the symptoms of pregnant women without toxic reaction or side effect for mother and fetus;therefore, it is worthy of clinical application.

Objective: To observe the clinical effect of Xiaobanxia Jupi Zhuru Decoction in treating pregnancy evil.Methods: 100 patients of pregnancy evil were selected from Jun 2013 to Jan 2015,according to the principle of randomization,patients were divided into control group (western medicine routine treatment) and observation group (western medicine routine treatment jointed Xiaobanxia Jupi Zhuru Decoction),while 50 cases in each group.The clinical therapeutic effect of two groups were compared.Results: The total efficiency of the observation group was higher than the control group,the difference was statistically significant (P<0.05).Conclusion: The treatment of pregnancy evil by the combination of Xiaobanxia Jupi Zhuru Decoction can significantly improve the therapeutic effect, shorten the course of disease and reduce the recurrence rate,and can significantly promote the embryo development.

目的 探讨血清腺苷脱氨酶(adenosine deaminase,ADA)及外周血异型淋巴细胞联合检测在传染性单核细胞增多症(IM)患儿诊断及鉴别诊断中的临床价值.方法 采用过氧化物酶法检测50例IM患儿血清ADA活性水平及外周血涂片分类100个白细胞,计数异型淋巴细胞百分比,并与50例同时期健康体检(排除EB病毒感染)对照组儿童进行比较.结果 血清ADA检测对小儿IM鉴别诊断特异性为71.0％、敏感性为55.6％、准确性为69.8％;外周血异型淋巴细胞分类计数特异性为61.1％、敏感性为58.6％、准确性为63.3％;联合两项指标检测特异性为76.9％、敏感性为67.8％、准确性为79.8％.结论 联合检测血清ADA及外周血异型淋巴细胞有助于小儿IM的诊断,较单一指标检测可明显提高诊断特异性、敏感性及准确性.患儿出现不规则发热,且血清ADA水平及异型淋巴细胞比例升高时,应考虑到有EB病毒感染的可能性.

【目的】探讨康莱特联合亚砷酸胸腔注射与热疗法治疗非小细胞肺癌(NSCLC)胸积液患者的疗效。【方法】100例肺癌胸腔积液患者，采用随机的原则分为两组，每组50例，观察组患者行康莱特与亚砷酸胸腔注射联合热疗法治疗；对照组单独使用亚砷酸胸腔注射联合热疗法治疗。比较两组患者免疫功能情况、治疗前后生活质量评分以及不良反应发生率。【结果】治疗后，观察组细胞免疫和体液免疫功能明显高于对照组，且差异具有显著性(P <0.05)；观察组的生活质量评分改善有效率为80%(40/50)明显高于对照组50%(25/50)，且差异具有显著性(P <0.05)。【结论】采用康莱特联合亚砷酸胸腔注射与热疗法能够更好地控制肺癌胸腔积液，提高患者的免疫功能，有效改善患者生存质量。