Background Infantile hemangioma is one of the most common benign soft tissue tumors in infants. The pathogenesis of infantile hemangioma remains unclear and twin studies regarding its incidence may help clarify disease pathogenesis. Thus, this study aimed to analyze the clinical characteristics of infantile hemangioma in twin patients and discuss its clinical incidence. Methods We retrospectively analyzed the data of 83 pairs of twins with infantile hemangioma admitted to the Guangdong Provincial Women and Children Hospital and Henan Provincial People’s Hospital between May 2016 and May 2022. Thirty-one pairs of twins among whom both developed infantile hemangioma and 52 pairs of twins among whom only one twin was affected were included. Analysis was performed using the Spearman correlation. Additionally, we analyzed the influence of factors such as sex, twin zygosity, preterm birth, birth weight, and assisted reproduction on the clinical characteristics of twins. Results We observed that disease occurrence in both twins correlated with assisted reproduction (χ2 = 13. 102, P < 0.05) and preterm birth (χ2 = 36.523, P < 0.05). Twin zygosity (χ2 = 0.716, P > 0.05) and total birth weight of twins (t=-3.369, P > 0.05) were not correlated with infantile hemangioma. However, among twins, the ones with lesser birth weight were more likely to develop infantile hemangioma. Conclusions The clinical characteristics of infantile hemangioma in twins were consistent with their epidemiological characteristics. Female sex, preterm birth, less birth weight, and assisted reproduction increased the probability of morbidity in both twins. Analysis of the characteristics of infantile hemangioma in twins may assist further research and clinical treatment.

目的 探讨数字化X线摄影锁骨前后位及前后轴位在婴幼儿锁骨检查中的应用价值.方法 回顾性分析本院临床怀疑婴幼儿锁骨骨折患者192例,行婴幼儿锁骨前后位及婴幼儿锁骨前后轴位拍摄,分析两项检查一次检查成功率及正确诊断骨折检出率,应用卡方检验法进行数据统计分析.结果 192例患者婴幼儿锁骨前后位、婴幼儿锁骨前后轴位一次拍摄成功分别为187例(97.4％)、185例(96.4％).192例锁骨检查中锁骨骨折136例,其中婴幼儿锁骨前后位检出110例;婴幼儿锁骨前后轴位检出108例,两项检查联合诊断检出126例,联合检查锁骨骨折检出率明显高于单项检查,与婴幼儿锁骨前后位、婴幼儿锁骨前后轴位分析,差异具有统计学意义.结论 婴儿常规锁骨拍摄,即应用改良方法拍摄婴幼儿锁骨前后位,必要时加婴幼儿锁骨前后轴位拍摄,婴幼儿锁骨前后位拍摄在显示锁骨前后面骨折有优势,锁骨前后轴位拍摄在显示锁骨S型弯及上下面骨折有优势,两者联合检查,有助于提高锁骨骨折检出率.

Objective:To explore the clinical characteristics of infantile hemangioma (IH) in twin children and to elucidate its pathogenic mechanism.Methods:Retrospective review was performed for clinical data of 72 pairs of IH twins admitted into Guangdong Women & Children's Hospital and Henan Provincial People's Hospital from May 2016 to June 2021.Twenty-five pairs of twins had identical diseases while 47 pairs of twins were affected only unilaterally. χ2 correlation analysis was performed for examining the influence of such factors as gender, twin zygosity, preterm birth, birth weight and assisted reproduction on clinical characteristics of twins. Results:Among 25 pairs of twins with identical diseases, there were 22 pairs of female twins, 2 pairs of male twins and 1 pair of pigeon twins; 24 pairs of monozygotic twins and 1 pair of dizygotic twins; 16 pairs of natural conception and 9 pairs of assisted reproductive twins; 20 pairs of preterm born twins and 5 pairs of twins born at term.And among 47 pairs of unilaterally affected twins, there were 17 pairs of female twins, 25 pairs of male twins and 5 pairs of pigeon twins; 37 pairs of monozygotic twins and 10 pairs of dizygotic twins; 8 pairs of natural conception and 39 pairs of assisted reproductive twins; 21 pairs of preterm born twins and 26 pairs of twins born at term.Futhermore, for 47 pairs of unilaterally affected twins, 89.4%(42/47) of affected twin had a lesser birth weight than the other one.And whether or not twins both have identical diseases was correlated with gender ( χ2=17.84, P<0.05) and yet not with twin zygosity ( χ2=3.76, P>0.05). It was correlated with assisted reproduction ( χ2=16.21, P<0.05) and preterm birth ( χ2=8.303, P<0.05). However, individual with lower birth weight in twins was more susceptible. Conclusions:Clinical characteristics of IH twins are basically consistent with their epidemiological characteristics.Female, preterm birth, low birth weight and assisted reproduction may elevate the probability of co-morbidity in twins.

Objective:To understand the relationship between vitamin D status and anemia in infants in Guangzhou, and to provide measures for the prevention of vitamin D deficiency and references for the prevention of anemia in infants.Methods:A cross-sectional analysis was used to investigated 8 530 infants who were 3-36 months old and took physical examination at Guangdong Woman and Children's Health Hospital in 2018, including 4 935 boys and 3 595 girls. Their blood samples were collected for the detection of 25-hydroxy vitamin D and hemoglobin. t test, χ2 test, χ2trend test, and Pearson correlation analysis were applied. Results:The level of 25-hydroxy vitamin D was (81.05±25.41) nmol/L in the infants. There was no statistical difference in the level of 25-hydroxy vitamin D between the boys and the girls ( P>0.05). The incidences of vitamin D deficiency and insufficiency were 7.68% (655/8 530) and 37.47% (3 196/8 530). There was no statistical difference in vitamin D status between the boys and the girls ( P>0.05). As the infants was elder, the serum level of 25-hydroxy vitamin D was lower ( P<0.05), and the incidences of vitamin D deficiency and insufficiency were higher ( χ2trend=143.200, P<0.001). The level of hemoglobin was (118.68±10.30)g/L in the infants. There were no statistical differences in the level of hemoglobin and the detection rate of anemia between the boys and the girls (both P>0.05). As the infants were elder, the level of hemoglobin was higher and the detection rate of anemia was lower ( χ2trend=446.532, P<0.001). The levels of hemoglobin in the vitamin D deficiency group and the vitamin D insufficiency group were lower than that in the vitamin D sufficiency group ( P<0.05). The incidences of anemia in the vitamin D deficiency group and the vitamin D insufficiency group were higher than that in the vitamin D sufficiency group ( P<0.05). The level of 25-hydroxy vitamin D was positively correlated with the hemoglobin level in the infants ( r=0.149, P<0.001). Conclusions:The incidence of vitamin D insufficiency is high in 6-36 months old children in Guangzhou. The level of 25-hydroxy vitamin D is positively associated with hemoglobin in infants. Vitamin D deficiency or insufficiency may be associated with anemia in infants. Comprehensive measures should be taken to improve the vitamin D status and anemia of infants.

Radiological therapy/examination is the primary source of artificial radiation exposure in humans. While its application has contributed to major advances in disease diagnosis and treatment, ionizing radiation exposure is associated with ovarian damage. The use of natural products, either alone or as an adjunct, has become increasingly common for reducing the side effects of radiological therapy during disease treatment. Herein, we explored the protective effect of folic acid (FA), a widely used B vitamin, against radiation-induced ovarian injury and its mechanism of action. Female mice with normal ovarian function were randomly divided into control, FA, radiation, and radiation + FA groups. The intervention strategy included daily intragastric administration of FA (5 mg/kg) for 3 weeks prior to radiation exposure. Mice in the radiation and radiation + FA groups received a single dose of 5 Gy X-ray irradiation. Changes in the estrous cycle were then recorded, and ovarian tissues were collected. Pathophysiological changes as well as reproductive and endocrine-related indexes were determined via H&E staining, immunohistochemistry, Western blot, and ELISA. The reproductive performance and emotional symptoms of animals were also monitored. Our results indicated that FA intervention effectively alleviated ovarian damage, leading to more regular estrous cycles, lesser impairment of follicular morphology and endocrine status, as well as greater germ cell preservation. Reduced levels of oxidative stress, inflammation, and enhanced DNA repair were associated these changes. FA pre-administration improved the reproductive performance, leading to higher pregnancy rates and greater litter sizes. Further, the anxiety levels of animals were significantly reduced. Our results indicate that FA pre-administration significantly alleviates radiation-induced ovarian damage in rodents, highlighting its potential as a protective strategy against radiation exposure in the female population.

Objective:To systematically evaluate the short-term efficacy and safety of robotic distal gastrectomy (RDG) and laparoscopic distal gastrectomy (LDG) with D2 lymphadenectomy in the treatment of distal gastric cancer.Methods:The databases of CNKI, Wanfang, CBM, Chongqing VIP, Pubmed, Cochrane Library, Embase, and Web of Science were searched. The Chinese and English literatures published before September 6, 2020 about comparative analysis of efficacies of RDG and LDG with D2 lymphadenectomy in the treatment of distal gastric cancer. After the methodologic quality was assessed and the valid data were extracted, RevMan 5.3 software was used for the final meta-analysis.Results:Nine retrospective studies from 8 literatures including 2 131 cases were enrolled in the study. There were 997 cases in the RDG group and 1 134 cases in the LDG group. There were no statistically significant differences in the operation time and incidence of postoperative complications between the two groups (both P>0.05). Compared with those in the LDG group, the RDG group had less intraoperative blood loss ( MD=-35.38, 95% CI -52.18～-18.59, Z=4.13, P<0.05), more lymph nodes resected ( MD=2.82, 95% CI 0.71～4.94, Z=2.62, P<0.05), shorter anal exhaust time, oral feeding time, drainage tube removal time, postoperative time out of bed, and hospital stay ( MD=-7.86, 95% CI -13.12～-2.60, Z=2.93, P<0.05; MD=-8.83, 95% CI -13.26～-4.40, Z=3.90, P<0.05; MD=-0.54, 95% CI -0.85～-0.23, Z=3.41, P<0.05; MD=-6.19, 95% CI -8.39～-4.00, Z=5.53, P<0.05; MD=-0.82, 95% CI -1.10～-0.54, Z=5.71, P<0.05), and higher hospitalization costs ( MD=16 159.90, 95% CI 12 249.54～20 070.26, Z=8.10, P<0.05). Conclusion:RDG is safer and more effective in the treatment of distal gastric cancer, with the advantages of less postoperative bleeding and more rapid recovery, and can achieve the same or better short-term clinical effect as LDG.

血管瘤是婴儿期临床最常见的一种良性肿瘤,发病率约为3％～5％[1].婴儿肝血管瘤是真正的血管瘤,是毛细血管内皮的增生改变[2].随着介入医学发展,介入肝动脉栓塞治疗术受到临床外科的重视,介入有创伤小、成功率高、疗效确切、可反复操作、术后并发症发生率低且不影响外科手术切除的优势[3].选取2016年6月至2019年6月于我院儿科和介入科收入院的19例婴幼儿肝血管瘤的患者作为研究对象.采用超选择介入栓塞治疗方案进行治疗,后研究结果进行统计分析,具体结果及经验总结报道如下.

目的 探讨Herlyn-Werner-Wunderlich综合征(HWWS)及其变异型的MRI表现特征.方法 搜集26例经手术及病理证实为HWWS患者的影像和临床资料,年龄11 ～35岁,平均(22±6.8)岁.回顾性分析其MRI平扫及增强扫描各序列的表现特征.结果 26例HWWS均合并阴道梗阻侧肾脏及输尿管缺如,14例右肾缺如,12例左肾缺如.其中经典型HWWS 22例,表现为双子宫双宫颈畸形,一侧阴道闭锁并同侧肾脏及输尿管缺如;3例变异型HWWS表现为完全性纵隔子宫畸形,一侧阴道闭锁并同侧肾脏及输尿管缺如,其中纵隔上有孔沟通两侧宫腔1例,1例变异型HWWS表现为双角子宫.26例患者梗阻侧盲端阴道、宫颈及宫腔内积血,T1WI呈高信号,T2WI呈低或者混杂信号,DWI(b=800)呈高信号,增强后无明显强化;盲端阴道及相应宫颈积脓,T1WI呈等稍高信号,T2 WI呈高信号,DWI(b=800)呈高信号,增强后边缘线状强化;宫颈间瘘管于T2WI序列呈高信号,增强后于强化的宫颈组织中呈现一条状不强化区.结论 HWWS及其变异型的MRI表现具有特征性,有助于临床术前分型评估及治疗方案的选择.

Objective:To investigate the value of magnetic resonance imaging (MRI) in the evaluation of perianal muscles in intestinal dysganglionosis (IDs).Methods:MRI was performed in 34 children with surgically proved IDs and 34 children without IDs, the development of levator ani muscle and anal sphincter muscle were analyzed.Results:The development of levator ani muscle and anal sphincter muscle in children without anorectal diseases were demonstrated well using MRI. Of the 34 IDs cases, there were 25 cases of HD and 9 cases of HAD. There were 27 cases (79.41%) of poor development of levator ani muscle and anal sphincter muscle. 22 cases (64.71%) manifested as irregular thickening of anal sphincter muscle shape with bilateral asymmetry. 5 cases (14.71%) manifested as irregular thickening of puborectalis muscle shape with bilateral asymmetry. 7 cases (20.58%) developed near-normal.Conclusion:MRI can clearly show the development of levator ani muscle and anal sphincter muscle, safe and radiation-free, which provides important imaging support for the development of surgical plan and prognosis for children with IDs.

Objective: To explore the expression of miRNA-145 and insulin-like growth factor 1 receptor (IGF-1R) in endometrial tissues of patients with hydrosalpinx-induced infertility and their influencing mechanism. Methods: A total of 37 patients with hydrosalpinx infertility (hydrosalpinx group) who visited our hospital from January to September 2019 were retrospectively analyzed. In the same period, 30 patients with endometriosis (EMs) and 28 normal women underwent abortion operation were selected as the EMs group and the control group, respectively. Meanwhile, patients in the hydrosalpinx group were divided into mild group, moderate group and severe group based on the degree of hydrosalpinx. Endometrial tissues were obtained from all study subjects. Real-time fluorescence quantitative PCR was used to determine the expression level of miRNA-145 in endometrial tissues, and IGF-1R expression level was measured by enzyme-linked immunosorbent assay. The expression levels of miRNA-145 and IGF-1R in endometrial tissues of the three groups of study subjects and patients with different degrees of hydrosalpinx were compared, and their correlations with hydrosalpinx were analyzed. Results: The age, parity and the number of cesarean sections in the hydrosalpinx group and EMs group were significantly higher than those in the control group (all P < 0.05), while there was no significant difference between hydrosalpinx group and EMs group (all P > 0.05). The expression level of miRNA-145 in the endometrial tissues of the hydrosalpinx group was significantly higher than that in the EMs group and control group (all P < 0.001), while the expression level of IGF-1R was significantly lower than that in the EMs group and control group (all P < 0.001). With the aggravation of hydrosalpinx, miRNA-145 expression showed an increasing trend and IGF-1R showed a decreasing trend in endometrial tissues of hydrosalpinx patients, and there were significant differences among the three groups (all P < 0.001). Pearson correlation analysis showed that there was a significant negative correlation between miRNA-145 expression level and IGF-1R in endometrial tissues of patients with hydrosalpinx infertility (r = -0.652, P < 0.01), and multiple linear regression analysis showed that there was a significant correlation between the severity of hydrosalpinx and miRNA-145 and IGF-1R expression levels (P < 0.001). Conclusion: The abnormal expression of miRNA-145 and IGF-1R may be an important mechanism affecting infertility caused by hydrosalpinx.

Objective:To evaluate the effectiveness of fluoroscopic balloon dilatation (FBD) for patients with anastomotic stricture after congenital esophageal atresia (CEA) repair.Methods:The medical records of 51 patients undergoing congenital esophageal atresia repair were retrospectively reviewed. All of them were diagnosed with anastomotic stricture and received FBD treatment. The differences of anastomotic diameter and stricture index (SI) before and after FBD treatment were compared. And the factors affecting the efficacy and the number of FBD treatments were explored.Results:The anastomotic diameter and SI before FBD treatment were 3.30 (2.4, 4.2) mm and 0.66 (0.53, 0.75), and those after the treatment were 6.70 (5.1, 9.3) mm and 0.42 (0.30, 0.53), with statistical differences (both P<0.01). After FBD, no anastomotic laceration was found by radiography in all the children; 43 children’s anastomotic diameter increased; and SI decreased. The treatment was effective, with an effective rate of 84.3%. There was a positive correlation between the month age of first FBD and the number of treatments ( P=0.02, r=0.32). However, anastomotic diameter and SI before FBD were not correlated with the number of FBD treatments ( P=0.08 and 0.31; r=-0.25 and 0.15). Conclusion:For patients with anastomotic stenosis after CEA repair, FBD is an effective and safe treatment.

Retroperitoneal ectopic pregnancy (REP) is an extremely rare type of ectopic pregnancy. Currently, surgery is the most widely used treatment method although it involves a high likelihood of intraoperative hemorrhage. In this case report, we describe a safe and effective alternative method for managing epigastric REP. We conducted a retrospective analysis of the clinical data of 2 patients with REP in the epigastrium who were treated at our hospital using our nonsurgical method. The treatment involved conservative management by computed tomographic-guided methotrexate injection in the gestational sac. We also present a literature review of 26 case reports and discuss the clinical features and various methods for treating REP. Our experience with the successful treatment of 2 patients suggests that the novel approach of computed tomographic-guided methotrexate injection in the gestational sac may be a safe and effective approach to manage REP. Further studies are warranted to confirm our findings.

Objective To explore the efficacy of transurethral retrograde balloon dilatation through cystoscope for postoperative ureteral stricture in children.Methods 7 cases with definite diagnosis of benign postoperative ureteral stricture on one side,who were treated at intervention and urinary surgery department of our hospital between November,2017 and December,2018,were retrospectively analyzed.Among them,5 cases were male,and 2 female.The youngest was 7 months old,and the oldest 8 years old.They were all diagnosed as postoperative ureteral stricture after laparoscopic ureteropelvis anastomosis,with a narrow length ＜ 2.0 cm.The location and degree of stricture and renal function should be known before the operation,and urinary tract infection should be controlled if there was.Transurethral retrograde high pressure balloon dilatation was operated through cystoscope and DSA.Double J tube was indwelled 3 to 6 months after the operation.The follow-up time was calculated from the time after the placement of the double J tube.The efficacy was analyzed according to the clinical symptoms and imaging manifestations of the patients during the follow-up.Results The surgeries of 7 cases were all successfully completed under general anesthesia,without changing the mode of operation,and no blood transfusion before and after operation and no complications occurred.They were discharged three days after the operation,with a follow-up of 3-12 months.1 year later,the obstruction of 5 cases disappeared and their renal function were improved.1 case suffered again severe stricture 2 months after balloon expansion,and the operation was replaced by laparoscopic ureteropelvis anastomosis;1 case suffered again stricture after 12 months' followup,and the operation was replaced by laparoscopic ureteropelvis anastomosis.The total effective rate of balloon dilatation was 71.4％ (5/7).Conclusion Transurethral retrograde balloon dilatation is safe,minimally invasive and effective for children with benign ureteral stricture with a narrow length ＜ 2 cm.Second laparoscopic surgery can be avoided for some cases and the hospitalization time can be shortened.Balloon dilatation can be the preferred method for the treatment of benign postoperative ureteral stricture in children.

目的 评估双侧髂内动脉球囊封堵技术在凶险型前置胎盘孕妇剖宫产中的应用效果.方法 回顾性分析74例凶险型前置胎盘产妇的临床资料,其中56例合并胎盘植入(植入组),18例未见胎盘植入(未植入组),并进行对比分析.结果 植入组的术中出血量、产后24 h出血量、术后住院时间和产后出血例数显著高于未植入组,差异有统计学意义(P＜0.05).两组均无产妇子宫切除.早产在植入组与未植入组的发生率分别为83.9％、88.9％,差异无统计学意义(P=0.894).结论 双侧髂内动球囊封堵技术能有效减少凶险型前置胎盘剖宫产术的术中出血、输血量和子宫切除率.对于合并胎盘植入的患者,预置球囊后仍有出血风险,必要时联合子宫动脉栓塞术.

目的 探讨MRI对子宫动脉化疗栓塞治疗宫颈癌疗效的评价价值.方法 回顾性分析经病理证实的44例宫颈癌患者的临床、MRI资料,所有患者均行子宫动脉化疗栓塞术治疗且术前、术后均行MR检查,评估治疗前后MRI影像变化.结果 术前MRI诊断宫颈癌病灶最大径平均值为(4.7±1.4) cm,术后病灶最大径平均值为(2.9±1.5) cm,治疗前后病灶最大径差异有统计学意义,P＜0.05;对比治疗前后宫颈癌病灶的ADC值,治疗前平均值为(0.904±0.2230)×10-3mm2/s,治疗后平均值为(1.041±0.231)×10-3mm2/s,二者差异有统计学意义,P＜0.05;鳞癌治疗有效率86.1％,高于其他病理类型总有效率50.0％,P＜0.05;对比鳞状细胞癌治疗前后ADC值变化,治疗前后两者差异有统计学意义,P＜0.05;对比其他病理类型宫颈癌治疗前后变化,二者差异无统计学意义,P＞0.05.结论 MRI有助于早期评价子宫动脉化疗栓塞治疗的疗效;且鳞状细胞癌对该治疗方案的反应优于其他病理类型宫颈癌.

Objective: To evaluate the clinical efficacy of vascular embolization combined with body surface injection of sclerosing agent for the treatment of high-flow hemangiomas in children. Methods: A total of 38 cases were enrolled in the study, including 28 cases with maxillofacial hemangiomas, 10 cases with limbs hemangiomas, and 6 cases with upper limb hemangiomas. The treatment plans were as follows: PVA with iodinated oil in 11 cases, PVA with bleomycin in 5 cases, and PVA with iodinated oil and bleomycin in 22 cases. A foam sclerosing agent mixture (bleomycin+1 ml add polyol+4 ml add air+1 ml dexamethasone+1 ml contrast medium) was injected into the angioma through the surface, and the involuting condition and related complication were recorded. Results: There was no complication in all patients, among which 18 children’s hemangiomas faded away in regular follow-up after one treatment, 13 children’s hemangiomas partly faded away and local symptom disappeared in regular follow-up after transcatheter arterial embolization combined with body surface injection sclerotherapy, 4 children's hemangiomas faded away after body surface injection sclerotherapy for two or three times, 3 children's hemangiomas size decreased after transcatheter arterial embolization, 1 child loss to follow-up, 1 child went to sugery therapy, and 1 child was with drug therapy. Conclusion: Transcatheter arterial embolization combined with body surface injection sclerotherapy is an important method which could be the preferred treatment in high-flow hemangiomas in children. Key words: Hemangiomas in children; Transcatheter arterial embolization; Sclerosing agent

Objective To explore prophylactic bilateral internal iliac arteries balloon occlusion in treating pernicious placenta previa complicated with placenta implantation before cesarean section.Methods Data of 32 patients with pernicious placenta previa complicated with placenta implantation underwent prophylactic bilateral internal iliac arteries balloon occlusion(Balloon Group)were analyzed retrospectively.40 patients with pernicious placenta previa complicated with placenta implantation without treatment of prophylactic bilateral internal iliac arteries balloon occlusion(Control Group)were selected.The mean blood loss and infusion amount during the operation,operative time,newborn Apgar score were compared between the two groups.Results The mean blood loss and infusion amount during the operation,operative time,newborn Apgar score of balloon group was superior to the control group and the difference was significant.All mothers and infants were healthy detected by clinical checking on 3-6 months after birth.Conclusion Prophylactic bilateral internal iliac arteries balloon occlusion is a safe and effective treatment before cesarean section used in pernicious placenta previa complicated with placenta implantation,and worthy of further promotion.

Objective To explore the association of the status of vitamin D with overweight and obese children in Guangzhou,and to provide measures for the prevention of vitamin D deficiency.Methods A cross sectional study was used to investigate physical examination and laboratory test among the children in Guangzhou.Chemiluminescence was used to detect the level of serum 25-hydroxy vitamin D [25-(OH)D].Results The average level of serum 25-(OH)D was (98.57±39.96) nmol/L with (98.58±39.64)nmol/L in boys and (98.56±40.58)nmol/L in girls and there was no statistical difference between different genders (P＞0.05).The prevalence rates of vitamin D deficiency and insufficiency were 8.68％ and 21.14 ％ respectively,and there was no statistical difference between different genders (P＞0.05).With the increasing of age,the level of serum 25-(OH)D decreased (P＜0.05),and the prevalence rates of vitamin D deficiency and insufficiency increased (P＜0.05).The level of serum 25-(OH)D was lower in overweight and obese children than those in normal children (P＜0.05).The prevalence rates of vitamin D deficiency and insufficiency in overweight and obese children were higher than those in normal children (P＜ 0.05).There was negative correlation between 25-(OH)D and BMI (P＜0.001).Conclusions The status of vitamin D is poor in school children as well as overweight and obese children in Guangzhou.Comprehensive measures should be taken to improve the status in vitamin D of children especially of school children,overweight and obese children in Guangzhou.

目的 探讨在计算机辅助下介入治疗原发性肝癌的应用价值.方法 将48例肝癌患者随机分为观察组和对照组,对照组27例采用常规肝动脉化疗栓塞(TACE)治疗;观察组21例采用优化栓塞治疗,利用计算机肝癌三维模型建立、血管三维重建的术前计划来指导介入治疗.结果 发现计算机辅助在TACE治疗上能将肿瘤及肿瘤供血三维重建,空间虚拟操作对优化术前计划、减少过度化疗栓塞对机体的打击、提高化疗栓塞术的疗效上有明显优势,并有助于实现肿瘤药物灌注栓塞更精确的量化治疗.结论 经过实践认为计算机辅助肝癌术前计划对明确栓塞目标、途径、方法、恰当应用化疗栓塞药物的剂量以及治疗前判断手术难度,超选择栓塞和微栓塞,提高TACE疗效有指导意义,尤其在术前计划、术中治疗方面具有广阔的发展空间.

目的:观察健脾补肾方联合针灸对肝癌肝动脉化疗栓塞术(TACE)后综合征患者生存质量的影响.方法:将80例原发性肝癌行TACE治疗后出现栓塞后综合征的患者随机分为2组各40例,治疗组术后给予健脾补肾方联合针灸治疗,对照组术后应用常规西药对症治疗.比较栓塞后综合征主要症状(包括疲乏、食欲下降、疼痛、腹胀、苦恼、发热)的严重程度、持续时间及生活质量测评评分,评价健脾补肾方联合针灸治疗对栓塞后综合征患者生存质量的影响.结果:运用健脾补肾方联合针灸治疗原发性肝癌栓塞后综合征,患者的疲乏、食欲下降、疼痛、腹胀、苦恼、发热等主要症状的严重程度低于对照组(P＜0.05),持续时间短于对照组(P＜0.05);生活质量FACT-G总得分高于对照组(P＜0.05).结论:健脾补肾方联合针灸治疗原发性肝癌栓塞后综合征疗效良好,能提高生存质量,减轻毒副作用,改善预后.