目的 比较龙胆泻肝汤颗粒剂及其汤剂治疗慢性乙肝的临床疗效.方法 选择肝胆湿热型慢性乙肝患者76例,根据患者自愿原则分为治疗组和对照组,各38例.治疗组采用龙胆泻肝汤颗粒剂治疗,对照组采用龙胆泻肝汤汤剂治疗,观察临床症状,体征,肝功能及疗效等.结果 两组患者治疗前后中医临床证候、肝功能(ALT,AST,TBIL)均明显改善(P＜0.01),但两组组间比较差异无显著性(P＞0.05);两组临床总有效率比较无显著性差异(P＞0.05).结论 龙胆泻肝汤颗粒剂及其汤剂治疗肝胆湿热型慢性乙肝均具有清肝胆湿热的临床疗效,且疗效相当,用药安全,颗粒剂方便可控值得临床推广.

Objective To study the effects of apigenin on the apoptosis of human bladder cancer cell line 5637.Methods 5637 cells were cultured with different concentrations of apigenin,the MTT assay was used to evaluate the cell inhibition rates.Apoptosis of 5637 cells was observed under a fluorescence microscope using Hoechst 33258 staining,5637 tumorigenicity was messaured by soft col-ony formation assay.Results Apigenin causes concentration -dependent inhibition of the proliferation of bladder cancer 5637 cells. 5637 cells treated with apigenin showed significant morphological changes of apoptosis,and the cell tumorigenicity was inhibited as api-genin concentration increased.Conclusion Apigenin can inhibit the proliferation and induce apoptosis of 5637 cells.

Objective:To analyze the objective index of TCMblood stasis syndrome in diabetic peripheral neuropathy.Methods:90 cases of patients with diabetic peripheral neuropathy patients were divided into three types according to the type of blood stasis syndrome,that is,the syndrome of Qi deficiency and blood stasis,Yin deficiency and blood stasis syndrome,Yang deficiency and blood stasis syndrome and other,30 patients in each group and compared their age,duration of diabetes,body mass index(body mass index,BMI),sugar he-moglobin,C-reactive protein(CRP),etc.Results:The glycosylated hemoglobin value of blood deficiency and blood stasis group was sig-nificantly higher than that of Qi deficiency and blood stasis group and Yang deficiency and blood stasis group(P <0.05).The incidence of BMI,average age,average course of the disease in the 3 groups were not statistically significant(P >0.05).Conclusion:The glycosy-lated hemoglobin of the patients in Yin deficiency and blood stasis syndrome was significantly higher,and the other indexes had no sig-nificant difference among the blood stasis syndrome..

Objective To compare the clinical effect of Yinchenhao granules and decoction in treating chronic hepatitis B with liver and gallbladder damp-heat syndrome. Methods 72 patients with chronic hepatitis B with liver and gallbladder damp-heat syndrome were randomLy divided into the control group and the treatment group,36 cases in each group. The treatment group adopted Yinchenhao Decoction,while the control group was treated by Yinchenhao Granules. And the clinical symptoms,signs,liver function and the curative effect were observed. Results The symptoms and signs after treatment in the two groups were obviously improved. The level of ALT, AST,TBIL and HBV-DNA were significantly reduced( P < 0. 05 or P < 0. 01),but without statistically significant differences between the two groups. The clinical total effective rate had no statistical difference between the symptom curative effect groups. Conclusion Both the Yinchenhao granules and decoction can protect the liver and increase the bile excretion in treating chronic hepatitis B with liver and gallbladder damp-heat syndrome. The curative effect of the two kinds of formulation is similar,but the granules formulation is more convenient and worthy of clinical promotion.

Objective To investigate the changes of serum interleukin -1β( IL-1β) level in patients with post stroke fatigue ( PSF) and effect of early nursing intervention , to provide references for prevention and treatment .Methods From December 2013 to June 2014, 105 patients with ischemic stroke were selected in our hospital , and they were randomly di-vided into control group (n=52) and intervention group (n=53) .Control group given routine treatment and nursing , while intervention group given early nursing intervention based on routine treatment and nursing.After 2 weeks of intervention , fatigue severity scale (FSS) was used to judge PSF, and blood glucose, HbA1c, IL-1β, HDL-C, LDL-C, TC, TG were detec-ted.Results The total score of FSS of intervention group was (2.9 ±1.5), was lower than that of control group of (3.8 ± 1.7) (P<0.05) .In the intervention group, 13 cases occurred PSF (intervention-PSF group), 40 cases did not (interven-tion-non PSF group ); in the control group , 13 cases occurred PSF ( control-PSF group ) , 29 cases did not ( control -non PSF group) .Blood glucose, HbA1c, IL-1β, HDL-C of intervention -PSF group were higher than those of control -PSF group and intervention-non PSF group , and those of control -PSF group were higher than those of control -non PSF group ( P<0.05).Conclusion Serum IL-1βlevel is higher in patients with PSF , which plays a important role in the onset and devel-opment of PSF , and early nursing intervention is helpful to reduce and postpone PSF .

Objective: The patients were given the integrative medicine oral therapy plus the autoimmune regulator method, and investigate clinical effects of the autoimmune regulator method on treating ankylosing spondylitis. Methods: 107 patients were divided into two groups, 51 in the control, and others in the treated. The control group was given the integrative medicine oral therapy, while the treated group was given the autoimmune regulator method more, compared clinical results. Results: After 1 course of treatment, two groups both had effect, but the treated group was significantly different from the control group (P<0.05), In the erythrocyte sedimentation rate and C-reactive protein, two groups were significantly improved after treatment (P<0.05). Conclusion: The integrative medicine oral therapy plus the autoimmune regulator method was effective in treating ankylosing spondylitis.

目的:了解热敏灸对慢性咳嗽患者生活质量的影响.方法:将80例慢性咳嗽患者随机分为观察组(40例)和对照组(40例).2组患者均常规给予接受抗组胺药和糖皮质激素药治疗;氯雷他定10mg1日1次,曲安奈德鼻喷雾剂喷鼻,每日1次.治疗组同时还加用热敏灸治疗,2组患者经3个疗程的相应治疗后,采用莱彻斯特咳嗽生活质量问卷(LCQ)对其进行评分.结果:2组患者经治疗后,其LCQ均有不同程度的提高,与治疗前比,治疗后观察组LCQ评分显著提高(P<0.01),对照组LCQ评分有明显提高(P<0.05);经治疗后,观察组LCQ评分及改善程度显著优于对照组(P<0.01).结论:热敏灸有利于慢性咳嗽患者生活质量的改善.

Objective To investigate the ankylosing spondylitis syndrome type and HLA-B27 and immune inflammation index correlation.Methods 60 patients with AS were randomly selected from March 2010 to March 2012 in our hospital and collaboration in the hospital department of traditional Chinese medicine,department of orthopedics,department of internal medicine and department of rehabilitation treatment,including kidney SHI-re-bi resistance,kidney yin deficiency,kidney deficiency in each 20 cases.Comparison of three kinds of syndromes of patients in the expression of HLA-B27,ESR,C reactive protein,platelet counts,immunoglobulin levels and other differences were observed.Results The kidney SHI-re-bi resistance,kidney yin deficiency,kidney deficiency of ankylosing spondylitis HLA-B27 positive rates were 95%,55%,35%,the index of kidney deficiency type heat blockage of ankylosing spondylitis in patients with ESR,CRP,PLT levels were significantly higher than kidney yin deficiency the indexkidney yang asthenia type(P 0.05),but the three types of immunoglobulin levels had no significant difference(P 0.05).Conclusion Ankylosing spondylitis syndrome type and HLA-B27,ESR,CRP,PLT has certain correlation.

目的:观察中药瘿气灵对Graves病(GD)常见证型患者的T淋巴细胞亚群尤其是CD3+CD4+、CD3+CD8+、CD3+CD4+/CD3+CD8+的影响。方法:将治疗对象155例随机分组根据中医辨证分型给药,观察瘿气灵对该病患者T淋巴细胞亚群的影响。结果:瘿气灵治疗GD的免疫调节可能与升高CD4+T%,降低CD8+T%,调整CD4+/CD8+的比例有关。结论:GD患者的确存在免疫损伤。瘿气灵能够升高GD患者外周血CD3+CD4+百分比,降低CD3+CD8+的百分比,调整CD3+CD4+/CD3+CD8+比例。说明瘿气灵能够增强机体的细胞免疫,减轻免疫损伤。尤其对于气阴两虚、阴虚火旺型比值改变较明显。

Professor Huang Yangmo focuses on the causes of disease and seeking the primary in the treatment of hypothyroidism.He thinks that the knotted qi and injuries due to over-exercise are the main causes of hypothyroidism,fire hyperactivity and yin deficiency and the deficiency of both qi and yin are the most common pathogenesis.Syndrome differentiation and drug administration according to the syndromes should be stressed in the treatment,and the traditional Chinese and Western medicine should be integrated to complement each other.