The physicians of previous generations have stated about disease name,disease syndrome,pathogenesis and treatment methods of reflux esophagitis which belongs to the category of "stomachache"," acid regurgitation"," sour regurgitation"," dysphagia"," gastric upset"," vomitting"," Yege"," stomach fullness"," chest fullness"," chronic pharygitis",etc.The causes of it are weak body constitution,lack of good care,or improper diet,emotional disorders,and chronic illness,internal injuries due to fatigue.In terms of pathogenesis,there are many factors,such as liver qi attacking the spleen,or heat pathogen attacking the stomach,or weak middle energizer failing to transport and transform,or cold pathogen attacking inside the body and hurting stomach yang,or accumulated phlegm or blood stasis.In terms of treatment,there are statements on principle,method,description and drugs.These are exact embodiments of TCM treatment based on syndrome differentiation and theory guidance for reflux esophagitis.

目的 探讨不同脑电双频指数(BIS)状态下对老年胃肠手术术中炎性因子的影响.方法 选择择期全麻下行胃肠手术的老年患者60例,性别不限,年龄65~75岁,ASA分级Ⅱ或Ⅲ级.按随机数字表法分为两组(n=30):深BIS组(D组)和浅BIS组(L组),D组术中BIS值维持在40~49之间,L组术中BIS值维持在50~59之间,从切皮至术毕通过丙泊酚靶控复合吸入七氟醚调节BIS值在目标值范围,记录麻醉开始(T0)、气管插管后即刻(T1)、切皮(T2)、术中1 h(T3)、术中2 h(T4)、术毕(T5)、拔管后5 min(T6)时的HR、MAP.于T0、T4、T6采中心静脉血2 mL用于检测血清TNF-α和IL-6浓度,记录术中输液量、出血量、尿量、丙泊酚用量、瑞芬太尼用量、麻醉时间和手术时间.结果 L组血浆TNF-α和IL-6的浓度在T6时明显低于D组(P<0.05).组内比较,两组血浆TNF-α的浓度在T6时均较T0时明显升高(P<0.05),两组血浆IL-6的浓度在T4和T6时均较T0时明显升高(P<0.05).L组丙泊酚用量明显少于D组(P<0.05).结论 全麻下老年胃肠道手术患者术中BIS值范围控制在50~59之间时的炎性因子表达水平较BIS值在40~49之间低;术中血流动力学均较平稳,相对较浅的麻醉深度即可满足手术要求,且不会增加炎性因子的释放.

Objective To investigate the effect of Yiqizhumai recipe on the treatment of slow arrhythmia. Methods 120 patients with slow arrhythmia were randomly divided into two groups. 80 cases in treatment group were treated by Yiqizhumai recipe. 40 cases in control group were treated by atropine hydrochloride tablets. The effect was evaluated after four weeks of treatment. Results There were 29 cases of sick sinus syndrome in treatment group. The total effective rate of sick sinus syndrome was 72. 41% in treatment group. There were 15 cases of sick sinus syndrome in control group. The total effective rate of sick sinus syndrome was 40. 00% in control group. There was significant difference between two groups on the total effective rate( P 0. 05). The average ventricular rate and rate of regularization in treatment group was higher than that in control group( P 0. 05). The total effective rate of bradycardia- tachycardia syndrome in treatment group( 60. 42%) was higher than that in control group( 21. 74%,P 0. 05). Conclusion Yiqizhumai recipe has definite effect on the treatment of slow arrhythmia.

目的:评价益气助脉方治疗缓慢性心律失常的疗效和安全性.方法:采用随机双盲、安慰剂对照的试验方法,120例受试者按照1∶2的比例随机分为试验组80例和对照组40例,试验组服用益气助脉方,对照组服用安慰剂,疗程均为4周.结果:试验组疾病疗效为76.92％,对照组为20.59％,试验组疗效优于对照组(P＜0.05);试验组临床症状疗效为91.03％,对照组为17.65％,试验组疗效亦优于对照组(P＜0.05).结论:益气助脉方治疗缓慢性心律失常安全有效,是治疗缓慢性心律失常的良药.

Objective To evaluate systematiclly the clinical efficiency and safety. Methods Choosing 14 RCT literatures which positive controlled by medicine such as atropine and aerolin and so on. There are 1014 cases which conclude treatment group 556 cases and control group 458 cases. Evaluate the efficiency and safety of yiqiwenyang treatment bradycardia arrhythmias by Meta analysis. Results Choosing 13 literatures which evaluation standard are clinical efficiency,and the results prompt that the clinical efficiency of yiqiwenyang is super than control group(OR=4. 27[3. 04,6. 01]);There are 3 literatures which evaluation standard are mean heart rate,and the results point out that yiqiwenyang can promote mean heart rate obviously than medicine(OR=6. 58[5. 27, 7. 89]);Choose 3 literatures which safety evaluation standard are adverse reaction,and the results point out that the adverse reactions of yiqiwenyang are less than control group obviously (OR=0. 07 [0. 02,0. 20]). Conclusion It is safety and efficiency that yiqiwenyang treat bradycardia arrhythmias,and it is worth to generalize.