Objective To explore the improvement of short-term focus group therapy (FBGT) on interpersonal problems and depressive symptoms in patients with mild to moderate depression.Methods A total of 60 patients with mild to moderate depression were randomly divided into the study group (30 cases)and the control group (30 cases).The study group received 8 short-term focus group treatments while taking the original drugs，and the control group received health education while taking the original drugs.Results The SDS score of the study group was significantly lower than that of the control group (P＜0.05).The total score of IIP-32 and the factor scores PA，BC，DE，FG，HI，JK，LM and no in the study group were improved compared with those in the control group (P＜0.05).Conclusion Short term focus group therapy can improve the interpersonal problems and depressive symptoms of patients with depression.

目的 分析小剂量氯氮平联合齐拉西酮治疗难治性精神分裂症的临床效果.方法 选取2016年4月—2018年4月本院收治的100例难治性精神分裂症患者,根据治疗方法 将其分为观察组(n=50)和对照组(n=50);对照组患者给予氯氮平治疗,观察组患者给予小剂量氯氮平联合齐拉西酮治疗,观察对比两组患者阳性、阴性症状量表(positive and negative syndrome scale,PANSS)和副反应量表(treatment emergent symptom scale,TESS)评分以及临床疗效.结果 治疗前,两组患者PANSS总分、阳性症状、阴性症状、精神病理评分对比差异无统计学意义;治疗后两组患者PANSS总分[(32.2±3.6)分vs.(48.9±3.1)分,t=8.295]、 阳性症状[(8.5±2.4)分vs.(14.5±2.7)分,t=4.427]、 阴性症状[(8.6±1.8)分vs.(15.7±1.3)分,t=4.713]、精神病理[(15.4±3.9)分vs.(18.9±3.7)分,t=4.202]评分对比差异均有统计学意义(P<0.05).观察组患者治疗总有效率为92.0％,对照组患者治疗总有效率为78.0％,两组对比差异有统计学意义(χ2=3.843,P<0.05).观察组患者嗜睡、便秘、直立性低血压、心电异常和体质量升高的发生率均显著低于对照组,对比差异有统计学意义(P<0.05).结论 对于难治性精神分裂症患者,小剂量氯氮平联合齐拉西酮治疗较氯氮平治疗临床疗效更佳,且不良反应发生率更低.

目的 观察氯氮平联合抗精神病药治疗精神分裂症阴性症状的临床疗效.方法 回顾性分析2017年5月-2019年5月该院收治的110例精神分裂症阴性症状患者,根据治疗方法分为观察组(n=55)和对照组(n=55);其中对照组患者实施常规抗精神分裂阴性药物进行治疗,观察组患者实施氯氮平联合常规抗精神分裂阴性药物进行治疗,观察两组患者的临床疗效、阴性症状量表评分以及不良反应发生率.结果 临床疗效上,观察组总有效率为94.5％,对照组患者总有效率为78.2％,两组比较差异有统计学意义(x2=6.253,P＜0.05).观察组治疗前阴性症状量表评分(26.7±4.2)分,治疗后(10.5±5.3)分;对照组治疗前阴性症状量表评分(26.1±6.9)分,治疗后(15.8±5.7)分;两组治疗前比较差异无统计学意义(t=0.983,P＞0.05),治疗后对比差异有统计学意义(t=4.875,P＜0.05).观察组不良反应发生率为7.3％,对照组不良反应发生率为21.8％,两组对比差异有统计学意义(x2=4.681,P＜0.05);两组患者不良反应均较轻微,患者可耐受,进行处理后症状逐渐消除.结论 精神分裂症阴性症状患者采用氯氮平联合常规抗精神病药治疗临床效果显著,同时不良反应降低,值得临床推广应用.

目的:探讨社区精神分裂症患者骨质疏松情况及相关因素.方法:收治精神分裂症患者128例,分为住院组和社区组,分析患者性别、年龄、骨密度、体重指数、催乳素等指标,同时分析骨质疏松的相关因素.结果:社区患者和住院患者比较,年龄、体重指数和骨密度均出现明显改变(P<0.05);且多元线性回归分析骨质疏松与年龄、体重指数相关.结论:社区精神分裂症患者骨密度高于住院患者,且体型瘦弱的高龄患者,容易出现骨质疏松.

目的 分析精神障碍患者应急医疗处置案例,为社区处置应急事件提供科学依据.方法 对北京市某城区2016年1月～2017年12月201例危险评估1～5级精神障碍患者应急医疗处置工作现场记录表进行统计、分析、评估.结果 201例患者实施应急处置中,在册患者163例,非在册38例,危害自身/他人安全事件或倾向152例,占75.62％,危险评估1级156例,占77.62％,≥2级45例,占22.39％.发生1次应急处置的患者186人次,≥2次15人次.结论 在应急医疗处置中以危害自身/他人安全事件或倾向事件为主.做好社区应急医疗处置工作,能有效控制和减少严重精神障碍患者危险行为的发生,维护社会安全.

Objective To know the morbidity rate and distribution features of mental diseases in the rural-urban fringe zone and provide a certain reference basis for carrying out the community prevention and cure and rehabilitation management work of mental disease in the rural-urban fringe zone in our city. Methods 34625 persons in some community in Huilong-guan area were given epidemiological investigation on mental disorders according to the epidemiology manual requirements, and the diagnostic standards were psychological and behavioral disorder classification (ICD-10) and classification and diag-nostic criteria of mental disorders in China third edition (CCMD-3), and the disease type and demographic factors were recorded. Results The survey showed that 3 830 cases were with mental disorder, accounting for 11.06%, and 3 768 cases were with mild mental disorder, among them, depression occurred to 1727 cases (4.99%), phobia occurred to 846 cases (2.44%), anxiety occurred to 722 cases (2.09%), obsession occurred to 346 cases (1.00%), others occurred to 127 cases (0.37%), among them, 62 cases were with severe mental disorder, accounting for 1.79‰, and schizophrenia was main (34 cases, 0.98‰), mental retardation with mental disorder occurred to 13 cases (0.66‰), mental disorder caused by epilepsy occurred to 8 cases (0.23‰), paranoid mental disorder occurred to 4 cases (0.12‰) and bipolar affective disorder occurred to 3 cases (0.09‰). Conclusion Schizophrenia, mental retardation with mental disorder and mental disorder caused by epilepsy are the main in patients with severe mental diseases in the rural-urban fringe zone in our city, which is the key of prevention and cure and rehabilitation management work in community in future.

目的 探讨喹硫平联合碳酸锂治疗双相障碍躁狂发作的临床效果及安全性.方法 164例双相障碍躁狂患者,分为观察组和对照组各82例,观察组采用喹硫平联合碳酸锂治疗,对照组采用喹硫平联合安慰剂治疗,采用双盲方法应用BRMS量表于治疗前和治疗1、2、4及6周后评定临床效果;采用副反应量表评价治疗后的不良反应发生情况.结果 两组患者治疗后各时点BRMS评分均明显降低,差异有统计学意义(P＜0.05);且观察组明显优于对照组,差异有统计学意义(P＜0.05).治疗后各时点观察组有效率均高于对照组(P＜0.05).治疗过程中两组均发生不良反应,但差异无统计学意义(P＞0.05).结论 双相障碍躁狂发作患者采用喹硫平联合碳酸锂药物进行治疗能够快速有效地缓解患者临床症状,效果良好,且不增加不良反应发生率.