目的:观察自拟中药颗粒剂对胃癌患者CA724的影响.方法:随机选择2020年1月-2021年12月至我院进行胃癌治疗的患者150例进行临床研究,所有患者均经病理检查或细胞学检查确定诊断.按照来诊时间排序,序列号为单号患者作为观察组,序列号为双号患者作为对照组,各75例.对照组患者均给予DCF方案进行化疗,观察组患者在对照组化疗方案基础上给予自拟中药颗粒治疗.比较两组患者治疗前后CA724、CEA、AC199等血清学指标变化情况、生存质量和中医症候评分.结果:两组患者治疗前CA724、CEA、CA199水平

目的:观察参苓胃消胶囊治疗脾虚腹痛疗效.方法:随机选择2020年1月-2020年12月至我院进行腹痛脾虚证治的患者80例进行观察.使用随机数字法将患者分为观察组和对照组各40例.对照组患者给予奥替溴铵片;观察组在对照组治疗方案基础上给予参苓胃消胶囊进行治疗.比较两组患者中医症候评分、临床疗效以及主要临床症状消失时间、治疗前后腹痛情况.结果:两组患者治疗前中医症候评分无明显差异(p＞0.05),治疗后与治疗前相比均明显升高(p＜0.05),但观察组评分高于对照组,且具有统计学差异(p＜0.05);观察组治疗

目的 研究健脾益气法对重症急性胰腺炎患者免疫功能、炎症反应及肠道黏膜屏障功能的影响.方法 选取2018年12月—2019年7月河北省沧州中西医结合医院收治的重症急性胰腺炎患者66例,随机分为实验组与对照组,每组33例.对照组给予常规治疗;实验组常规治疗+健脾益气法治疗.观察两组患者疗效、免疫功能、炎症反应、肠道黏膜屏障功能和中医证候评分、急性生理学与慢性健康状况评估Ⅱ(APACHEⅡ)及Balthazar CT评分.结果 实验组患者有效率高于对照组(P<0.05).实验组患者治疗前后CD4+、CD4+/CD8+及Treg的差值低于对照组,而CD8+的差值高于对照组(P<0.05).实验组患者治疗前后TNF-α、IL-6及CRP的差值高于对照组(P<0.05).实验组患者治疗前后血浆内毒素和血清DAO、D-乳酸及淀粉酶的差值高于对照组(P<0.05).实验组治疗前后中医证候评分的差值高于对照组(P<0.05).实验组患者治疗前后APACHEⅡ、Balthazar CT评分的差值高于对照组(P<0.05).结论 重症急性胰腺炎患者采用健脾益气方治疗疗效明显,可改善肠道黏膜屏障功能,提高机体免疫功能,减轻炎症反应.

笔者从中医体质角度出发收集了 60 例重度急性胰腺炎(SAP)患者临床资料 ,进行归纳分析 ,现将结果报告如下 . 1 资料与方法 1 .1 一般资料 60 例患者均为 2014 年 11 月至 2016 年 11 月本院消化内科病房收治的重度 SAP 患者 ,其中男性 46 例 ,女性 14 例 ;年龄 23 ～ 68 岁 ,平均(42 ± 6)岁 ,发病至就诊时间 2 ～ 72 h ,平均时间(16 ± 8)h ,均为重度急性胰腺炎患者 .

目的 观察复方谷氨酰胺肠溶胶囊(谷参胶囊)对急性胰腺炎后期辨证属脾胃气虚型患者的治疗效果.方法 选取我院2014年～2016年收治的急性胰腺炎患者中后期辨证为脾胃气虚型患者随机分为治疗组和对照组,治疗组在常规治疗基础上加用谷参胶囊治疗,比较两组患者中医症状评分、CT分级的差异性.结果 两组中医疗效评价;差异无统计学意义.(p>0.05),但治疗组在改善患者胃脘痛、胃脘痞满、食欲减退、食后腹胀、早饱、乏力症状方面优于对照组;差异有统计学意义(P<0.05).治疗组CT分级较对照组改善;差异有统计学意义(P<0.05).结论 复方谷氨酰胺肠溶胶囊对改善急性胰腺炎后期脾胃气虚型患者症状及胰腺炎症、促进渗出液吸收临床疗效确切.

目的 探讨益肝化湿饮治疗乙肝肝硬化的临床应用价值.方法 选取乙肝肝硬化患者56例,随机分为治疗组和对照组各28例,对照组给予西医常规治疗,治疗组在此基础上加用益肝化湿饮治疗,比较两组患者的临床疗效.结果 治疗组总有效率85.71%,对照组总有效率57.14%,治疗组患者的临床疗效优于对照组,差异具有统计学意义(P<0.05);治疗组的肝功能ALT、Alb、TBil指标变化明显优于对照组,具有统计学意义(P<0.05).结论 益肝化湿饮治疗乙肝肝硬化具有较好的临床疗效,值得在临床上推广应用.

Objective: To explore the rabeprazole combined with mosapride in treatment of reflux esophagitis (RE) clinical curative effect.Methods: 50 cases of RE patients, male 27 cases, female 23 cases, age 20~60 years, average 40 years old. Were randomly divided into treatment group and control group, each of 25 cases. The treatment group was given oral rabeprazole met and mosapride in the treatment, the control group were given mosapride. Observed after 8 weeks of treatment, two groups of clinical symptoms, endoscopic grading changes, adverse reaction.Results:The total efficiency of RE improvement of clinical symptoms and endoscopic esophagitis curative effect of the treatment group were significantly higher than those in the control group (P<0.05). The two groups were no serious adverse reactions, good safety.Conclusion: Rabeprazole with the joint use of mosapride has a good therapeutic effect on RE, the adverse reaction is lower.

肠易激综合征（irritable bowel syndrome ，IBS）是一种功能性肠病，罗马Ⅲ亚型分类标准将其分为腹泻型（IBS-D ）、便秘型（IBS-C ）、混合型（IBS-M ）及不定型（IBS-U ），其中以腹泻型发病率高。随着社会的发展，生活节奏的加快，此病在临床上越发多见。因其病因及发病机制尚不清楚，临床上西医多以对症治疗为主，疗效尚不尽人意。本人研究自拟参苓胃消胶囊治疗IBS-D ，取得良好效果，现报告如下。

[ABSTRACT]Objective:To investigate the curative effect of wuling capsule combined with mosapride in the treatment of functional dyspepsia with depression. Methods: 60 cases of functional dyspepsia with depression were randomly divided into control group, treatment group, 30 cases in each. The control group with oral administration of mosapride in treatment, the treatment group in the control group plus wuling capsule treatment, two groups were observed in patients with clinical symptoms and depression score changes. Results:After the treatment of two total score of symptoms were significantly reduced, and the treatment group was better than that of the control group (P<0.05);depression score:the control group before and after treatment, compared with no significant decrease (P>0.05), while the treatment group decreased significantly after treatment, and better than the control group after treatment (score P<0.05). Conclusion:Wuling capsule combined with mosapride than alone application of mosapride is more effective in improving the clinical benefit and depressive symptoms in patients with functional dyspepsia.

目的:研究通络益脑丸治疗血管性痴呆的临床疗效。方法:将92例肾虚血瘀型血管性痴呆患者随机分为治疗组和对照组各46例,治疗组予通络益脑丸口服,对照组予尼莫地平片及银杏叶片口服。两组均连续治疗3个月后观察临床疗效。结果:治疗组总有效率为82.6%,对照组总有效率为60.9%,治疗组疗效优于对照组,差异有统计学意义(P<0.05)。结论:通络益脑丸治疗血管性痴呆有较好临床疗效。

Objective To evaluate the therapeutic effects of Deanxit combined with Domperidone on postprandial distress syndrome with anxiety and depression. Methods Eighty cases of postprandial distress syndrome with anxiety and depression were randomized into two groups, 40 cases in each group. Domperidone was given to the control group, Deanxit and Domperidone was given to treatment group for 4 weeks. The clinical symptoms, HAMD scores, HAMA scores and gastric emptying were assessed after treatment. Results The total effective rate of clinical symptoms improved in control group and treatment group was 62.5% and 87.5%, the difference was statistically significant(χ2=7.05, P 0.05). HAMA scores in the control group and treatment group after treatment were(17.08±6.76) points and(11.60±5.08) points respectively, the difference was statistically significant(t = 4.10, P 0.05); HAMD scores in the control group and treatment group after treatment were(23.93±4.74)points and(14.53±3.97) points respectively, the difference was statistically significant(t = 9.62, P 0.05). The gastric emptying rate was improved in two groups and the treatment group was superior to the control group [(71.00±8.90)% vs(65.23±7.79)%], the difference was statistically significant(t = 2.35, P 0.05). Conclusion The method of Deanxit combined with Domperidone can significantly reduce anxiety and depression syndromes of postprandial distress syndrome with anxiety and depression, improve the clinical symptoms and gastric emptying significantly.

Objective:To explore Zhenjvjiangya tablet combination with amlodipine tablet on myocardial endothelium-derived vasoactive substances influence the circadian rhythm. Methods: 64 healthy SD rats, 10 weeks old, weighing 250 to 300 g, male and female, in groups of 32, were randomly divided into two groups(each large group was divided into four groups, each group of 8):(1) control group:amlodipine tablets given to 2.5mg/(kg.d) gavage. (2) experimental group:gavage amlodipine tablets, based on the early, to give Zhenjvjiangya tablet to 40mg/(kg.d) gavage.Continuous administration of 4 weeks. Radioimmunoassay and nitrate reductase assay rats myocardial endothelin-1(ET-1) and nitric oxide(NO) levels.Results:Control group and the experimental group after treatment of myocardial tissue NO rhythm values were increased, ET-1 rhythm curve median decrease(P<0.05), the control group changed little. Compared with before treatment, after treatment, both groups myocardial ET-1 and NO rhythm curve peak phase shift occurs(P<0.05), the ET-1 and NO rhythm changes.Conclusion:Zhenjvjiangya tablet and amlodipine tablets compared to amlodipine alone significantly increased NO levels can reduce the ET-1, control blood pressure and protect the myocardium.

Objective: To study Zhenjvjiangya tablet combined with Amlodipine tablet on blood pressure and Myocardial Remodeling and endothelial function in renal hypertensive rat(RHR).Methods: The two-kidney and one-clip rat method was established.The tail artery blood pressure and LVWI and endothelin,nitric oxide level in myocardium were measured after administration with Zhenjvjiangya tablet and Amlodipine tablet.Results: Effect of Zhenjvjiangya tablet combined with Amlodipine tablet on blood pressure is remarkable,and can increase the nitri coxide level and decrease endothelin and LVWI.Conclusion: Zhenjvjiangya tablet combined with Amlodipine tablet can obviously reduce the blood pressure,increas the nitric oxide level and decrease endothelin to protect myocardium.

<正>脑血管病是老年人的常见病、多发病,随着生活水平的提高,原发性高血压、糖尿病、高脂血症逐年增多,且逐渐年轻化,脑梗死的发病率也越来越高,较重者逐渐发展成血管性痴呆。中医中药是我国的一大资源宝库,且中医善治未病,运用中药防病治病有广阔前景。2011-05—

Objective To study the effects of zhenjujiangya tablet combined with amlodipine tablet or amlodipine tablet alone on the circadian rhythms of systolic blood pressure and endothelial vasoactive substances in rats. Methods Sixty-four SPRD rats were divided into two groups randomly: Group Ⅰ [ administrated with amlodipine(2.5 mg·kg-1·d-1)for four weeks ] and Group Ⅱ [ administrated with zhenjujiangya tablet(40 mg·kg-1·d-1)combined with amlodipine tablet(2.5 mg·kg-1·d-1)].Before and after treatment,systolic blood pressure and plasma endothelin1(ET-1) concentration and nitric oxide(NO) concentration were determined. Results Systolic blood pressure and plasma ET-1 concentration in group Ⅱ were lower than in group Ⅰ.Plasma level of NO after treatment in group Ⅱ was higher than in group Ⅰ.The peak phase of systolic blood pressure and endothelial vasoactive substances in both groups showed significant changes [ peak phase of systolic blood pressure in group Ⅰ was-47°(20∶51)vs.33°(21∶47)in group Ⅱ,peak phase of NO in group Ⅰ was 55°(04∶00) vs.65°(03∶20)in group Ⅱ and ET-1 was 200°(13∶10) in group Ⅰ vs.95°(06∶12) in group Ⅱ,all P0.05]. Conclusions Zhenjujiangya tablet combined with amlodipine tablet can significantly reduce systolic blood pressure and plasma ET-1 concentration and increase plasma NO concentration.

Objective:Observe the clinical effect of Shenling Weixiao capsule combined with domperidone on the deficiency of spleen qi and stomach qi type functional dyspepsia.Method:One-hundred and eight patients were divided into two groups in random,54 cases were treated by Shenling Weixiao capsule combined with domperidone in treat group,54 cases treated by domperidone in conrtol group.Both have a course of 14 days treatment.Result:The effective rate of the treat group's 90.7% was better than the conrtol group's 72.2%(P0.05).As to the improvement of gastric emptying function,the treat group had a better result than the conrtol group(P0.05).Conclusion:The therapeutic method of Shenling Weixiao capsule combined with domperidone have a better clinical effect than that of domperidone only used.

目的观察疏肝降逆汤治疗功能性消化不良的效果。方法将108例符合纳入标准的功能性消化不良患者随机分为2组。治疗组55例,口服疏肝降逆汤每日1剂;对照组53例,口服雷贝拉唑10 mg 1次/d,疗程为2周。结果应用疏肝降逆汤和雷贝拉唑治疗功能性消化不良均能明显改善患者的临床症状,治疗组总有效率为95%,对照组总有效率为75%;2组治疗后各症状总积分均明显低于治疗前(P均<0.05),2组疗效指数相比,治疗组优于对照组(P<0.05)。结论疏肝降逆汤对功能性消化不良具有良好的疗效。

功能性消化不良(FD)是临床上常见的一种功能性胃肠病,由于发病机制尚未完全阐明,迄今仍缺乏令人满意的治疗药物.笔者用参苓胃消胶囊治疗FD, 取得良好效果,现报道如下.

反流性食管炎(reflux esophagitis,RE)系由于胃和(或)十二指肠内容物反流入食管,引起食管黏膜的炎症、糜烂、溃疡和纤维化等病变.临床表现主要为烧心、泛酸、胸骨后烧灼样疼痛及吞咽困难、嗳气、嘈杂等[1].2006-08-2008-08,我们应用疏肝降逆汤配合雷贝拉唑治疗肝郁型反流性食管炎57例,并与单纯雷贝拉唑治疗54例对照观察,结果如下.

<正>患者,男,42岁。因乏力7 d于2007年12月6日就诊。既往体健,无遗传病、家族病史。查体:BP150/90 mm Hg(1 mmHg=0.132 kPa),胸部皮肤红紫,眼睑无水肿,球结膜充血,心肺未见异常,脾于肋下1 cm,下肢无水肿。血WBC 6.93×10~9/L,RBC 6.43×10~(12)/L,Hb 204 g/L,HCT 0.68,MCV 89 fl,MCH