目的:分析2017 年黑龙江省肿瘤登记地区女性乳腺癌发病和死亡情况并对2013-2017 年变化趋势进行探讨.方法:收集来自黑龙江省12 个肿瘤登记地区上报的乳腺癌发病、死亡和人口数据.分别计算女性乳腺癌城乡和年龄组对应的发病率、死亡率、中标率、世标率、0～74 岁累积率.结果:2017 年黑龙江省肿瘤登记地区女性乳腺癌发病1450 例,死亡288 例,粗发病率为60.27/10 万,中标发病率为36.65/10 万,粗死亡率为11.97/10 万,中标死亡率为6.61/10 万.城市地区女性乳腺癌发病(死亡)率高于农村地区.在40 岁后女性乳腺癌发病率明显升高,发病率在60～64 岁年龄组达到高峰(122.97/10 万);25 岁前无死亡病例,在65 岁年龄前,随着年龄增长死亡率增加,随后死亡率稍有下降,至 85 岁及以上年龄组死亡率达到峰值(50.64/10 万).2013-2017 年均为45～64 岁年龄组的发病(死亡)率最高.结论:女性乳腺癌是黑龙江省常见的恶性肿瘤之一,农村地区适龄女性仍是肿瘤防治重点人群.

目的 了解黑龙江省2018年恶性肿瘤发病和死亡情况及2013-2018年变化趋势,并进行预测分析,为制定有效的肿瘤防控策略提供依据.方法 2013-2018年黑龙江省恶性肿瘤发病死亡数据来自中国肿瘤登记平台中黑龙江省各登记处提交的肿瘤登记数据,采用SAS 9.4、Excel 2013计算发病(死亡)率、中国人口标化率(中标率)、世界人口标化率(世标率)、0～74岁累积发病(死亡)率和前10位恶性肿瘤发病(死亡)顺位等指标.采用Joinpoint回归模型分析2013-2018年恶性肿瘤变化趋势,用灰色模型GM(1,1)预测恶性肿瘤未来3年变化趋势.结果 2018年黑龙江省肿瘤登记地区恶性肿瘤发病率和死亡率分别为305.44/10万、193.85/10万,中标率分别为184.33/10万、107.76/10万.其中男性发病率(310.09/10万)和死亡率(234.73/10万)均高于女性(300.85/10万、153.53/10万).2018年黑龙江省肿瘤登记地区恶性肿瘤发病率和死亡率均随年龄增长而上升.无论城市和农村地区,88％的男性和76％的女性恶性肿瘤发病均发生在50岁及以上年龄组,92％的男性和91％的女性恶性肿瘤死亡均发生在50岁及以上年龄组.发病前5位恶性肿瘤分别为肺癌、乳腺癌、肝癌、结直肠癌、甲状腺癌,死亡前5位恶性肿瘤分别为肺癌、肝癌、结直肠癌、胃癌和乳腺癌.2013-2018年黑龙江省恶性肿瘤的中标发病率呈上升趋势(P＜0.05),中标死亡率变化趋势无统计学意义(P＞0.05),灰色预测模型GM(1,1)预测结果显示,黑龙江省未来3年标化发病率和标化死亡率均上升,预计到2021年,标化发病率和标化死亡率分别升高到199.26/10万和110.33/10万.结论 黑龙江省恶性肿瘤疾病负担仍然较高,应针对不同地区和不同癌种,在高危人群中采取综合防控措施,减缓恶性肿瘤的疾病负担.

目的 分析2013-2017年黑龙江省肿瘤登记地区甲状腺癌流行变化趋势.方法 收集2013-2017年黑龙江省12个肿瘤登记地区连续上报的甲状腺癌登记数据,计算甲状腺癌发病率、死亡率、中国人口标化发病(死亡)率、世界人口标化率、0～<75岁累积发病(死亡)率以及年度变化百分比.结果 2013-2017年黑龙江省肿瘤登记地区甲状腺癌发病4639例,死亡158例;甲状腺癌发病率为18.92/10万,中标率为14.12/10万;死亡率为0.64/10万,中标率为0.40/10万;甲状腺癌发病率和死亡率均呈现显著增加趋势,且女性(29.28/10万、0.86/10万)高于男性(8.39/10万、0.43/10万),城市地区(22.75/10万、0.74/10万)高于农村地区(9.40/10万、0.41/10万).2013-2017年黑龙江省肿瘤登记地区甲状腺癌年均发病率呈显著上升趋势,年度变化百分比(APC)=15.58％,P<0.05;死亡率总体有上升趋势,但差异无统计学意义,APC=7.71％,P>0.05.结论 黑龙江省肿瘤登记地区甲状腺癌流行情况依然严峻,女性群体仍是甲状腺癌的重点防控对象.

目的:分析黑龙江省2018年恶性肿瘤发病和死亡情况及其流行特征.方法:2021年黑龙江省癌症中心收集并审核通过的11个肿瘤登记处提交的2018年肿瘤登记数据,计算发病(死亡)率、中国人口标化率(中标率)、世界人口标化率(世标率)、0～74岁累积发病(死亡)率和前10位恶性肿瘤发病(死亡)顺位等指标.结果:2018年黑龙江省肿瘤登记地区恶性肿瘤发病率为305.44/10万,中标率为184.33/10万.其中,男性发病率为310.09/10万,高于女性(发病率为300.85/10万).无论城市和农村地区,88％的男性和76％的女性恶性肿瘤发病均发生在50岁及以上年龄组.肺癌、乳腺癌、肝癌和结直肠癌是黑龙江省常见恶性肿瘤.2018年黑龙江省肿瘤登记地区恶性肿瘤死亡率为193.85/10万,中标率为107.76/10万;其中男性死亡率为234.73/10万,高于女性(死亡率为153.53/10万).无论城市和农村地区,92％的男性和91％的女性恶性肿瘤死亡均发生在50岁及以上年龄组.肺癌、肝癌、结直肠癌和胃癌是黑龙江省主要的恶性肿瘤死因.结论:黑龙江省恶性肿瘤疾病负担仍然较高,应针对不同地区和不同癌种,在高危人群采取综合防控措施,减轻恶性肿瘤的疾病负担.

胰腺癌是全世界最致命的恶性肿瘤之一,也是发达国家癌症死亡率的主要原因之一.尽管已经确定了某些危险因素,如吸烟、肥胖、遗传、糖尿病等可以导致胰腺癌的发生,但目前仍没有关于胰腺癌的筛查建议,因此一级预防至关重要.了解胰腺癌的流行病学和危险因素是阐明胰腺癌病因的关键,也是制定预防策略的基石.本文就胰腺癌流行现状和影响因素作一综述,以期为胰腺癌的一级预防提出防治策略.

Objective To analyze the incidence, mortality and time trend of lung cancer in Heilongjiang Cancer Registries from 2013 to 2017. Methods We calculated the incidence (mortality) rate and age-standardized incidence (mortality) rate of lung cancer in Heilongjiang Cancer Registries from 2013 to 2017. Chinese population census in 2000 and World Segi's standard population were used for age-standardization. Annual percentage change (APC) was calculated using Joinpoint software. Results The incidence of lung cancer in Heilongjiang Cancer Registries from 2013 to 2017 was 63.44/105 and ASR China was 36.14/105. The incidence of lung cancer in males (78.08/105) was higher than that in females (49.04/105). The incidence of lung cancer in rural areas (65.54/105) was higher than that in urban areas (58.20/105). From 2013 to 2017, the mortality rate of lung cancer in Heilongjiang Cancer Registries was 57.02/105, and ASR China was 32.53/105. The mortality rate of lung cancer in males (69.92/105) was higher than that in females (44.40/105). The mortality rate of lung cancer in rural areas (60.68/105) was higher than that in urban areas (48.02/105). The incidence of lung cancer in the 55-year-old age group showed a downward trend (APC=-5.0%, t=-5.1, P < 0.05), and the mortality rate of lung cancer in the 70-year-old group showed a downward trend (APC=-4.9%, t=-5.0). Conclusion Heilongjiang Province is a high incidence area of lung cancer. The prevention and control of lung cancer should be further strengthened according to the epidemiological characteristics of lung cancer in this province.

目的 分析2013—2017年黑龙江省肿瘤登记地区膀胱癌发病与死亡情况及时间变化趋势.方法 收集2013—2017年黑龙江省肿瘤登记地区上报的膀胱癌发病与死亡病例资料,计算发病(死亡)率、标化发病(死亡)率、累积率(0～74岁)等,标化率采用2000年全国人口普查标准人口构成和Segi's世界标准人口构成作为标准.年度变化百分比(APC)使用JoinPoint软件计算.结果 2013—2017年黑龙江省肿瘤登记地区膀胱癌发病率为6.16/10万,中标率为3.48/10万,累计率(0～74岁)为0.39％;其中男性发病率(9.29/10万)高于女性(3.09/10万),城市地区发病率(7.11/10万)高于农村地区(3.80/10万).2013—2017年黑龙江省肿瘤登记地区膀胱癌死亡率为2.77/10万,中标率为1.49/10万,累积率(0～74岁)为0.14％;其中男性死亡率(3.91/10万)高于女性(1.64/10万),城市地区死亡率(3.17/10万)高于农村地区(1.76/10万).2013—2017年黑龙江省肿瘤登记地区膀胱癌发病中标率呈升高趋势,APC为11.6％,差异有统计学意义(P<0.05),2013—2017年死亡中标率也呈升高趋势,APC为7.3％,但差异无统计学意义(P>0.05).结论 膀胱癌是威胁黑龙江省居民身心健康的恶性肿瘤之一,应对高风险人群做好积极防治工作.

目的 了解黑龙江省居民癌症防治核心知识的知晓情况,为制订我省癌症防治策略提供科学依据.方法 采用非随机抽样方法,通过问卷星对黑龙江省居民进行癌症防治核心知识知晓情况的调查,根据问卷的有效性最终选取1000份问卷纳入分析.比较调查对象的基本情况、癌症防治核心知识知晓情况,并利用多因素线性回归方程探讨癌症防治核心知识知晓情况的影响因素.结果 黑龙江省居民女性比男性、城市地区比农村地区、大专以上比高中以下、不吸烟比吸烟人群癌症防治核心知识知晓情况得分高(均P<0.05);职业方面,在校学生的癌症防治核心知晓情况得分最高,退休人员的癌症防治核心知晓情况得分最低(P<0.05);各年龄组和不同民族之间癌症防治核心知晓情况得分差异均无统计学意义(均P>0.05).城乡、文化程度和职业是癌症防治核心知识知晓情况的影响因素.结论 黑龙江省肿瘤防治工作应考虑城乡、文化程度以及职业等影响因素,针对不同人群进一步加强癌症防治宣传教育工作,不断提升我省居民的健康素养.

目的 分析黑龙江省肿瘤登记地区肝癌发病死亡情况及时间变化趋势.方法 收集2013—2017年黑龙江省肿瘤登记地区上报的肝癌发病与死亡资料,计算发病(死亡)率、标化发病(死亡)率、累积率(0～74岁)等,标化率采用2000年全国人口普查标准人口构成和Segi's世界标准人口构成作为标准.年度变化百分比(APC)使用Joinpoint软件计算.结果 2013—2017年黑龙江省肿瘤登记地区肝癌发病率为29.13/10万,中标率为17.18/10万,累积率(0～74岁)为1.96％.其中男性肝癌发病率(42.59/10万)高于女性(15.90/10万),农村地区肝癌发病率(35.05/10万)高于城市地区(26.75/10万).2013—2017年黑龙江省肿瘤登记地区肝癌死亡率为26.53/10万,中标率为15.90/10万,累积率(0～74岁)为1.78％.其中男性肝癌死亡率(38.33/10万)高于女性(14.93/10万),农村地区肝癌死亡率(30.65/10万)高于城市地区(24.88/10万).2013—2017年发病中标率呈下降趋势,死亡中标率无明显变化趋势(P>0.05),男性发病中标率呈下降趋势(P<0.05).结论 黑龙江省肝癌负担较重,发病率整体呈下降趋势,死亡趋势较平稳.防治工作中应重点关注男性及农村地区,采取综合措施进行有效预防与控制.

目的:分析2013—2017年黑龙江省肿瘤登记地区前列腺癌发病死亡情况及变化趋势.方法:收集2013—2017年黑龙江省肿瘤登记地区上报的前列腺癌发病与死亡资料,计算发病(死亡)率、标化发病(死亡)率、累积率(0～74岁)等,标化率采用2000年全国人口普查标准人口构成和Segi's世界标准人口构成作为标准.年度变化百分比(APC)使用Joinpoint软件计算.结果:2013—2017年黑龙江省肿瘤登记地区前列腺癌发病率为6.50/10万,中标发病率为3.71/10万,累积率(0～74岁)为0.35％.城市地区前列腺癌发病率(8.05/10万)高于农村地区(2.83/10万).2013—2017年黑龙江省肿瘤登记地区前列腺癌死亡率为3.41/10万,中标死亡率为1.90/10万,累积率(0～74岁)为0.16％.城市地区前列腺癌死亡率(4.20/10万)高于农村地区(1.53/10万).前列腺癌发病率和死亡率均随年龄升高呈上升趋势.2013—2017年黑龙江省肿瘤登记地区前列腺癌中标发病率和中标死亡率均呈上升趋势,但差异无统计学意义(P<0.05).结论:黑龙江省肿瘤登记地区前列腺癌发病率和死亡率均随年龄的增长而上升,城市地区高于农村地区,建议加强重点人群尤其是高龄人群的前列腺癌防治.

目的 分析黑龙江省2017年恶性肿瘤发病和死亡情况及其流行特征.方法 2020年黑龙江省癌症中心收集并审核通过的10个肿瘤登记处的2017年资料,计算发病(死亡)率、中国人口标化率(中标率)、世界人口标化率(世标率)、累积发病(死亡)率(0～74岁)和前10位恶性肿瘤发病(死亡)顺位等指标.结果 2017年黑龙江省肿瘤登记地区发病率为308.74/10万,中标率为174.27/10万,世标率为169.89/10万,累积发病率(0～74岁)为18.78％.肺癌、乳腺癌、结直肠癌和肝癌是黑龙江省常见恶性肿瘤.2017年黑龙江省肿瘤登记地区死亡率为192.89/10万,中标率为99.95/10万,世标率为99.62/10万,累积死亡率(0～74岁)为10.68％.肺癌、肝癌、结直肠癌和胃癌是黑龙江省主要的恶性肿瘤死因.结论 黑龙江省恶性肿瘤疾病负担不断升高,应针对不同地区和不同癌种,在高危人群采取综合防控措施,降低恶性肿瘤死亡率.

Up to 90% of patients after rectal resection who experience various degrees of low anterior resection syndrome (LARS). At present, there are a variety of methods for the treatment of LARS, including pelvic floor rehabilitation, sacral nerve stimulation, transanal irrigation and drug treatment. However, there is still no consensus or guidelines. The recent research progress of the recovery of anal function after surgical treatment of rectal cancer is reviewed in this paper.

Objective:To explore the incidence and mortality of esophageal cancer in the cancer registration areas of Heilongjiang province from 2013 to 2017 and their trends of change over time.Methods:The esophageal cancer incidence, mortality and population data reported by 12 cancer registration areas of Heilongjiang province were collected. Among them, the data of 11 areas met the check standards, including 7 cities above the prefecture level (abbreviated as urban area), 4 counties and county-level cities (abbreviated as rural area). The crude incidence and mortality rates of esophageal cancer in 11 cancer registration areas of Heilongjiang province from 2013 to 2017, and their standardized rates by Chinese population (adjusted according to the standard population composition of the 2000 census of China) and world population (adjusted using Segi world standard population composition), and the cumulative incidence or mortality rate from 0 to 74 years old (abbreviated as cumulative incidence or mortality rate) were calculated. Joinpoint regression was used to calculate the annual percentage change (APC) of the incidence and mortality rates, and the trend analysis was performed.Results:From 2013 to 2017, the crude incidence rate of esophageal cancer in the cancer registration areas of Heilongjiang province was 6.40/100 000, the standardized incidence rate by Chinese population was 3.63/100 000, and the cumulative incidence rate was 0.44%. The crude incidence rate of esophageal cancer in males (11.61/100 000) was higher than that in females (1.27/100 000). The crude incidence rate of esophageal cancer in rural area (6.27/100 000) was lower than that in urban area (6.71/100 000). From 2013 to 2017, the crude mortality rate of esophageal cancer in the cancer registration areas of Heilongjiang province was 5.32/100 000, the standardized mortality rate by Chinese population was 3.01/100 000, and the cumulative mortality rate was 0.35%. The crude mortality rate of esophageal cancer in males (9.56/100 000) was higher than that in females (1.15/100 000). The crude mortality rate of esophageal cancer in rural area (5.13/100 000) was lower than that in urban area (5.39/100 000). Joinpoint regression analysis showed that from 2013 to 2017, the incidence and mortality rates of esophageal cancer in the entire population and males had an increasing trend, but the differences were not statistically significant (all P > 0.05), and the standardized incidence rate by Chinese population in females had a downward trend, and the difference was statistically significant (APC = -7.92, 95% CI -11.52- -4.21, P < 0.01). Conclusions:The incidence and mortality rates of esophageal cancer in Heilongjiang province have been increasing in recent years, and the burden of disease is still heavy. In the male population, the primary prevention, early detection and early treatment of esophageal cancer should be paid more attention.

目的 了解2013-2017年黑龙江省居民胰腺癌发病和死亡趋势,为胰腺癌防控提供依据.方法 通过中国肿瘤登记平台系统收集2013-2017年黑龙江省居民胰腺癌发病和死亡资料,计算胰腺癌的发病率和死亡率,采用2000年中国人口普查标准人口构成计算中标率,采用Segi's世界标准人口构成计算世标率,采用年度变化百分比(APC)分析胰腺癌的发病和死亡趋势.结果 2013-2017年黑龙江省居民胰腺癌发病率为8.83/10万,中标率为5.11/10万,世标率为5.08/10万,发病顺位居全部恶性肿瘤的第八位;死亡率为8.19/10万,中标率为4.77/10万,世标率为4.72/10万,死亡顺位居全部恶性肿瘤的第六位.男性胰腺癌发病中标率为6.28/10万,女性为4.02/10万,男性发病中标率为女性的1.6倍.男性胰腺癌死亡中标率为5.76/10万,女性为3.84/10万,男性死亡中标率为女性的1.5倍.不同地区的男女胰腺癌发病率和死亡率均随年龄增长呈上升趋势.2013-2017年黑龙江省总体、不同地区、不同性别胰腺癌发病和死亡的中标率均未见明显变化趋势(P＞0.05).结论 2013-2017年黑龙江省居民胰腺癌发病率和死亡率较高,男性和老年人为主要危险人群.

癌症是严重威胁人类生命健康的疾病之一,已经成为全球的公共卫生问题.目前癌症患者晚期较多,导致生存率较低,如果癌症能够早期发现,会大大提高生存率,降低癌症的疾病负担.目前肿瘤的筛查与早诊早治是肿瘤二级预防的主要手段,能够早发现、早诊断和早治疗,提高患者生活质量.本文从几大高发癌种对目前癌症筛查现状、成效以及筛查方法进行阐述,以期为科学、合理选择和推广适宜的癌症筛查策略提供参考.

The aim of the research is to explore the relationship between hyperthyroidism, iodine, antithyroid drugs (propylthiouracil) and vascular endothelial injury. In total, 136 SD rats were randomly allocated into the control group, the hyperthyroidism group, the hyperthyroidism propylthiouracil group, the hyperthyroidism low iodine group, the high iodine group, and the endothelial injury group. Rats were raised for 60 days. Afterward, indicators concerning endothelial damage were determined, including the von Willebrand Factor (vWF), thrombomodulin (TM), nitric oxide (NO), endothelin 1 (ET-1), and P-selectin, as well as the plant hemagglutinin sample type oxidized low-density lipoprotein receptor 1 (LOX-1) from the aorta and the number of endothelial progenitor cells (EPCs) in whole blood. The hyperthyroidism group had significantly higher values for vWF, TM, NO, ET-1, and P-selectin in serum and a higher number of EPCs in whole blood compared with the control group, similar to the LOX-1 expression in abdominal aorta. The hyperthyroidism low iodine group had significantly higher values for vWF, ET-1, and P-selectin in serum and a higher number of EPCs in whole blood compared with those of the control group, as was the case for LOX-1 expression in the abdominal aorta. The hyperthyroidism propylthiouracil group had significantly higher values for FT 4 in the serum compared with those in the control group. The electron microscope showed that hyperthyroidism caused a certain degree of endothelial injury to the abdominal aorta in rats. Hyperthyroidism can damage the vascular endothelium and is a high-risk factor for cardio-cerebrovascular disease. Propylthiouracil could be used in the treatment of hyperthyroidism, thus protecting endothelial cells from damage.

Objective:To investigate the effects of thyroxine (T 4) and propylthiouracil (PTU) on nitric oxide synthase expression in human umbilical vein endothelial cells (HUVEC cells). Methods:HUVEC cells were cultured in vitro, the experiment was divided into 6 groups: control (without T 4 and PTU), 10 -9, 10 -7, 10 -4 mol/L T 4, PTU (5 μg/ml PTU), and 10 -4 mol/L T 4 + PTU, the action time was 24 h. CCK-8 method was used to detect cell activity; nitrate reductase method was used to detect nitric oxide (NO), total nitric oxide synthase (TNOS) and endothelial nitric oxide synthase (eNOS) contents; Western blotting was used to detect eNOS protein expression level. Results:The differences of cell survival rates [(100.00 ± 0.00)%, (96.73 ± 1.17)%, (86.20 ± 7.54)%, (47.37 ± 9.10)%, (53.37 ± 5.47)%, (53.40 ± 8.84)%] among the 6 groups were statistically significant ( F = 29.42, P < 0.05). Compared with the control group, the cell survival rates of 10 -7, 10 -4 mol/L T 4, PTU, and 10 -4 mol/L T 4 + PTU groups were significantly reduced ( P < 0.05). There were statistically significant differences in the contents of NO and TNOS among the 6 groups ( F = 3.93, 3.46, P < 0.05). Compared with the control group, the TNOS content in PTU group was significantly reduced ( P < 0.05); compared with the 10 -4 mol/L T 4 group, the NO contents in PTU and 10 -4 mol/L T 4 + PTU groups were significantly reduced ( P < 0.05). There were no significant differences in eNOS content and protein expression level among the 6 groups ( F = 0.24, 0.17, P > 0.05). Conclusions:High concentration of T 4 can cause damage to the activity of HUVEC cells cultured in vitro, and PTU can alleviate it by regulating NO and TNOS. The specific mechanism of action still needs to be further studied in molecular biological experiments.

目的:分析黑龙江省肿瘤登记地区2015年肝癌的发病和死亡情况.方法:经过质量审核后,7个肿瘤登记处数据被纳入分析,按照地区(城乡)、性别分层计算肝癌发病率、死亡率,采用2000年中国标准人口和SEGI世界标准人口结构分别计算中国人口和世界人口年龄标化发病/死亡率.结果:黑龙江省肿瘤登记地区肝癌死亡发病比为0.92,病理诊断率(MV％)为50.73％,死亡补发病比例为3.21％.黑龙江省肿瘤登记地区2015年肝癌发病粗率为27.44/10万(男性40.30/10万,女性14.75/10万),中国人口标化率为16.31/10万,世界人口标化率为16.08/10万;城市地区发病粗率为24.74/10万,中国人口标化率为13.87/10万;农村地区发病粗率为35.27/10万,中国人口标化率为24.95/10万.黑龙江省肿瘤登记地区2015年肝癌死亡粗率为25.20/10万(男性37.03/10万,女性13.51/10万),中国人口标化率为14.87/10万,世界人口标化率为14.75/10万;城市地区死亡粗率为23.18/10万,中国人口标化率为12.85/10万;农村地区死亡粗率为31.05/10万,中国人口标化率为21.96/10万.结论:必须将农村人口以及男性作为肝癌防治的重点对象,推进肝癌早诊早治以及肝癌的机会性筛查,提高早期肝癌的检出率,减少肝癌的发病与死亡造成的疾病负担.

Objective To observe the relationship between hyperthyroidism and vascular endothelial injury.Methods From 2016 to 2017,data of 60 patients with simple hyperthyroidism,autoimmune thyroid disease,cardiovascular and cerebrovascular diseases were collected from the Second Affiliated Hospital of Harbin Medical University.And 60 healthy subjects were enrolled in the same period as a healthycontrol group.The enzyme-linked immunosorbent assay (ELISA) was used to detect the content of vascular endothelial injury markers (vWF),thrombomodulin (TM),endothelin-1 (ET-1),P-selectin in serum of all subjects,as well as the serum thyroid stimulating hormone (TSH),free triiodothyronine (FT3),free thyroxine (FT4),anti-thyroglobulin antibody (TgAb),and anti-thyroid peroxidase antibody (TPOAb) in patients with cardiovascular and cerebrovascular diseases levels.The correlation analysis of vascular endothelial injury in the simple hyperthyroidism group,autoimmune thyroid disease group,cardiovascular and cerebrovascular diseases group and healthy control group was conducted.Results There were statistically significant differences between the he althy control group,the simple hyperthyroidism group,the autoimmune thyroid disease group and the cardiovascular and cerebrovascular diseases group in the serum levels of vWF,TM,ET-1 and P-selectin,respectively (F =6.56,9.19,7.88,12.45,P ＜ 0.05),and the simple hyperthyroidism group,autoimmune thyroid disease group,cardiovascular and cerebrovascular diseases group were significantly higher than the healthy control group (P ＜ 0.05).Correlation analysis showed that the vascular endothelial injury in the patients with simple hyperthyroidism,autoimmune thyroid disease,and cardiovascular and cerebrovascular diseases groups was statistically significantly different compared with the healthy control group,respectively (x2 =5.08,5.08,8.16,P ＜ 0.05);the risk of vascular endothelial injury in each diseased group was 2.37,2.37,and 3.07 times higher than that of the healthy control group,respectively.The abnormal rates of TSH,FT3,FT4,TgAb and TPOAb in patients with cardiovascular and cerebrovascular diseases were 18.33％ (11/60),15.00％ (9/60),15.00％ (9/60),10.00％ (6/60) and 11.7％ (7/60),respectively.Conclusion Simple hyperthyroidism and autoimmune thyroid disease are risk factors of vascular endothelial injury.