Objective To construct a model of Fat-1/APPPS1 transgenic mice and a cellular model of microglia and explore the improvement effect and underlying mechanism of n-3 polyunsaturated fatty acids (n-3 PUFAs) on the learning and memory abilities of APPPS1 mice by regulating microglial activation and polarization. Methods After the male mice with heterozygous Fat-1 genotype were mated with the female ones with heterozygous APPPS1 genotype, genetic identification was used to screen the male offspring with Fat-1/APPPS1 genotype. Then after the male wild-type (WT) mice and those with Fat-1, Fat-1/APPPS1, and APPPS1 genotypes were bred until 9 months old, their learning and memory abilities were evaluated with Morris water maze (MWM) test. In addition, gas chromatography-mass spectrometry (GC-MS) was performed to detect the concentration of PUFAs in the brain, and immunohistochemistry (IHC) was applied to detect the deposition of β-amyloid protein (Aβ) in the hippocampal regions. Moreover, immunofluorescence assay, qRT-PCR, and enzyme-linked immunosorbent assays (ELISA) were conducted to measure inflammation, and transcription and expression of Iba-1 (indicating the microglial activation) and CD86 and CD206 (indicating microglial polarization) in central nervous system (CNS). After pretreated with DHA+EPA (25 μmol/mL ∶25 μmol/mL), microglial model of inflammatory injury was established in immortalized mouse BV2 cells induced by LPS (1 μg/mL). Afterwards, immunofluorescence assay, qRT-PCR and Western blotting were used to detect inflammation and microglial activation and polarization. Results Compared with the APPPS1 mice, endogenous n-3 PUFAs effectively improved the learning and memory disorders in Fat-1/APPPS1 ones (P < 0.05), remarkably alleviated Aβ deposition in the hippocampal regions (P < 0.05), evidently reduced CNS inflammation and microglial activation (P < 0.05) and transformed the activated microglia from M1 to M2 (P < 0.05). Furthermore, BV2 cells with DHA+EPA pretreatment obviously resisted LPS-induced cellular inflammation and induced activated ones from M1 to M2 (P < 0.05). Conclusion n-3 PUFAs inhibit the microglial activation, regulate the microglial polarization from M1 to M2, reduce CNS inflammation, and thus alleviate learning and memory disorders in APPPS1 mice.

Backgroud: Estrogen deficiency is the leading cause of postmenopausal osteoporosis(PMOP) and phytoestrogens soy isoflavones (SI) have been shown to improve PMOP. Equol (Eq), an in vivo metabolite of phytoestrogens soy isoflavones (SI), has a more stable structure and stronger biological activity than its parent compound and has the greatest estrogenic activity. However, there are few studies on the therapeutic effect of Eq on PMOP. Purpose: To explore the therapeutic effect and mechanisms of Eq on POMP. Methods: Osteoblast-like cells ROS1728 were cultured with different doses of Eq, estradiol (E2), separately. The effect of Eq on the proliferation, apoptosis, cell cycle of osteoblasts were detected by CCK-8 and flow cytometry, and the expression of OPG/RANK/RANKL signaling pathway of osteoblasts was detected by Quantitative real-time PCR (qRT-PCR) and Western blot (WB), and RNA silencing technology were carried out to explore the receptors through which Eq plays a role. Then PMOP rat model was established and treated by Eq or E2 to further verification of the effect and mechanism of Eq on PMOP. Result: Eq promoted the proliferation and inhibited the apoptosis of osteoblasts and increased the proportion of osteoblasts in the S phase and G2/M phase in a dose-dependent manner. Mechanistically, Eq treatment upregulated the expression of OPG and OPG/RANKL ratio in osteoblasts and this regulatory effect was mainly mediated through the ER beta receptor. Furthermore, in vivo study, Eq improved microstructure and BMD of the femur of PMOP rat model, which imitated the osteoprotective effect of E2. Moreover, the Eq or E2 treatment increased serum levels of Ca, 1,25(OH)2D3, bone Gla-protein(BGP), and Type I procollagen (PC1), and reduced serum levels of phosphorus (P), parathyroid hormone(PTH), pyridinol (PYD), tartrate-resistant acid phosphatase (TRAP) and urinary level of deoxypyridinoline (DPD) in the treatment OVX group compared with the untreated OVX group. Meanwhile, Eq or E2 markedly induced the mRNA and protein expression of OPG and OPG/RANKL ratio. Conclusion: Eq can combine with ER beta and exert a protective effect on PMOP by upregulating OPG/RANKL pathway.

ObjectiveTo observe the effect of equol（Eq）intervention on osteoblasts induced by high glucose and fat, and to explore its mechanism of action.MethodsAfter ROS1728 osteoblasts were treated with different concentrations of Eq, sodium palmitate（PA）and glucose（GLU）for 48 h, nuclear apoptosis was observed by HE staining and cell survival rate was detected by CCK-8 assay in order to determine the optimal concentrations of GLU, PA and Eq interventions to induce cellular model of diabetic osteoporosis. ROS1728 cells were then divided into control group（5.5 mmol/L GLU）, model group（30 mmol/L GLU+250 μmol/L PA）, and low, medium and high dose Eq treatment groups（model+1×10-8, 1×10-7 and 1×10-6 mol/L Eq）. CCK8 assay was used to detect cell viability, and flow cytometry for cell apoptosis. Hoechst33342 staining and HE staining were employed to observe apoptotic nuclei. Mitochondrial structure, mitochondrial membrane potential（MMP）changes, and protein levels of Sirt1, PGC-1α, Bcl-2, Bax and Cleaved caspase-3 were observed by transmission electron microscopy, Mito-Tracker Red CMXRos（mitochondrial red fluorescent probe）staining, and Western blotting, respectively.ResultsCompared with the control group, treatment of 30 mmol/L GLU and 250 μmol/L PA significantly reduced the cell viability rate（P<0.05）and increased the apoptotic rate（P<0.05）, and the optimal concentrations were determined to induce high glucose and fat environment of osteoblasts. While Eq intervention significantly increased the survival rate and decreased the apoptotic rate（P<0.05）, attenuated the damage of mitochondrial structure, elevated MMP（P<0.05）and decreased ROS level（P<0.05）, as well as up-regulated the expression levels of Sirt1, PGC-1α and Bcl-2 and down-regulated those of Bax and Cleaved caspase-3（P<0.05）.ConclusionEq intervention could effectively reduce mitochondrial damage, oxidative stress and apoptosis of osteoblasts induced by high glucose and fat, which might be partially related to its activation of Sirt1 and PGC-1α.

BACKGROUND:This study aims to explore the effect of mobile phone-based telemedicine management of glycemic control of type 2 diabetes mellitus (T2DM).METHODS:Patients with T2DM were followed up in Chongqing Jiulongpo District Yuzhoulu Community Health Center, and randomly divided into the telemedicine group (n=47) and the control group (n=50). The control group received regularly routine intervention. The telemedicine management group used the mobile phone to manage their health condition remotely.RESULTS:Both groups had similar baseline characteristics. After a follow-up period of 12 months intervention, the weight, body mass index, waist circumference, systolic blood pressure, body fat percentage, body fat mass, body water and muscle mass, fasting blood glucose, glycosylated hemoglobin, total costs of diabetes treatment for 1 month and the quality-of-life score were significantly improved in the telemedicine group (P<0.05). And compared with the control group, body fat composition, fasting blood glucose, glycosylated hemoglobin and the cost of change shows a significant improvement (P<0.05). Positive correlation was detected between fasting blood glucose and body composition parameters, such as body fat percentage, lean body mass and body fat mass in the telemedicine group (r=0.56, P<0.05; r=0.37, P<0.05; r=0.56, P<0.05).CONCLUSIONS:Compared with conventional intervention, the mobile phone-based telemedicine management can help patients with T2DM to improve glycemic level and quality of life.

Strict and appropriate glycaemic control has a positive impact on long-term clinical outcomes in patients with type 2 diabetes mellitus (T2DM) by delaying and slowing the progression of complications related to diabetes (UK Prospective Diabetes Study (UKPDS) Group, 1998; Klaus-Dieter et al., 2011). Specific treatment such as oral hypoglycaemic agents or insulin is given to patients with T2DM according to their condition. Importantly, the adjustment of suboptimal dietary and lifestyle habits has become the primary therapy for T2DM and an important adjunctive treatment in insulin-dependent T2DM (Tuomilehto et al., 2011). However, there are an increasing number of patients who have never received systematic or scientific management and guidance on their daily diet, leading to a poor glycaemic control or malnutrition. Reducing hyperglycaemia to an appropriate range without significant hypoglycaemia is the primary goal; however, over nutrition and malnutrition in diabetic patients can cause serious concern (Franz et al., 2017).

目的 探讨围术期肠内外序贯营养治疗对膀胱全切回肠代膀胱术患者临床预后的影响及临床效果观察.方法 57例行膀胱全切回肠代膀胱术的膀胱癌患者根据围术期营养支持方式不同分为2组.观察组27例,接受优化的围术期序贯营养治疗;对照组30例,采用本院常规围术期营养治疗.比较两组患者术后的一般情况、肝脏功能、营养状况、临床并发症、住院总费用及日均营养费用.结果 除观察组碱性磷酸酶水平,两组患者手术前后肝脏功能指标变化差异无统计学意义(P＞0.05).观察组术后维生素A结合蛋白[(31.26±10.16)mg/L vs.(24.83士8.48)mg/L,P=0.012]、清蛋白[(39.53±4.11)g/L vs.(38.55±5.62)g/L,P=0.035]及前清蛋白[(158.44±41.67)g/L vs.(130.40±44.04)g/L,P=0.017]均高于对照组,差异有统计学意义.观察组并发症发生率明显低于对照组(x 2=4.041,P=0.044).观察组日均营养费用高于对照组(220.05±77.08)元 vs.(171.93±88.73)元,P=0.034],而住院总费用[(9.20±1.66)万元 vs.(10.19±1.97)万元,P=0.046]及住院时间[(18.22±2.99)d vs.(20.67±5.58)d,P=0.047]较对照组降低,差异有统计学意义.结论 膀胱全切回肠代膀胱术患者围术期的优化肠内外序贯营养治疗是安全、合理、有效的营养治疗方式,在改善患者临床预后、降低并发症发生率方面优于常规围术期营养支持.

目的:研究家庭肠内营养(EN)对老年髋部骨折病人术后人体成分的影响,为推进家庭EN提供科学依据.方法:选取2019年6月～2020年5月在新桥医院骨科诊断为髋部骨折,行全髋或半髋关节置换的老年病人156例,按照随机数字表分为两组.对照组采用常规院外饮食宣教,实验组采用EN联合个体化食谱定制.两组病人均在出院当天、出院后1个月时行人体成分分析,Harris髋关节功能评分,并记录两组病人血浆蛋白水平及伤口愈合情况.结果:出院后1个月,实验组病人体质量、骨骼肌、体脂肪、蛋白质、血浆蛋白水平、Harris评分均明显优于对照组(P＜0.05),伤口愈合不良发生率也明显低于对照组(1.4％vs 8.5％,P＜0.05).结论:合理的家庭EN能显著改善老年髋部骨折病人的营养状况,增加机体瘦体组织,促进伤口愈合及康复.

In this study, we investigated the effect of exenatide (EXE), a glucagon-like peptide (GLP)-1 receptor agonist, on kidney function, obesity indices, and glucose control in overweight/obese patients with type 2 diabetes mellitus (T2DM). A total of 159 overweight/obese patients with T2DM were randomized to the EXE group or insulin glargine (GLAR) control group for a total treatment period of 24 weeks. EXE intervention significantly reduced the urine albumin concentration (UAC) at week 12 and 24 endpoints ( P < 0.001 at week 12 and 24). The levels of the anthropometric, glucose and lipid parameters (TG and HDL-c), and inflammation biomarkers (CRP and TNF-α) in the EXE group were improved at 12 weeks or 24 weeks, respectively. Meanwhile, a comparison between two groups showed significant changes in anthropometric parameters, glucose parameters, lipid parameters (TG and HDL-c), and Inflammation biomarkers (CRP, IL-6, and TNF-α). Serum fibroblast growth factor 21 (FGF21) was increased in the EXE group ( P = 0.005) at week 24, and the change was significantly improved compared with GLAR group ( P = 0.003). Correlation network analysis showed that FGF21 had a more central role in improving metabolism in the EXE group, and the change of FGF 21 was significantly negatively correlated with UAC at week 12 and week 24, respectively ( r = − 0.297, P = 0.010; r = − 0.294, P = 0.012). Our results showed that EXE could help patients improve UAC, glycemic levels, and inflammatory biomarkers after a follow-up period of 24 weeks intervention. These EXE effects may be partly mediated by FGF 21, indicating that EXE is an effective and safe way to control albuminuria in overweight/obese patients with T2DM.

To evaluate the effect of medical nutritional therapy (MNT) combined with low glycaemic index (LGI) formula at breakfast for 4 weeks on the glycaemic control of patients with type 2 diabetes mellitus (T2DM). Ninety-six participants were recruited and randomly equally divided into two groups. The intervention group was offered with 40g LGI formula at breakfast adjusted according to MNT, and the control group with regular MNT. After 4 weeks, fasting blood glucose, glycated albumin (GA), insulin, C-peptide levels and metabolic index were compared between the two groups. Compared to the intervention group, the total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and the change of FBG (-0.64 +/- 1.4 vs. 0.3 +/- 2.2; p < 0.05) and 2h-PBG (-1.8 +/- 3.6 vs.0.8 +/- 3.2; p < 0.01) in the control group were significantly decreased. The LGI formulations, having a significant effect on controlling glucose and lipid metabolism, could be used as a non-pharmacological intervention for T2DM self-management.

Objective: To retrospectively investigate the comparative efficacy, safety and cost-benefits of three nutritional treatment schemes including short peptide jejunal nutrition (SPJN), whole protein jejunal nutrition (WPJN), and partial parenteral nutrition (PPN) in patients underwent esophagectomy for esophageal cancer in our hospital. This study was carried out in accordance with the conceptual framework of nutritional therapy in fast-track rehabilitation surgery. Methods: We retrospectively reviewed 305 patients who were assigned to receive esophagectomy for esophageal cancer. Eligible patients was naturally divided into SPJN group [ n = 98 (32.1%)], WPJN group [ n = 95 (31.1%)], and PPN group [ n = 112 (36.7%)] according to the type of nutritional scheme which was actually prescribed to patients by the attendingphysician in clinical practice. The differences of the serum total protein (TP), albumin (ALB), pre-albumin (PA), hemoglobin (HGB), white blood cells (WBCs), red blood cells (RBCs) and neutrophils were compared among 3 nutritional schemes groups. We also investigated the relationship of the fluid intake, urine output, gastric juice drainage volume and thoracic drainage volume among 3 nutritional groups at 3 days after surgery. Moreover, the differences of cost-benefit indexes, complications, length of hospitalization and hospital expenditure were also compared. Results: The serum TP, ALB, and PA in the SPJN group were all higher than those in the WPJN and PPN groups ( p < 0.05). The gastric juice volume of gastrointestinal decompression drainage and fluid volume of thoracic drainage in the SPJN group were all less than that in the WPJN group ( p < 0.05). The overall hospital stay and post-operative hospital stay in the SPJN group were all shorter than that in WPJN group ( p < 0.05). Moreover, the incidence of post-operative complications including anastomotic leakage, infection, and gastrointestinal reaction was remarkably lower in the SPJN group compared to the WPJN group ( p < 0.05). Interesting, hospital expenditure in the PPN group was less than that in the SPJN and the WPJN groups ( p < 0.001). Conclusion: Patients may obtain benefits in improving protein level after receiving SPJN scheme at the early stage after esophagectomy. Meanwhile, patients may obtain benefits in improving post-operative complications and hospital stay after receiving SPJN or PPN compared to WPJN protocol. However, the difference between SPJN and PPN requires further study because no difference was detected in terms of clinical outcomes including complications and the length of hospitalization although PPN may achieve a possible decrease of medical expenditure.

目的 探讨应用基于"互联网+"的远程糖尿病营养与体质量管理系统对社区2型糖尿病患者(T2DM)管理的效果研究.方法 选取重庆市某社区卫生服务中心社区门诊随访的T2DM患者97例,随机分为远程组(47例)和对照组(50例).对照组采取常规门诊干预措施;远程组接受远程糖尿病营养与体质量管理系统的管理.结果 远程组空腹血糖(FBG)、糖化血红蛋白(HbA1C)、HbA1C达标率、体质量、身体质量指数(BMI)、腰围、人体成分指标较干预前得到明显改善,差异有统计学意义(P<0.05),最近1个月糖尿病治疗费用较干预前有减少,差异有统计学意义(P<0.05),生活质量得分较干预前提高,且与对照组相比,远程组的FBG、HbA1C水平和HbA1C达标率、体脂成分指标,以及最近1个月糖尿病诊疗费用的变化更加明显,差异有统计学意义(P<0.05).同时远程组干预前后体质量减少情况与患者上传数据频数呈正相关(r=0.792,P<0.01).结论 远程管理模式有助于改善T2DM患者的糖代谢指标,提高血糖控制达标率,减少T2DM患者经济负担,提高T2DM患者生活质量.

营养不良为肿瘤患者最常见的并发症及致死因素,在晚期肿瘤患者中更为多见.由于住院时间缩短,治疗方式及目标改变,越来越多的患者选择在家庭中接受营养治疗,合理、有效地家庭营养治疗对改善晚期肿瘤患者的预后及生活质量具有积极作用,其中家庭肠内营养由于简便、安全成为晚期肿瘤患者家庭营养治疗首选的应用方式.规范的家庭肠内营养能够有效降低患者营养不良的发生率,不仅有助于改善和维持患者营养状况,提高生活质量,而且能够满足其生理、心理需要,避免了长期住院,有利于节省医疗费用,有明显的社会效益.然而,家庭肠内营养实施目前仍面临着多方面的挑战,包括肠内喂养装置、肠内营养配方组分、实践创新、医疗保障等.目前亟待探索规范、安全、可靠的管理实施方式来实现家庭肠内营养治疗,为建立规范的晚期肿瘤患者的家庭肠内营养模式提供思路.

目的:根据快速康复外科的理念,探讨关节置换围手术期营养支持效果,为关节置换患者围手术期营养治疗提供科学依据.方法:观察2014年1月-2015年12月陆军军医大学新桥医院骨关节病区行关节置换术患者,排除自动出院、严重肝肾功能障碍及高血糖等患者,最终试验组纳入66例、对照组纳入107例.试验组根据快速康复外科理念给予围手术期整蛋白型肠内营养制剂+短肽型肠内营养+益生菌制剂精细化营养治疗方案;对照组常规自行给予营养支持;对比两组患者术前、术后第1天、术后第3天共3次的C反应蛋白、白细胞、红细胞、血红蛋白、血小板计数、血清总蛋白、白蛋白、前白蛋白及术后12月内的并发症情况(创口愈合延迟、感染等).结果:术前,试验组C反应蛋白、白细胞显著高于对照组[(19.1±40.5) mg/Lvs (7.0±8.8) mg/L,P=0.034;(6.9±2.4)×109/L vs (5.9±1.7)×109/L,P=0.002],两组患者术后第1天与术后第3天的各项实验室指标差值比较,试验组血红蛋白下降幅度显著低于对照组[(8.06±11.63) g/L vs (12.27±10.50) g/L,P=0.041];试验组术后1年内并发症发率显著低于对照组(3.0％ vs 13.1％,P=0.027).结论:关节置换围手术期精细化营养治疗可减轻患者术后的炎症反应,减少术后创口愈合延迟、感染等并发症.

目的:比较给予危重症病人同等热卡不同蛋白的营养治疗方案对脏器功能及营养状况的改善效果. 方法:回顾性分析260例行肠外营养和(或)肠内营养治疗7d及7d以上的危重症病人.其中氮热比1:100～133组69例、氮热比1:133～ 167组129例、氮热比1:168 ～ 200组62例. 结果:营养治疗前后,各组危重症病人自身对比,血清平均TP、ALB、PA、TLC均明显升高(P＜0.01),血清平均ALT、AST、SCr无明显差异(P＞0.05).其中氮热比1:100～ 133组的危重症病人营养治疗后的TP、ALB、PA、TLC高于其余两组(P＜0.05),呼吸机脱机时间短于其余两组(P＜0.05).血清平均ALT、AST、SCr、住院时间、住院总费用各组间差异无统计学意义. 结论:氮热比1:100 ～ 133组的危重症病人营养治疗效果优于氮热比偏高组,且并不增加病人脏器负担.

目的:比较不同年龄段关节置换患者术前营养状况有无差异,以及采取快速康复围手术期营养治疗后,营养治疗效果有无差异.方法:收集300例初次行单侧全髋或全膝置换术的患者,按照年龄进行分组.非老年组<65岁,普通老年组65～79岁,高龄老年组≥80岁,每组各100例.结果:入院时,高龄老年组血清平均ALB、PA、HGB、TLC均明显低于普通老年组和非老年组(P<0.01),普通老年组血清平均ALB、PA、HGB、TLC均低于非老年组(P<0.05).出院时,行围手术期营养治疗后,各年龄组患者血浆ALB、PA、HGB、TLC均比术后第一天明显上升(P<0.01),且高龄老年组较其余两组上升更明显(P<0.05),普通老年组较非老年组上升更明显(P<0.05).结论:拟行关节置换的高龄老年患者和普通老年患者入院时营养状况较非老年患者差,但行围手术期营养干预后,营养治疗效果明显优于非老年组.

目的 总结1例甲状腺功能减退合并右半结肠癌根治术后胃瘫综合征的临床诊治过程及经验.方法 对笔者所在医院近期收治的1例甲状腺功能减退合并右半结肠癌根治术后胃瘫综合征患者开展普通外科、内分泌科、营养科、放射科及病理科专家参与的多学科协作(MDT)会诊讨论.结果 MDT讨论结果认为,该例患者术前诊断右半结肠癌明确,行右半结肠癌根治术后出现胃瘫综合征,且患者术前合并有甲状腺功能减退,胃瘫的发生可能与甲状腺功能减退有关,建议在术后补充甲状腺素钠、营养支持治疗.按照MDT讨论结果,在胃瘫发生后给予补充甲状腺素钠、营养支持治疗,患者胃瘫逐渐治愈,顺利出院.结论 甲状腺功能减退可能是右半结肠癌根治术后胃瘫综合征发生的高危因素之一,MDT机制可为甲状腺功能减退合并右半结肠癌根治术后胃瘫综合征的患者提供个体化的优选治疗方案,使患者获益.

Objective To observe the tolerance of 2 kinds of enteral products and recovery of gastrointestinal function in postoperative spine patients,and evaluate the effect of the early nutritional support.Methods A total of 100 postoperative patients in the orthopedic department of our hospital from March to May 2015 were enrolled in this study.They were divided into the study group (n =50,given the peptidebased enteral products) and the the control group (n =50,given the whole protein enteral products).The serum contents of total proteins,albumin and pre-albumin,first flatus time after surgery,and bowel sounds and incidences of bloating,diarrhea,nausea and vomiting within 24 h postoperatively were measured and recorded,and the results were compared between the 2 groups.Results The first flatus time after surgery was significantly shorter in the study group than the control (14.4 ±5.1 vs 16.8 ±5.0 h,P =0.021).The study group also had obviously lower incidences of bloating and nausea when compared with the control (4％ vs 18％,P =0.025;6％ vs 24％,P =0.012).No significant differences were seen in the serum contents of total proteins,albumin and pre-albumin between the 2 groups after nutrition support (P ＞ 0.05).Conclusion The peptide-based enteral products significantly shorten the recovery time of gastrointestinal function and increase gastrointestinal tolerance in the patients after spinal operation.

Aim: To investigate the effect of a macro-nutrient preload (Inzone Vitality) on blood glucose levels and pregnancy outcomes of gestational diabetes. The preload method involves the ingestion of a smaller amount of a macronutrient composition half an hour before regular meals. The hypothesis was that preload treatment will reduce postprandial glycemia in gestational diabetes.Methods: Sixty-six diagnosed cases of gestational diabetes were randomly selected from gynecology and obstetrics outpatient clinic at Xinqiao Hospital in Chongqing. The patients were divided into an intervention group (33 cases) and a control group (33 cases), according to odd-even numbers of the random cases. The intervention group was treated with a macro-nutrient preload given 0.5 h before regular meals and the control group was given a comparative treatment consisting of a milk powder with similar energy content. The two groups were studied until delivery and the measured parameters included fasting blood glucose (FBG), 2-hour postprandial blood glucose (2h-PBG), delivery mode and neonatal birth weight.Results: The two groups showed no differences in FBG or 2h-PBG before the nutritional intervention. FBG and 2h-PBG after intervention and before delivery were significantly lower in the intervention group, treated with the macro nutrient preload compared to the control group (P < 0.01). Changes in FBG and 2h-PBG before and after the intervention were investigated and the difference in the intervention group was significantly greater than corresponding values in the control group (P < 0.05, P < 0.01). The neonatal birth weight and delivery mode was not significantly different (P > 0.05).Conclusion: A macro-nutrient composition, used as a preload, is effective in controlling FBG and PBG of gestational diabetes. (C) 2016 The Author(s). Published by Elsevier Inc.

目的:了解添加n-3鱼油脂肪乳全合一静脉营养是否可改善肠外营养引起的肝功能损害和胆汁淤积.方法:将100例需要中长期全合一静脉营养支持的患者随机分为2组:对照组50例,使用普通脂肪乳剂250mL;实验组50例,使用普通脂肪乳剂250mL加鱼油脂肪乳剂100mL.输注肠外营养1w后,比较输注前后2组患者血浆转氨酶、胆红素及血浆蛋白水平.结果:肠外营养治疗前后,实验组患者自身对比,血清平均总胆红素(TBIL)、直接胆红素(DBIL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)均明显降低(P＜0.05).对照组患者自身对比,血清平均ALT、碱性磷酸酶(ALP)、γ-谷氨酰转移酶(γ-GT)均明显升高(P＜0.05).实验组在肠外营养支持后血清平均TBIL、DBIL、ALT、AST、ALP、γ-GT均明显低于对照组(P＜0.01).结论:添加n-3鱼油脂肪乳可改善患者的肝功能损害和胆汁淤积.