Objective To collect information on nutrition of vitamin D in Xuzhou children aged 0～5 in winter,and to instruct parents how to properly use vitamin D.Method The serum samples were collected from 242 cases at the age of 0 ～5 who received conventional healthcare in the outpatient of children healthcare at the Xuzhou Maternial and Child Health Care Hospital,and the serum levels of 25-hydroxy vitaminD [25(OH)D]were determined using immunochromatography.Results The mean level of 25(OH)D was (51.34±19.38) nmol/L in these 242 cases aged 0～5.108 cases,accounting for 44.63 ％ of them,exhibited adequate levels of 25 (OH)D,while 55.37 ％ of them showed low levels of 25 (OH)D (deficient in 26.45％,scarce in 28.93％).There was no significant difference in the level of 25(OH)D between girls and boys at the age of 0～5 (P＞0.05).Children at the age of 3～5 had significantly lower level of 25(OH)D compared to those less than 1 year old (P＜0.05).Conclusions In Xuzhou City,children at the age of 0～5 years old generally exhibited low levels of 25 (OH)D.Therefore,attention should be paid to the 25(OH)D test and supplementation.

目的：探讨减少头孢地嗪钠与热毒宁注射液联合用药的不良反应方法。方法按条件随机抽选患者分成观察组和对照组。观察组在头孢地嗪钠和热毒宁注射液输液之间用5％葡萄糖注射液冲洗输液管路；对照组头孢地嗪钠和热毒宁注射液直接联用，观察2组不良反应发生情况。结果观察组不良反应发生率（6．00％）显著低于对照组（16．00％），差异有统计学意义（P＜0．01）。结论用5％葡萄糖注射液冲管可以降低头孢地嗪和热毒宁注射液联用的不良反应。