Vitiligo is a common depigmented skin disease characterized by being easy to diagnose but difficult to cure,and the mechanism is closely related to qi and blood. Combined with the theory and clinical practice of Chinese medicine, the treatment of vitiligo is based on the theory of "harmony of qi and blood". The disharmony of qi and blood is the pathogenesis of vitiligo and the essential treatment is to dispel wind, nourish liver and kidney and warm yang on the basis of harmonizing qi and blood to nourish the skin. According to the theory of "harmony of qi and blood", the pathogenesis of vitiligo were discussed from the disharmony of qi and blood, and the treatment principles were summarized, expecting to provide relevant references for treating vitiligo.

反应性穿通性胶原病是一种罕见难治性皮肤病,从中医"毒、瘀、虚"理论出发,认为该病病机为风湿热邪首犯肌表,厚积成毒,久病入络,化为瘀血,正气亏虚,抗邪无力,形成"毒、瘀、虚"相互影响的状态.治疗上,针对患者疾病发展特点,予解毒、化瘀、扶正补虚,使顽毒得解,瘀血得消,正气得护,为中医药治疗反应性穿通性胶原病提供较为完整的思路.

目的:探讨温阳生肌膏对糖尿病大鼠阴证慢性创面的治疗机制.方法:60只雄性SD大鼠采用高脂乳剂灌胃+腹腔注射链脲佐菌素的方法制备2型糖尿病大鼠模型,再以股部外侧注射氢化可的松及用打孔器在背部两侧制备全层皮肤缺损的方法制备阴证创面模型.将模型大鼠随机分为模型组、实验组和对照组(n=20).模型组不做处理,其余2组分别给予温阳生肌膏和象皮生肌膏外敷,每日1次,共21 d.观察造模后3、7、14、21 d创面愈合大体情况和造模后14 d的创面组织病理学变化;免疫组化检测造模后7和14 d创面组织CD34和血管内皮生长因子(VEGF)的表达;测定造模后3、7、14 d微血管密度(MVD)的变化.结果:实验组大鼠创面愈合率明显高于模型组及对照组(P<0.05);造模后3～7 d,实验组皮损处新生肉芽组织MVD较模型组及对照组显著升高(P<0.05);造模后14 d,实验组皮损处新生肉芽组织CD14和VEGF水平与模型组及对照组相比较显著升高(P<0.05);实验组肉芽组织生长旺盛,毛细血管丰富,炎症细胞较少.结论:温阳生肌膏可促进糖尿病大鼠阴证创面的愈合,其作用机制可能与增加局部皮损处新生肉芽组织中的新生微血管数量有关.

以药食同源药物和马蹄粉为主要原料并配以辅料,以感官评分为指标,考查中药汁、梨汁、柠檬汁及马蹄粉添加量对马蹄糕品质的影响,采用单因素试验及正交试验确定配方.结果 表明,最佳配方为中药汁40 mL(灰树花10 g,山药10 g,茯苓10 g,黄芪10 g,藕10 g,葛根10 g,党参6 g,甘草6 g,加水1 000 mL,浸泡30 min,煎煮40 min),梨汁70 mL,柠檬汁25 mL,马蹄粉35 g.按照最佳配方研制出的马蹄糕性状稳定、颜色均匀、口感风味良好.