Objective: To explore the potential molecular targets and mechanisms of the “Schizonepetae HerbaSaposhnikoviae Radi” drug pair in the treatment of psoriasis based on computer network pharmacology and molecular docking technology. Methods: The TCMSP database was used to screen the effective active ingredients and targets of “Schizonepetae Herba-Saposhnikoviae Radi” drug pair. The psoriasis-related targets were GeneCards, OMIM and other databases, and the intersection targets were obtained by Venny 2.1.0. Cytoscape 3.7.2 software and STRING database were used to construct the drug-disease mapping target gene network map and PPI protein interaction network, and the key effective active ingredients and core target proteins were screened. The intersection targets were enriched by GO and KEGG pathways through R language program. Finally, the molecular docking experiment was carried out by AutoDock Vina 1.1.2software, and the results were visualized by PyMol 2.5.4 software. Results: A total of 27 effective active ingredients of Schizonepeta tenuifolia-Saposhnikovia divaricata herb pair were screened and obtained. The key effective active ingredients of the herb pair were quercetin, β-sitosterol and wogonin, and mainly through AKT1, TP53, TNF, IL6, VEGFA, JUN, IL1 B,CASP3, ESR1, PTGS2, MYC and other core target proteins. The enrichment analysis of GO and KEGG pathways suggested that drug pairs mainly interfered with psoriasis by regulating Pl3 K-Akt signaling pathway, IL-17 signaling pathway, TNF signaling pathway, AGE-RAGE signaling pathway in diabetic complications; molecular docking results confirmed that there was a good binding ability between the key active ingredients and the core target proteins. Conclusion: The mechanism of “Schizonepetae Herba-Saposhnikoviae Radix” interfering with psoriasis has the characteristics of multi-component, multitarget and multi-pathway, which not only provides the theoretical basis for the future clinical treatment of psoriasis with prescription, but also adds the scientific basis for the treatment of psoriasis by the method of “dredging the xuanfu”.

总结席建元基于玄府理论运用汗法辨治寻常型银屑病经验.席建元认为"玄府闭塞"为该病的病机要点,广义汗法及狭义汗法均可调和阴阳,使正汗得出,从而恢复玄府的正常生理功能.其提出汗法开玄是寻常型银屑病的基本治则,以辛温发汗、养阴发汗等为治法,临床疗效满意.附验案2则以佐证.

<正>每一个职业都像六面的骰子,它的多面性意味着通向成功的无限可能。医药代表也是如此。只有走近它细细观察,才会领略每一面的不同图案、不同精彩。职业是社会当中随着经济、社会、科技的发展而出现的逐渐成熟的群体,我国在评定一个职业时遵循五大原则,即目的性、群体性、社会性、规范性、稳定性。