Sarcopenia is an age-related disease characterized by loss of muscle mass and strength, and its prevalence is increasing. Exercise is an effective treatment to improve muscle mass, muscle strength, and functional activity in sarcopenic older adults. Kinesio taping (KT) and extracorporeal shock wave therapy (ESWT) are widely-used treatments for musculoskeletal disorders and can increase muscle performance and/or muscle mass. However, the potential synergistic effects of combining KT and ESWT with exercise for primary sarcopenia remain unknown. This study aims to determine whether the addition of KT and ESWT could enhance the beneficial effects of exercise on sarcopenia. Nighty-four older adults (60 to 75 years old) with sarcopenia will be recruited and assigned randomly into two groups: (1) exercise + placebo ESWT + placebo taping and (2) exercise + ESWT + KT. All participants will undergo an 8-week treatment program, and outcomes will be measured at recruitment and 1, 4, and 8 weeks after the initial treatment. The primary outcome will be skeletal muscle index, and the secondary outcomes will be knee muscle strength, muscle tone, gait speed, timed-up-and-go test, five-time chair test, Short Physical Performance Battery, and biomarkers in blood. Two-way repeated measure ANOVA will be used to analyze the differences between the two groups at each time point. This RCT will fill crucial evidence gaps by evaluating the first combined KT + ESWT + exercise protocol for sarcopenia. Our results will determine whether this novel strategy outperforms standard exercise therapy while expanding KT/ESWT indications beyond their current musculoskeletal uses. Chinese Clinical Trial Registry (http//www.chictr.org.cn) register number ChiCTR2200064269.

Chronic obstructive pulmonary disease (COPD) is marked by both lung-related and systemic symptoms, notably chronic inflammation. Despite pulmonary rehabilitation (PR) being a critical treatment for COPD, its influence on systemic inflammation remains unclear. This meta-analysis was conducted to assess PR's effect on circulating inflammatory markers in COPD patients. We systematically reviewed databases like PubMed, EMBASE, and Web of Science to select randomized controlled trials and observational studies that investigated the impact of PR on systemic inflammation. We calculated the mean differences (MD) in inflammatory markers before and after PR using a random-effects model and assessed the risk of bias with established tools. Our study included six investigations (four RCTs, two observational) with 147 COPD patients. Our findings show notable increases in IL-6 (MD 0.44, 95% CI 0.17-0.70, P = 0.001), CRP (MD 0.56, 95% CI 0.31-0.81, P<0.00001), and TNF-alpha (MD 0.41, 95% CI 0.12-0.70, P = 0.005) following PR. However, sensitivity analysis pinpointed the study by El-Kader et al. as a key influence on these results. Excluding this study led to nonsignificant changes. Thus, our meta-analysis uncovers an unanticipated rise in inflammatory markers post-PR in COPD patients, questioning the assumed anti-inflammatory benefits of PR.

Most rehabilitation therapists in China are graduates from the major of rehabilitation therapeutics, which focuses highly on training in skills and capacities. However, problems still exist in its overall product as well as process, such as the disconnect between the genuine and expected competency level of graduates, the dissonance between education in theory and training in practice, and discordance of medical education in schools and in hospitals. Based on this, the Rehabilitation Therapeutics program in Shanghai Sanda University cooperated with Shanghai General Hospital and developed a ″2+ 1+ 1″ system, which is a three-phase training model, based on a real integration of theory and practice as well as a set of clinically oriented course system. Meanwhile, mechanism for deepening cooperation was implemented and teacher-group in ″bi-positioning″ was set for student education. This model has effectively improved the quality of professional development and talent training, shortened the identity formation process from students to rehabilitation therapist and provided experience and reference for the cultivation of applied talents in rehabilitation therapy.

OBJECTIVE:This randomized controlled trial aims to compare the effects of high versus low dose extracorporeal shockwave therapy (ESWT) on immune system activation and regulation in elderly patients with osteoarthritis.METHODS:120 patients aged 65 years and older with knee osteoarthritis will be randomly allocated to receive either high dose (0.25 mJ/mm2) or low dose (0.10 mJ/mm2) ESWT administered weekly for 4 weeks. Serum cytokines, stimulated immune cell subsets, and T regulatory cells will be measured at baseline, 4 weeks after intervention and at 1-month follow-up.RESULTS:High dose ESWT will increase pro-inflammatory cytokines and decrease immunosuppressive T regulatory cells compared to low dose ESWT in elderly osteoarthritis patients may be the outcome mainly.CONCLUSION:This study will provide evidence on ESWT dosing protocols and their differential immunomodulatory effects, which can guide optimal use for musculoskeletal conditions in geriatric populations.

This study was aimed to investigate the influence of miR-33-5p on the M1/M2 polarization of microglia and the underlying mechanism. Transcriptome sequencing was performed using microglia from miR-33-5p mimic and control groups. In total, 507 differentially expressed genes, including 314 upregulated genes and 193 downregulated genes, were identified. The subnetwork of module A, which was extracted from the protein-protein interaction networks, mainly contained the downregulated genes. Cdk1,Ccnb,and Cdc20, the members of module-A networks with the highest degrees, possess the potential of being biomarkers of ischemic stroke due to their function in the cell cycle. NFY, a transcription factor, was predicted to have the regulatory relation with nine downregulated genes. Overall, our findings will provide a valuable foundation for genetic mechanisms and treatment studies of ischemic stroke.

在发达国家美国，康复科已是较成熟的医学相关学科，其教育培养体系、从业资格认证、学科分化等较为规范。随着我国人口老龄化的形势和大健康产业的进展，康复相关行业的人才培养、专业化进程有待大力推进。康复治疗学重点针对功能障碍进行干预，而功能障碍的诊断和治疗往往需回归解剖结构，本文则基于解剖学重要性、应用价值，结合相关数据比较，浅探中国与美国的康复治疗学专业(物理治疗方向)差异，旨在为我国康复治疗相关专业发展提供借鉴与思考。

Objective:To evaluate the efficacy of combining extracorporeal shock wave therapy (ESWT) with local anesthesia in treating chronic plantar fasciitis.Methods:Reports of randomized and controlled trials about treating plantar fasciitis using ESWT were sought in the CNKI, Wanfang, Pubmed, Embase, Cochrane Library and Web of Science databases from their inception until October 2018. Each report found was screened by two independent researchers and the characteristics were abstracted. The risk of bias was assessed according to the methods recommended in the Cochrane Handbook. Version 5.3 of the RevMan software was used for the meta-analysis.Results:Eight reports of randomized and controlled trials were identified covering 779 patients treated with shock wave therapy and 710 controls. The meta-analysis showed that ESWT could significantly relieve the pain and improve functioning. Local anesthesia did not affect the outcome. Focued and radial shock wave were both significantly more effective than placebo stimulation, so as the medium and high-intensity.Conclusions:ESWT can significantly relieve the pain and improve the walking ability of patients with chronic plantar fasciitis. The use of local anesthesia during the intervention and different ESWT modes and intensities will not affect its efficacy.

To provide references for safe and effective implementing rehabilitation treatment during hospitalization,in this article,we exploratively discusses the principle and strategy of treatment for inpatients with COVID-19 based on clinical characteristics as infectious pulmonary diseases.The foundation of rehabilitation intervention in COVID-19 is'integration of prevention,treatment and rehabilitation'frame.The earlier the rehabilitation intervention starts,the better the prognosis will be,in the stable stage of the disease.Anoxia is the main clinical manifestation for inpatients with COVID-19.The best intervention point for inpatient's rehabilitation may be resolving the disease-caused anoxia via systemic management approaches safely and efficiently in rehabilitation medicine.Thus,this article proposes that we should keep on the principle,'No Excess,No Absence',and use the strategy basing on'Energy Conservation and Emission Reduction'as common goal management in the cooperation of multidisciplinary team approach on inpatient of COVID-19 rehabilitation.The series of stabilization,relaxation and energy-saving on'physical-mental level'were the major methods.And meanwhile the interaction among evaluation and intervention on individual and environment at the same time with the inclusion of COVID-19 prevention and control will rule into rehabilitation management process.The rehabilitation intervention on COVID-19 inpatients is not only the technique-oriented but also a systemic management process.The option of health efficacy promotion approaches via systemic vision is the demonstration of the most important concept in rehabilitation medicine,'People Frist of All'.The cognition on various meaning in rehabilitation medicine will provide new for rehabilitation field.

目的:评价肌内效贴中较常用的功能矫正贴扎技术改善脑卒中后足下垂患者步行功能的即刻效果.方法:选取60例脑卒中后足下垂患者,随机分为试验贴扎组(KT组)、安慰贴扎组(PT组)、空白贴扎组(ZT组)各20例.KT组使用肌内效贴布实施足下垂功能矫正贴扎技术,PT组使用相同品牌、规格、颜色的肌内效贴布施行安慰性贴扎,ZT组不实施任何贴扎.KT组、PT组患者贴扎前后分别进行评估,ZT组患者间隔20min进行2次评估,评估指标采用10m步行测试(10MWT)、TUGT起立-行走计时测试及Berg平衡量表(BBS)等.结果:3组患者行功能矫正贴扎后,KT组10m步行及TUGT所需的时间较贴扎前及PT组和ZT组均明显减少(P＜0.05),PT组和ZT组干预前后比较差异无统计学意义.3组贴扎前后及组间的BBS评分比较均差异无统计学意义.结论:功能矫正贴扎技术能即刻改善脑卒中后足下垂患者步行功能,在平衡能力的改善及长期疗效方面仍有待进一步研究.

Objective: To compare the efficacy of kinesio taping on chronic non-specific low back pain with that of other general physical therapies. Methods: Relevant studies published up to 31 July 2018 were searched in electronic databases (PubMed, Web of Science, Science Direct, Physiotherapy Evidence Database (PEDro), Cochrane Library, Wan-fang Data, Vip Data and China National Knowledge Infrastructure). The quality of included studies was assessed using a risk of bias assessment tool, as recommended by the Cochrane Collaboration. Data from visual analogue scales and Oswestry Disability Index were extracted as selected outcome indicators. Tests of heterogeneity were performed. Weighted mean difference (WMD) data with its 95% confidence intervals (95% CI) were used as a measure of effect sizes, in order to pool the results from each included study using either a fixed or random effects model (where appropriate and possible). Results: Eight studies fulfilled the inclusion and exclusion criteria. The quality of included studies was moderate. Patients with chronic non-specific low back pain in the kinesio taping group achieved better pain relief (WMD= -1.22; 95% CI -1.49 to -0.96, I-2 = 91%, p< 0.00001) and activities of daily living (WMD= -7.11; 95% CI -8.70 to -5.51, I-2 =77%, p < 0.0001) than those in the control group. Conclusion: Kinesio taping may be a new, simple and convenient choice for intervention in low back pain. In the future, we can measure the efficacy about kinesio taping via clinical application in order to prove the possibility of treatment for low back pain.

Objective. The purpose of this study was to investigate the effect of kinesio taping on the walking ability in patients with foot drop after stroke. Methods. Sixty patients were randomly divided into the experimental group (with kinesio taping) and the control group (without kinesio taping). The 10-Meter Walking Test (10MWT), Timed Up and Go Test (TUGT), stride length, stance phase, swing phase, and foot rotation of the involved side were measured with the German ZEBRIS gait running platform analysis system and were used to evaluate and compare the immediate effects of kinesio taping. All the measurements were made in duplicate for each patient. Results. The demographic variables of patients in both groups were comparable before the treatment (p>0.05). After kinesio taping treatment, significant improvement was found in the 10MWT and the TUGT for patients in the experimental group (p<0.05). There were significant differences in the 10MWT and TUGT between the experimental and control groups after treatment (p<0.05). In terms of gait, we found significant improvement in stride length (p<0.001), stance phase (p<0.001), swing phase (p<0.001), and foot rotation (p<0.001) of the involved side in experimental group after treatment compared with those before treatment. Further, the functional outcomes and gait ability were significantly improved in the experimental group after treatment (p<0.05), compared to the control group. Conclusion. Kinesio taping can immediately improve the walking function of patients with foot drop after stroke.

目的:探讨肌内效贴对脑卒中后足下垂患者步行功能改善的即时效果.方法:选取60例脑卒中后足下垂患者,随机分为实验组和对照组,各30例.对照组最终脱落1例.实验组患者使用肌内效贴进行足下垂功能矫正干预,对照组不进行贴扎干预,两组均进行常规康复治疗.两组均进行两次评估,其中实验组贴扎前、贴扎后即刻各进行一次评估,对照组分上下午各进行一次评估.采用10米步行测试(ten-meter walking test,10MWT)、步态跑台分析系统对患者步行功能参数即时改善情况进行评估与比较.结果:实验组贴扎后较贴扎前10MWT时间缩短,跨步长增加,患侧支撑相百分比增加,摆动相百分比减少(均P<0.05).对照组两次评估比较各数据未见差异(P>0.05).与对照组比较,实验组二次评估10MWT时间、患侧摆动相百分比减少;患侧支撑相百分比、跨步长增加(均P<0.05).结论:肌内效贴可增加患者的跨步长、缩短患侧下肢的摆动相、延长患侧下肢的支撑相,进而提高患者步行效率.

前庭康复是干预前庭功能障碍所致前庭、视觉、平衡等功能异常的治疗方法,近年来在康复治疗的整体模式中逐加重视.脑卒中患者常出现中枢性前庭功能障碍,表现为听觉、视觉、眼球运动、平衡等问题.前庭康复在脑卒中康复治疗中的应用,可完善整体功能训练,促进转移、步行等功能性活动能力提高.前庭康复在我国起步较晚,其在脑卒中康复中的应用,尚待普及化、专业化.本文对前庭康复在脑卒中康复治疗中的应用进行综述,旨在为相关治疗应用提供理论依据.