Aim of this study was to analyze the state of coronary arteries in patients with acute coronary syndrome according to polymorphism of integrin β-3 (ITGB3) gene. All patients were divided into 2 groups: carries and non-carries of PLA2 allele. Carriers of PLA2 allele compared with noncarriers had lesser grades of coronary artery stenoses but greater number of involved arteries. Carriers had more repetitive acute coronary events.

PLA polymorphism of platelet integrin receptor, GpIIIa glycoprotein, (PLA polymorphism of the ITGB3 gene) is associated with the risk of myocardial infarction and CHD especially in young subjects. We analyzed ITGB3 gene polymorphism in patients with acute coronary insufficiency. It was shown that increased AP and altered blood lipid spectrum in the acute period of disease in carriers of the PLA allele (PLA1/PLA2 and PLA2/PLA2 genotypes) can be regarded as manifestations of stress reaction. The data obtained indicate that the PLA2 allele is a predictor of complications of acute coronary insufficiency. This observation is of importance for the choice of adequate therapy for the patients with this disorder.

ITGB3 polymorphism affects some particular features of acute coronary insufficiency (ACI) and initially determines different patients’ condition according to the genotype of comorbidity, characteristics of atherosclerotic process in the coronary arteries, speed of the development of ACI, patient’s response to stress, platelet-vascular hemostasis mechanism, tolerance to drug therapy.

The study analyzed changes in parameters of the central and intracardiac hemodynamics during the development of experimental arterial hypertension, which were assessed as the adaptive in nature. The development of hypertension demonstrated staging of the adaptive processes. The development of the adaptive responses was characterized by changes in the magnitude and probabilistic distribution of the hemodynamic parameters.

This study showed that monitoring arterial pressure and heart rate during a few consecutive days allows for early diagnosis of cardiovascular disorders long before manifestation of its clinical symptoms. It is maintained that atrial fibrillation and fluttering are preceded by systemic disturbances of systolic pressure regulation.

The data of research show that frequency of conduction and repolarization disturbances among young people at the age of 20-23 years exceeds the specified earlier level. On the basis of the received data, it is two suggestion concerning pathogenesis of these disturbances: first of them is a total effect of a vegetative dysfunction and second hormonal imbalance to the electrophysiological processes of heart during the period of a genital formation.

The authors analyse effect of GPIIIA gene (PI a allele) polymorphism on the frequency of complicated coronary heart disease in patients with dyslipidemia and hypertensive disease. Specific features of ventricular repolarization (T-wave variability) in patients with acute coronary syndrome are described.

Trivariate correlation analysis of hemodynamic indices of the cardiovascular system in rabbits with diphtheria showed that adaptation of this system to direct action of diphtherin can be visualized by analysis of trivariate correlation tightness for indices of intraventricular pressure in the left and right ventricles and indices of systemic blood pressure. Using empirical production functions for systemic blood pressure indices we found that the contribution of intraventricular pressure in the left and right ventricles on blood pressure values is changed in diphtheria compared to the control. Basing on entropy analysis we established that the regimen of control over values of working intraventricular pressure in both left and right ventricles in diphtheria is changed from quasidetermined to stochastic.

Analysis of the effects of seasonal changes in the myocardium on variability of arterial and intraventricular pressure in both ventricles showed that the objects of homeostatic regulation were the values of these parameters and their probability distribution. The adaptation mechanisms are mainly visualized by the analysis of the characteristics of probability distribution of the parameters (asymmetry and excess coefficients).

In this paper the variability analysis of standard ECG segments durations for 16 students of medical faculty at rest and after physical load was carried out. Changes in ECG segments durations with the conservation of constancy of their probabilistic distribution were determined. Obtained results show the principal possibility of the existence of differences in the control of ECG segments duration's probability distributions.

Using the experimental model of a hypertension on a rabit there have been dicovered the mechanism of the alive organizm's system regulation via the increase of the share of controled information processes. Moreover there have been also recorded the effect of miocard hypertrophy connected with changes of apoptosis and the effect of the demage of the structure and the function connected with the violation of hydro-electrolytic, energetic exchage, changes of vascular tone. The treatment with β-blockers of lopressor only changes the system standard of controle, but does not remove the structure demage effect.

The disturbances of the Information process in systems at every its stage lead to pathological system's formation by the way of the change in system's steadiness towards the external influences. This proposition is proved by the probabilistic method in the experimental study of electrical rabbit miocard's steadiness to the testing electrical impulses applied to rabbit's miocard conjugate with the definite ECG point. The disturbances of the information process in every its stage may be the reason of pathological system's formation by the way of the change in system's steadiness towards the external influences.