A The latest fashion breakthrough is taking"activewear"in an entirely new direction:researchers at Nottingham Trent University have developed a new fabric(布料)that is able to recharge electronic devices like mobile phones and smartwatches.

胆囊切除术后胆囊和Oddi括约肌原有的协调作用丧失,导致Oddi括约肌功能障碍、运动节律和收缩幅度发生改变,进而使胆管扩张和胆汁排泄节律紊乱,引起胆源性腹痛、胃肠道功能紊乱、继发胆管结石及胆囊切除术后综合征等一系列症状.现就胆囊切除术对Oddi括约肌功能的影响做一简要综述.

The expression of lysine methyltransferase SET8, which is involved in carcinogenesis of many types of human cancers through monomethylation of histone H4 lysine 20 (H4K20), is associated with the prognosis of hepatocellular carcinoma (HCC). We performed a functional analysis for SET8 to assess its effect on HCC progression. SET8 knockdown inhibited proliferation, migration and invasion of HCC cells. SET8 knockdown also inhibited tumour growth in a human xenograft mouse model. Overexpression of SET8 displayed the reverse effect, while treatment with the SET8 inhibitor UNC0379 produced an effect similar to SET8 knockdown. In addition, drug sensitivity testing in SET8-siRNA transfected HCC cells indicated that docetaxel inhibited cell growth dramatically, as demonstrated by the Cell Counting Kit-8 (CCK-8) assay. Furthermore, gene expression microarray analysis showed that genes altered after SET8 knockdown were clustered in pathways related to tumorigenesis and metastasis. Our data suggests that targeting SET8 for HCC therapy can inhibit the proliferation and invasion of HCC cells as well as increase their sensitivity to chemotherapy.

胆囊切除术后胆囊和Oddi括约肌原有的协调作用丧失，可导致Oddi括约肌功能障碍，运动节律和收缩幅度发生改变，可导致胆管扩张，胆汁排泄节律紊乱，在胆源性腹痛、胃肠道功能紊乱、继发胆管结石及胆囊切除术后综合征中发挥一定的作用。本文就Oddi括约肌功能障碍在胆囊切除术后的并发症中的作用做一简要综述。