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1РАСПРОСТРАНЕННОСТЬ ДИАБЕТИЧЕСКОЙ РЕТИНОПАТИИ И КАТАРАКТЫ У ВЗРОСЛЫХ БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ 1 И 2 ТИПА

оксана владимировна маслова,ю и сунцов,л л болотская,т м миленькая,в к александрова

2008引用：23

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2Диабетическая ретинопатия и антиоксиданты

T M Milenkaya,E G Bessmertnaya,V K Aleksandrova, I M Ishchenko,т м миленькая,е г бессмертная,в к александрова, и м ищенко

2003

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3МЕЖКЛЕТОЧНЫЕ МОЛЕКУЛЫ АДГЕЗИИ ICAM - 1 (CD 54) И ICAM - 3 (CD 50 ) У ПАЦИЕНТОВ С ПРОЛИФЕРАТИВНОЙ ДИАБЕТИЧЕСКОЙ РЕТИНОПАТИЕЙ

т в кочемасова,марина владимировна шестакова,т м миленькая,н б смирнова,в а горелышева,е р полосухина,а ю барышников,и и дедов

2002引用：23

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4Межклеточные Молекулы Адгезии ICAM - 1 (CD 54) И ICAM - 3 (CD 50 ) У Пациентов С Пролиферативной Диабетической Ретинопатией

Т. В. Кочемасова,М. В. Шестакова,Т. М. Миленькая,Т. П. Бардымова,Вера Анатольевна Горелышева,Е. Р. Полосухина,А. Ю. Барышников,И. И. Дедов

Our study is devoted to investigation of expression of extracellular adhesion molecules ICAM-1 (CD54) and ICAM3 (CD50) in patients with proliferative diabetic retinopathia. It was shown that patients with proliferative stage of retinopathia and essentic neovascularisation have the statistically convincing increase of percent of CD54-positive lymphocytes and granulocytes of peripheral blood in comparison with healthy donors. This percent was 25,1 ±4,8% and 52,5±1,6% vs 12,4±3,0 and 8,3±3,0, respectively. At the same time in the stage of stabilization of the process in the eyeground the percent of CD54-positive lymphocytes and granulocytes in patients does not differ from the latter in healthy donors. So the expression of ICAM-1 (CD54) could be represent like implicit index of activity of the process, inter alia in the eye-ground. The study of expression of ICAM-3 (CD50) did not give statistically convincing difference between patients and the control group.

2002Российский биотерапевтический журнал

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5ЭФФЕКТИВНОСТЬ ПРИМЕНЕНИЯ ПРЕПАРАТА ВЕССЕЛ ДУЭ Ф У БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ ТИПА 1 И 2 С ДИАБЕТИЧЕСКОЙ РЕТИНОПАТИЕЙ

т м миленькая, а шахмалиева, марина владимировна шестакова,л а чугунова,а ю токмакова,е г бессмертная

2002

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6[Associative Analysis of the Connection Between Mutation C1167T in the Catalase Gene and Polymorphic Marker D6S392 Nearby the Mn-dependent Superoxide Dismutase Gene with Diabetic Microangiopathies].

D A Chistiakov,K V Savost'ianov,L A Chugunova,M Sh Shamkhalova,M V Shestakova,T M Milen'kaia, V, I,V G Debabov

AIMTo study allele polymorphism of two variable regions [C1167T substitution in the catalase (CAT) gene D6S392 microsatellite near the Mn-dependent superoxide dismutase (SOD2) gene] was studied in insulin-dependent diabetic (IDDM) patients with (n = 36) or without (n = 56) diabetic nephropathy, and with (n = 30) or without (n = 44) diabetic retinopathy.MATERIAL AND METHODSBoth polymorphic regions were amplified using polymerase chain reaction (PCR). PCR products were separated using polyacrylamide (D6S366) or agarose (C1167T) gel electrophoresis. In a case of C1167, PCR-amplified products were digested with BstXI restriction endonuclease before electrophoresis. A significance of the difference between allele distributions in complicated and uncomplicated IDDM patients was estimated using the exact Fisher's test.RESULTSNo significant difference was observed in allele and genotype frequencies in complicated and uncomplicated IDDM subjects.CONCLUSIONC1167 polymorphism in the CAT gene and D6S366 near the SOD2 gene are not associated with the development of diabetic nephropathy and diabetic retinopathy in IDDM.

2002PubMed引用：24

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7Роль Межклеточной Молекулы Адгезии-1 В Развитии Диабетической Ретинопатии