Various drugs are used in modern pharmaceuticals nowadays that affect the blood hemostasis processes. Their spectrum is quite wide and well-studied. Nevertheless, the question of the synthesis of new drugs acting on hemostasis with fewer side effects remains open. Thus, we chose aminocaproic acid for our work as this substance has a well-known property: the effect of inhibition of fibrinolysis. By means of blocking plasminogen activators and by partially inhibiting the action of plasmin, aminocaproic acid can have a specific hemostatic effect in the case of bleeding associated with increased fibrinolysis. Considering this information, aminocaproic acid was chosen for our research. We synthesized various compositions of compounds based on aminocaproic acid. Based on the above observations, we selected several organic compounds with various aggregate, antiaggregate and antiviral properties. In view of further using them in the synthesis of new organic compounds with a more complex molecular structure, we have obtained the following complex organic compounds of aminocaproic acid with taurine, lithium taurate, calcium taurate, lysine and aspirin. The resulting compounds were tested in an aggregometer using platelet-saturated human blood plasma to determine anti- or pro-aggregate activity. The compounds showed varying degrees of expression in the effect on platelet functional activity.
The study of condition of the system of hemoglobin, release of peptide com- pounds, and proteolytic activity of human erythrocytes under conditions of hy- perglycemia of varying degrees is carried out. The increase in the level of hy- perglycemia is accompanied by a decrease of affinity of hemoglobin to oxygen and the growth of level of metgemoglobin, the glycosylated hemoglobin level is increased in conditions of severe hyperglycemia. The level of formation of pep- tides in erythrocytes and the level of output of their cells is determined by the increase in trypsin-like activity in cytosol and increased membrane permeability of red blood cells.
The study of condition of the system of hemoglobin, release of peptide com- pounds, and proteolytic activity of human erythrocytes under conditions of hy- perglycemia of varying degrees is carried out. The increase in the level of hy- perglycemia is accompanied by a decrease of affinity of hemoglobin to oxygen and the growth of level of metgemoglobin, the glycosylated hemoglobin level is increased in conditions of severe hyperglycemia. The level of formation of pep- tides in erythrocytes and the level of output of their cells is determined by the increase in trypsin-like activity in cytosol and increased membrane permeability of red blood cells.
Проведен сравнительный анализ антибактериальной активности вновь синтезированных производных адамантана и бензимидазола и биологически активных пептидных соединений, выделенных из гемолимфы личинок восковой моли. Анализ показал, что антибактериальные пептиды в концентрации 10-15 мкг/мл обладают наибольшим бактерицидным эффектом по отношению к Escherichia coli по сравнению с синтетическими антибиотиками.
A series of 1-adamantylacetamides with potential antimicrobic activity is synthesized from 2-, 3-, 4-nitroanilines, 2-nitro-4-methylaniline, 2,6-dichloro-4-nitroaniline.
N-(1-adamantoil)-D,L-histidine reduces thrombocytes aggregation, induced by serotonin on 41%. 3 (1adamantancarboxamidoethyl)indol strengthens serotonin-induced aggregation on 26%.
A series of 1-adamantoylaminopyridines have been synthesized using reactions between 1-adamantoyl chloride with the corresponding aminopyridines. It is established that N-(1-adamantoyl)-3-aminopyridine and N-(1-adamantoyl)-2-aminopyridine decrease serotonin-induced thrombocyte aggregation.
Adamantoylated aminopyridines were synthesized by reaction of 1-adamantoylchloride with the corresponding aminopyridines. Decreases in serotonin-induced platelet aggregation were seen in the presence of N-(1-adamantoyl)-3-aminopyridine and N-(1-adamantoyl)-2-aminopyridine.
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