Citation: Epple A, Paffhausen JE, Fink C, Enk A, Sedlaczek O, Haenssle HA. Chronic recurrent multifocal osteomyelitiswith psoriatic skin manifestations in a 12-year-old female. Dermatol Pract Concept. 2018;8(4):297-298 DOI: https://doi.org/10.5826/dpc.0804a09

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 16, Issue 1 p. 104-107 Diagnosequiz Braun-gelblicher Plaque am Penisschaft Andreas Epple, Corresponding Author Andreas Epple mail@andreas-epple.de Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany (Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland) Die ersten beiden Autoren haben in gleichem Maße zu der vorliegenden Arbeit beigetragen. Korrespondenzanschrift Andreas Epple Hautklinik Ruprecht-Karls-Universität Heidelberg Im Neuenheimer Feld 440 69120 Heidelberg, Deutschland E-Mail: mail@andreas-epple.deSearch for more papers by this authorNina Trenkler, Nina Trenkler Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany (Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland) Die ersten beiden Autoren haben in gleichem Maße zu der vorliegenden Arbeit beigetragen.Search for more papers by this authorAlexander Enk, Alexander Enk Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany (Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland)Search for more papers by this authorEva Hadaschik, Eva Hadaschik Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany (Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland)Search for more papers by this authorPeter Karl Kohl, Peter Karl Kohl Department of Dermatology and Venereology, Vivantes Hospital Neukölln, Berlin, Germany (Klinik für Dermatologie und Venerologie, Vivantes Klinikum Neukölln, Berlin, Deutschland)Search for more papers by this authorWolfgang Hartschuh, Wolfgang Hartschuh Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany (Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland)Search for more papers by this author Andreas Epple, Corresponding Author Andreas Epple mail@andreas-epple.de Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany (Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland) Die ersten beiden Autoren haben in gleichem Maße zu der vorliegenden Arbeit beigetragen. Korrespondenzanschrift Andreas Epple Hautklinik Ruprecht-Karls-Universität Heidelberg Im Neuenheimer Feld 440 69120 Heidelberg, Deutschland E-Mail: mail@andreas-epple.deSearch for more papers by this authorNina Trenkler, Nina Trenkler Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany (Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland) Die ersten beiden Autoren haben in gleichem Maße zu der vorliegenden Arbeit beigetragen.Search for more papers by this authorAlexander Enk, Alexander Enk Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany (Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland)Search for more papers by this authorEva Hadaschik, Eva Hadaschik Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany (Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland)Search for more papers by this authorPeter Karl Kohl, Peter Karl Kohl Department of Dermatology and Venereology, Vivantes Hospital Neukölln, Berlin, Germany (Klinik für Dermatologie und Venerologie, Vivantes Klinikum Neukölln, Berlin, Deutschland)Search for more papers by this authorWolfgang Hartschuh, Wolfgang Hartschuh Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany (Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland)Search for more papers by this author First published: 08 January 2018 https://doi.org/10.1111/ddg.13295_g AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume16, Issue1January 2018Pages 104-107 RelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 16, Issue 2 p. 210-212 Clinical Letter Hyalinosis cutis et mucosae: eine klinische Fallvorstellung mit besonderer Berücksichtigung von Schleimhautveränderungen Andreas Epple, Corresponding Author Andreas Epple mail@andreas-epple.de Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland Korrespondenzanschrift Andreas Epple Department of Dermatology (Hautklinik) University Hospital Heidelberg (Universitätsklinikum Heidelberg) Im Neuenheimer Feld 440 69120 Heidelberg, Germany (Deutschland) E-mail: mail@andreas-epple.deSearch for more papers by this authorElti Hoxha, Elti Hoxha Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland Diese Autoren haben in gleichem Maße zu dieser Arbeit beigetragen.Search for more papers by this authorRoland Schneiderbauer, Roland Schneiderbauer Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, DeutschlandSearch for more papers by this authorAlexandra Jappel, Alexandra Jappel Hals-Nasen-Ohren-Klinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, DeutschlandSearch for more papers by this authorRonald Koschny, Ronald Koschny Klinik für Gastroenterologie, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, DeutschlandSearch for more papers by this authorAlexander Enk, Alexander Enk Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, DeutschlandSearch for more papers by this authorHolger A. Haenssle, Holger A. Haenssle Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, DeutschlandSearch for more papers by this author Andreas Epple, Corresponding Author Andreas Epple mail@andreas-epple.de Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland Korrespondenzanschrift Andreas Epple Department of Dermatology (Hautklinik) University Hospital Heidelberg (Universitätsklinikum Heidelberg) Im Neuenheimer Feld 440 69120 Heidelberg, Germany (Deutschland) E-mail: mail@andreas-epple.deSearch for more papers by this authorElti Hoxha, Elti Hoxha Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Deutschland Diese Autoren haben in gleichem Maße zu dieser Arbeit beigetragen.Search for more papers by this authorRoland Schneiderbauer, Roland Schneiderbauer Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, DeutschlandSearch for more papers by this authorAlexandra Jappel, Alexandra Jappel Hals-Nasen-Ohren-Klinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, DeutschlandSearch for more papers by this authorRonald Koschny, Ronald Koschny Klinik für Gastroenterologie, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, DeutschlandSearch for more papers by this authorAlexander Enk, Alexander Enk Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, DeutschlandSearch for more papers by this authorHolger A. Haenssle, Holger A. Haenssle Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, DeutschlandSearch for more papers by this author First published: 08 February 2018 https://doi.org/10.1111/ddg.13416_g AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume16, Issue2February 2018Pages 210-212 RelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 16, Issue 2 p. 211-213 Clinical Letter Hyalinosis cutis et mucosae: A clinical investigation with special regard to mucosal changes Andreas Epple, Corresponding Author Andreas Epple mail@andreas-epple.de Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany These authors contributed equally to this work. Correspondence to Andreas Epple Department of Dermatology University Hospital Heidelberg Im Neuenheimer Feld 440 69120 Heidelberg, Germany E-mail: mail@andreas-epple.deSearch for more papers by this authorElti Hoxha, Elti Hoxha Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany These authors contributed equally to this work.Search for more papers by this authorRoland Schneiderbauer, Roland Schneiderbauer Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, GermanySearch for more papers by this authorAlexandra Jappel, Alexandra Jappel Department of Rhinootolaryngology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, GermanySearch for more papers by this authorRonald Koschny, Ronald Koschny Department of Gastroenterology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, GermanySearch for more papers by this authorAlexander Enk, Alexander Enk Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, GermanySearch for more papers by this authorHolger A. Haenssle, Holger A. Haenssle Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, GermanySearch for more papers by this author Andreas Epple, Corresponding Author Andreas Epple mail@andreas-epple.de Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany These authors contributed equally to this work. Correspondence to Andreas Epple Department of Dermatology University Hospital Heidelberg Im Neuenheimer Feld 440 69120 Heidelberg, Germany E-mail: mail@andreas-epple.deSearch for more papers by this authorElti Hoxha, Elti Hoxha Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Germany These authors contributed equally to this work.Search for more papers by this authorRoland Schneiderbauer, Roland Schneiderbauer Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, GermanySearch for more papers by this authorAlexandra Jappel, Alexandra Jappel Department of Rhinootolaryngology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, GermanySearch for more papers by this authorRonald Koschny, Ronald Koschny Department of Gastroenterology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, GermanySearch for more papers by this authorAlexander Enk, Alexander Enk Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, GermanySearch for more papers by this authorHolger A. Haenssle, Holger A. Haenssle Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, GermanySearch for more papers by this author First published: 16 January 2018 https://doi.org/10.1111/ddg.13416Citations: 1 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume16, Issue2February 2018Pages 211-213 RelatedInformation

BACKGROUND:Several autosomal dominant disorders may manifest in mosaic patterns with cutaneous involvement. Genomic mosaicism results from postzygotic autosomal mutations, giving rise to clonal proliferation of two genetically distinct cell groups, which clinically present as lesions following the lines of Blaschko.OBJECTIVE:To increase the awareness of the clinical variability of mosaic manifestations in autosomal dominant skin disorders in order to avoid delayed diagnosis.METHODS:Clinicopathologic correlation in a case series including three patients with mosaic manifestations of different autosomal dominant skin diseases.RESULTS:Here, we describe a patient with type 1 segmental mosaicism of epidermolytic ichthyosis (case 1) and two patients with either type 1 (case 2) or type 2 (case 3) segmental neurofibromatosis 1 (NF1).CONCLUSION:Dermatologists should be familiar with mosaic manifestations of autosomal dominant skin diseases to ensure appropriate guidance of the affected patient. Genetic counselling is mandatory as even limited forms of mosaicism may involve the patient's germline with a moderately increased risk to transmit the mutation to their offspring, resulting in a more severe, generalized form of the respective disease.

Journal of the European Academy of Dermatology and VenereologyVolume 32, Issue 3 p. e94-e95 Letter to the Editor Granulomatous skin reactions after tumour vaccine in two patients C. Menzer, Corresponding Author C. Menzer christian.menzer@med.uni-heidelberg.de Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, GermanyContributed equally to the work.Correspondence: C. Menzer. E-mail: christian.menzer@med.uni-heidelberg.deSearch for more papers by this authorA. Epple, A. Epple Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, GermanyContributed equally to the work.Search for more papers by this authorM. Kogut, M. Kogut Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, GermanySearch for more papers by this authorA. Enk, A. Enk Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, GermanySearch for more papers by this authorE. Hadaschik, E. Hadaschik Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, GermanySearch for more papers by this authorK. Schaekel, K. Schaekel Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, GermanySearch for more papers by this author C. Menzer, Corresponding Author C. Menzer christian.menzer@med.uni-heidelberg.de Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, GermanyContributed equally to the work.Correspondence: C. Menzer. E-mail: christian.menzer@med.uni-heidelberg.deSearch for more papers by this authorA. Epple, A. Epple Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, GermanyContributed equally to the work.Search for more papers by this authorM. Kogut, M. Kogut Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, GermanySearch for more papers by this authorA. Enk, A. Enk Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, GermanySearch for more papers by this authorE. Hadaschik, E. Hadaschik Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, GermanySearch for more papers by this authorK. Schaekel, K. Schaekel Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, GermanySearch for more papers by this author First published: 28 August 2017 https://doi.org/10.1111/jdv.14546Citations: 3 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume32, Issue3March 2018Pages e94-e95 RelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 15, Issue 4 p. 457-460 Diagnosequiz Impetiginisierte, mit gelb-braunen Krusten belegte faziale Dermatitis bei einem 85-jährigen Mann Nina Trenkler, Nina Trenkler Universitäts-Hautklinik Heidelberg, Ruprecht-Karls-Universität HeidelbergSearch for more papers by this authorChristine Fink, Christine Fink Universitäts-Hautklinik Heidelberg, Ruprecht-Karls-Universität HeidelbergSearch for more papers by this authorAndreas Epple, Andreas Epple Universitäts-Hautklinik Heidelberg, Ruprecht-Karls-Universität HeidelbergSearch for more papers by this authorFerdinand Toberer, Ferdinand Toberer Universitäts-Hautklinik Heidelberg, Ruprecht-Karls-Universität HeidelbergSearch for more papers by this authorAlexander Enk, Alexander Enk Universitäts-Hautklinik Heidelberg, Ruprecht-Karls-Universität HeidelbergSearch for more papers by this authorHolger A. Haenssle, Corresponding Author Holger A. Haenssle holger.haenssle@med.uni-heidelberg.de Universitäts-Hautklinik Heidelberg, Ruprecht-Karls-Universität Heidelberg Korrespondenzanschrift Priv.-Doz. Dr. med. Holger A. Haenssle Universitäts-Hautklinik Heidelberg Ruprecht-Karls-Universität Heidelberg Im Neuenheimer Feld 440 69120 Heidelberg E-mail: holger.haenssle@med.uni-heidelberg.deSearch for more papers by this author Nina Trenkler, Nina Trenkler Universitäts-Hautklinik Heidelberg, Ruprecht-Karls-Universität HeidelbergSearch for more papers by this authorChristine Fink, Christine Fink Universitäts-Hautklinik Heidelberg, Ruprecht-Karls-Universität HeidelbergSearch for more papers by this authorAndreas Epple, Andreas Epple Universitäts-Hautklinik Heidelberg, Ruprecht-Karls-Universität HeidelbergSearch for more papers by this authorFerdinand Toberer, Ferdinand Toberer Universitäts-Hautklinik Heidelberg, Ruprecht-Karls-Universität HeidelbergSearch for more papers by this authorAlexander Enk, Alexander Enk Universitäts-Hautklinik Heidelberg, Ruprecht-Karls-Universität HeidelbergSearch for more papers by this authorHolger A. Haenssle, Corresponding Author Holger A. Haenssle holger.haenssle@med.uni-heidelberg.de Universitäts-Hautklinik Heidelberg, Ruprecht-Karls-Universität Heidelberg Korrespondenzanschrift Priv.-Doz. Dr. med. Holger A. Haenssle Universitäts-Hautklinik Heidelberg Ruprecht-Karls-Universität Heidelberg Im Neuenheimer Feld 440 69120 Heidelberg E-mail: holger.haenssle@med.uni-heidelberg.deSearch for more papers by this author First published: 05 April 2017 https://doi.org/10.1111/ddg.13059_gAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume15, Issue4April 2017Pages 457-460 RelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 16, Issue 1 p. 104-107 Case for Diagnosis Brownish-yellowish plaque on the penis shaft Andreas Epple, Corresponding Author Andreas Epple mail@andreas-epple.de Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University, Heidelberg, Germany The first two authors contributed equally to the work. Correspondence to Andreas Epple Department of Dermatology Ruprecht Karls University Heidelberg Im Neuenheimer Feld 440 69120 Heidelberg, Germany E-mail: mail@andreas-epple.deSearch for more papers by this authorNina Trenkler, Nina Trenkler Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University, Heidelberg, Germany The first two authors contributed equally to the work.Search for more papers by this authorAlexander Enk, Alexander Enk Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University, Heidelberg, GermanySearch for more papers by this authorEva Hadaschik, Eva Hadaschik Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University, Heidelberg, GermanySearch for more papers by this authorPeter Karl Kohl, Peter Karl Kohl Department of Dermatology and Venereology, Vivantes Hospital Neukölln, Berlin, GermanySearch for more papers by this authorWolfgang Hartschuh, Wolfgang Hartschuh Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University, Heidelberg, GermanySearch for more papers by this author Andreas Epple, Corresponding Author Andreas Epple mail@andreas-epple.de Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University, Heidelberg, Germany The first two authors contributed equally to the work. Correspondence to Andreas Epple Department of Dermatology Ruprecht Karls University Heidelberg Im Neuenheimer Feld 440 69120 Heidelberg, Germany E-mail: mail@andreas-epple.deSearch for more papers by this authorNina Trenkler, Nina Trenkler Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University, Heidelberg, Germany The first two authors contributed equally to the work.Search for more papers by this authorAlexander Enk, Alexander Enk Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University, Heidelberg, GermanySearch for more papers by this authorEva Hadaschik, Eva Hadaschik Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University, Heidelberg, GermanySearch for more papers by this authorPeter Karl Kohl, Peter Karl Kohl Department of Dermatology and Venereology, Vivantes Hospital Neukölln, Berlin, GermanySearch for more papers by this authorWolfgang Hartschuh, Wolfgang Hartschuh Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University, Heidelberg, GermanySearch for more papers by this author First published: 02 August 2017 https://doi.org/10.1111/ddg.13295 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume16, Issue1January 2018Pages 104-107 RelatedInformation

The treatment of keloids remains complex and challenging. A multitude of different treatment options exists. While current guidelines frequently promote the combination of intralesional triamcinolone acetonide (TAC) and cryotherapy as a first-line therapy for keloids, its efficacy has mainly been proven clinically and objective evaluation is widely missing. Here, we aimed to evaluate the efficacy of TAC and cryotherapy for the improvement of keloids by employing two well-recognized questionnaires for the evaluation of scar appearance and patient's quality of life. Twenty keloid patients from our outpatient scar clinic were treated with individual doses of TAC and cryotherapy in four consecutive sessions. Retrospectively, Patient and Observer Scar Assessment Scale (POSAS) and Dermatology Life Quality Index (DLQI) questionnaire data from those patients were analyzed to evaluate changes over five visits (one baseline, four after treatment). Both overall patient and observer scores of the POSAS significantly decreased (41.10 +/- 9.771 to 29.85 +/- 11.42 [p < 0.001] and 33.75 +/- 6.231 to 22.70 +/- 5.992 [p < 0.001], respectively), while DLQI scores significantly declined over the time period studied, indicating significant improvements in scar appearance. Objective evaluation confirmed the clinically demonstrated improvements of scar appearance and symptoms after treatments with TAC and cryotherapy which was associated with significant improvements in quality of life as indicated by DLQI measures. Standardized questionnaires help in objectifying clinical improvements; however, more detailed options for scar documentation, such as objective imaging, may be additionally required for an in-depth analysis of treatment progress.

A 75-year-old male patient was admitted for generalized wart-like skin lesions also affecting the oral and esophageal mucosa. The cutaneous lesions had progressively developed over the past 14 weeks and were severely pruritic. Moreover, the patient reported the development of palmar hyperkeratosis, weight loss of 15 kg over the past six weeks, and night sweats. His past medical history was unremarkable, especially with regard to endocrinopathies or dermatological disorders.

BACKGROUND:Currently, different types of treatments for pathological scars are available, however, to date, there is no established method of measurement to objectively assess therapeutic outcome. Treatment success is usually evaluated clinically by the physician and patient. Non-invasive imaging techniques, such as HD-OCT (high-definition optical coherence tomography), may represent a valuable diagnostic tool to objectively measure therapeutic outcome.OBJECTIVES:To compare HD-OCT with ultrasound and subjective evaluation tools, such as questionnaires.MATERIALS & METHODS:In total, eight patients with pathological scars were treated in this pilot study with cryotherapy and intralesional steroid injections, and evaluated pre- and post-treatment using clinical examination, photography, sonography, and HD-OCT. The analysis of objective and subjective measuring methods was used to draw direct comparisons.RESULTS:HD-OCT revealed reduced epidermal and dermal thickness of the scar after four treatments with triamcinolone acetonide and cryotherapy. Based on sonography, a total reduction in scar height and reduction in scar depth was demonstrated. Both methods correlated well with the injected amount of triamcinolone acetonide. In addition, a positive correlation between well-established subjective and objective evaluation methods was found.CONCLUSION:We demonstrate that HD-OCT may be used as an objective diagnostic instrument to evaluate skin thickness under therapy for pathological scars, and serves as a valuable adjunctive device in combination with ultrasound and subjective evaluation tools. This provides additional information for the therapist concerning the quality and success of the applied treatment.

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 14, Issue 9 p. 952-955 Diagnosequiz Verruköse kutane und ösophageale Papeln, hyperpigmentierte Beugezonen und samtige palmare Hyperkeratose Beate Muehe, Beate Muehe Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-University Heidelberg, Deutschland Die ersten beiden Autoren haben in gleichem Maße zu der vorliegenden Arbeit beigetragen.Search for more papers by this authorAndreas Epple, Andreas Epple Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-University Heidelberg, Deutschland Die ersten beiden Autoren haben in gleichem Maße zu der vorliegenden Arbeit beigetragen.Search for more papers by this authorAlexander Enk, Alexander Enk Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-University Heidelberg, DeutschlandSearch for more papers by this authorHolger A. Haenssle, Holger A. Haenssle Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-University Heidelberg, DeutschlandSearch for more papers by this author Beate Muehe, Beate Muehe Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-University Heidelberg, Deutschland Die ersten beiden Autoren haben in gleichem Maße zu der vorliegenden Arbeit beigetragen.Search for more papers by this authorAndreas Epple, Andreas Epple Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-University Heidelberg, Deutschland Die ersten beiden Autoren haben in gleichem Maße zu der vorliegenden Arbeit beigetragen.Search for more papers by this authorAlexander Enk, Alexander Enk Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-University Heidelberg, DeutschlandSearch for more papers by this authorHolger A. Haenssle, Holger A. Haenssle Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-University Heidelberg, DeutschlandSearch for more papers by this author First published: 08 September 2016 https://doi.org/10.1111/ddg.12921_g AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume14, Issue9September 2016Pages 952-955 RelatedInformation

BackgroundMeasuring quality of life through questionnaires is a common method to evaluate the impact of different afflictions on the patient's well-being, especially in the field of dermatology where appearance changing afflictions are common.ObjectivesA variety of questionnaires has been used to distinguish different skin conditions like psoriasis, atopic dermatitis and scars. Using the Dermatology Life Quality Index (DLQI), we investigated different scar types regarding their impact on quality of life.MethodsWe assessed the quality of life in 130 patients presenting to our outpatient scar clinic for the first time using the DLQI. Scars were analysed according to their clinical appearance (physiological scars, keloids, hypertrophic scars, atrophic scars, self-harm scars). Physiological scars were established as a baseline for further comparison between groups.ResultsPatients in the physiological scar group scored a mean DLQI score of 2.073.56, patients in the keloid-, hypertrophic scar-, atrophic scar- and self-harm scar group scored values of 6.06 +/- 4.00, 2.53 +/- 2.48, 7.26 +/- 6.72 and 12.00 +/- 3.85 respectively. When compared to the baseline group the difference in the overall score for keloids was +3.99 (P<0.001), hypertrophic scars scored +0.45 (ns), atrophic scars +5.19 (P<0.01) and self-harm scars +9.93 (P<0.001).ConclusionUsing the DLQI, we could demonstrate that different subsets of pathological scars do affect patients in a different magnitude. The DLQI provides a promising adjunct for quantifying the quality of life in patients suffering from keloids, atrophic- and self-harm scars and may constitute an interesting additional tool for monitoring the progress of scar treatments.

Acne scars are common and stigmatizing for the affected patients. Besides surgery, chemical peels, microdermabrasion, and microneedling, the treatment with fractional laser is a standard therapy. The results of reducing acne scars treated either with a fractional Er:YAG (erbium-doped yttrium-aluminum-garnet [Er:Y3Al5O1]) or a carbon dioxide (CO 2 ) laser at different wavelengths were compared and evaluated in the pilot study presented here. Fourteen patients with severe scars on both cheeks were treated four times in a random split-face approach: on one side with Er:YAG laser and on the contralateral side with CO2 laser following a standardized protocol. Therapeutic success was evaluated through the use of a high-resolution, 3D small-field capture system (PRIMOS), digital photography, and the Patient and Observer Scar Assessment Scale (POSAS) questionnaire. The evaluation was performed by a blinded investigator. Treatment results displayed a higher efficacy of the fractional CO2 laser compared with the Er:YAG laser as displayed by digital photographs. Additionally, objective (high-resolution, 3D small-field capture; PRIMOS) and subjective (POSAS) measuring results correlated positively in certain qualities (color, stiffness, thickness, surface, overall opinion). Using a novel scientific approach, we evaluated the therapeutic efficacy of different fractional lasers on acne scars using a rater-blinded approach. Compared with an Er:YAG laser, better skin smoothening was achieved by fractional CO2 laser treatment.