目的:探讨子宫内膜异位症的中医病因病机等,从而发掘治疗本病的新思路。方法:通过本病的病理特征结合现代医学全面认识到"瘀、湿、浊、毒"的概念及致病特点。结果:子宫内膜异位结其病位在络,本质属于络病。

Objective To establish a method for determining twelve anthraquinones in cassia semen.Methods Diamonsil C18(150 mm×4.6 mm,5 μm)was used with the mobile phase consisting of acetonitrile-0.1% formic acid solution gradient at a flow rate of 1.0 ml · min-1.The detection wavelength was set at 280 nm and the column temperature was 25 ℃.Results Complete separation was obtained within 80 min for twelve compounds(casside,2-gluco-aurantioobtusin,2-gluco-obtusin,2-gluco-chrysoobtusin,auranto-obtusin,rhein,chrysoobtusin,obtusin,aloe-emodin,1-desmethylobtusin,chrysophanol,physcion).A linear relationship between the peak area and concentration of each compound was obtained.The average recovery(n=6) of the above compounds was 98.1%(RSD1.2%),98.9%(RSD2.1%),96.87%(RSD2.87%),97.12%(RSD2.1%),102.8%(RSD1.3%),98.92%(RSD2.0%),96.15%(RSD1.7%),98.5%(RSD1.9%),103.2%(RSD1.9%),102.3%(RSD2.6%),98.9%(RSD1.6%),97.67%(RSD1.4%).Conclusion The method established,sensitive,accurate and well repeatable,can be used for determination of anthraquinones in cassia semen.

目的筛选决明子中蒽醌类化学成分的最佳提取方法。方法采用HPLC/UV法,以游离蒽醌、蒽醌苷类及12种蒽醌总质量分数为评判指标,通过L9(34)正交试验设计,考察乙醇质量分数、提取时间、固液比和提取次数等因素对决明子蒽醌类化学成分提取效果的影响。结果最佳提取方法为50倍70%乙醇回流提取1次,提取时间2 h。结论综合比较后,该提取方法对决明子药材中蒽醌类成分提取效率最高,操作经济省时,合理可靠,为决明子的进一步分析研究提供科学依据。

Objective To explore the content of chikusetsu-saponin Ⅳa in Panax pseudo-ginseng in different harvesting time and decide the best harvest period.Methods Samples were ultrasonic extracted in 60 % alcohol for 40 min,filtered,and took filtrate as the testing solution,and measured the peak area by HPLC.Chromatographic column was Kromasil-C18(5 um,4.6 mm×150 mm),acetonitrile-0.2 %phosphoric acid solution(36:64) were used as mobile phase and the column temperature at 30 ℃,flow velocity was 1.0 mL/min and wave-length 203 nm.Results The cumulant of chikusetsu-saponin Ⅳa in Panax pseudo-ginseng varied greatly in different harvesting time and in July it was the highest.Conclusion The optimum time to harvest determined by content of chikusetsu-saponin Ⅳa in Panax pseudo-ginseng may be July.

目的:观察祛瘀、清热、化湿、解毒类中药配伍治疗子宫内膜异位症(痛经、症瘕)的疗效.方法:采用自拟祛瘀解毒消症汤(由红藤、白花蛇舌草、薏苡仁、生黄芪、瓦楞子、荔枝核、山慈菇、藿香、蜈蚣、血竭、土鳖虫、制乳香、制没药、炙甘草等组成),治疗本病45例,并与文献报道的罗氏内异方(对照1组43例)和祛瘀解毒汤(对照2组40例)进行对照观察.结果:试验组和对照1组、对照2组总有效率分别为95.56%、74.42%、77.5%,P＜0.01,有较显著的差异.结论:该方有祛瘀通络、解毒化浊、消症止痛的功效.

目的:介绍张晓峰主任医师治疗闭经类月经失调的经验。方法:跟师学习,总结所长。结论:导师张晓峰主任医师认为月经后期、月经量少、闭经等闭经类月经失调其主要病机为肾阳微弱、阴血亏虚,故以温肾养血立法组方并结合周期疗法加以治疗,临床获得较理想效果。

<正>孙思邈是我国古代著名的医药学家,被尊称为"药王",其所著《备急千金要方》和《千金翼方》被后人统称为《千金方》,是我国第一部百科全书。孙思邈对妇人病尤为重视,将"妇人方"三卷列于《备急千金要方》卷首,并在该书序例中说

Chief Physician Zhang Xiaofeng thinks that the pathogenic characteristics of premenopausal and postmenopausal diseases is one core and two aspects,and eeficiency of yin and yang.The core is kidney deficiency.And kidney deficiency can be divided into yang deficiency and yin deficiency.In treatment,we should give attention to both yin and yang,and regulating both yin and yang.Meanwhile,he thinks that since the pathogenic characteristics are unbalance of yin and yang in kidney,functional unbalance of kidney,liver,heart and spleen,we should balance yin and yang,and harmonize the functions of the viscus.

Objective:To observe the effect of compound Shajizi suppository on model rats with vaginal and cervical erosion.Methods:Experiment 1:48 rats were randomly divided into blank group,model group,Gongjing Yankang suppository group,compound Shajizi suppository treatment group 1(high dosage),group 2(middle dosage) and group 3(low dosage).The vaginal and cervical erosion model rats were induced by intravaginal injection of phenol mucilage.Experiment 2:48 rats were divided into 6 groups as the same way mentioned above.The vaginal and cervical erosion model rats were induced by submucosal injection of staphylococcus.Results:Experiment 1:compared with the model group,vaginal and cervical mass indexes were decreased,the pathological lesions of mucosa and submucosa were significantly improved in compound Shajizi suppository treatment groups.Experiment 2:compared with the model group,vaginal and cervical mass indexes and the number of white blood cell were decreased,the pathological lesions of mucosa and submucosa were significantly alleviated in compound Shajizi suppository treatment groups.Conclusion:Compound Shajizi suppository has therapeutic effect on vaginal and cervical erosion model rats which were induced by chemical burn and biotic factors.

当归芍药散出自<金匮要略*妇人妊娠病脉证并治>篇,原载两条:一在<妇人妊娠病脉证并治第二十>篇中,有"妇人怀娠,腹中痛,当归芍药散主之";二在<妇人杂病脉证并治第二十二>篇中,有"妇人腹中诸疾痛,当归芍药散主之".可见其用均在妇人病.该方以芍药养血柔肝,缓急止痛,佐以当归、川芎调肝养血,更配以茯苓、白术、泽泻健脾利湿, 使肝血足而气条达,脾运健而湿邪除,肝脾调和而诸证自愈.由于该方具有肝脾同治、气血两和、虚实兼顾的作用,故成为治疗妇人诸多疾病的良方,在临床上得到了广泛的应用.