: Between 1978 and 1985 a total of 49 patients (20 women and 29 men, aged 31-78 years) were operated upon for liver metastases of a colorectal carcinoma. Metastasis recurrences occurred in 42 of 46 patients (91%). Three patients died in connection with the operation (6.1%). The five-year survival rate was 10.7%. Neither number, site and volume of the metastases, level of carcinoembryonic antigen concentration, tumour differentiation, stage or site of primary tumour, nor type of operation (enucleation or hemihepatectomy) had any influence on survival rate. Since most of the recurrences in the liver had occurred after enucleation at the site of the previous resection, it is feasible that the results could be improved by extending the area of resection.

Intermittent jaundice and recurrent colicky upper abdominal pain in two patients, aged 46 and 48 years, were found by endoscopy to be due to an adenoma of the papilla of Vater. Transduodenal local excision with papilloplasty made both patients free of symptoms.

Der hier vorliegende Band ist die Dokumentation einer Tagung, die im Oktober 2013 im Archiv der deutschen Jugendbewegung auf Burg Ludwigstein stattfand (siehe die Tagungsankundigung unter [http://www.hsozkult.de/event/id/termine-22612]). Er bietet zum einen Impressionen uber die Landschaft der freien Archive zu den Jugendund den (neuen) sozialen Bewegungen und enthalt zum anderen einige Denkanstose uber deren Situation und Perspektiven. Den Rahmen bilden die – vollig unterschiedlichen – Situationen dieser Archive, dann die Debatte darum, welchen Wert welche Quellen haben und drittens die Zukunft des Archivs auf Ludwigstein selbst. Die dem heterogenen Feld entsprechenden, sehr unterschiedlichen, insgesamt neun Beitrage stellen einzelne Archive und ihre Selbstverortung vor (Archiv des Hamburger Instituts fur Sozialforschung, Archiv der Jugendkulturen, Berlin) oder skizzieren anhand zweier konkreter Forschungsbeispiele – Krautrock beziehungsweise Jugendzentrumsbewegung – die vorgefundene Uberlieferungssituation. MitarbeiterInnen der Stadtarchive Hannover und Gottingen erzahlen schlieslich davon, welche und wie viele Dokumente aus Protestbewegungen sie jeweils verwahren. Jurgen Bacia und Cornelia Wenzel geben anhand ihrer im Buch Bewegung bewahren. Freie Archive und die Geschichte von unten (Berlin 2013) dokumentierten Ergebnisse einen Uberblick uber die, wie sie es nennen, „freien Archive“ zu den und der neuen sozialen Bewegungen. Michael Koltan, langjahriger Mitarbeiter des Archivs der sozialen Bewegungen in Baden (Freiburg) fragt schlieslich mehr als

Tumor samples of 26 consecutive colorectal carcinomas were studied for the presence of steroid hormone receptors for estrogen and progesterone. In all cases, the estradiol receptor binding capacity was below 2 fmol/mg cytosol protein. In 4 of 26 samples, progesterone receptor levels from 13 to 23 fmol/mg cytosol protein were observed. Because of the identification of steroid receptors in some cases and single reports in literature about tumor regression under hormone therapy of colorectal carcinoma, further investigations seem indicated to study the hormone sensitivity of colorectal carcinoma.

Das TNM Project Committee der UICC und das DSK

Im Zeitraum von 1978–1986 wurden 51 Patienten wegen Lebermetastasen kolorektaler Karzinome operiert. Metastasenrezidive traten in 89% auf. Die Fünf-Jahres-Überlebensrate betrug 10,7%, die mediane Überlebenszeit 24 Monate. Die Operationsletalität lag bei 7,8%. Die Überlebenszeit war statistisch signifikant länger als die eines Vergleichskollektives unserer Klinik mit Spontanverlauf von Lebermetastasen. Die Höhe des CEA-Spiegels korrelierte signifikant mit dem Volumen der resezierten Metastasen. Anzahl, Lokalisation und Volumen der Metastasen, Höhe des CEA-Spiegels, Tumordifferenzierung, Stadium und Lokalisation des Primärtumors und Art der Operation hatten keinen Einfluß auf das Überleben.

s 3 tumors and lymphomas. Under these conditions most animals develop measurable growing tumors by day 7 and show multiple lung and lymph node metastases when autopsied on day 21. However, the production of metastases depends on the number of cells injected and on the ATS dose used. Using melanoma cell lines, we showed that this model is highly sensitive, since large numbers of metastases were still obtained following the s.c. implant of as low as 10 s cells, and since tumors and metastases were regularly obtained irrespective of the tumorigenicity of cells in athymic nude mice. From a tumorigenic, but poorly metastatic, melanoma cell line (M4Be), we selected in vivo variants with increased tumorigenicity and metastatic ability, but no variant with organ specificity or high tumorigenicity and low metastatic ability. In vitro cloning of this cell line showed heterogeneity and yielded clones with different metastatic abilities. Some of these clones have been characterized and show specific karyotype features. Thus, the experimental model described allows the quantitative and qualitative study of the metastatic ability of human tumors. 5A I n c r e a s e d ce l lu lar di f ferent iat ion and d e c r e a s e d m e t a s t a t i c potcnt ia l o f FEMX h u m a n m e l a n o m a ce l l s s e l e c t e d through repet i t ive in travenous in jec t ions of m e t a s t a t i c ce l l s in nude m i c e O. FODSTAD, I. KJONNIKSEN, A. BROGGER, V. A. FLORENES and A. PIHL Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Oslo 3, Norway After i.v. injection of F E M X human melanoma cells in athymic, nude mice, extrapulmonary metastases develop within approximately 50 days in tissues such as s.c. lymph nodes and brown fat. In attempts to select a possible subpopulation of F E M X cells with increased metastatic potential, single cell suspensions prepared directly from s.c. metastases were injected i.v. into recipient nude mice, and the procedure was repeated each time a new generation of metastasis developed. Cells from each generation were also injected s.c. into other animals and seeded out in tissue culture flasks, and the growth of the resulting s.c. tumors and monolayers was followed. Contrary to expectations, the lag time before the appearance of new metastases increased with increasing number of passages, and when cells from the fifth generation were used, no metastases developed in the recipient mice. Concurrently, the growth rate of the corresponding in vivo and in vitro cultivated cells decreased. Moreover, increased tyrosinase activity and loss of marker chromosomes indicated increased cellular differentiation as a result of the repetitive in vivo selection. The changes in metastatic capacity and cellular characteristics were found to be reversible, as cells from the non-metastatic fifth generation of variants regained the initial metastatic ability of the F E M X cells when grown for 3 months as s.c. xenografts before i.v. injection. Almost identical results were obtained when a new round of selection experiments were performed. The possible implication of the present findings for the understanding of mechanisms involved in metastasis formation is discussed. 6A Extrapulmonary , t i s sue-spec i f i c m e t a s t a s i s f ormat ion in nude m i e e in jec ted in travenous ly wi th FEMX-I h u m a n m e l a n o m a ce l l s O. FODSTAD, I. KJONNIKSEN, S. AAMDAL, J. M. NESLAND and A. PIHL Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Oslo 3, Norway Extrapulmonary metastases are formed in adult, nude mice after intravenous injection of cells prepared from F E M X I human malignant melanoma xenografts. Tumors develop in subcutaneous, mesenteral, and mediastinal lymph nodes, in brown fat and in the adrenal medulla, whereas lung colony formation is not observed. The s.c. metastases become apparent after a lag time of approximately 50 days. Cells obtained directly from an established in vitro cell line showed a dramatically reduced ability for metastasis formation in vivo. That the

Intermittent jaundice and recurrent colicky upper abdominal pain in two patients, aged 46 and 48 years, were found by endoscopy to be due to an adenoma of the papilla of Vater. Transduodenal local excision with papilloplasty made both patients free of symptoms.

Durch eine Reduzierung der Blutungsgefahr sollte die endoskopische Oesophagusdissektion eine effektive Verbesserung der stumpfen Dissektion darstellen. Der cervicale Oesophagus wurde freipräpariert, durchtrennt und an einer Magensonde fixiert, die durch eine Gastrotomie unter Zug ausgeleitet wurde. Gefässe und anhaftende Lymphknoten spannten sich am invertierenden Oesophagus radiär an. Über das transcervical eingeführte Endoskop wurden Blutgefässe instrumentell unter Sicht durch resorbierbare Clips ligiert oder elektrocoaguliert und durchtrennt. Auf diese Weise liess sich der gesamte Oesophagus freipräparieren und nach abdominell durchziehen.

This article reports on five children treated surgically during 1973-1975 for posttraumatic radioulnar synostosis. The synostoses had developed as a complication after a proximal radial fracture. Lesion of the proximal ulna plays an important part in creating such an osseous union. Another factor of equal importance is the traumatization of the tissues during surgical treatment of the fracture, especially if debris of the periosteum and fine bone fragments additionally enter into the space between radius and ulna. Formation of excess callus, and hence synostosis, is also promoted if repositioning or re-repositioning of a proximal radial fracture is effected too late. The article presents the technique of surgical treatment of proximal radioulnar synostosis with Lyodura sheathing. Follow-up examination of the five children during an observation period of five years showed good results in two children, a moderate result in one, and poor results of surgery in two cases. Improved results may be expected from further improvement of the surgical method, such as resection of the bicipital tuberosity (tuberositas radii) or from additional partial sheathing of the ulna at the side facing the radius.