目的 观察六神胶囊治疗轻中度寻常痤疮的疗效.方法 收集2020年4月至2020年8月于苏州大学附属第一医院皮肤科门诊就诊的轻、中度寻常痤疮患者87例.治疗组患者口服六神丸胶囊1粒/次,每天3次,饭后服用;对照组患者口服丹参酮胶囊1g/次,每天3次.2组患者均外用克林霉素磷酸酯凝胶,点涂皮损处,每日2次.连续治疗8周.观察皮损数目变化情况,对比疗效、不良反应.结果 治疗8周后,治疗组有效率79.55％,对照组有效率72.09％,两组差异无统计学意义(P>0.05).结论 六神胶囊治疗轻中度寻常痤疮有良好疗效,且不良反应少.

目的:总结乳房外Paget病(EMPD)的临床、组织病理学特点.方法:对2006年-2016年就诊于苏州大学附属第一医院的68例EMPD患者的临床、病理资料进行回顾性统计分析.结果:患者男女比例为7.5∶1;平均发病年龄为(72.02±11.42)岁.单发性皮损62例占91.18％,皮损多累及生殖器部位,临床诊断与病理诊断符合率为86.76％.免疫组化细胞角蛋白(CK)7、癌胚抗原(CEA)表达阳性,CK5/6表达部位与正常对照组不同,CK20、黑色素瘤抗体(HMB)-45表达阴性.术后复发率为30％,12例复发病例中,10例肿瘤细胞累及附属器或真皮.结论:乳房外Paget病多见于老年男性,病程缓慢,组织病理提示浸润性生长的复发率高,免疫组化提示EMPD有腺体分化能力,本病术后复发率高,需长期临床随访.

目的 调查分析常州地区变态反应性疾病患者常见过敏原的分布情况,比较不同年龄阶段、不同季节的过敏原有无差异.方法 选取本院2016年1月~2018年1月收治的1491例变态反应性皮肤病患者,采用16种过敏原对患者进行皮肤点刺试验,生理盐水作阴性对照,以组胺作阳性对照.结果 1491例变态反应性皮肤病患者常见过敏原阳性率从高到低依次为:粉尘螨89.67%、户尘螨86.38%、油菜花7.11%、葎草花粉6.37%蟑螂4.76%、猫毛3.76%.过敏原的季节性来分析:粉尘螨、户尘螨、夏季最高;春天比其他三个季节低;各种花粉在夏季最低,蟑螂夏季最高.粉尘螨、户尘螨、猫毛、狗上皮、狗毛季节性变化不是太明显.粉尘螨、户尘螨、猫毛、牛奶、鸡蛋黄未成年组高于成年组(P<0.05).葎草花粉、油菜花粉、蟑螂成年组高于未成年组(P<0.05).过敏原在同年龄阶段的男女中间的差异不明显(P>0.05).结论 在常州地区,最主要的过敏原为粉尘螨、户尘螨、油菜花,过敏原在不同季节、不同年龄阶段分布不同,为本地区常见变态反应性疾病的防治提供科学依据,皮肤点刺试验用于明确变态反应性疾病致敏原因安全有效.

目的:观察硅凝胶敷料和积雪苷霜软膏预防面部色素痣术后不良反应的临床疗效及安全性.方法:采用前瞻性研究,将94例面部色素痣术后患者随机分成3组,硅凝胶敷料组32例,积雪苷霜软膏组30例,对照组32例,分别在术后4周及12周,根据温哥华瘢痕评估量表对切口部位的色素沉着、红斑、质地及高度评分,并对有无缝合痕迹进行评估.结果:术后4周,硅凝胶敷料组红斑、质地及高度评分均明显低于对照组(P＜0.05),硅凝胶敷料组红斑及高度评分明显低于积雪苷霜软膏组(P＜0.05).3组间色素沉着评分及缝合痕迹发生率差异无统计学意义(P＞0.05).术后12周,硅凝胶敷料组和积雪苷霜软膏组色素沉着、红斑及质地评分均明显低于对照组(P＜0.05).硅凝胶敷料组质地评分明显低于积雪苷霜软膏组(P＜0.05).硅凝胶敷料组缝合痕迹发生率明显低于积雪苷霜软膏组和对照组(P＜0.05),而积雪苷霜软膏组与对照组相比差异无统计学意义(P＞0.05).结论:面部色素痣术后应用硅凝胶敷料和积雪苷霜软膏均能够有效减轻红斑及色素沉着,硅凝胶敷料在软化瘢痕质地及改善缝合痕迹方面明显优于积雪苷霜软膏.

Several studies have recently demonstrated that patients with obstructive sleep apnea (OSA) have a high prevalence of cancer and cancer-related mortality.A large number of animal experiments and clinical studies have further confirmed that OSA can be involved in tumorigenesis and progression.The mechanism may involve oxidative stress,systemic inflammation,sympathetic outflow,immune dysfunction,exosomes,hypoxia-inducible factor (HIF),and so on.

目的 研究育龄期女性梅毒患者实施个性化护理的效果.方法 选取2014年12月~2016年11月在我院门诊就诊的育龄期梅毒患者120例,将其随机分为两组,对照组58例患者实施常规护理干预,观察组62例采用个性化护理.对比两组育龄期梅毒患者的心理状况、用药依从性以及护理满意度.结果 观察组育龄期梅毒患者护理后的焦虑评分(41.27±3.06)分和抑郁评分(37.84±5.24)分均比对照组患者低,差异有统计学意义(P<0.05),用药依从性95.16%和护理满意度96.77%高于对照组,差异有统计学意义(P<0.05).结论 个性化护理应用在育龄期女性梅毒患者中的效果令人满意.

Objective To evaluate the clinical efficacy of collagen dressing on skin nursing after intense pulsed light (IPL) treatment of facial freckles.Methods A total of 150 patients with facial freckles were randomly divided into two groups.The nursing group (80 cases) was treated with collagen dressing immediately after IPL therapy,and the control group (70 cases) was treated with ice compress.The assessment was executed at day 1,2,3,7 and 14 after the treatment.The syndrome of pain and dry were assessed,and the duration of erythema,edema and scab were compared between the two groups.Results Compared with the control group,the side effects and discomfort of nursing group were remarkably reduced,and the difference was statistically significant (P＜0.05).Conclusion Application of collagen dressing after IPL treatment may obviously promote skin repairing,alleviate pain symptoms,et al,as well as improve the comfort degree of the patients.

现今社会儿童死于虐待案件层出不穷，已成为近年来国家所重视的社会问题。大部分受虐的儿童不会主动告知任何人，对自我也易产生负向认知，也可能因年幼而无法自行通报求助，往往造成更严重的虐待事件发生。儿童受虐事件的发生会使儿童在生理、安全及爱与归属感的需求无法获得满足，不但会造成儿童身心健康、人际关系等问题，也可能对家庭中的亲子关系及社会造成影响。

目的:探讨10％5-氨基酮戊酸(ALA)光动力疗法治疗中重度痤疮的有效性及安全性.方法:96例中重度痤疮患者,随机分为两组.治疗组:48例,给予5-氨基酮戊酸光动力疗法,每周治疗1次,共治疗3次;对照组:48例,给予红蓝光照射治疗,每周治疗2次,共治疗4～8周.结果:治疗结束后3个月,治疗组有效率为83.00％,对照组为60.87％,两组疗效比较有显著性差异(P＜0.05).治疗组在各个随访期的疗效均明显高于对照组,无明显严重的不良反应.结论:10％的5-氨基酮戊酸光动力疗法治疗中重度痤疮疗效显著,不良反应少.

Objective To evaluate key points in nursing patients with urethral condylomata acuminate(CA) treated with 5-aminolevulinic acid photodynamic therapy(5-ALA-PDT) in combination with carbon dioxide laser.Methods In forty-two patients with urethral CA,the lesion was exposed to photodynamic illumination precisely after the local dermal trauma was eliminated by CO2 laser and then coated with 5-ALA.Health instruction,psychological and topical care were carried out actively before,during and after the treatment.Results In the 42 CA patients,CA clearance rate was 85.23% in week 1 post to treatment,and the recurrence rate was 7.14% in follow-up during 12 weeks after treatment.Minor adverse events were observed,and there was no scar or urethral stricture.Conclusion ALA-PDT combined with carbon dioxide laser is generally safe and effective with low recurrence rate.Good nursing may ensure and improve its efficacy and reduce incidence of adverse events.