目的:观察金乌骨通胶囊联合塞来昔布胶囊治疗强直性脊柱炎(AS)的临床疗效.方法:选取天津中医药大学第一附属医院2017年4月～2020年4月期间收治的126例AS患者.采用双色球法(红色、绿色)将患者分为对照组(红色)和研究组(绿色),各63例.对照组接受塞来昔布胶囊治疗,研究组接受金乌骨通胶囊联合塞来昔布胶囊治疗,两组均治疗3个月.治疗3个月后,观察两组疗效,记录治疗期间不良反应发生率,对比两组治疗前、治疗3个月后的临床症状缓解情况、生存质量及实验室指标变化.结果:研究组的临床总有效率高于对照组(P＜0.05).治疗3个月后,研究组巴氏强直性脊柱炎疾病活动指数(BASDAI)、巴氏强直性脊柱炎功能指数(BASFI)评分低于对照组,枕墙距小于对照组,腰椎活动度、胸廓活动度大于对照组(P＜0.05).治疗3个月后,研究组世界卫生组织生存质量简表(WHOQOL-BRIEF)各维度评分高于对照组(P＜0.05).治疗3个月后,研究组血沉(ESR)、C-反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)低于对照组(P＜0.05).两组不良反应发生率组间比较无统计学差异(P＞0.05).结论:金乌骨通胶囊联合塞来昔布胶囊治疗AS患者,可促进其临床症状及生存质量改善,降低ESR及炎性因子水平,是一种安全有效的治疗方案.

"从我的父亲到我,再到我的儿子,我家祖孙三代都是石油工作者."在与师园林交谈时,这是他给笔者说的第一句话.他们三代人深深扎根石油行业,一起见证了中石油和田销售公司从无到有、从落后到辉煌的全过程.虽然他们所处的时代不同,但对石油行业的热爱是相同的.他们虽然人生阅历不同,但艰苦奋斗、爱岗敬业的精神是相同的.

《老老恒言》是中医老年养生的代表性著作,作者曹庭栋尤为重视起居养生,书中载有日常起居用具30余种,文章从中选取“枕”作为研究对象,从形态、材质、填充物及特殊功能等方面探讨枕的养生作用机制及应用价值,以期为现代老年人养生及养生保健器具的开发起到一定的指导作用.

针灸学》为中医学专业必修课程,是一门理论与实践并重的课程.讲好这门课需要研读针灸经典论著、掌握腧穴定位、熟练刺灸操作、建立辨经辨证思维,这都是青年教师面临的专业内容挑战.随着科技的发展,课堂板书授课已不再是学生获取知识的唯一途径,教学形式、教学方法的改变是青年教师教学面临的新考验.本文从专业水平、课堂教学、自身修养、师生交流4个方面,探讨青年教师应如何培养教学基本功.

目的:探讨推拿治疗生殖系统疾病的效应及机制.方法:收集以推拿手法治疗生殖系统疾病的相关文献,深入研究手法作用方向及作用机制,并对推拿治疗生殖系统疾病做一研究与展望.结果:推拿手法适用于不孕症、慢性盆腔炎、子宫肌瘤、早泄等疾病的治疗,临床多在腹部及脊柱部位操作.结论:推拿手法治疗生殖系统疾患疗效明确,其机制主要与调节生殖激素分泌、神经传导及脊柱结构有关.

Objective To investigate the effects of bushen and shugan treatment on the protein and mRNA expression of HOXA10 in mouse womb. Methods 90 female mice were randomly divided into 6 groups: high and low dose bushen group; high and low dose shugan group;super stimulate ovulation control group (COH) and blank control group, with 15 mice in each group. The daily injection of saline was performed in each group for 8 d. All the mice in each group injected with PMSG in the 9th day and injected HCG after 48 h except the mice in control group. The female mice in each group was mated with the male mice, followed by observation of the pregnancy on the second morningand further drug treatment, high and low dose bushen group were given with 5.4 g/ml or 2.7 g/ml oral liquid filling kidney menstrual function party; high and low dose shugan group were given with 0.6 g/ml or 0.3 g/ml liver xiaoyao pill for suspension liquid, and the COH and the blank control group were injected with saline for 4 d. After sacrifice of the mice, immunohistochemistry and RT-PCR method was used to analyze HOXA10 expression in mouse uterus, and female progestational hormone expression level was compared.Results Expression of serum E2 and P in each treatment group was significantly higher than that of the blank control group and the COH group (P < 0.05), and the high dose group was superior to the low-dose group (P < 0.05). Comparison between the high dose groups had no statistical significance (P > 0.05). The HOXA10 gene expression in COH group was reduced as compared with blank control group (P < 0.05), whereas the expression of HOXA10 in the high-dose bushen group and the high-dose shugan group were increased compared with the COH group (P < 0.05). No statistically significant difference was seen between the high-dose bushen group and the high-dose shugan group (P > 0.05). Conclusion Bushen tiaojing recipe and xiaoyao pill can raise the ultra female serum progesterone level of mice, increase HOXA10 expression in uterus and improve the endometrial receptivity, thus promoting embryo implantation.

Objective To investigate the influence of bushen treatment and shugan treatment on Wnt pathway of endometrial cells in mice stimulated to ovulate. Methods 90 mice were randomly divided into 6 groups: high and low dose of bushen group; high and low dose of shugan group;Super ovulation stimulated control group (COH) and blank control group, with each group having 15 mice. Mice in each group were given saline daily by intraperitoneal injection for 8 continuous days. On the 9th day, each group, except for the blank control group, was injected with PMSG, and 48 h later, the mice were given HCG. All the mice were mated with male mice according to 1:1 ratio, and were filled the stomach after examining female vaginal in the next morning. Bushen high and low dose group were given oral liquid filling kidney menstrual function party of 5.4 and 2.7 g/ml, respectively, while shugan high and low dose group were given xiaoyao pill for suspension liquid of 0.6 and 0.3 g/ml, respectively. COH group and the blank control group were given saline for 4 days. The expression of Wnt7a and beta-catenin mRNA in all the mice were measured by RT-PCR. Results Compared with the blank control group, the expression of Wnt7a and β-catenin in the COH group were decreased (P <0.05). Compared with the COH group, the expression of Wnt7a and β-catenin in the bushen high dose group and the shugan high dose group were increased (P < 0.05). There was no statistically significant difference between these two high dose groups (P >0.05). Conclusion Bushen tiaojing recipe and xiaoyao pill can improve the endometrium tolerance of mice and promote embryo implantation. The mechanism is correlated to the increase in expression level of Wnt7a and β-catenin and activation of Wnt/β-catenin signal transduction pathway.

Massage is an important part of traditional Chinese medicine.The study of quantization and parameters of massage manipulation can contribute to improve the quality of massage skill.It is helpful to promote the development of massage and the wide spread in the whole country and even in the world.In order to provide reference for the quantitative study and application of massage manipulation,the research on the morphological characteristics,manipulation frequency,intensity,time and other aspects of massage related to techniques in recent years are reviewed and summarized in this paper.

卒中相关性肺炎是脑卒中最常见并发症之一,其病菌易产生抗生素耐药性,对患者的肢体和语言等相关功能的恢复产生不利影响,治疗棘手,严重影响患者的预后[1].有研究表明,脑卒中急性期患者中有约10％ ～ 47％发生肺部感染,而死于肺部感染者占脑卒中死亡病例的1/3[2-4].卒中相关性肺炎是卒中常见的并发症,其发病率为7％～22％[5],其肺部感染的控制程度,影响到卒中患者的转归和预后[6].有学者报道,约1/10住院1个月内的卒中患者死于肺炎[7].卒中并发肺部感染的患者,30d内病死率为无感染者患者死亡率的3倍.因此,尽早发现卒中相关性肺炎的危险因素,针对不同的危险因素作出相应的防治措施对卒中患者的预后至关重要[8].

目的:探讨捏脊疗法调节胃肠运动可能机制.方法:以0.5mg/mL山莨菪碱注射液静脉注射复制胃运动过缓模型,观察捏脊疗法对胃运动过缓家兔耳中动脉血浆的胃饥饿素(Ghrenlin)、血管活性肠肽(VIP)含量的影响.结果:捏脊疗法可以促进急性胃运动过缓家兔动脉血浆内的Ghrenlin、VIP水平恢复.结论:捏脊疗法调节胃肠功能的作用机制可能为通过改变神经肽类物质的浓度进而调节胃肠道的功能活动.

推拿是将手法作为治疗手段的中医外治疗法之一,临床应用比较广泛,主要涉及内科、儿科、妇科、骨伤科等病症.虽然推拿治疗的发展历程比较久远,但“有力、均匀、柔和、持久、深透”这10个字仍然是臼前手法的评判标准.其正确性毋容置疑,但这一标准只是个抽象的比喻,不同的人对其有不同的理解.目前临床应用推拿手法治疗具有随意性和盲目性的特点,这是因为他们多是根据各自的经验及患者的反馈开展治疗.手法操作的特异性与不同人操作技术的功力和质量的优劣相关,这就直接影响到治疗效果.近年来人们开始认识到推拿手法的量化与规范化研究的重要性.本文就近年来推拿手法量化、规范化的研究进展综述如下.

目的:探讨大柴胡汤在临床的应用规律,从而更有效地指导临床应用.方法:全面检索中国生物医学文献数据库(CBM)、中国知网(CNKI)、维普中文科技期刊全文数据库(VIP)和万方医药期刊数据库(WF),对该方近三十年公开发表的期刊报道进行整理,按照Excel2007建立的信息采集表提取数据,建立临床研究文献疾病谱,对临床文献进行评价.结果:大柴胡汤共纳入1543篇文献.其中理论研究795篇、临床研究422篇、实验研究192篇、其他134篇.结论:大柴胡汤的高频系统病症集中在消化系统疾病,其高频病种分布在急性胆囊炎、急性胰腺炎等较为急性的病种.

Chiropractic therapy is a common practice in pediatric massage, especially in the treatment of pediatric digestive and respiratory system diseases. This paper investigated the mechanism of chiropractic therapy from traditional theories and modern researches, and summarized the role characteristics based on the systematic review and analysis of literatures about chiropractic therapy, in order to promote its mechanism researches and clinical application.

颈性头痛主要累及枕大、枕小神经和耳大神经及伴行血管等组织,这些神经血管行走于颈枕肌肉之间,易受枕后腱弓内组织炎症刺激或挛缩肌肉压迫,产生疼痛症状.颈性头痛主要累及枕大、枕小神经和耳大神经及伴行血管等组织,这些神经血管行走于颈枕肌肉之间,易受枕后腱弓内组织炎症刺激或挛缩肌肉压迫,产生疼痛症状.枕骨下缘穴位点按法配合牵引治疗颈性头痛,作用相辅相成,提高了疗效,能缩短治疗时间和治疗周期.

通过对国内外近年国内外捏脊疗法的实验技法进行系统回顾,从其实验技法的操作部位,操作时间,操作方向及操作遍数等方面归纳整理,总结捏脊疗法的疗效与机体内分泌激素变化、影响调控多条基因表达、改善神经体液免疫的调节之间的机理,系统总结捏脊疗法的实验技法,为捏脊疗法的实验技法研究提供应用指导.

[Objective] To understand the current domestic situation of the unhealthy accident in massage, promote the standardization of massage and so improving the security of massage therapy. [Methods] Using a retrospective journal researching serial methods, all the case report literature about unhealthy accidents in massage among Chinese Journal Full-test Databaseon CNKI, CQVIP Chinese Science Technology journal full-text Database, Wangfang Database and Chinese biomedical literature database were retrieved and a statistic analysis was performed about the used methods, the types of accidental situation, the primary disease, the cause of the accident and the number of the cases. [Results] The 202 effective literature, including 709 cases altogether were retrieved. The analyzed results indicated that the unhealthy accidents in massage were mainly bone fracture and dislocation, nerve damage(sympathetic nerve excitement disorder), dizziness, paraplegia, herniation of intervertebral disk and so on. A low degree of standard was existed in pulling manipulation,pressing maneuver, traction and passive inflection and protraction of extremities and they were easy to induce some unhealthy accidents.[Conclusion] The improving of the security of some massages are still needed. The standardization of massage methods is an important way to promote its security, in which the relevant work needs to be done in full operation soon.

目的:观察捏脊法于不同施术部位(督脉、膀胱经)对正常家兔胃运动的影响.方法:家兔行自制胃运动应力传感器植入术后,记录家兔胃运动情况,观察量化的捏脊于不同经脉施术对家兔正常胃运动的影响.结果:膀胱经捏脊对家兔胃运动波幅有促进作用(P＜0.05),督脉捏脊对家兔胃运动波幅可能有促进趋势(P＞0.05),捏脊对家兔胃运动频率无明显影响.结论:量化捏脊操作于不同施术经脉对正常家兔胃运动均有影响,膀胱经施术对家兔胃运动波幅促进效应较督脉施术更明显.这可能是捏脊治了消化系统疾病的机理之一.