Aryabhatta Knowledge University (AKU Patna) is a collegiate public state university located in Mithapur, Patna, Bihar, India. It was named after the Indian astronomer Aryabhatta.Apart from a few notable exceptions, AKU has authority over technical education all over the state of Bihar, and it functions as the state technological university of Bihar. It is recognised and approved by AICTE. It is a statutory requirement for colleges offering any program in engineering, medical or technology in the state to be affiliated with the university.
We report the draft genome sequence of Salmonella enterica subsp. enterica serovar Choleraesuis strain GS-198, isolated from retail poultry meat in Mathura, Uttar Pradesh, India. The draft genome comprised 87 contigs with a total length of 4,937,349 bp and a G + C content of 52.2
In the present study, an eco-friendly synthesis route was adopted for the synthesis of silver nanoparticles (Ag NPs) utilizing citrus fruit extract as a natural reducing and stabilizing agent. The primary objective of this research is to establish a sustainable methodology for the green synthesis of silver nanoparticles and to conduct a comprehensive evaluation of their structural characteristics, as well as their antimicrobial and antioxidant activities. Advanced analytical techniques, including XRD, FTIR, HRTEM, UV–Visible spectroscopy, and EDX, were utilized to confirm crystallinity, functional group contributions, and nanoparticle size. The crystallite size of silver nanoparticles was measured 17 nm, approximately. FTIR spectroscopy identified molecular bonding within the normal range of 627 cm− 1 to 3787 cm− 1. HRTEM analysis revealed the formation of spherical nanoparticles with an average particle size of 16 nm (approximately), while EDX and elemental mapping confirmed the presence of silver in the synthesized nanomaterials. UV–Visible spectroscopy of the as-synthesized Ag nanoparticles showed a surface plasmon resonance at approximately 433 nm and a band gap of 1.94 eV. The antibacterial potential of Ag NPs was evaluated using MIC values against S. aureus (SA87) and E. coli (EC19), investigating their enhanced interactions with different bacterial strains. The antioxidant activity of the synthesized nanoparticles was also assessed to highlight their dual functionality, paving the way for potential therapeutic applications in infection control and oxidative stress management. Antimicrobial testing revealed higher efficacy of Ag NPs against EC19 (MIC: 50.9 µg/ml) than SA87 (MIC: 68.7 µg/ml). Antioxidant assays confirmed their dual functionality, attributing bacterial inhibition and radical scavenging to enhanced surface reactivity, consistent with prior studies.
In the present report, aurivillius phase Bi5FeTi3O15 (BFTO) nanoparticles with enhanced charge separation, attributed to their ferroelectric properties, have been successfully synthesized through a sol-gel method, and subsequently investigated their photocatalytic activity. Various analytical techniques, including X-ray diffraction(XRD), Raman Spectroscopy, Scanning electron microscopy (SEM), Energy Dispersive X-ray analysis (EDS), Fourier transform infrared spectroscopy (FTIR), Energy Dispersive X-Ray Fluorescence (EDXRF) and UV-Vis spectroscopy have been employed to investigate the structural features, surface morphology, and optical properties of the as-prepared samples. The XRD and subsequent Rietveld refinement confirmed that the BFTO nanoparticles exhibit a single-phase orthorhombic structure with the space group A21am. Furthermore, EDXRF and EDS confirm the formation of BFTO, UV-Vis spectra confirmed the occurrence of a direct band gap in the BFTO nanoparticles with a band gap energy of 2.7 eV. Under an applied voltage of 8000 V, the remanent polarization (Pr) and coercive field have been evaluated as 53.88 µC/cm² and 256.034 kV/cm, respectively. In addition, the degradation of Methyl Orange (MO) in an aqueous solution under visible light has been carried out to assess the photocatalytic activity of the as-synthesised BFTO nanoparticles. After nearly 3 h in white light irradiation, a notable rise in MO deterioration has been noted. Because of their high effectiveness in breaking down MO dye, BFTO nanoparticles show a lot of promise as a photocatalyst for the breakdown of hazardous vulnerable compounds and other organic pollutants when exposed to visible light.
Introduction: A new era in drug discovery must start. Almost all pharmaceutical development methods use computer-based data and findings. This article highlights advanced simulation techniques for drug development. By 2040, the worldwide cancer burden will reach 30 million new cases, with the highest growth in low—and middle-income nations. By 2040, cancer diagnoses are predicted to grow by 55 percent, reaching 6.23 million in the Americas. Kinetic profiles of ligand binding mechanisms and drug-target affinities must be investigated. Methodology: A systematic literature review was conducted using multiple academic and scientific databases, including ResearchGate, ScienceDirect, CORE Library, Google, Web of Science, Google Scholar, and Scientific Digital Library Online (SciELO). The search covered publications from August 2009 to August 2024 to ensure the inclusion of foundational and recent studies. Result and Discussion: Plant-derived drugs include methyl transferase inhibitors, DNA damage inhibitors, HDAC inhibitors, and mitotic disruptors—the compounds' anticancer effectiveness and clinical trial development. MTAs are currently used in cancer detection since they target specific driver genes or diagnostics. This method is constrained by the high gene alterations in multiple driving genes in each tumor. Digital drug assignment (DDA) method that prioritizes potential.
