Dokuz Eylül University (Turkish: Dokuz Eylül Üniversitesi) (DEÜ) is a university in İzmir, Turkey. It was founded in 1982 and is organized in 15 faculties. DEU is the first university which applied the problem-based learning method in Turkey, beginning in the School of Medicine in 1997.Several components of Dokuz Eylül University have attained a goal of continuous development in education, research and practice through the ISO 9001 2000 Quality Management System certificate: Social Sciences Institute and School of Maritime Business and Management (2001), University Presidency (2003) and Medical Faculty and Health Sciences Institute (2004).
Gender norms and sociodemographic resources shape women's perceptions of intimate partner violence (IPV). Understanding these factors within primary care settings is essential for implementing context-specific screening and counseling practices. To examine the sociodemographic and generational correlates of women's gender role and IPV-related attitudes, and evaluate the predictors of actual lifetime IPV exposure, this study included 1091 women aged 18 years and older registered at training family health centers in Türkiye. Lifetime IPV exposure rates were substantial. More egalitarian and anti-violence attitudes were associated with higher education, formal employment, and younger generations. Lower education, low income, and relationship separation were stronger predictors of victimization than individual attitudinal scores, with older generational cohorts facing a much higher risk of economic violence. Women's attitudes toward IPV and actual vulnerability are grounded in generational shifts and individual-level resources that dictate relational power. In primary care, the high sub-clinical burden of non-physical violence emphasizes the need for proactive, direct questioning strategies to improve disclosure.
Alzheimer’s disease (AD) is a complex neurodegenerative condition involving β-amyloid (Aβ) deposition, tau abnormalities, neuroinflammation, neuronal degeneration, and progressive impairment of cognitive functions. Despite extensive research, effective disease-modifying therapies remain limited, highlighting the need for translationally relevant models and repurposable therapeutic candidates. Dexmedetomidine (DEX), an α2-adrenergic receptor agonist with known neuroprotective properties, was investigated in an adult zebrafish model of AD established through cerebroventricular administration of Aβ42. DEX treatment significantly reduced Aβ accumulation and was associated with reduced amyloidogenic gene expression, indicating transcriptional changes in amyloidogenic pathway-related genes. DEX attenuated neuroinflammation by reducing glial activation, lowering pro-inflammatory cytokine gene expression, and increasing expression of the anti-inflammatory gene il10. Immunofluorescence assessment further demonstrated reduced astrogliosis and preserved neuronal marker integrity, as indicated by increased HuC/D levels. Interestingly, DEX attenuated Aβ-induced proliferative responses, characterized by decreased PCNA expression, while enhancing cleaved caspase-3 levels, suggesting changes in proliferation and apoptotic signaling under Aβ stress conditions. Behavioral assessments further demonstrated that DEX alleviated Aβ42-induced anxiety- and aggression-like behaviors, improving behavioral phenotypes in this model. Overall, these findings underscore the multi-level effects of DEX in modulating AD-related pathological features. As a clinically available agent, DEX represents a promising candidate for repurposing in neurodegenerative disease contexts. Further preclinical studies in mammalian models are warranted to validate its translational relevance and therapeutic potential.
Degenerative lumbar spine disorder (DLSD) is a significant public health concern, presenting with low back pain, radicular leg pain, and reduced quality of life. Although conservative management is the first-line treatment, some patients require surgery due to persistent symptoms or progressive neurological deficits. Lumbar instrumented fusion is a commonly performed procedure for DLSD. Adjacent segment degeneration (ASD) is a frequent complication after spinal fusion, occurring at either the cranial or caudal side of the fusion mass. While the role of spinopelvic parameters in ASD is well recognized, radiological predictors for poor outcomes and complications remain less understood. This study aimed to identify preoperative radiological predictors of ASD in patients who underwent short-segment decompression and fusion for DLSD. We cross-sectionally evaluated radiological data of the patients who underwent short-segment decompression and spinal fusion for DLSD at a tertiary spine clinic between 2013 and 2023. In 209 patients, 31.6
This study investigates how the thermodynamic properties of a two-dimensional quantum dot are influenced by a magnetic field and the type of impurity present. Using a Gaussian confinement potential, variations in the mean energy, entropy, and heat capacity were analyzed for attractive and repulsive impurities at different magnetic field strengths. The results show that the magnetic field strengthens the geometric confinement, thereby increasing the separation between energy levels. For attractive impurities, stronger geometric confinement results in a greater separation of energy levels, which suppresses thermal transitions. However, repulsive impurities exhibit weaker geometric confinement, leading to smaller energy-level separations and enhanced thermal transitions. This leads to a pronounced Schottky anomaly at low temperatures. The results obtained from this study are expected to make significant contributions to experimental research in the development of optoelectronic devices based on quantum-confined systems.
Ovarian cancer (OC) accounts for a significant percentage of cancer-related deaths in women worldwide. A small proportion of ovarian cancers, usually in women under 40, originate from germ cells and stromal cells within the ovary, but the vast majority are epithelial malignancies. The preferred treatment for ovarian malignancies consists of platinum-based chemotherapy and surgical intervention. Chemoresistance in ovarian cancer is a complex problem that significantly impedes tratment efficacy. Many pathways contribute to this resistance, including genetic factors, tumor microenvironment interactions, and lifestyle variables such as obesity. Understanding these mechanisms is crucial for developing effective treatment solutions. The circadian rhythm, or circadian clock, regulates the sleep–wake cycle, body temperature, hormone secretion, metabolism, and many physiological processes. Circadian genes are highly expressed in the ovaries, which regulate ovulation. Disruption of circadian rhythm asociated with many risk factors for ovarian cancer. This article examines the relationship between circadian rhythm and chemotherapy resistance in ovarian cancer, and reviews circadian rhythm to reduce chemotherapy resistance in this context.
