Dr. Cipto Mangunkusumo National Central Public Hospital (Indonesian: Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, abbreviated as RSUPN Dr. Cipto Mangunkusumo or RSCM), is a government run hospital located at Salemba in Jakarta, Indonesia. The hospital was established in 1919 as the Centrale Burgelijke Ziekeninrichting (CBZ), which has undergone various changes in name and status since then, but since 1964 it is named after Cipto Mangunkusumo, an Indonesian independence leader and Sukarno's political mentor. It is a government run general hospital as well serves as teaching hospital for University of Indonesia. RSCM provides primary, secondary and tertiary care, acts as a national referral center for government hospitals and is a place for general practitioners, specialist doctors and subspecialists, nurses and other health workers. The hospital has almost all advanced diagnostic and therapeutic medical technology.
Abstract At the 2024 annual meeting of the Japanese Society for Dialysis Therapy (JSDT), a symposium on disaster preparedness in dialysis facilities was held, featuring a comprehensive report from Indonesia. Indonesia has a history of frequent disasters, including earthquakes, tsunamis, and floods caused by tropical cyclones. This article describes strategies and countermeasures designed to protect dialysis centers in Indonesia from the impacts of natural disasters. By recognizing the essential role these centers have in delivering life-sustaining treatment to individuals with end-stage kidney disease (ESKD) and examining existing protocols, disaster response plans, and lessons from past incidents, this article provides insights into proactive strategies that, perhaps, should facilitate protection of dialysis facilities and ensure continuity of care even amid adverse environmental conditions. During the preparation of this manuscript, an earthquake struck Myanmar on 28 March 2025, resulting in extensive damage that was reported worldwide. The regions surrounding Mandalay and Naypyidaw were particularly impacted. Prof. Kriang Tungsanga of the Nephrology Society of Thailand (NST) acted swiftly by obtaining information from a past president of the Myanmar Nephro-Urology Society (MNUS) and promptly contacted us on the Japanese side. Dialysis professionals from Japan, Thailand, and Myanmar had established collaborative ties through activities within the International Society of Nephrology (ISN) Oceania and Southeast Asia Regional Board, and the Japanese Society for Dialysis therapy international forum being held during the JSDT annual meeting. Through this network, dialysis supplies were urgently dispatched from Japan to the disaster-stricken areas in Myanmar. This paper chronologically outlines the methods and characteristics of international dialysis supply support to a conflict-affected country.
Background: Antimicrobial-resistant Escherichia coli and Klebsiella pneumoniae represent an increasing challenge in community-acquired pediatric diarrheal infections. Understanding the genomic basis and dissemination of resistance in outpatient settings is essential for guiding antimicrobial use. Methods: Eighteen Gram-negative isolates obtained from pediatric outpatients with acute diarrhea were analyzed using selective culture methods, antimicrobial susceptibility testing, and whole-genome sequencing. Multilocus sequence typing, serotyping, virulence profiling, antimicrobial resistance gene detection, plasmid replicon typing, mobile genetic element analysis, and core genome-based phylogenetic analysis were performed. Phenotypic resistance profiles were correlated with genomic resistance determinants. Results:Klebsiella pneumoniae (55.56%) and Escherichia coli (44.44%) were identified, with all isolates exhibiting putative multidrug resistance-associated genomic profiles. Extended-spectrum β-lactamase genes, particularly blaCTX-M variants, were strongly associated with resistance to third-generation cephalosporins. In contrast, fluoroquinolone resistance correlated with gyrA and parC mutations and plasmid-mediated qnr genes. Phylogenetic analysis revealed diverse lineages harboring resistance determinants. In silico plasmid analysis revealed that key resistance genes co-occurred with IncF-type plasmids and mobile genetic elements, including ISEcp1, IS26, and class 1 integrons, suggesting putative plasmid association rather than confirmed localization. Conclusions: These findings highlight the small scale of plasmid-mediated antimicrobial resistance among E. coli and K. pneumoniae causing pediatric community-acquired diarrhea. The integration of phenotypic and genomic analyses underscores the need for continuous resistance surveillance to support rational antibiotic use in outpatient settings.
The advancement of internet accessibility and equity is a key component of Indonesia’s development strategy. This study assesses the current state of internet distribution across the country and evaluates measurable progress toward equitable digital connectivity. Using data from SUSENAS [73] and OOKLA Speedtest Global Index [61], we analyze critical indicators such as internet penetration rates, average download speeds, and socio-economic disparities. The results reveal substantial progress in several regions—for example, internet penetration in Central Java increased from 62
Background Marathon running has numerous cardiovascular effects. Studies report transient physiological changes, while others identify possible harmful cardiovascular changes. This systematic review and meta-analysis aimed to characterise acute cardiac effects of marathon running.Methods A systematic search was conducted in PubMed, Embase, and SPORTDiscus up to 11 April 2025. Studies were included if they reported (i) primary data (ii) in English (iii) healthy adults completing a road marathon, (iv) quantitative pre- and post-marathon cardiac effects. After data extraction (myocardial biomarkers, morphology, and function), random-effect meta-analyses were performed to determine mean differences and relative changes between pre- and post-marathon. Meta-regression analyses were performed in metrics with ≥7 studies.Results Of 9080 articles, 69 were eligible for systematic review (3274 participants: age 30–55 years, >80% men) and 49 for meta-analysis on three biomarkers, 18 echocardiography metrics, and five cardiac MRI metrics. Marathon running-induced increases in circulating troponin T (+42 (32.6, 52.3) ng/L; p<0.001), troponin I (+77 (55.1, 98.3) ng/L; p<0.001) and N-terminal pro B-type natriuretic peptide (NT-proBNP) (+114 (89.0, 138.6) ng/L; p<0.001). On echocardiography, left ventricular (LV) volume and diastolic function, and right ventricular (RV) systolic function decreased post-marathon, while RV end-systolic and diastolic volumes increased. Cardiac MRI revealed an increase in LV ejection fraction. On meta-regression analysis, these responses varied according to age, sex, training status and marathon performance.Conclusion Marathon running induces acute changes in biomarkers of myocardial injury, cardiac structure and function. The clinical significance and potential for harm of these changes are yet to be established.PROSPERO registration number CRD42023399120
Objective: This study aims to analyze dinicopathological and radiographic predictors of recurrence inpatients with ameloblastoma treated at a national referral hospital in Indonesia. Material and Method: This cross-sectional study was conducted at Dr. Cipto Mangunkusumo Hospital (RSCM), a national referral center in Jakarta, Indonesia. A total of 163 patients with histopathologically confirmed ameloblastoma were treated between January 2014 and December 2024. Patients who did not undergo surgical treatment or had incomplete records were excluded from the analysis. Demographic and clinicopathological parameters were analyzed for their association with tumor recurrence using thechi-square test, Fisher's exact test, and binary logistic regression. Results: The study had a mean age of 34.2 years, with the majority of patients aged 20-45 years (62.0%). The majority of tumors arose in the mandible (92.6%) and showed multilocular lesions (85.9%). Recurrence rate was 29.4%. Multivariate analysis revealed that radical surgical treatment was strongly associated with a lower recurrence rate (OR 0.013, 95% Cl 0.004--0.041; p Conclusion: Both surgical approach and locularity are significant predictors of ameloblastoma recurrence. These findings support individualized treatment planning based on risk stratification.
