Niğde Ömer Halisdemir University (Turkish: Niğde Ömer Halisdemir Üniversitesi) (Formerly known as "Nigde University" until 2016 and "Ömer Halisdemir University" for few months in 2016) is a public higher educational institution located in Niğde, Central Anatolia in Turkey. It has six faculties, two institutes, two colleges and six vocational colleges. The university campus is situated 6 km (3.7 mi) southwest of Niğde.The university was renamed in honor of Sgt. Maj. Ömer Halisdemir (1974–2016), a non-commissioned officer, who was killed on duty in the night of 2016 Turkish coup d'état attempt, right after he shot dead a pro-coup general and prevented so the coupists capture the headquarters of the Special Forces Command in Ankara. He is remembered as a major contributor to the failure of the coup attempt. He was a native of Çukurkuyu town in Bor, Niğde..
Lipid oxidation under UV exposure remains a critical challenge for maintaining the stability of omega-3-rich oils, with most current approaches relying on chemical antioxidants. This study explores a novel structural stabilization strategy by employing a chewing gum matrix as a physical protective barrier rather than a conventional antioxidant system. Fish oil samples were exposed to UV light in the presence of butylated hydroxytoluene (BHT), potato peel extracts obtained via maceration and supercritical extraction, a control group, and fish oil incorporated into a gum base (GB). Oxidative stability was assessed using peroxide value, p-anisidine value, free fatty acids, acid value, and volatile oxidation profiling via an electronic nose system. Among antioxidant treatments, BHT showed the highest protective effect, while the maceration extract provided moderate protection and the supercritical extract exhibited limited efficacy. Notably, fish oil incorporated into the gum matrix displayed minimal changes in both chemical and volatile parameters throughout UV exposure, suggesting that the gum base functions as an effective structural barrier against photo-oxidation. Fatty acid composition remained largely unchanged across treatments. These findings demonstrate that matrix-driven protection represents a promising alternative to conventional antioxidant strategies and highlight the potential of chewing gum systems as innovative delivery platforms for stabilizing functional lipids.
Migraine chronification is associated with increased clinical burden, yet structural neuroimaging findings remain inconsistent. We compared global and regional brain volumes among patients with episodic migraine (EM), chronic migraine (CM), and healthy controls (HC) using an automated whole-brain volumetric approach. This retrospective study included 58 CM patients, 55 EM patients, and 60 age- and sex-matched HC. Diagnoses were established according to the International Classification of Headache Disorders, 3rd edition (ICHD-3). Structural MRI data acquired on a 1.5-T scanner were processed using the automated volBrain pipeline. Regional brain volumes were compared using one-way ANOVA. To address multiple testing across 220 regions, family-wise error rate (FWER) was controlled with Holm–Bonferroni and false discovery rate (FDR) with Benjamini–Hochberg. Cohen’s d values were calculated as exploratory effect sizes. Monthly attack frequency was significantly higher in CM than EM (p < 0.001), while disease duration was similar. No significant differences were observed among EM, CM, and HC in global or regional brain volumes after FWER and FDR correction. Regions showing nominal uncorrected differences demonstrated small and inconsistent effect sizes. With rigorous whole-brain correction, automated volumetry did not reveal robust structural differences between episodic and chronic migraine. If present, migraine-related morphometric alterations are likely subtle and methodologically sensitive. Larger longitudinal studies using higher-resolution imaging are needed.
The present study explores the impact of Ag incorporation and Ag deposition sequence in the precursor stack on the structural and optical behavior of CZTS thin films, as well as the performance enhancement of Cu2ZnSnS4 (CZTS) based thin film photodetectors (PDs) achieved through Ag doping and variations in stacking order. The fabricated Ag-doped CZTS thin films were prepared by the magnetron sputtering method using multiple layer stacking orders, as follows: ZnS/Cu/Sn/Cu (CZTS-I), ZnS/Cu/Sn/Cu/Ag (CZTS-II), ZnS/Cu/Sn/Ag/Cu (CZTS-III), ZnS/Cu/Ag/Sn/Cu (CZTS-IV), ZnS/Ag/Cu/Sn/Cu (CZTS-V), and Ag/ZnS/Cu/Sn/Cu (CZTS-VI). Raman analysis confirmed the kesterite CZTS structure while also revealing the existence of the Cu2SnS3 (CTS) secondary phase in the CZTS films, which disappeared with Ag-doping. CZTS-IV and CZTS-V exhibited enhanced grain growth, a dense structure, and a smooth surface. The band gap showed a slight upward shift from 1.44 eV (CZTS-I) to 1.54 eV (CZTS-V). The PL emission was observed at similar to 1.37 eV, appearing below the optical band gap due to Donor-Acceptor Pair (DAP) recombination. Among the prepared films, the CZTS-IV sample showed the highest PL intensity, indicating a significant reduction in non-radiative recombination centers. Urbach energy (E-U) of the CZTS and Ag-doped CZTS samples revealed that E-U value decreased as the position of Ag in the precursor layer changed from the top to the bottom, reaching an optimal level in CZTS-IV (279 meV). Current-voltage (I-V) measurements indicated a linear relationship between current and voltage under both dark and illuminated conditions, confirming the ohmic nature of all devices. The fastest rise and fall times (11 ms each) were achieved by the CZTS-IV thin-film PD under blue light at 2 V, attributed to its superior structural and optical properties. CZTS-II demonstrated the highest responsivity (R = 2.40 mA/W), detectivity (D & lowast; = 3.4 & times; 10(8) Jones), and external quantum efficiency (EQE = 0.662) under blue light. These improvements are credited to both Ag-doping and the optimized stacking order. It was seen that the Ag layer precursor stacking sequence plays a crucial role in the structural evolution of CZTS films by regulating elemental interdiffusion, intermediate phase formation, and grain growth during sulfurization. This study highlights the potential of Ag-doped CZTS thin-film PDs for future high-performance devices.
Quercetin is a naturally occurring and valuable bioactive compound found in various vegetables and fruits. The determination of quercetin concentrations in foodstuffs is of great importance; however, it is challenging due to matrix interference. A new sorbent, an aliphatic polyester, polybutylene dodecanedioate was synthesized for extraction of quercetin. It was characterized by NMR, FTIR, XPS, and DSC spectroscopy. A dispersive solid-phase microextraction method for spectrophotometric determination of quercetin in foodstuffs was developed using synthesized adsorbent. Under the optimized conditions, the proposed method showed a linear working range of 15-900 ng/mL, a limit of detection of 4.5 ng/mL, and an enrichment factor of 175 determined using matrix-compatible aqueous model solutions. Quercetin concentrations in vegetables, fruits, and beverages were determined to range from 1.20 to 42.0 mg per 100 g, with spike-test recovery values ranging from 91 to 99%. Determination of quercetin in the real samples was completed within only 10 min by the proposed methodology.
This descriptive qualitative study explored how individuals with cancer perceive their illness across different stages and contexts. Using a reflexive thematic analysis (RTA) framework, the study followed the Standards for Reporting Qualitative Research (SRQR) for transparency. Data were gathered through six semi-structured focus group discussions with 35 patients diagnosed with breast, lung, colorectal, or gastric cancer. Purposive sampling continued until sufficient information was obtained. Analysis yielded four overarching themes: (1) paradox of illness description, (2) paradox of disease causation, (3) paradox of treatment effects, and (4) paradox of life disruption. Participants expressed ambivalent understandings of cancer, some viewing it as a manageable, flu-like condition, while others experienced it as a life-threatening, identity-defining event. Similar tensions emerged regarding perceived causes, treatment responses, and the illness's broader impact. These paradoxes highlight the complexity of cancer perceptions and the need for individualised, psychosocially informed care across the illness trajectory.
