Pakuan University (UNPAK) is the oldest and biggest private university in Bogor.[citation needed] It was established on 1 November 1980 under the Foundation Pakuan Siliwangi. Pakuan University is at Jl. Pakuan PO Box 452, Bogor. In the academic year 2012/2013, UNPAK offered 32 programs of study. Dr. Bibin Rubini, MPd has been the rector of UNPAK since elected in 2008.
Pancreatic cancer is one of the deadliest malignancies and a leading cause of cancer-related mortality worldwide. It is often diagnosed at advanced stages, characterized by angiogenesis, metastasis, and resistance to conventional therapies, making it particularly difficult to treat. Therefore, the discovery of safer and more effective therapeutic options is urgently needed. Zingiber officinale var. rubrum known as red ginger is a traditional medicinal plant recognized for its therapeutic properties, particularly its anticancer potential. This present work utilized an extensive in silico methodology to assess the antiangiogenic potential of red ginger bioactive compounds by targeting VEGFA, a key regulator of angiogenesis. Drug-likeness screening, toxicity prediction, permeability analysis, and biological activity profiling were used to identify lead compounds. Enrichment analysis revealed involvement in cancer-associated pathways such as PI3K-Akt, MAPK, Ras, and Rap1. Molecular docking and dynamics simulations showed that apigenin, (+)-catechin, and (-)-epicatechin bind effectively to VEGFA, with performance comparable to or better than the reference drug Sunitinib. Apigenin demonstrated the highest complex stability, followed by (+)-catechin and (-)-epicatechin. These findings highlight the inhibition. Additional lab-based experiments are needed to validate their molecular mechanisms and clinical potential.
Xanthosoma undipes K. Koch (Beneng taro) leaves are rich in bioactive compounds with reported antioxidant and anticancer potential. This study evaluated the antioxidant activity of ethanol extracts from Beneng taro leaves cultivated in three locations, identified active compounds using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and assessed their anticancer potential through in silico analysis. Extraction was performed with 96% ethanol, followed by phytochemical screening, quantification of total flavonoids and phenolics, and antioxidant evaluation using the DPPH assay. LC-MS/MS identified several bioactive phenolic and flavonoid compounds, including quercetin, isorhamnetin, hispidulin, oleocanthal and cyclovalone, as key contributors to antioxidant activity. Leaves from high-altitude Cisarua (TB-1) had the highest flavonoid (94.49 ± 1.61 mg QE/g) and phenolic (97.35 ± 1.74 mg GAE/g) contents, with the strongest antioxidant activity (IC50 = 42.96 μg/mL). Drug-likeness screening indicated favourable pharmacokinetic properties for several compounds. Molecular docking revealed strong binding affinities of quercetin, isorhamnetin, hispidulin, cochliophilin A, cyclovalone and oleocanthal to Kirsten rat sarcoma viral oncogene homolog (KRAS), a key oncogenic protein regulating cell growth, division and mutation, suggesting potential anticancer effects. These findings indicate that cultivation at higher altitudes enhances bioactive compound levels and antioxidant potential. Future studies should isolate active compounds, validate their effects in vivo, optimise cultivation practices, and explore their development into functional foods or nutraceuticals.
Metastasis is a major cause of mortality in breast cancer, making it a critical target in therapeutic strategies. Morinda citrifolia L., a tropical medicinal plant, has shown promise due to its bioactive compounds. This study investigates the anti-metastatic potential of M. citrifolia compounds by targeting matrix metalloproteinase-9 (MMP-9), a key protein involved in tumor invasion and metastasis. An integrative in silico approach was employed, including drug-likeness and toxicity screening, biological activity prediction, membrane permeability analysis, target protein identification, enrichment analysis, protein structure validation, molecular docking, and molecular dynamics simulations. Among the screened compounds, quercetin and obtusin exhibited strong binding affinity for MMP-9. We suggest that quercetin inhibits MMP-9 via zinc chelation and multi-point hydrogen bonding, while obtusin acts through cavity remodeling and potential allosteric modulation. Both compounds overlap with Marimastat's binding site, an established MMP-9 inhibitor, but engage the enzyme through distinct molecular interactions, highlighting their complementary mechanisms. Quercetin and obtusin from M. citrifolia inhibit MMP-9 through different yet complementary modes of action, suggesting their potential as anti-metastatic agents. These findings support further investigation through in vitro and in vivo studies to validate their therapeutic efficacy.
Integrating sustainability into primary mathematics education remains a significant challenge in Indonesia, particularly in aligning numeracy learning with Education for Sustainable Development (ESD) and green economy principles. This study aimed to design and validate the Green Economy and Numeracy Integration for Understanding Sustainability (GENIUS) learning model, a structured framework intended to integrate sustainability and green economy principles into primary mathematics education through contextualized, reflective, and student-centered instructional practices. Guided by constructivist learning theory, contextual learning, and the ESD competency framework, a mixed-methods design recruited 78 unique primary school teachers in Bogor City, West Java, selected through purposive sampling. Data were collected through questionnaires (n = 52), semi-structured interviews (n = 15), and classroom observations (n = 8), with overlapping participation across instruments, to examine teachers’ needs and instructional constraints. The needs analysis revealed that although most teachers showed positive attitudes toward sustainability-oriented instruction, major barriers included limited ESD understanding, rigid curriculum structures, and insufficient contextual resources. Based on these findings, the GENIUS model was developed with components including learning objectives, instructional syntax, roles of teachers and students, support systems, and contextual materials. Expert validation by mathematics education experts, ESD specialists, and experienced primary teachers used Aiken’s V to assess content and construct validity. Results indicate high validity across components (V ≥ 0.85), exceeding accepted thresholds and indicating coherence and practical feasibility. This study demonstrates the novelty of the GENIUS model for ESD numeracy learning.
Background:Black oncom biscuit contains contains vitamin B6 and that is a derivative product of black oncom (peanut meal fermented by Rhizopus oligosporus). Aim:Thisstudy analyzed the effect of black oncom subtitution (black oncom flour and black oncom biscuit) on body weight (BW), feed intake, growth rate, and vitamin B6 status in rats with vitamin B6 deficiency. Methods:Male rats were randomly selected into five groups and it respectively received five treatments which contained 3 g/kg feed of methionine, i.e., normal diet as control (C group), vitamin B6 deficient (≤ 0.6 mg/kg) diet (D group), vitamin B6 deficient (≤ 0.6 mg/kg) diet with pyridoxine HCl (7 mg/kg) substitution (DP), vitamin B6 deficient (≤ 0.6 mg/kg) diet with 15.05 g/kg feed of black oncom flour substitution (DOF), and vitamin B6 deficient (≤ 0.6 mg/kg) diet with 76.89 g/kg feed of black oncom biscuit substitution (DOB) for 7 weeks. Results:The BW, feed intake, and growth rate of the DOF and DOB groups were not different from those of the C group, whereas the D and feed intake were significantly reduced in the D group compared to the C group. Plasma pyridoxal 5' phosphate levels were decreased in the D group, and increased in the DOF and DOB groups (p > 0.05). Plasma homocysteine was increased in the D and DOF groups, but decreased in the DOB group (p > 0.05). Conclusion:This study demonstrated the potential benefits of black oncom in maintaining BW, growth rate, and vitamin B6 status.
