Human papillomavirus (HPV) types 6 and 11 cause 90% of condyloma acuminata (CA). Timely vaccination reduces CA-related disease burdens, especially among sexually inexperienced college students, a critical catch-up group for vaccination. Few studies investigate sexually inexperienced college students' views on CA and HPV vaccination, despite research on general student HPV awareness. This cross-sectional study was conducted in Guangdong in May 2017, and recruited college students who self-identified as having no prior sexual relations. Participants completed a WeChat-based online questionnaire to assess their knowledge of HPV, CA, and acceptance of HPV vaccination for CA. A total of 2037 valid questionnaires were collected and analyzed. Knowledge of CA (26.3%) and HPV (18.9%) was low among college students who self-reported no sexual experience, as was the HPV vaccination rate (2.6%). However, their acceptance of the HPV vaccine for CA was relatively high (54.7%). Respondents were more likely to have received the HPV vaccine for CA if they had heard of CA (OR = 1.40, 95% CI: 1.05-1.85), had actively learned about CA (OR = 1.62, 95% CI: 1.10-2.38), considered the vaccine safe (OR = 1.94, 95% CI: 1.03-3.65), and believed the vaccine effective in preventing CA (OR = 5.08, 95% CI: 2.05-12.59). Sexually inexperienced college students demonstrated insufficient knowledge of CA and HPV vaccines. Higher awareness of the safety and efficacy of the HPV vaccine, as well as knowledge about CA, were positive associated with the willingness to receive the HPV vaccine.

Condyloma acuminata (CA) is a prevalent sexually transmitted infection caused by low-risk human papillomavirus (HPV) types, such as HPV 6 and HPV 11. The HPV vaccine, which includes the L1 protein for HPV types 6 and 11, effectively prevents CA. In China, the primary vaccination strategy targets the prevention of cervical cancer caused by high-risk HPV, and HPV vaccination is not routinely recommended for men. Most men face a lower risk of high-risk HPV-related cancers; however, sexually active adolescent males are at a notable risk of CA due to low-risk HPV infection. Additionally, CA significantly facilitates the spread of HIV, underscoring the need for vigilance. This cross-sectional study was conducted in Guangzhou in March 2017, recruited 350 men who had engaged in sexual activity, comprising 161 young men who have sex with women (YMSW) and 189 young men who have sex with men (YMSM). Participants completed an online survey to assess their knowledge, attitudes, and behaviors related to HPV vaccination. Among the participants, 133 (38.0

Abstract Background Condyloma acuminata (CA) is a common, and recurrent sexually transmitted disease (STD) that greatly contributes to direct health care costs and has a substantial psychosocial impact. Human papillomavirus (HPV) vaccination (containing L1 protein for HPV types 6 and 11) effectively controls CA. Objectives We investigated attitudes toward the HPV vaccine for CA and willingness to undergo vaccination among STD clinic attendees in China. Methods Attendees at STD clinics at two selected hospitals in Guangdong and Jiangsu Provinces from May to September 2017 were requested to complete a self-administered questionnaire for this cross-sectional study. Results The participants’ median age was 28 years (IQR: 24.0–34.0), and the sex ratio was balanced; 63.5% were from Guangdong, 36.5% were from Jiangsu, and 44.5% had a history of CA. The vaccine acceptance rate was high among the participants (85.8%,235/274) to whom the HPV vaccine for CA was available, especially among those who had heard of CA (89.0%, AOR = 3.14, 95% CI: 1.29–7.63, p = 0.0114). 95 (34.7%) of 274 participants had a positive attitude toward the HPV vaccine for CA. STD clinic attendees who had heard of the connection between HPV and CA (AOR = 2.56, 95% CI: 1.31-5.00, p = 0.0060), had heard of the HPV vaccines or cervical cancer vaccines (AOR = 1.90, 95% CI: 1.02–3.54, p = 0.0444) and had ever proactively discussed CA or the vaccine with others (AOR = 1.95, 95% CI:1.00-3.79, p = 0.0488) had better attitudes toward the HPV vaccine for CA. Over half of the participants (52.5%) expected the price of the HPV vaccine for CA to be under $90. Conclusion The acceptance of the HPV vaccine for CA was high among STD clinic attendees in China, and the participants’ self-perceived knowledge of CA and HPV was associated with better attitudes toward the HPV vaccine for CA. Education to improve knowledge is vital for reducing vaccine hesitancy.

临床医学生医学科研能力的培养非常重要.我国医疗卫生事业亟需培养出医学科学研究及创新型人才.该文通过对南通大学医学院本科生进行科研基本素养及需求的调研,发现科研意识薄弱、创新思维能力缺乏、科研知识与技能缺乏是当下临床医学专业本科生科研素养的现状.通过分析研究学习著名高校本科生培养经验,在其基础上提出针对学生需求制订"医学科研"系列课程.将医学统计学、医学科研方法和文献检索及文献导读、科学家讲科研、科研制图及文章撰写等几门课整合成一门综合课程.通过科研小组制度,引导对科研有兴趣的学生加入科研兴趣小组,并通过提出问题、分析问题、设计解决方案和小组合作解决问题等部分,积极激发学生的科研兴趣,建立科研思维,全方位促进学生科研能力发展.

1 病历摘要 患儿男,12岁.因双上肢红斑伴瘙痒1d,于2020年6月9日来我院门诊就诊.患儿1d前在学校食堂食用烹饪过的未完全煮熟的香菇后双上肢出现红斑伴轻度瘙痒,无发热、头晕、胸闷及疼痛等其他症状.既往体健,无药物过敏史,近期无感冒及其他病史,无化学物品接触史.家族中无类似疾病患者.

IntroductionSyphilitic balanitis of Follmann (SBF) is a rare condition of primary syphilis which is characterized by any kind of balanitis with or without chancre on the penis combined with the presence of swollen inguinal lymph nodes confirmed by the finding of Treponema pallidum in the lesions or by the positive serological syphilitic testing. Timely identification of the SBF is very important in properly treating the disease stopping the spread of syphilis.Case presentationA 42year-old heterosexual male patient came to our clinic and complained of a painless, hard erythema nodule with a whitish scale in his coronal sulcus of the penis for about a week. The dermatologic examination revealed an infiltrative, hard erythematous lesion surrounding the coronal sulcus of the patient’s penis, with mild erosion and a small amount of exudation. There was a whitish pseudomembrane-like covering on the surface of the erythematous lesion in the coronal sulcus, which is mimicked as candidal balanitis. The result of the fungus microscopic examination was negative, while the laboratory findings showed positive results in serologic syphilitic testing. The patient was diagnosed with primary syphilis and intramuscularly treated with a dose of benzylpenicillin of 2.4 million units. The patient’s skin lesions disappeared completely 60 days after penicillin treatment.ConclusionTo our knowledge, this is the first SBF case reported in China. Syphilitic balanitis of Follmann may have variable clinical appearances. We emphasize that when balanitis with risky sexual activities or with sexually transmitted diseases, the diagnosis of SBF should be kept in mind.

目的:了解高年级医学生性行为、对常见法定报告性传播疾病及HIV阻断药知晓率现状,为开展大学生性健康教育提供参考.方法:对某医学院99例临床医学专业四年级大学生进行性行为、法定报告性传播疾病及HIV阻断药知晓率进行调查.结果:高年级医学生性行为发生率24.24％,无保护性行为、多个性伴侣发生率分别为37.50％和2.02％,男性性行为发生率高于女性(P=0.003).对艾滋病、梅毒、淋病、尖锐湿疣、沙眼衣原体感染及生殖器疱疹的知晓率分别为56.57％、58.58％、25.25％、23.23％、4.04％和1.01％.对HIV阻断药知晓率为86.87％,药物获取地点知晓率及有效使用时间回答正确率分别为37.37％和68.89％.结论:高年级医学生存在较高的性行为发生率和危险性行为率,对淋病、尖锐湿疣、沙眼衣原体感染及生殖器疱疹知识教育亟待加强,HIV阻断药宣教需要更具体细致.

Objective To explore the practical effect of case-oriented situational teaching mode in the teaching of Dermatovenereology.Methods A case-oriented situational teaching mode consisting of clinical cases presentation, STD transmission simulation game, skin lesions pictures display, and theoretical explanation was adopted for four classes of 2018 clinical medicine undergraduates ofMedical School of Nantong University, which were taught by the teaching and research department of Dermatovenereology of the Affiliated Hospital of Nantong University in the "Sexually Transmitted Diseases" chapter of the 2021 fall Dermatovenereology teaching course. Pre-and post-class questionnaires were collected from the medical students involved in the course before and after the class using the Questionnaire Star software and analysed by statistical methods.Results A total of 103 clinical medicine undergraduates participated in the classroom teaching, of which 99 students actively filled out the pre-class questionnaires, and all the undergraduates who participated in this teaching filled out the post-class questionnaires（103 copies）. The filling rate was 3.89% higher than pre-class. The post-class interestingness of medical students in the "Sexually Transmitted Diseases" course was significantly higher than pre-class（χ~2=20.03, P=0.000 2）. The results of the after-class survey indicated that the medical students′ interestingness in each teaching link from high to low was: clinical case presentation（39.81%）, STD transmission simulation game（31.07%）, skin lesions pictures display（22.33%） and theoretical explanation（6.08%）. 70.87% of the medical students were very satisfied with the situational teaching mode, and 73.79% of the medical students believed that the teaching effect of the situational teaching mode was quite good. 56.31% of the students commented that the situational teaching mode had deepened their professional knowledge memory, and 43.69% of the medical students thought that it had improved their awareness of safe sex.Conclusion The application of case-oriented situational teaching mode in the course of Dermatovenereology can improve students′ interestingness in the course and active thinking ability, and promote the teaching quality and teaching satisfaction.

The dissemination of the fact that the human papillomavirus (HPV) vaccine can protect females as well as males is greatly beneficial for the control of condyloma acuminata (CA). We aimed to investigate the acceptance of the HPV vaccine for CA among men who have sex with men (MSM) in China. A cross-sectional online survey in the adult MSM population from 31 regions in China was carried out via WeChat in May 2017. Information on demographic characteristics, sexual behaviors, history of HIV and HPV infection, awareness of CA and HPV/CA vaccines, acceptance of CA vaccination, and behavioral intentions for vaccination were collected through a self-administered questionnaire. In total, 902 questionnaires were analyzed; the prevalence of CA was 13.3% (120/902), the HIV positivity rate was 15.1% (136/902), and the coinfection rate of HIV and CA was 3.9% (35/902). In the MSM population, the knowledge of CA and HPV/CA vaccines was poor, but the acceptance rate of the CA vaccine was high (85.1%, 768/902). Data indicated that MSM who had a history of anal intercourse (OR = 1.9), had heard of CA (OR = 2.9), knew the treatments for CA (OR = 2.0), had heard of HPV vaccines/cervical cancer vaccines (OR = 1.9), and received education about CA (OR = 1.9) were associated with the intention to use CA vaccines. With current moderate levels of CA and HPV/CA vaccine awareness, more emphasis should be placed on improving education and other behavioral interventions for high-risk populations such as MSM in China.

Prevalence of co-infecting sexually transmitted infections (STIs) among patients newly diagnosed with anogenital warts is under-reported. Our objective is to determine the prevalence of six common STIs, Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Mycoplasma genitalium (MG), genital herpes (herpes simplex virus type 2 [HSV-2]), HIV, and syphilis for patients visiting a sexual health clinic in Guangzhou, China. Demographics, sexual health, and medical histories were collected at patient intake. Patients diagnosed with anogenital warts (N = 200) were invited to participate. We collected urine samples, and urethral, cervical, and rectal swabs to test for CT, NG, and MG, and blood samples for serological detection of HSV-2, syphilis, and HIV. Overall 49 (24.5%) had a co-infection (22.2% of men and 27.7% of women). All six STIs were observed among men: CT (6.8%), NG (3.4%), MG (5.1%), HIV (4.3%), HSV-2 (4.3%), and syphilis (1.7%). Women had fewer STIs, but at higher rates: CT (13.3%), MG (6.0%), and HSV-2 (8.4%). Individual men had up to two co-infections, while women had no more than one co-infection. Chlamydia was the most common STI. Patients aged 18–25 years (35.4%) had the highest prevalence. Although opportunistic screening is often applied for high-risk groups, expansion to patients with anogenital warts in all health-care settings would improve detection of problematic asymptomatic co-infections, thereby increasing China’s capacity to contribute toward global surveillance systems.

目的 探讨分析老年恶性皮肤肿瘤患者的临床特征.方法 收集2014年1月至2019年8月在南通大学附属医院住院治疗的恶性皮肤肿瘤患者的临床及病理资料.分析其中老年(≥60岁)恶性皮肤肿瘤患者的性别、年龄、组织学分类、病理分型及病变部位的特点,并与非老年(<60岁)恶性皮肤肿瘤患者进行对比.结果 265例老年及30例非老年恶性皮肤肿瘤患者分别纳入病例组及对照组.与非老年患者相比较,老年恶性皮肤肿瘤患者具有明显的自身临床特征,肿瘤组织学分类、病理分型及分布部位与非老年患者差异有统计学意义(均P<0.05).老年恶性皮肤肿瘤患者的组织学分类主要为表皮肿瘤(89.43％);病理分型主要为非黑色素瘤性恶性皮肤肿瘤(95.47％),其中又以鳞状细胞癌、基底细胞癌为主;主要发病部位为头面部(75.85％),其次为四肢(14.34％),再次为躯干与肛门生殖器(均为4.91％).不同病理亚型的老年恶性皮肤肿瘤患者之间的性别、年龄段及部位分布差异有统计学意义(均P<0.05).结论 老年恶性皮肤肿瘤患者的组织学分类、病理类型及分布部位均具有显著自身的临床特征.组织学分类主要为表皮肿瘤,主要病理亚型为鳞状细胞癌和基底细胞癌,好发于头面部,提示对于老年患者的头面部的新生肿物应及早干预.

目的:了解头面部皮肤肿瘤患者临床流行病学特征.方法:收集南通大学附属医院2014年1月-2019年住院治疗的头面部皮肤肿瘤患者的临床及病理资料.分析头面部皮肤肿瘤患者性别、年龄与病理分型特点;比较良恶性皮肤肿瘤的性别、年龄及病变部位分布差异.结果:共收集263例头面部皮肤肿瘤患者,其中恶性肿瘤201例(76.43％),癌前病变27例(10.27％),良性肿瘤35例(13.31％).恶性肿瘤中非黑色素瘤性恶性皮肤肿瘤199例,主要为鳞状细胞癌131例、基底细胞癌56例,年龄≥60岁者233例,男女比例为1∶1.3.恶性肿瘤及癌前病变均主要位于面颊区、额颞区及鼻及鼻旁区;良性肿瘤主要为头皮部、额颞区.良恶性肿瘤患者性别、年龄段及主要发病部位的差异均具统计学意义(P＜ 0.05或0.01).结论:头面部皮肤肿瘤多为恶性肿瘤,应及早干预年龄≥60岁且肿瘤分布于面颊区等易晒部位的女性患者.

目的:探讨尖锐湿疣(CA)患者的焦虑、抑郁状况,为制定CA综合治疗方案提供循证医学依据.方法:选择性病门诊的CA患者为研究对象.采用自行设计的调查问卷、自评焦虑量表(SAS)和自评抑郁量表(SDS)对患者焦虑和抑郁状况进行调查,并与中国常模对比,分析CA患者的心理状态与普通人群的差异,并分析相关影响因素.结果:共调查89例CA患者,SAS评分为(36.28±7.16)分,SDS评分为(39.00±9.74)分,总粗分均值均高于中国常模(U值分别为7.98、5.23,P值均＜0.01).出现焦虑24例(26.97％),抑郁36例(40.45％),程度多为轻度,同时有焦虑和抑郁者20例(占22.47％).CA患者出现焦虑的影响因素主要为性取向非异性恋,而低收入、使用成瘾性药物则为发生抑郁的主要影响因素.结论:CA患者中焦虑与抑郁发生率较高,宜在临床诊疗中采取心理干预措施.

BackgroundA high rectal and oropharyngeal sexually transmitted infection (STI) burden has been reported among men who have sex with men (MSM) in many regions, but little data exists on rectal and oropharyngeal STIs among MSM in China. The purpose of this study was to determine the prevalence of gonorrhea and chlamydia at different anatomic sites among MSM in Guangzhou, China.MethodsWe recruited a cross-sectional sample of MSM in one Chinese city and collected detailed information about socio-demographic characteristics and sexual behaviors. Men had urine, rectal, and pharyngeal swab samples tested for gonorrhea and chlamydia using nucleic acid amplification tests (NAAT). Univariate and multivariate logistic regressions were used to evaluate factors associated with gonorrhea and chlamydia. Among men without any STI symptoms, we also examined the prevalence of gonorrhea and chlamydia by anatomical site.ResultsWe enrolled 463 men between January 2015 and March 2017. A total of 58/463 (12.5%) of men had gonorrhea and 84/463 (18.1%) had chlamydia. MSM with gonorrhea were more likely to have been recruited from the STI clinic (OR 3.41, 95% CI 1.94-5.99), living with HIV (OR 2.41, 95% CI 1.18-4.92), diagnosed had STI co-infection (OR 2.55, 95% CI 1.39-4.69). MSM with chlamydia were more likely to be students (OR 1.8, 95% CI 0.99-3.39). Most gonorrhea (34/58, 59%) and chlamydia (64/84, 76%) infections were not associated with STI symptoms.ConclusionAsymptomatic gonorrhea and chlamydia infection were common in this sample of Chinese MSM. Further research is necessary to determine optimal STI screening programs.

We report the presence of the second human pegivirus (HPgV-2) in Guangdong and Sichuan Provinces in China. The prevalence of HPgV-2 in hepatitis C virus/HIV-1-co-infected persons who inject drugs was 12.9% in Guangdong and 15.9% in Sichuan. This population is at high risk for HPgV-2 infection.

患者,男,30岁. 主诉:包皮龟头红斑、糜烂1年余. 现病史:患者1年前无明显诱因出现包皮红斑,无明显自觉症状,未处理. 1年来,红斑面积逐渐增大并出现糜烂,少许浆液性渗出. 患者曾多次于外院就诊,诊断为"包皮龟头炎",外用抗真菌、抗细菌、激素类药膏,无明显疗效. 遂至我院门诊就诊. 患者起病以来精神、胃纳可、睡眠欠佳,大、小便正常,体重无明显改变.

Background. The epidemiology of HPV in men who have sex with men (MSM) in Guangzhou, China, had not been reported previously. Methods. HIV-infected and HIV-uninfected MSM were recruited from a Guangzhou-based MSM clinic in 2013. Sociodemographic characteristics and sexual behaviors were collected. An anal cytological sample was taken for HPV testing. Results. We recruited 79 HIV-infected and 85 HIV-uninfected MSM. The median age was 26 years in both groups. The positivities of anal HPV of any type (81.0% versus 48.2%), any high risk type (50.6% versus 27.1%), any low risk type (55.7% versus 31.8%), and any 9-valent vaccine type (74.7% versus 36.5%) were all significantly higher among HIV-infected compared to that among HIV-negative MSM (p for all < 0.05). The great majority of HPV-infected MSM were infected with 9-valent vaccine types (59 out of 64 HIV-infected and 31 out of 41 HIV-uninfected). Anal bacterial infections were associated with higher anal HPV positivity and greater number of anal HPV types. Conclusion. Sexually active MSM in Guangzhou, especially those infected with HIV, had high and multiple HPV detections. The majority of these cases were potentially preventable by HPV vaccine. Regular anal exams and early HPV vaccination are warranted in this population.

目的:了解类脂质渐进性坏死的临床特征,提高对本病的认识.方法:对8例确诊的类脂质渐进性坏死患者的临床资料进行相关分析.结果:类脂质渐进性坏死为好发于女性的慢性肉芽肿性皮肤病,临床表现为胫前紫红色至红褐色斑块,边缘隆起,中央为黄褐色萎缩伴毛细血管扩张,常伴发糖尿病.病理特征为栅栏状肉芽肿性皮炎,呈层状外观.结论:类脂质渐进性坏死临床较罕见,加强对该病的认识,有助于减少误诊,及早明确诊断.

Introduction High prevalence of anorectal Chlamydia trachomatis (CT) and Neisseria gonorrhoea (NG) have been reported among men who have sex with men (MSM) in many settings. Regular rectal CT and NG screening have been recommended in the United States and other countries, but little data exists on rectal and oropharyngeal CT and NG among Chinese MSM. The aim of this study was to determine the prevalence of CT and NG in different anatomic sites among Chinese MSM. Methods Participants were enrolled in a free sexually transmitted diseases (STD) screening program if they self-reported MSM status and had never previously received rectal or oral STD screening. Exclusion criteria included taking antibiotics in the past month. Sociodemographic information, sexual history, and medical history data were collected before taking any samples. Samples were obtained from the rectum, oropharynx, and urethra according to sexual exposure sites. Nucleic acid amplification tests (NAAT) were used to detect CT and NG. Results 380 MSM were enrolled between January 2015 and December 2016. The mean age of participants was 29.79±9.10 years, and 18.2% (69/380) were married. Anorectal CT was detected in 18.6% (44/237) of samples and anorectal NG in 10.1% (24/237). Urethral CT was detected in 12.3% (27/219) of samples, and urethral NG in 7.8% (17/219) of samples as well. Of 255 oropharyngeal samples, CT was detected in only 2.0% (5/255) and NG in 5.1% (13/255). Two participants (1.5%,2/132) were infected with CT and 1 (0.8%, 1/132) with NG at both rectal and urethral sites, three participants (1.4%,3/208) were infected with CT and 8 (3.9%, 8/208) with NG at both rectal and oropharyngeal anatomic sites. None participants were infected at three anatomic sites. Conclusion Our findings show that the prevalence of chlamydial and gonococcal infections are high among Chinese MSM, efforts to control CT and NG infection among this key population is of significant public health importance.