(1,3-Dimethyl-5-nitro-5-hexahydropyrimidinyl)propionic acid methyl ester (I) was obtained with a 83% yield using a Mannich type reaction of 4-nitrobutanoic acid methyl ester with excess formalin and methylamine. It was found that compound I possesses low toxicity and shows antiarrhythmic activity on models of arrhythmia induced by intravenous injections of calcium chloride and aconitine in rats.

The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3O,28O-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, antiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids.

Взаимодействием метилового эфира 4-нитробутановой кислоты с избытком формалина и метиламина в условиях реакции Манниха синтезирован метиловый эфир (1,3-диметил-5-нитро-5-гексагидропиримидинил)пропионовой кислоты (I) с выходом 83 %. Показано, что соединение I обладает низкой токсичностью и проявляет антиаритмическую активность на моделях аритмий, вызванных внутривенным введением аконитина и хлорида кальция крысам.

Exo-2-amino-exo-3-aminomethylbicyclo[2.2.1]heptane (I) and 5-amino-exo-3-azatricyclo[5.2.1.02,6]decan-4-one (II) were synthesized and characterized with respect to antiarrhythmic activity. Compound II exhibited antiarrhythmic activity with ED50 = 0.28 and 0.33 mg/kg on the aconitine and calcium chloride models of arrhythmia, respectively. Compound I did not show antiarrhythmic activity and exhibited acute toxicity corresponding to LD50 = 450 mg/kg.

Exo -2-amino- exo -3-aminomethylbicyclo[2.2.1]heptane (I) and 5-amino- exo -3-azatricyclo[5.2.1.0 2,6 ]decan-4-one (II) were synthesized and characterized with respect to antiarrhythmic activity. Compound II exhibited antiarrhythmic activity with ED 50 = 0.28 and 0.33 mg/kg on the aconitine and calcium chloride models of arrhythmia, respectively. Compound I did not show antiarrhythmic activity and had an acute toxicity corresponding to LD 50 = 450 mg/kg.

Взаимодействием моноацетатов бетулина, бетулиновой кислоты и аллобетулина с янтарным и фталевым ангидридами или хлорангидридом никотиновой кислоты синтезированы новые тритерпеновые гемисукцинаты, гемифталаты и никотинаты с выходами 52 - 95 %. Среди исследованных соединений наиболее выраженной противовоспалительной активностью обладал 28-O-гемифталат 3-O-ацетилбетулина, его действие было аналогично влиянию ортофена. Выраженный антиульцерогенный эффект, аналогичный действию карбеноксолона, показал 28-O-гемисукцинат 3-O-ацетилбетулина.

ChemInformVolume 35, Issue 44 Heterocyclic Compounds Synthesis and Antiarrhythmic Activity of the Hydrochlorides of N-(2-Hydroxyethyl)cytisine (III) and 3-(2-Hydroxyethyl)-1,5-dinitro-3-azabicyclo[3.3.1]non-6-ene (VII). R. Yu Khisamutdinova, R. Yu Khisamutdinova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorN. N. Yarmukhamedov, N. N. Yarmukhamedov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorS. F. Gabdrakhmanova, S. F. Gabdrakhmanova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. T. Karachurina, L. T. Karachurina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorT. A. Sapozhnikova, T. A. Sapozhnikova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorN. Z. Baibulatova, N. Z. Baibulatova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorN. Zh. Baschenko, N. Zh. Baschenko Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorF. S. Zarudii, F. S. Zarudii Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this author R. Yu Khisamutdinova, R. Yu Khisamutdinova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorN. N. Yarmukhamedov, N. N. Yarmukhamedov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorS. F. Gabdrakhmanova, S. F. Gabdrakhmanova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. T. Karachurina, L. T. Karachurina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorT. A. Sapozhnikova, T. A. Sapozhnikova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorN. Z. Baibulatova, N. Z. Baibulatova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorN. Zh. Baschenko, N. Zh. Baschenko Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorF. S. Zarudii, F. S. Zarudii Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this author First published: 12 October 2004 https://doi.org/10.1002/chin.200444170Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume35, Issue44November 2, 2004 RelatedInformation

AbstractFor Abstract see ChemInform Abstract in Full Text.

ChemInformVolume 35, Issue 37 Natural Products Synthesis and Pharmacological Activity of Acylated Oximes of Betulonic Acid and 28-Oxo-allobetulone. O. B. Flekhter, O. B. Flekhter Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorE. I. Boreko, E. I. Boreko Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. R. Nigmatullina, L. R. Nigmatullina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorN. I. Pavlova, N. I. Pavlova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorN. I. Medvedeva, N. I. Medvedeva Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorS. N. Nikolaeva, S. N. Nikolaeva Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorE. V. Tret'yakova, E. V. Tret'yakova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorO. V. Savinova, O. V. Savinova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. A. Baltina, L. A. Baltina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. T. Karachurina, L. T. Karachurina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authoret al. et al., et al. et al. Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this author O. B. Flekhter, O. B. Flekhter Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorE. I. Boreko, E. I. Boreko Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. R. Nigmatullina, L. R. Nigmatullina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorN. I. Pavlova, N. I. Pavlova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorN. I. Medvedeva, N. I. Medvedeva Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorS. N. Nikolaeva, S. N. Nikolaeva Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorE. V. Tret'yakova, E. V. Tret'yakova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorO. V. Savinova, O. V. Savinova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. A. Baltina, L. A. Baltina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. T. Karachurina, L. T. Karachurina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authoret al. et al., et al. et al. Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this author First published: 19 August 2004 https://doi.org/10.1002/chin.200437180Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References O. B. Flekhter, E. I. Boreko, L. R. Nigmatullina, N. I. Pavlova, N. I. Medvedeva, S. N. Nikolaeva, E. V. Tret'yakova, O. V. Savinova, L. A. Baltina, L. T. Karachurina, et al. et al., Synthesis and Pharmacological Activity of Acylated Oximes of Betulonic Acid and 28-Oxo-allobetulone., Khim.-Farm. Zh., 2004, 38, 31–34. Google Scholar Volume35, Issue37September 14, 2004 ReferencesRelatedInformation

ChemInformVolume 34, Issue 4 Natural Products Preparation of Betulinic Acids from Betulin Extract. Antiviral and Antiulcer Activity of Some Related Terpenoids. O. B. Flekhter, O. B. Flekhter Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. R. Nigmatullina, L. R. Nigmatullina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. A. Baltina, L. A. Baltina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. T. Karachurina, L. T. Karachurina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorF. Z. Galin, F. Z. Galin Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorF. S. Zarudii, F. S. Zarudii Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. A. Tolstikov, G. A. Tolstikov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorE. I. Boreko, E. I. Boreko Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorN. I. Pavlova, N. I. Pavlova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorS. N. Nikolaeva, S. N. Nikolaeva Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authoret al. et al., et al. et al. Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this author O. B. Flekhter, O. B. Flekhter Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. R. Nigmatullina, L. R. Nigmatullina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. A. Baltina, L. A. Baltina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. T. Karachurina, L. T. Karachurina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorF. Z. Galin, F. Z. Galin Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorF. S. Zarudii, F. S. Zarudii Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. A. Tolstikov, G. A. Tolstikov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorE. I. Boreko, E. I. Boreko Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorN. I. Pavlova, N. I. Pavlova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorS. N. Nikolaeva, S. N. Nikolaeva Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authoret al. et al., et al. et al. Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this author First published: 05 March 2003 https://doi.org/10.1002/chin.200304177Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume34, Issue4January 28, 2003 RelatedInformation

AbstractFor Abstract see ChemInform Abstract in Full Text.

ChemInformVolume 34, Issue 4 Natural Products Antiinflammatory Activity of Quinopimaric Acids and Synthesis of Amides of These Acids. O. B. Flekhter, O. B. Flekhter Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorE. V. Tret'yakova, E. V. Tret'yakova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorF. Z. Galin, F. Z. Galin Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. T. Karachurina, L. T. Karachurina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. V. Spirikhin, L. V. Spirikhin Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorF. S. Zarudii, F. S. Zarudii Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. A. Tolstikov, G. A. Tolstikov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this author O. B. Flekhter, O. B. Flekhter Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorE. V. Tret'yakova, E. V. Tret'yakova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorF. Z. Galin, F. Z. Galin Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. T. Karachurina, L. T. Karachurina Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. V. Spirikhin, L. V. Spirikhin Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorF. S. Zarudii, F. S. Zarudii Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. A. Tolstikov, G. A. Tolstikov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this author First published: 05 March 2003 https://doi.org/10.1002/chin.200304176Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume34, Issue4January 28, 2003 RelatedInformation

11-Deoxymisoprostol showed gastroprotector activity on the acute models of ulcers induced by acetylsalicylic acid and ethanol and produced curative effect on the chronic ulceration model induced by acetic acid. The positive effect is manifested by a decrease in the number of destructions and in the total area of chronic damage in the mucous membrane of the stomach. In addition, 11-deoxymisoprostol showed antiphlogistic activity on the acute edema models induced by carrageenan and formalin, by decreasing the model foot edema growth in experimental animals. The drug also decreased the level of lipid peroxidation in the rat blood serum on the background of acute ethanol ulceration.

The results of pharmacological tests showed that betulin bishemiphthalate possesses hepatoprotector, antioxidant, and immunotropic properties. Administered in combination with hydroxymethyluracil, that betulin bishemiphthalate prevented the loss of experimental animals upon irradiation.

Narrow fractions of polyprenols isolated from birch (C35-C45) and fir (C70-C85) greenery were used to prepare esters of polyprenylacetic acids that exhibited high anti-ulcer activity comparable and in several instances exceeding that of the known anti-ulcer preparation omeprazole (omez).