Oral mucositis (OM) is a common complication in hematopoietic stem cell transplantation (HSCT). This study aimed to analyze OM characteristics, risk factors, and preventive strategies. Medical records of 551 patients undergoing HSCT from June 2019 to June 2022 were retrospectively reviewed. OM incidence, clinical features, and associated risk factors were analyzed. 128 patients (23.2

ObjectiveThis study aimed to investigate the incidence, treatment status, and impact position of impacted third molars (ITM) and their effects on patients undergoing hematopoietic stem cell transplantation (HSCT).MethodsA retrospective analysis was conducted on the medical records of 454 patients who underwent HSCT, out of which 188 patients had ITM. The presence of ITM and its association with transplant-related infections and complications were recorded and analyzed.ResultsPatients with ITM were significantly younger. The number of mandibular ITM was notably higher than maxillary ones, and the risk of pericoronitis in mandibular ITM was significantly higher than in maxillary ones. Out of 311 ITM in 188 patients, 25 were extracted before transplantation. The proportion of extraction and treatment for ITM with pericoronitis or caries was significantly higher than that for ITM without such problems. Moreover, patients with a history of pre-transplant pericoronitis had a significantly higher probability of developing tooth-related complications during transplantation, caused by pericoronitis in ITM compared to patients without a history of pericoronitis.ConclusionPre-transplant examination and treatment of ITM are essential, especially in cases with a history of pericoronitis. Oral intervention can significantly reduce the occurrence of tooth-related complications related to ITM during transplantation.

PURPOSE:To investigate the short-term and long-term effects of all-ceramic onlay on restoration of premolars and its influence on dental function.METHODS:Ninety-five premolars receiving root canal treatment in People's Hospital of Peking University from January 2017 to January 2018 were enrolled, and randomly divided into two groups based on different repairing methods. Patients in the control group (n=47) received full crown restoration, while patients in the experimental group(n=48) received all-ceramic onlay restoration. The success, survival and failure rates of the teeth were compared. The United States Public Health Service(USPHS) and occlusal function of the prosthesis were compared 6, 12 and 36 months after treatment. The data were processed using SPSS 19.0 software package.RESULTS:The success and survival rate of the experimental group were higher than those of the control group, but without significant difference (P＞0.05). The morphology, marginal integrity, marginal coloration, surface texture, secondary caries, gingival health and proximal contacts showed no significant difference between the two groups 12 months after treatment(P＞0.05). Thirty-six months after treatment, the marginal integrity, marginal coloration and surface texture showed no significant difference between the two groups (P＞0.05), while the morphology, secondary caries, gingival health and proximal contacts were significantly better in the experimental group than in the control group (P＜0.05). The occlusal function between the affected side and contralateral side of both groups showed no significant difference 6, 12 and 36 months after treatment(P＞0.05).CONCLUSIONS:All-ceramic onlay restoration of premolars has high success and survival rate, and good short-term and long-term restoration effect, which is beneficial to improve the occlusal function of the affected teeth.

背景:引导骨再生技术是解决种植区域骨缺损的有效方法,但是选择何种骨替代材料尚存有一定争议.目的:探讨不同材料应用于即刻种植下颌后牙区周围骨缺损的治疗效果.方法:选择2016年5月至2019年1月北京大学人民医院口腔科收治的138例下颌后牙区周围骨缺损患者,采用随机数字表法分3组,在即刻种植手术中分别植入Bio-Oss、Bone Plant、PerioGlas骨替代材料,每组46例.术后定期随访,比较3组种植体成功率、边缘骨水平、颊舌侧骨板宽度、垂直高度、牙周指标及患者满意度.研究获得北京大学人民医院伦理委员会批准,批准号:[伦审(R20160412)].结果 与结论:①术后12个月时,Bone Plant组种植体成功率高于PerioGlas组(P<0.05),其余组间两两比较差异无显著性意义(P>0.05);②Bio-Oss组、Bone Plant组术后6,12个月的边缘骨水平低于PerioGlas组(P<0.05),颊舌侧骨板宽度、垂直高度高于PerioGlas组(P<0.05);Bone Plant组术后6,12个月的垂直高度高于Bio-Oss组(P<0.05),两组间边缘骨水平、颊舌侧骨板宽度比较差异无显著性意义(P>0.05);③术后6,12个月时,3组间牙周探诊深度、探诊出血阳性率、牙龈指数比较差异均无显著性意义(P>0.05);④3组间患者满意度比较差异无显著性意义(P>0.05);⑤结果表明,Bio-Oss、PerioGlas、Bone Plant均具有一定诱导骨再生和成骨效果,Bio-Oss吸收慢但可维持一定骨板宽度,Bone Plant维持骨缺损垂直高度和空间稳定效果好,是较为理想的骨替代材料.

PURPOSE:To investigate the effect of dental varnish containing fluoride either with casein phosphopeptide-amorphous calcium phosphate(CPP-ACP) or bioglass on root caries.METHODS:The active roots collected in Peking University People's Hospital from April 2017 to October 2018 were randomly divided into group A, group B, group C, and group D, each with 18 teeth. All groups received toothbrushing containing fluoride, in addition, group B received another 5% sodium fluoride, group C added 5% sodium fluoride + CPP-ACP, and group D added 5% sodium fluoride + bioglass. The severity, surface roughness and mineral concentration of root caries before and after brushing were observed. SPSS 23.0 software package was used to determine the correlation between root severity and surface roughness.RESULTS:After 50 days of brushing, the hardness of group B, C and D was significantly improved (P<0.05), and was significantly better than that of group A (P<0.05). The hardness was the highest in group D after 50 days of brushing, followed by group C and B, with significant difference(P<0.05). The surface roughness scores of group B and C were significantly higher than those of group A and D after 7 days of brushing(P<0.05). The surface roughness scores of group B were significantly higher than those of group A, C and D after 14 days of brushing(P<0.05). The surface roughness scores of group D were significantly higher than those of group B and C after 50 days of brushing(P<0.05). The severity score of root caries in group A was negatively correlated with surface roughness (P<0.05). The mineral concentration of each group was increased 50 days after brushing (P<0.05).CONCLUSIONS:Application of dental varnish containing fluoride either with CPP-ACP or bioglass can effectively prevent root caries. Compared with CPP-ACP, bioglass is more stable, and can effectively improve the mineral concentration on tooth surface.

目的:2型糖尿病(diabetes mellitus,DM)患者代谢变化对炎症因子的影响及其在慢性牙周炎(chronic pe-riodontitis,CP)和种植体周围炎(peri-implantitis,P-IM)的基因表达.方法:选择2016年6月～2018年12月我院口腔种植科治疗的143例牙周病患者作为研究对象,并选择同期牙周健康者24例作为对照组.比较牙周病暴露因素、临床指标、牙周及种植体周围肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-8(interleukin-8,IL-8)等炎症因子mRNA的表达及各炎症因子的相关性分析.结果:与对照组比较,年龄大、空腹血糖水平高、糖化血红蛋白(glycosylated hemoglobin,HbA1c)水平高及有吸烟史为CP及P-IM疾病暴露因素;牙周病患者菌斑指数(plaque index,PLI)、牙龈指数(gingival index,GI)、探诊出血(bleeding on pro-bing,BOP)指数、探诊深度(probing depth,PD)、附着丧失(attachment loss,AL)及牙槽骨丧失(bone loss,BL)百分比均高于对照组;血糖控制不良患者GI、PD、AL及BL均明显高于血糖控制良好患者;合并DM患者中TNF-α在P-IM患者中表达更明显,IL-6及IL-8在CP患者中表达更明显;TNF-α、IL-6及IL-8在血糖控制不良患者中处于高表达状态;TNF-α、IL-6及IL-8与PLI、GI、BOP、PD、AL及BL呈正相关(P<0.05).结论:不合并DM患者中,P-IM中炎症反应较CP严重;合并DM患者可通过影响体内炎症因子的表达,加重CP及P-IM疾病的进展,且DM患者体内高血糖状态对GI、PD、AL及BL影响较大,治疗上应积极控制血糖.

为了探讨口腔种植修复患者血清CRP及尿DPd的变化及与种植体周围炎的相关性,本研究选择本院收治的人工种植修复患者100例作为研究对象,根据是否发生种植体周围炎分为种植修复组(n=83)和种植体周围炎组(n=17).选择同期健康体检者作为对照组(n=30).分别监测不同时间段的各组受试者的血清C反应蛋白(CRP)及尿脱氧吡啶啉(DPd)水平.研究结果表明:种植修复组患者在术后1周时血清CRP水平显著升高(p＜0.05),然后在术后1个月呈现下降趋势,术后3个月时的血清CRP水平与术前无显著差异(p＞0.05).种植修复组患者的尿DPd水平在术后1周后显著升高(p＜0.05),并且在术后1个月达到最高,此后至3个月时一直保持较高水平.种植体周围炎组患者治疗前的血清CRP和尿DPd水平均显著高于健康对照组(p＜0.05).治疗1周后,患者血清CRP水平较治疗前显著下降.然而,种植体周围炎患者的尿DPd水平在整个治疗过程中始终保持较高水平(p＞0.05).种植体周围炎患者的血清CRP和尿DPd水平在甲硝唑治疗前显著高于未感染者和健康体检者(p＜0.05).两组患者的血清CRP和尿DPd水平呈显著正相关(p＜0.05).初步的研究结论表明:种植体周围炎可导致口腔种植修复患者的血清CRP和尿DPd浓度显著升高,并且CRP和DPd参与牙槽骨的吸收转化.

牙周再生定义为完全恢复失去的牙周组织及其原始结构和功能.富生长因子血浆(PRGF)是促进丢失的牙周组织恢复的生长因子浓缩悬浮液.为了评估PRGF联合引导组织再生(GTR)治疗术与仅GTR治疗术在治疗慢性牙周炎患者牙周骨内缺损的临床效果,42处牙周骨缺损的慢性牙周炎患者(n=14)随机分配到试验组(PRGF+GTR)和对照组(仅GTR).临床和射线检测结果评估术前和术后6个月的:牙龈指数(GI)、牙周探诊深度(PD)、临床附着水平(CAL)、缺损深度(Radiological defect depth)以及骨充填(Bone fill).术前和术后6个月的临床参数显示对照组平均牙周探诊深度降低(3.37±1.62) mm (p＜0.001),试验组平均牙周探诊深度降低(4.13±1.59) mm (p＜0.001).对照组(5.42±1.99)和试验组(5.99±1.77)临床附着水平平均变化以及牙龈指数平均变化(对照组(1.89±0.32)和试验组(1.68±0.58))有显著性差异(p＜0.001).比较各组间临床参数,无统计学显著差异.对照组和试验组平均骨缺损充填为(1.06±0.81)和(1.0±0.97),该差异无统计学意义.6个月的随访中,PRGF+GTR联合治疗以及单独GTR治疗对慢性牙周炎患者的临床附着水平和缺损深度有显著改善作用.PRGF+GTR联合治疗中,PRGF对慢性牙周炎患者的临床附着水平和缺损深度无累加效应.

Objective To investigate the state of early marginal bone resorption of different implants in posterior-tooth areas and to explore the related influencing factors. Methods The clinical data were retrospectively analyzed in 96 patients undergoing posterior implant restoration with bone tissue level implants (bone tissue level implant group) and 104 patients with soft tissue level implants (soft tissue level implant group) from Feb. 2013 to Feb. 2016. All patients underwent X-ray examination immediately and at 12 weeks after implantation. With the changes of implants marginal alveolar bone heights as the evaluation basis of early marginal bone resorption, the early mesial and distal marginal bone losses were compared between the two groups. The differences in periodontal health indexes (plaque index [PLI], bleeding index [SBI] and probing depth [PD]) and marginal fitness of implants at 12 weeks after implantation were recorded and analyzed. Pain score (numerical rating scale [NRS]) within 4 weeks after implantation were compared between the two groups. The 200 patients were divided into excellent group (bone resorption<1.5 mm) and poor group (bone absorption≥1.5 mm) according to the state of early marginal bone loss. The general data, including age, gender, location of missed teeth, local health of implant, implant diameter, implant length, implanting methods, and smoking, were compared between the two groups. The independent risk factors of early marginal bone resorption of implants were analyzed by logistic regression analysis. Results There were no significant differences in early mesial or distal marginal bone losses, periodontal health indexes (PLI,SBI, or PD) or grade A rate of marginal fitness of implants between the bone tissue level implant group and soft tissue level implant group at 12 weeks after implantation (all P>0.05); there was no significant difference in NRS score between the two groups within 4 weeks after implantation (P>0.05). The differences in age, gender, location of missed teeth, implant diameter, implant length and other general data were not statistically significant between the excellent group (n=148) and the poor group (n=52, all P>0.05). Logistic regression analysis showed that non-embedded implanting, poor local health environment of implant and smoking were independent risk factors of early implant marginal bone resorption (all P<0.05). Conclusion Bone tissue level implant and soft tissue level implant have similar early marginal bone resorption and high value in posterior-teeth implant restoration. Non-embedded implanting, poor local health environment of implant and smoking are closely related to early marginal bone resorption and need to be taken into account.

OBJECTIVE:To estimate the bond strength between different resin composite interfaces, and to evaluate the effect of saliva contamination and management with the contamination on the bond strength.METHODS:Two commercial resin composites containing different types of fillers (AP-X: barium-glass; P60: quartz) were tested in this study. The basic composite blocks were made of AP-X. After wet-ground flatted, the experimental groups were divided into three groups according to the surface treatment: (1)Direct bonding group: the bonding surface was rinsed with distilled water for 20 s, then dried with oil-free air for 20 s; (2)Saliva contamination group: the bonding surface was bathed in saliva for 30 min, then distilled water was rinsed for 20 s and dried with oil-free air for 20 s; (3)Saliva contamination and 75% ethanol wiping group: bonding surface bathed in saliva for 30 min, then wipe the surface with 75% ethanol, distilled water rinse for 20 s and dry with oil-free air for 20 s; The control group was made of the basic composite bulks of AP-X directly bonding with composite P60. Cut each resin block into 1 mm×1 mm×14 mm sticks, observing the micro-structures and detecting the micro-tensile strength of the resin composite interfaces. The bonding strength was measured using micro-tensile tester, then calculated and statistically analyzed by one-way ANOVA.RESULTS:Scanning electronic microscope observation revealed that the control group as well as the direct bonding subgroups, two different resin tags were in good contact with each other. The saliva contamination subgroups had lots of gaps or craters, indicating saliva might have been trapped in the composite buildup and wiping the surface with 75% ethanol had no effect. The micro-tensile bond strength of the control group was (84.07±1.57) MPa and significantly higher than all the other 3 experimental subgroups(P<0.001). In experimental groups, the micro-tensile strength of 3 subgroups was (76.08±2.42) MPa, (70.98±2.33) MPa and (71.08±2.33) MPa, respectively. The saliva contamination subgroup was significant lower than the direct bonding subgroup(P<0.001), but no statistical significance with the ethanol wiping subgroup(P=0.893).CONCLUSION:The bond strength of inner polymerization of resin-resin was greater, but decreased after resin composites interfacial bonding. Saliva contamination reduced the tensile bond strength between resin composites surface, wiping the surface with 75% ethanol had no effect.

BACKGROUND:The post space cleaning using ultrasonic file can improve the bonding strength of fiber postscemented with the self-adhesive resin cement, but the effect on apical sealing ability is stil unclear. OBJECTIVE:To evaluate the effect of the post space cleaning using ultrasonic file on apical microleakage fol owing treatment with two kinds of root canal sealers at two different residual lengths of root canal fil ing. METHODS:Eighty extracted human maxil ary anterior teeth with single-rooted canal were selected, and equivalently randomized into groups A and B (n=40 per group), fol owed by fil ed with Cortisomol or AH-plus, respectively. Groups A and B were randomly subdivided into four groups according to the residual length of root canal fil ing and with or without ultrasonic cleaning (n=10 per group):A1, B1 groups:residual 5 mm, no ultrasonic cleaning;A2, B2 groups:residual 5 mm, ultrasonic cleaning;A3, B3 groups:residual 3 mm, no ultrasonic cleaning;A4, B4 groups:residual 3 mm, ultrasonic cleaning. Subsequently, the apical microleakage was measured using dye method and transparent specimen technique under stereomicroscope. RESULTS AND CONCLUSION:The apical microleakage of each group was as fol ows:A1 (0.73±0.21) mm, A2 (1.37±0.55) mm, A3 (1.18±0.36) mm, A4 (2.05±0.62) mm, B1 (0.34±0.18) mm, B2 (0.47±0.14) mm, B3 (0.59±0.23) mm, B4 (1.39±0.50) mm. The three-factor analysis of variance revealed that the ultrasonic cleaning, root canal sealers and residual length of root canal fil ing al had a significant effects on the apical microleakage (P<0.05), and there were significant differences in the apical microleakage between groups A1 and A2, groups A3 and A4, groups B3 and B4, groups A2 and A4, groups B2 and B4 (P<0.05). These results indicate that the ultrasonic cleaning increases the apical microleakage fol owing the use of Cortisomol at 5 and 3 mm residual length, as wel as the use of AH-Plus at 3 mm residual length. Moreover, for the same root canal sealer, the longer residual length of root canal fil ing indicates, the less microleakage after ultrasonic cleaning.

Objective To observe the effects of Er-YAG and surgical resection in the treatment of oral cav-ity mucous cyst. Methods A total of 63 patients with oral cavity mucous cyst ,selected in our hospital from March 2013 to May 2014,were divided into control group(n=31)and experimental group(n=32)based on dif-ferent therapies. The oral cavity mucous cysts in the experimental group and the control group were treated with Er-YAG and surgical resection ,respectively. The two groups were compared in terms of therapeutic effect. Results The cure rate in the two groups had no significant difference (P>0.05). The operation time in the experiment group was significantly shorter than the control group(P<0.05). In the experiment group,the incidence of intra-operative blood loss,postoperative edema and postoperative scarring were significantly lower than those of the con-trol group(P<0.05),but the two-year recurrence rate in the two groups had no significant difference(P>0.05). The SAS scores had no significant difference between the two groups at 1 week after operation (P > 0.05),but they were significantly higher in the experiment group than in the control group before operation and 3 days after op-eration(P < 0.05). In HAD emotional determination,the numbers of patients who had the manifestation of anxi-ety and depression in the experiment group were smaller than control group before operation and 3 days after opera-tion(P<0.05),but there was no significantly difference between the two groups at 1 week after operation(P >0.05). Conclusions The curative effect of Er-YAG in the treatment of oral mucous cysts is close to that by the conventional surgery,but the former is advantageous for easier operation,less postoperative complications and alle-viation of patientspsychology pressure,worthy of clinical spreading.

PURPOSE:The plant-derived natural product 4-O-methylhonokiol (MH) has been reported to possess tremendous pharmacological potential ranging from neuroprotection to anticancer activity. However, the anticancer activity of MH in oral squamous cell carcinoma (OSCC) cells has not been evaluated. In the present study, MH was evaluated for its anticancer activity against OSSC PE/CA-PJ41 cells and the possible underlying mechanism was determined.METHODS:Cell cytotoxicity was evaluated by colorimetrybased MTT assay while the effects on cell cycle phase distribution were assessed by flow cytometry. Effects of MH on reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP) were evaluated by flow cytometry. Western blot assay was finally utilized to study the effects of MH on key cancer and apoptosis-linked proteins including Bax and Bcl-2.RESULTS:MH induced cytotoxicity in OSCC PE/CA-PJ41 cells with an observed IC50 of 1.25 μM. It also caused significant increase in the production of ROS and disrupted the MMP in a dose-dependent manner. The reduction in MMP favored mitochondrial apoptotic pathway which was further confirmed by determining the expression of Bax and Bcl-2. It was observed that MH downregulated the expression of Bax and upregulated the expression of MMP, ultimately leading to apoptosis of OSSC PE/CA-PJ41 cells. Additionally, MH also caused G2/M cell cycle arrest in a dose-dependent manner.CONCLUSION:Taken together, our results indicate that 4-Omethylhonokiol may prove a potential natural anticancer molecule against human oral carcinoma cells.

OBJECTIVE To determine the expression profile and potential roles of CD24 in oral squamous cell carcinoma and explore the values of CD24 function as a potential target of clinical therapy. METHODS Semi-quantitative immunohistochemistry was used to construct the expression profile of CD24 in 78 human oral tissues and 59 Hamster buccal pouch tissues. Real-time RT-PCR and Western blot were used to analyze the CD24 expression levels in oral DOK4 cells, oral cancer CAL-27 and WSU-HN6 cells. Then these two cancer cell lines were selected to evaluate the effect of all-trans retinoic acid (ATRA) and CD24 antibody on CD24 expression, and the proliferation and tumorsphere formation capacity of these two cell lines. RESULTS CD24 expression was found significantly elevated in both human and animal tissues compared with normal and benign tissues (P<0.05), as well as in oral cancer CAL-27 and WSU-HN6 cells compared with DOK cells (P<0.05). CAL-27 and WSU-HN6 cells possess increased proliferative and specific tumorsphere formation capability compared with DOK cells (P<0.05). Both ATRA and CD24 antibody were able to effectively inhibit the proliferation and tumorsphere formation of CAL-27 and WSU-HN6 cells (P<0.05). Among them ATRA at least involved partially in the proliferation by down-regulating the CD24 expression (P<0.05), while CD24 antibody blocking had no effect on the CD24 expression. CONCLUSION CD24 was upregulated in oral cancer and functioned as a potential factor that promoted the proliferation and tumorsphere formation of CAL-27 and WSU-HN6 cells. Both ATRA and CD24 antibody might effectively inhibit the proliferation and tumorsphere formation of CAL-27 and WSU-HN6 cells and function as a potential therapy target.

Objective: To investigate the specific growth factor and its content in different preparation conditions of PRF,CGF,qualitative analysis of both macroscopic properties and microstructure characteristics,provide a theoretical basis for the clinical application of PRF and CGF.Methods:Eight subjects by PRF and CGF centrifuge vacuum negative pressure producing PRF and CGF; with anticoagulant glass vacuum tube negative pressure collecting whole blood was taken as the control group. The application of enzyme linked immunosorbent assay (ELISA) for each sample in the growth factor PDGF-BB,TGF- β1,BMP2 qualitative and quantitative microplate detection.Results:(1) Observed in PRF and CGF samples:there are some differences in the appearance of the eye between the groups.(2) To observe PRF and CGF sample random sampling under light microscope and electron microscope,fibrin structure had no obvious difference.(3) Except the control group,A,B,C,D group were detected PDGF-BB and TGF-β1 groups,BMP-2 were not detected.Conclusion:Four different centrifugation conditions of preparation of PRF and CGF in:(1) were observed in a large number of enrichment of platelet and leukocyte; (2) the basic physical characteristics are similar,the determination of some growth factor content existence difference,the results of this experiment will help to guide the clinical application.

BACKGROUND:The bonding interface of resin cements with dentin is unstables, therefore, improvement on the bonding strength is of great significance. OBJECTIVE:To evaluate the effects of different pretreatments to post space on bonding strength of the self-adhesive resin cement EmbraceCoreTM Resin Cement to fiber posts after phosphoric acid etching or self-etching. METHODS:Twenty-five human mandible canines or premolars with single-rooted canal were selected. After conventional root canal treatment and post space preparation, they were randomly divided into five groups (n=5 per group):group I (control group):0.9%normal saline irrigation;group II:etching with 35%phosphoric acid for 15 seconds;group III:self-etching with CLEARFILTM SE BOND binder for 20 seconds;group IV:etching with 35%phosphoric acid for 15 seconds and bonding with single bong 2;group V:self-etching with CLEARFILTM SE BOND binder for 20 seconds and bonding with CLEARFILTM SE BOND binder. Fiber posts were edusing self-adhesive resin cement EmbraceCoreTM Resin Cement. The thin-slice push-out test was performed to record the bonding strengths, and the failure modes of fiber posts were observed by stereomicroscope. RESULTS AND CONCLUSION:The bond strength of groups I-V were as fol ows:(8.66±2.43), (7.05±3.0), (7.37±2.83), (9.88±2.9), and (10.04±2.86) MPa. Groups II, IV and V showed significantly different bond strength from the group I (P<0.05), but there were no significant differences between groups III and I (P>0.05). The main failure models in the groups I, II and III were A1 and A2, and less B1 and B2 appeared. The failure modes in the groups IV and V also focused on the A1 and A2, but B1 and B2 increased gradual y. These results indicate that neither the pretreatments by phosphoric acid etching nor by self-etching in root canal dentin can improve the bonding strength of EmbraceCoreTM Resin Cement to fiber posts, but the use of binder relative to phosphoric acid etching or self-ctching is helpful.

目的 开发一种应用在上颌窦内提升术中的黏膜支架,维持上颌窦内提升空间,降低黏膜破裂风险并使种植体根端成骨的形态趋于完善.方法 实验用小型猪一头,全麻下拔除双侧第一第二上磨牙,造成缺牙状态.2个月后随机选取一侧上颌进行上颌窦内提升并植入自主研发上颌窦黏膜支架,同期植入骨粉及种植体,对侧上颌行常规上颌窦内提升术同期植入骨粉及种植体.术后即刻拍CBCT评价支架植入情况及上颌窦内提升效果.结果 CBCT显示实验侧上颌窦黏膜支架位于种植体尖端正上方,呈半球状撑开,骨粉均匀分布于其内部,种植体四周及正上方均匀包绕骨粉.对照侧骨粉分布不均匀,偏离种植体尖端中心,大部分位于种植体尖端一侧,另一侧及种植体正上方骨粉量较少.结论 上颌窦内提升黏膜支架能够起到一定的维持提升空间、保护上颌窦黏膜、稳定和限制骨移植物位置和分布、改善内提升效果的作用.

Objective:To explore the relationship between the scores of anxiety,depression and the salivary levels of dehydydroepiandrosterone(DHEA)in the patients with oral lichen planus(OLP),and to clarify the correlation between them.Methods:Thirty-one patients with erosive oral lichen planus(EOLP),40 patients with non-EOLP and 31 controls were investigated by the instruments Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD),respectively.The saliva of objects in various groups was collected in the morning for the determination of DHEA levels by radioimmunoassay to explore the relationship between the scores of anxiety,depression and the salivary levels of DHEA in various groups.Results:The scores of HAMA and HAMD of the patients in EOLP group were significantly higher than those in control group and non-EOLP group(P0.01).The level of salivary DHEA of the patients in EOLP group was lower than that in control group,but there was no significant difference between two groups(P0.05).There were no significant differences of the scores of HAMA HAMD and the levels of salivary DHEA of the objects between non-EOLP group and control group(P0.05).The level of salivary DHEA of the patients in EOLP group was negatively correlated with their scores of HAMA(r=-0.948)and HAMD(r=-0.966).The level of salivary DHEA of the patients in non-EOLP group was also negatively correlated with their scores of HAMA(r=-0.962)and HAMD(r=-0.971).Conclusion:The occurrence and development of EOLP is related to anxiety and depression,and its mechanism may be related to the decrease of salivary DHEA level in the patients with EOLP.

目的:获得新疆地区汉族和维吾尔族正常成人颜面比例特征及不同民族之间的差异.方法:从乌鲁木齐市在校大学生中,按一定标准随机选取一定数量的汉族和维吾尔族正常成人(男女分开)为研究对象,按照同一标准分别对每位受试者拍摄正面像;将资料导入计算机,选择20个软组织标志点,利用Photoshop软件对正面像进行15个项目的定点测量,建立19项颜面比值,利用SPSS19.0软件包对比值结果进行独立样本t检验.结果:与女性相比,男性面部偏短宽,鼻翼宽度较大.不论男女,汉族人眼裂宽度、口裂宽度较小,而内眦及鼻翼宽度较大.结论:新疆地区汉族与维吾尔族男女颜面比例存在一定差异.

Objective:To observe the effect of “bulk-fill”flowable resin in filling deep wedge-shaped defects.Methods:50 pa-tients with totally 85 pairs of premolars with deep wedge-shaped defects(depth >2 mm)were included.Each pair of the defects was randomly divided into the test group and the control group,the defects were treated by “bulk-fill”flowable resin with single cure tech-nique and conventional flowable resin with incremental layering technique respectively,the tooth sensitive rate 1 week after filling,the filling failure rate,the edge coloring and secondary caries rate 2 years after filling of the 2 groups were compared.Results:There was no significant difference between the 2 groups in the sensitive rate 1 week after filling,the failure rate and the edge coloring and sec-ondary caries rate 2 years after filling(P >0.05).Conclusion:The “bulk-filled”flowable resin using single cure technique can ac-quire the same clinical effect as conventional flowable resin using incremental layering technique in filling deep wedge-shaped defects.