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1静脉用药调配中心医嘱审核结果与不合理用药干预效果观察

马静,唐军

目的分析静脉用药调配中心医嘱审核结果与不合理用药干预效果.方法选择南京医科大学第二附属医院2019年1—12月静脉用药调配中心医嘱300张为对照组,未接受医嘱审核干预,另选择2020年1—12月静脉用药调配中心医嘱300张为观察组,接受医嘱审核干预.比较2组不合理事件发生情况及用药调配管理满意度.结果观察组药物相互作用、配伍禁忌、用法用量不合理和稀释溶媒选择不当发生率均低于对照组(P<0.01);观察组用药调配管理总满意度为99.33％,高于对照组的85.67％(χ2=40.384,P<0.001).结论医院静脉用药调配中心医嘱审核中发现不合理用药问题,积极干预后不合理用药问题明显减少,用药调配管理满意度明显上升.

2022Chinese Journal of Clinical Rational Drug Use（2022）

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2Application Effect and Adverse Reaction Analysis of Cefoperazone Sodium and Sulbactam Sodium for Injection

Jun Tang,Pingyu Liu

目的:探究注射用头孢哌酮钠舒巴坦钠的应用效果及不良反应.方法:选取某院2018年4月～2019年4月期间80例接受抗感染治疗患者的临床资料进行回顾性分析,根据不同的治疗药物将患者分为参照组和研究组各40例,即应用注射用头孢他啶治疗的患者纳入参照组,而应用注射用头孢哌酮钠舒巴坦钠治疗的患者纳入研究组,记录两组临床疗效与不良反应发生率.结果:参照组、研究组总有效率分别为75.00％、97.50％,比较发现研究组总有效率更高(P<0.05);参照组、研究组不良反应发生率分别为10.00％、27.50％,比较发现研究组不良反应发生率高于参照组(P<0.05).结论:注射用头孢哌酮钠舒巴坦钠用于抗感染治疗的临床疗效优于注射用头孢他啶,但其不良反应发生率明显较高,临床应用需根据患者病情、体质谨慎选择药物与剂量,保证患者用药安全.

2020Journal of Mathematical Medicine（2020）引用：3

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3Clinical efficacy of aspirin clopidogrel combined with alprostadil in the treatment of cerebral infarction caused by middle cerebral artery stenosis

Tang Jun,Wang Yi-jun,Liu Qing-ping

目的:观察阿司匹林、氯吡格雷联合前列地尔治疗动脉狭窄致脑梗死的临床效果.方法:选取94例动脉狭窄致脑梗死患者作为研究对象.采用随机数字表法将患者分为对照组和观察组各47例.两组均给予常规降压、降糖、调脂、营养支持等治疗.对照组在此基础上给予阿司匹林肠溶片治疗,首次剂量300 mg,以后100 mg/d;硫酸氢氯吡格雷片75 mg/次,1次/d.观察组在对照组基础上加用前列地尔注射液1～2 mL,与10 mL生理盐水混合后缓慢静注,1次/d.两组均治疗14 d.①比较两组治疗前后神经功能(NIHSS量表)和日常生活能力(ADL量表),②比较两组血小板聚集率和血液黏度;③比较两组疗效;④统计两组不良反应发生情况.结果:治疗后,观察组NIHSS和ADL量表评分均明显优于对照组,血小板聚集率和血液粘度均明显小于对照组,治疗总有效率明显高于对照组,差异有统计学意义.两组不良反应发生率比较差异无统计学意义.结论:阿司匹林、氯吡格雷联合前列地尔治疗动脉狭窄致脑梗死的效果确切,且安全性好.

2020Journal of Hunan Normal University(Medical Science)（2020）引用：3

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4Efficacy Observation of Acyclovir and Famciclovir in the Treatment of Herpes Zoster

Jun Tang,Liu Ping-yu

OBJECTIVE:To observe therapeutic efficacy of acyclovir and famciclovir in the treatment of herpes zoster. METHODS: 302 cases of herpes zoster admitted in our hospital were randomly divided into group A and B. 150 cases in group A were given acyclovir, and 152 cases in group B were given famciclovir. Times of response, scab form, analgesia, recovery in 2 groups were recorded in detail. RESULTS: After 1 week following-up, the cure rate of group A was 37.8% and that of group B was 52.5%, there was statistical significance (P0.05). After 2 and 3 weeks following-up, the effective rate, cure rate and total effective rate in 2 groups had no statistical significance (P0.05). The incidence of postherpetic neuralgia of group B(6.0%) was lower than group A(14.3%), there was statistical significance (P0.05).CONCLUSION: Famciclovir compared with acyclovir in the treatment of herpes zoster has a rapid onset.

2011Zhongguo yaofang（2011）引用：23

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5加替沙星56例不良反应分析

唐军,刘平羽,周鸣

目的:分析加替沙星所致的不良反应及特点,为临床合理用药提供参考。方法:对我院发生的56例加替沙星不良反应报告进行统计分析。结果:加替沙星的不良反应主要为皮肤过敏反应和胃肠道反应,分别占41.07%、23.21%,其次涉及神经系统、骨骼肌系统等方面。所有患者经治疗都好转且无后遗症。结论:对于加替沙星引起的不良反应,应密切重视,严格掌握其适应证和禁忌证,合理选药,提高用药安全性

2011Chinese Journal of Pharmacoepidemiology（2011）引用：5

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6The Improvement of Chemotherapy Combined with Thymopetidum on Cellular Immunity of Patients with Gastrointestinal Malignant Tumor in the Later Stage

唐军,刘平羽,周鸣

Objective: To study the influence of chemotherapy combined with thymopetidum on cellular immunity of patients with gastrointestinal malignant tumor in the later stage. Methods:80 cases were divided into two groups:testing group (40 cases,with thymopetidum and chemotherapy) and control group (40 cases,with chemotherapy only). 25 cases without malignant tumors were selected as normal group. The activity of T-lymphocyte subgroup and its cytokines as IL-2 (Th_1) and IL-10 (Th_2) in peripheral blood of each group were investigated before treatment and at the tenth day after treatment of two weeks. Results: Before treatment, T-lymphocyte subset (CD_3~+,CD_4~+ and the ratio of CD_4VCD_8~+) and IL-2 of patients with gatrointestinal malignant tumor were lower than those of normal group(P < 0.05),while the values of CD_8~+ and IL-10 were higher obviously compared with normal group(P < 0.05). After treated for two weeks ,CD_3~+CD_4~+ and the ratio of CD_4~+/CD_8~+ were higher than those of before treatment in two groups(P < 0.05) ,and the changes in testing group were more obviously than those in control group (P < 0.05). In testing group,IL-2 was lower and IL-10 was higher than before treatment(P< 0.05),while there was no significant change after treatment in control group. The efficacy of testing group was higher than that of control group(P < 0.05). Conclusions:The immunity of T-lymphocyte subgroup was suppressed in the patients with gastrointestinal malignant tumor and the expression of Th_2 type cytokines was enhanced. The cellular immunity of patients was improved by killing the tumor cells and removing the immunosuppressive agent after the chemotherapy together with Thymopetidum.

2009Acta Universitatis Medicinalis Nanjing（2009）引用：4

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7Effects of Volatile Mixtures of Polyurethane Paint for Decorative Use on Lipid Peroxidation in Mice

陈宇炼,程建,王洁,唐军,宋小军

目的探讨装潢聚氨酯漆挥发物对小鼠脂质过氧化反应的影响.方法将某聚氨酯漆分别以96 cm2(低剂量组)和160 cm2(高剂量组)均匀涂抹于普通木板供染毒用,静式吸入染毒,每日涂1次,每日吸入染毒2 h,连续4周后,测定雌性昆明小鼠外周血中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性及谷胱甘肽(GSH)和丙二醛(MDA)含量.结果低剂量组GSH-Px活性、高剂量组GSH含量和GSH-Px活性均显著高于对照组,SOD活性及MDA含量无显著变化.结论聚氨酯漆挥发物能使小鼠抗氧化反应增强.

2001JOURNAL OF ENVIRONMENT AND HEALTH（2001）引用：1

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8Effects of Volatiles Mixture of Polyurethane Paint for Decorative Use on Broncho-alveolar Lava ge Fluid Elements of Rats

陈宇炼,程建, 王洁,唐军,宋小军

<span id="ChDivSummary" name="ChDivSummary" class="abstract-text">目的　为研究装潢聚氨酯漆挥发物的肺脏毒性。方法　分别在大鼠吸入高、低剂量聚氨酯漆挥发物 1、3、7天（每天2h）后进行肺灌洗液成分测定。结果　接触聚氨酯漆挥发物后 ,肺灌洗液中酸性磷酸酶在接触 7天后比对照组明显增高 ,而巨噬细胞计数、乳酸脱氢酶、碱性磷酸酶、白蛋白均未见明显改变。结论　聚氨酯漆挥发物对机体肺脏巨噬细胞有一定的损伤作用。</span>

2001CHINA PUBLIC HEALTH（2001）

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