目的 对近20年全文期刊数据库和ACCESS肿瘤转移数据库中药治疗肿瘤转移方药进行归纳,探讨肿瘤转移的用药规律.方法 对所选文献的方剂中药物的使用频次、功效归类等规律进行研究,归纳总结肿瘤转移常见证型治法.结果 治疗肿瘤转移常用内服中药前五位是黄芪、甘草、莪术、当归、丹参;具有利水消肿、祛湿化痰功效的药物占40%.结论 肿瘤转移发病机理为痰毒流注,络损血瘀,患者大多有痰湿、气虚、血瘀之征.

Objective The influence of Chinese Medicine Relieve Pain Plaster to the expression of pERK and p-p38 in the spinal cord dorsal root ganglion of bone pain rats.Methods 108 female Wistar rats(180 ～ 220 g) were randomly divided into 3 groups,respectively,into blank control group(group Con,n = 24) sham operation group(group Sham,n = 24),bone cancer pain model group(group Ca,n = 60).The 3 groups were in operation before the 2 day,after every 4 day for determination of mechanical pain threshold(MWT) and thermal pain threshold(TWL).On the 7 day postoperatively confirmed after injecting,the success of the model rats were randomly divided into two groups,namely the model group(group Ca,n = 25) and Chinese Traditional Medicine Relieve Pain Plaster group(group CM,n = 18).After 7 days,14 days and 21 days in each group were sacrificed rats(n≥8),rat spinal cord lumbar L4-6 modified by immunohistochemical method,the determination of the change of pERK and p-p38 in spinal dorsal horn.Results Spinal cord dorsal horn neuronal p-p38 expression: group Ca number of positive neurons increased,after 7,14,21 days in group Sham compared with statistical difference(P 0.05);group CM after 14,21 days in group Con and group Sham were compared statistically difference narrowed gradually(P 0.05).Conclusion Chinese Traditional Medicine Relieve Pain Plaster to the bone cancer pain has obvious analgesic effect,and effects on spinal dorsal horn c-fos effects,possibly by reducing spinal dorsal root ganglion pERK,p-p38 expression and arise,namely through MAPK-CREB signal transduction pathway completed.

Objective :To establish the S180 sarcoma oppression mice sciatic nerve cancer pain model.Methods :The experimental mice were divided into blank group,control group,model group.The blank control group was without treatment.The control group received normal saline,model group.The sciatic nerve muscle plexus was given injection containing S180 cell 2 ×106/0.2 mL for each mouse.Groups were observed at first,3,5,7,9,11,13,15,17 days with mice tail flick method,measuring the mice pain threshold.Results :By the mice tail tenderness experiments 9 days after modeling,the control group had significant difference when compared with model group(P0.05).Conclusion :From the pain behavior studies,on the ninth day after modeling,S180 sarcoma of the oppression of the sciatic nerve pain model was successfully reproduced.

目的 研究延颈交界区肿瘤的临床特点诊断与手术疗效.方法 回顾性分析15例延颈交界区肿瘤的临床特点和MRI影像,手术和预后,其中行经后正中入路手术13例,经远外侧入路2例.结果 髓内室管膜瘤1例,星形细胞瘤1例;髓外颅颈型脊膜瘤8例,髓外神经鞘瘤5例;全切除11例,次全切除3例,部分切除1例;出院时好转及治愈11例,无变化3例,死亡1例.结论 延颈交界处肿瘤以良性肿瘤多见,熟悉延颈交界区解剖,应用显微外科技术,尽量减少对延脊髓的牵拉,选择合适手术入路是提高疗效的关键.