目的 评价中药止痛贴联合吗啡治疗中重度癌痛(肝癌、骨转移癌)的有效性和安全性.方法 中重度癌痛(肝癌、骨转移癌)患者264例,其中肝癌和骨转移癌患者各132例,分为试验组和对照组(n=66),分别给予中药止痛贴或安慰剂外用贴敷疼痛部位,每日每个部位1贴,同时加服吗啡,给药7d后比较止痛效果、中医证候疗效等.结果 肝癌患者试验组主诉疼痛程度平均下降(1.1±0.8)分,爆发痛平均(0.9±2.2)次·例-1·周-1,治疗满意度均优于对照组(P＜0.05);骨转移癌患者试验组睡眠时间平均增加(1.6±1.9)h,疼痛影响评估平均减少(16.1±9.1)分,爆发痛平均(0.4±0.7)次·例-1·周-1,治疗满意度均优于对照组(P＜0.05).两组不良事件主要是合并口服止痛药有关的恶心、呕吐、便秘,未见与中药止痛贴有关不良反应.结论 中药止痛贴联合吗啡能缓解中重度癌痛(肝癌、骨转移癌),能减少疼痛影响及提高治疗满意度,安全性高.

目的 对近20年全文期刊数据库和ACCESS肿瘤转移数据库中药治疗肿瘤转移方药进行归纳,探讨肿瘤转移的用药规律.方法 对所选文献的方剂中药物的使用频次、功效归类等规律进行研究,归纳总结肿瘤转移常见证型治法.结果 治疗肿瘤转移常用内服中药前五位是黄芪、甘草、莪术、当归、丹参;具有利水消肿、祛湿化痰功效的药物占40%.结论 肿瘤转移发病机理为痰毒流注,络损血瘀,患者大多有痰湿、气虚、血瘀之征.

Objective: To evaluate the effectiveness and safety of TCM external treatment combined with morphine in treatment of the pain of bone metastases. Methods: The stratfiied randomized method, double-blind method and placebo-controlled method were conducted in the trials. 264 cases patients with the pain of bone metastases(blood stasis syndrome) were divided into mild pain group, moderate pain group and severe pain group. Meanwhile, 264 healthy subjects were selected as normal control group. The experiment groups were given external treatment of analgesic paste, and the moderate pain group and the severe pain group were additionally injected the morphine. While, the normal control group was given the placebo. The effect of analgesia and TCM syndromes were compared after 7 days. Results: In the mild pain group: the NRS scores at rest state and at motion state dropped by an average of 1.7 and 1.8 points, respectively; the pain time reduced by an average of 2.7 hours; the sleep time increased by an average 1.3 hours; the breakthrough pain occurred 0.4 times a week per capita. The effect of analgesia and TCM syndromes in the mild pain group were superior to those in the normal group(P0.05). In moderate pain group and the severe pain group: the NRS scores at rest state and at motion state dropped by an average of 3.3 and 3.2 points, respectively; the pain time reduced by an average of 7.3 hours; the sleep time increased by an average 1.6 hours; the breakthrough pain occurred 0.4 times a week per capita. The effect of analgesia and the treatment satisfaction in the moderate pain group and the severe pain group were superior to those in the normal group(P0.05). There was no adverse reaction related to the external treatment of analgesic paste in the course of the experiment. Conclusion: TCM analgesic paste could relieve the pain of bone metastases, which had advantages on improving sleep, reducing pain and increasing the treatment satisfaction.

This study aimed to explore the rationality of herbaceous compatibility of peony liquorice decoction by analyzing the pharmacokinetic parameters of peoniflorin and glycyrrhetinic acid in SD rats' plasma. A HPLC/MS/MS method was used to detect the concentrations of peoniflorin and glycyrrhetinic acid in plasma of SD rats which were administrated with peony, liquorice and peony liquorice decoction, respecttively. Compared with the rats having single administration of either peony or liquorice, it took less time for the glycyrrhetinic acid in the plasma of rats administered with peony liquorice decoction to reach the peak concentration and its maximum concentration level was also increased. Moreover, the peoniflorin's peak concentration was increased, and the relative bioavailability was also enhanced. The half-life reduction happened to both peoniflorin and glycyrrhetinic acid. The liquorice promoted the absorption of peoniflorin in peony and enhanced its in vitro concentration, which in turn induced stronger and more powerful functions from the peoniflorin, such as spasmolysis, pain relief and calmness. The peony had shortened the time for glycyrrhetinic acid in liquorice to appear in intracorporal and had increased the quantity of glycyrrhetinic acid in intracorporal, bringing out the effects of anti-ulcer, spasmolysis, and anti-inflammation. This experiment had proven the rationality of the peony liquorice decoction compatibility in terms of pharmacokinetics.

目的:通过动物实验观察外用中药"川乌不痛膏"对不同疗程的镇痛药效,以获得最佳疗程.方法:利用小鼠醋酸扭体实验以扭体抑制情况来验证疗效.结果:"川乌不痛膏"腹部外敷对小鼠腹腔注射冰醋酸扭体有抑制作用,而且表现出明显的疗程与疗效关系,不同疗程组与空白对照组比较差异有显著性.结论:"川乌不痛膏"外敷有明显的止痛治疗作用,并且连续贴敷3天镇痛效果最好.

目的:研究甘草及六一散在大鼠血浆中甘草次酸药动学参数的差异,以探索六一散配伍的合理性.方法:将甘草及六一散制成水煎液,分别灌胃给予SD大鼠,采用HPLC/MS/MS法测定大鼠血浆中甘草次酸的血药浓度,并计算主要药动学参数.结果:给予六一散或甘草后大鼠血浆中甘草次酸的Tmax,Cmax,T1/2,AUC0-480:给六一散后分别为:(45.0±10.6)min,(532.8±257.7)ng·mL-1,(72.6±36.5)min,(26 568.7±7 682.7)ng·mL-1·min-1;给甘草后分别为(240.0±30.4)min,(480.7±157.6)ng·mL-1,(141.4±26.7)min,(100 447.4±58 896.2)ng·mL-1·min.结论:相对于单用甘草,给予六一散水煎液后大鼠血浆中的甘草次酸达峰时间提前,达峰浓度提高,有利于复方快速而集中的发挥药效.

根据中医学脏腑经络理论,总结现代医家治疗咽炎的经验,以咽喉与肺肾生理病理关系上为切入点,同时结合咽炎发病特点,提出急性咽炎的发病是在机体肺肾阴虚的前提下,感受外邪,邪毒由口鼻而入,直袭肺之门户,邪毒与阴虚相得益彰,而表现为咽喉红肿疼痛等症状。以此理论指导临床,取得了显著的临床疗效,值得进一步研究和推广。

The study is designed to understand the rationality of herbaceous compatibility of a peony liquorice decoction through analyzing the pharmacokinetic parameters of peoniflorin and glycyrrhetinic acid in SD rats plasma. A HPLC/ MS/MS method was used to detect the concentration of peoniflorin and glycyrrhetinic acid in SD rats administrated with peony, liquorice or peony liquorice decoction. Results show that peoniflorin and glycyrrhetinic acid in peony liquorice decoction have a short Tpeak, a high Cmax, and a short T1/2. Comparing with the sole administration of peony or liquorice, the peony liquorice decoction was able to make glycyrrhetinic acid in rat plasma reach the peak concen-tration in a faster manner, with an increased Cmax. Peoniflorin’s peak concentration got enhanced, and so did the relative bioavailability. Both the ingredients have showed a reduced half-life. It is believed that liquorice facilitates the absorption of peoniflorin in peony, and enhances in vivo concentration, which is possibly associated with the pharma-cokinetic effects of peoniflorin, including spasmolysis, analgesia, and tranquilization. Peony promotes the releases of glycyrrhetinic acid in liquorice, in terms of both time and quantity, allowing an enhanced anti-ulcer, spasmolysis, and anti-inflammatory effect. The experiment has proved the rationality of peony liquorice decoction compatibilities in the context of pharmacokinetics.

AIM: To explore the changed regularity of the pharmacokinetic parameters in animal plasma of astragaloside Ⅳ and ferulic acid when Astragalus and Angelica were used solely or compatibly in Dang-guibuxue Tang, and to study the rationality of herbaceous compatibility of Dangguibuxue Tang. METHODS: The New Zealand white rabbits or SD rats were administrated with Astragalus, Angelica or Dangguibuxue Tang, respectively. The blood concentrations of ferulic acid in rabbits administrated with Dangguibuxue Tang or Angelica were analysised by HPLC, while the blood concentration of astragaloside IV in rats administrated with Dangguibuxue Tang or Astragalus were analysised by HPLC/MS/MS and the main pharmacokinetics parameters were calculated. RESULTS: Compared with single administration of Angelica, the pharmacokinetic parameters of ferulic acid in rabbit plasma almost did not show any change when administrated with Dangguibuxue Tang. Compared with administration with Astragalus alone , the t_(max) of Astragaloside Ⅳ in rat plasma was decreased significantly [ from (4.00 ± 1.54) h to (2.00 ± 0.95) h] when given Dangguibuxue Tang, and its peak concentration was increased doublely [C_(max) from (60 ± 7) μg/L to (146 ± 27) μg/L)]. CONCLUSION: Angelica increases the vitality of Astragaloside Ⅳ in Astragalus in the body after the combination, and it advances the process of effectiveness of astragaloside Ⅳ, which embodies the adjuvant contribution of ministerial drug of Angelica. The experiment proves the rationality of Dangguibuxue Tang in terms of pharmaeokinetics.

Objective:By observing the anti-tumor effect of Rhubarb, Radix Angelicae, Radix Aucklandia,which were most frequently used in treating abdominal mass in Prescripitons for Universal Relief,mixed with different ratio on those Holland lump mouse vaccinated with Lewis lung cancer, the best ratio of those three medicine was discussed. Methods: Build up the models for Holland lump mouse vaccinated with Lewis lung cancer, and divided the mice into several groups for different medicine treatment using Rhubarb, Rhubarb plus Radix Aucklandia, Rhubarb plus Radix Angelicae, and Rhubarb plus Radix Angelicae and Radix Aucklandia, respectively. By measurement of the weight of tumors, calculate percentage of the anti-tumor effect for different medicine groups. Results: In comparison with the model group, the group of Rhubarb plus Radix Aucklandia has the anti-tumor effect of 78.52% for Lewis lung cancer and spleen index is (2.349±0.58)mg/g which has statistics significance(P0.05).Both of these two medicine composition are with rather good anti-tumor effect (P0.05).Conclusion:Considering anti-tumor rate and spleen index, Rhubarb plus Radix Angelicae shows best effect of anti-tumor.

对于胰腺,古代论述很少,现代医家从各自角度提出"胰脾一体说"等观点以求对传统理论有所补充。本文在参考文献的基础上,提出胰腺在功能上当归属古之脾肾二脏的观点。

Objective To discuss the rationality of compatibility proportion of Dangguibuxue Tang.Methods The active component of angelica out from combine-decocted juice when astragali and angelica with diverse compatibility proportion and single-decocted juice were dectected by reversing high performance liquid chromatography.Results When astragali and angelica in classic compatibility proportion as 5:1,the rate of ferulaic acid was maximum.Conclusion Astragali and angelica's compatibility proportion with 5:1 in Dangguibuxue Tang is rational.

目的 观察大黄.当归,木香的不同配伍组合对Lewis肺癌.肉瘤-s180、艾氏腹水癌荷瘤小鼠抑瘤作用的影响,探讨.大黄.当归、木香的最佳配伍关系.方法 制备lewis.肉瘤-s180、艾氏腹水癌荷瘤小鼠动物模型,随机分为模型组,大黄.当归组,大黄组,大黄、木香组,大黄.木香、当归组;通过测定荷瘤小鼠的瘤重.计算抑瘤卒观察不同配伍组对肿瘤生长的影响.结果 与模型组比较,大黄当归组对Lcewis肺癌、肉瘤-sI80.艾氏腹水癌抑瘤率分别达到78.52%、44.57%.64.95%;大黄.木香.当归组对Lewis ,肺癌.肉瘤-s180,艾氏腹水癌的抑瘤率分别达到4 7.53%、32.57%、52.99%,两个用药组合均具有很好的抑瘤作用(P＜0.05).