Hyperuricemia (HUA), characterized by elevated serum uric acid levels (>420 μmol/L), is a metabolic disorder linked to gout, cardiovascular diseases, renal disorders, diabetes, polycystic ovary syndrome (PCOS), and non-alcoholic fatty liver disease (NAFLD). Traditional Chinese Medicine (TCM) offers a holistic approach to HUA management, employing dialectical treatments to address underlying pathogenesis, reduce uric acid, mitigate inflammation, and protect organ function. This review synthesizes recent advances in TCM for HUA and its comorbidities, drawing from pharmacological studies of single herbs, compound formulas, and TCM pathogenesis theories. We introduce innovative strategies, including network pharmacology, metabolomics, personalized TCM diagnostics, and nanotechnology, to enhance therapeutic precision and efficacy. By integrating TCM's traditional wisdom—emphasizing balance among vital energies like “qi” (vital energy) and bodily fluids, with modern scientific methodologies, this review highlights potential risks, toxicities, and challenges in TCM application, aiming to improve patient outcomes in HUA and related diseases.

目的 探讨替罗非班联合益气活血化瘀方对冠心病慢性心力衰竭(CHF)合并2型糖尿病(T2DM)患者经皮冠状动脉介入(PCI)术后冠状动脉血流参数和血液流变学指标的影响.方法 选取行PCI术的160例气滞血瘀型冠心病CHF合并T2DM患者,随机将其分为替罗非班组(n=80)和联合用药组(n=80).两组均采用常规对症支持联合替罗非班治疗,联合用药组在此基础上加用益气活血化瘀方.比较两组治疗前、治疗14 d后中医证候总积分、冠状动脉血流参数、血管内皮功能和血液流变学指标,以及两组术中、治疗14 d内不良反应的发生情况.结果 治疗14 d后,联合用药组冠状动脉舒张期峰流速、收缩期峰流速、血流速度储备、舒张期速度-时间积分和血清一氧化氮水平均高于替罗非班组,中医证候总积分、全血高切黏度、全血低切黏度、全血红细胞压积与全血纤维蛋白原水平,以及血清内皮素-1水平均低于替罗非班组(均P＜0.05);两组术中、治疗14 d内不良反应发生率差异无统计学意义(P＞0.05).结论 替罗非班联合益气活血化瘀方能有效地改善冠心病CHF合并T2DM患者冠状动脉血流情况和血管内皮功能,降低血液黏度,具有较好的临床疗效与安全性.

目的:探究定心颗粒联合胺碘酮对房颤(AF)射频消融术后患者早期复发及心肌损伤和炎性因子的影响.方法:选取我院2019年1月—2020年12月收治的80例AF射频消融术后患者,随机分为联合组(n=40)和常规组(n=40).两组均接受胺碘酮常规治疗,联合组加用定心颗粒.分析两组术前及术后3个月左房内径(LAD)、心肌损伤标志物、炎性因子等变化情况,收集两组术后早期复发情况.结果:联合组临床总有效率高于常规组(P<0.05);术后3个月联合组NT-proBNP、cTnI、LAD、hs-CRP、IL-6水平低于常规组(P<0.05);联合组早期复发率低于常规组(P<0.05).结论:AF射频消融术后患者应用定心颗粒联合胺碘酮可进一步提高临床疗效,缩小LAD,抑制心肌细胞损伤,缓解炎性反应,减少早期复发.

目的 探讨宁心通痹汤联合阿利沙坦酯治疗冠心病不稳定型心绞痛患者的临床效果.方法 选取2019年7月至2021年9月厦门市中医院心内科收治的150例冠心病不稳定型心绞痛患者作为研究对象.采用随机数字表法分为对照组(n=75)和观察组(n=75).两组采用阿利沙坦酯治疗,观察组加用宁心通痹汤.比较两组治疗前后中医证候总积分、心肌缺血状态、心率变异性、治疗后心绞痛发生情况及治疗期间不良反应发生情况.结果 观察组治疗后中医证候总积分低于对照组,差异有统计学意义(P＜0.05);观察组治疗后的窦性心搏RR间期标准差、RR间期平均值标准差和相邻RR间期差值均方根水平均高于对照组,差异有统计学意义(P＜0.05);观察组治疗后的心肌缺血总负荷、QT离散度、JT离散度均低于对照组,差异有统计学意义(P＜0.05);观察组治疗后心绞痛发作频率、硝酸甘油用量低于对照组,持续时间短于对照组,差异有统计学意义(P＜0.05);两组各项不良反应发生率比较,差异无统计学意义(P＞0.05).结论 宁心通痹汤联合阿利沙坦酯能有效改善冠心病不稳定型心绞痛患者临床症状,提高心率变异性,具有较高的临床疗效.

Effects of simvastatin on serum level of adiponectin, a protein conferring benefits in both cardiovascular and metabolic system, are not fully determined.

目的：探讨定心颗粒治疗高血压合并阵发性房颤患者的临床效果。方法：将70例患者随机分为观察组和对照组，各35例。在两组均给予降压治疗的基础上，观察组给予定心颗粒，对照组给予胺碘酮治疗。疗程为8周，观察两组治疗前后动态血压及监测动态心电图，并评估治疗后的效果。结果：两组患者24 h动态血压、清晨血压均降低，差异有统计学意义(P<0.01)，但观察组控制清晨血压的效果优于对照组，差异有统计学意义(P<0.05)；观察组治疗后24 h平均心率、房颤发作持续时间均降低，差异有统计学意义(P<0.01)，且观察组的临床疗效优于对照组，差异有统计学意义(P<0.05)。结论：定心颗粒配合降压药治疗高血压合并阵发性房颤患者，可有效控制患者清晨血压，降低心率，缩短房颤发作持续时间，提高中医临床疗效。

目的:观察中西药合用治疗糖尿病瘙痒症的效果.方法:100例随机分成A组和B组各50例,两组均行常规西药治疗,A组加用中药治疗.结果:总有效率A组明显优于B组,血糖控制情况A组也优于B组,两组比较差异均有统计学意义(P<0.05).结论:中西药联用治疗糖尿病瘙痒症疗效理想且血糖控制较好.

目的 通过采用高脂饮食喂养apoE缺失(apoE-/-)小鼠建立动脉粥样硬化(AS)模型,比较阿托伐他汀联合载脂蛋白A-I(apoA-I)模拟肽(L-4F)对AS小鼠血清氧磷酯酶(PON1)、髓过氧化物酶(MPO)活性及血清低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平的影响.方法 雄性apoE-/-小鼠50只,高脂饲料喂养作为模型组,另外取适龄C57BL/6J小鼠20只给予普通饲料喂养作为正常对照组,实验4周后,处死2组小鼠各10只,检测相应血清指标,作为基线参考.其余apoE-/-小鼠分为模型对照组(单纯高脂饮食)、阿托伐他汀组(高脂饮食基础上给予阿托伐他汀治疗)、L-4F组(高脂饮食基础上给予L-4F治疗)、阿托伐他汀联合L-4F组(高脂饮食基础上给予阿托伐他汀+L-4F治疗),每组10只.实验第8周末处死5组小鼠,并取小鼠血清检测各血清指标.结果 实验第8周末,与模型对照组比较,各药物组血清PON1活性显著升高(均P＜0.05),MPO活性显著下降(均P＜0.05);与模型对照组比较,阿托伐他汀组、阿托伐他汀联合L-4F组LDL-C水平显著减低(P＜0.05,P＜0.01),HDbC水平显著升高(P＜0.05,P＜0.01),L-4F组LDL-C、HDL-C水平差异无统计学意义(均P＞0.05).实验第8周末,阿托伐他汀联合L-4F组较阿托伐他汀组及L-4F组PON1活性、HDL-C水平显著升高(均P＜0.05);MPO活性、LDL-C水平显著降低(均P＜0.01).结论 阿托伐他汀、L-4F均可通过升高血清PON1活性,降低MPO活性,从而改善HDL抗氧化、抗炎功能,延缓AS进展.L-4F对LDL-C、HDL-C水平无影响.阿托伐他汀联合L-4F不仅降低LDL-C,升高HDL-C,而且更有效的改善HDL抗氧化、抗炎功能,从而延缓AS进展,优于单药使用.

OBJECTIVE:Cystatin C is a well established marker of kidney function. There is evidence that cystatin C concentrations are also associated with myocardial infarction. The purpose of the present study is to clarify the link between cystatin C with myocardial infarction using a meta-analysis approach.METHODS:We searched articles indexed in the Pubmed and Sciencedirect published as of August 2015 that met our predefined criteria. A meta-analysis was used to pool estimates of the multivariate adjusted relative risk (RR) with 95% confidence interval (CI), of the association between cystatin C and subsequent risk of myocardial infarction.RESULTS:Four eligible articles with 10491 subjects from 5 cohort studies were considered in the analysis. Overall, the random-effects meta-analysis results indicated that the highest cystatin C category versus lowest was associated with greater risk of myocardial infarction (RR, 1.78; 95% CI, 1.27 to 2.49; P=0.001). No evidence of publication bias was observed.CONCLUSIONS:This meta-analysis showed that cystatin C is strongly and independently associated with subsequent risk of myocardial infarction. Further investigation is warranted to clarify whether measurement of cystatin C can usefully reduce the myocardial infarction beyond established predictors already in clinical use.

Objective To investigate the Dingxin granule treatment of hypertension complicated with frequent clinical curative effect of early ventricular.Methods 100 patients were randomly divided into 2 groups, the observation group and the control group, 50 cases in each group. Two groups were given the same antihypertensive drugs and metoprolol succinate sustained-release tablets in the treatment, the observation given traditional Chinese medicine prescription of Dingxin granule group on the basis of; two groups were given experimental observation on treatment for 4 weeks, to observe the changes of the two groups before and after the test hs CRP level, 24 dynamic electrocardiogram, and ventricular premature beat the therapeutic effect.ResultsThe observation group can signiifcantly reduce the hs-CRP level and reduce the number of early times, compared with the control group (P<0.01), and the effect of early treatment is better than the control group (P<0.01). At the same time, the average heart rate of the observation group was not signiifcantly decreased, no signiifcant (P>0.05). Conclusion Dingxin Granule on the stability of ventricular rate has a certain role, combined with metoprolol in the treatment of hypertensive disease with frequent ventricular early patients can signiifcantly reduce hs CRP levels and reduced the number of PVCs and for room early curative effect to be remarkable.

Objective To explore the effects of baicalin on the expression of TAFI,NF-κB,and ACE2 in the atherosclerotic rats and discuss the anti-atherosclerosis mechanisms of baicalin.Methods The subjects were healthy male Wistar rats.The rats were divided into sham operation group,model group,baicalin high dose group (1 50 mg·kg-1 ·d-1 )and baicalin low dose group (100 mg·kg-1 ·d-1 ).Plasma TAFI activity were detected with enzymatic assays.The expression of NF-κB and ACE2 were detec-ted with immunohistochemical staining.Results Compared with sham group,the rest groups of TAFI and ACE2 activity were sig-nificantly higher (P <0.05),and the expression of NF-κB,had significant decreased (P <0.05).Compared with the model group, the level of TAFI and ACE2 in baicalin drug group was significantly lower than the model group (P <0.05),and the expression of NF-κB,had significant increased.Conclusion Baicalin can reduce TAFI and ACE2 level,and upregulate the expression of NF-κB to play its role in anti atherosclerosis.

Background and purpose: Young Chinese male adults have faced increasing psychological stress. Whether this is associated with the increased risk of coronary artery disease (CAD) in young Chinese males remains unclear. This study aimed to evaluate the correlation and underlying mechanisms of perceived stress and CAD in young male patients.Methods: A total of 178 male patients diagnosed as young CAD (aged <= 55 years) by coronary angiography (CAG) were enrolled, and 181 age-matched non-CAD individuals were set as control group. Traditional cardiovascular risk factors and levels of epinephrine and norepinephrine were measured, and perceived stress status was accessed by Perceived Stress Scale (PSS).Results: The PSS score was correlated with levels of epinephrine (r = 0.45), norepinephrine (r = 0.41), high-sensitivity C-reactive protein (hs-CRP) (r = 0.38, p < 0.01), and current smoking (r = 0.32) (all p < 0.05). Multivariate logistic regression analysis showed that smoking (OR, 3.12; 95%CI, 1.23-7.91), triglycerides (OR, 1.42; 95%CI, 1.04-1.94), hs-CRP (OR, 3.57; 95%CI, 1.65-7.72), and PSS score (OR, 1.81; 95% CI, 1.23-2.66) were independently correlated with CAD in young patients. The association between PSS score and risk of CAD become insignificant (OR, 1.43; 95%CI, 0.96-2.13) when further adjusted for the levels of epinephrine and norepinephrine.Conclusions: After adjustment for multiple cardiovascular risk factors, high perceived stress was an independent risk factor for CAD in young Chinese male patients. Abnormal activation of the sympathetic nervous system may play an important role linking perceived stress with the risk of CAD. (C) 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

Objective To observe the effect of XuanFu Syndrome Differentiation treating Acute Ischemic Stroke. Methods120 cases with acute cerebral infraction were randomly divided into 2 groups. 60 cases in control group were given western medicine treatment while 60 cases in treatment group on the basis of western medicine were given XuanFu Syndrome Differentiation Treatment for (28±3) days.Results Total effective rate in treatment group was 93.3%, which was obviously higher than 73.3% in control group (P<0.01), neurologic impairment score (NIHSS)integration, disability (mRS) in treatment group were signiifcantly improved. Compared with control group, there were signiifcant statistical differences (P<0.05). LDC-C after treatment were decreased, Compared with control group, there were statistically signiifcant differences (P<0.05). ConclusionXuanFu Syndrome Differentiation Treatment is effective in treating Acute Ischemic Stroke.

目的：观察定心颗粒治疗阵发性房颤并慢性心衰的临床疗效。方法：将100例患者随机分为2组，即观察组和对照组，每组各50例。两组患者均给予相应基础疾病药物治疗；并根据病情继续使用标准抗心衰药物，观察组给予定心颗粒，对照组给予胺碘酮治疗。两组均予治疗12周，观察两组治疗前后24 h动态心电图平均心率、房颤发作持续时间；超声心动图检查指标，左室舒张末期内径（LVEDD）、收缩末期内径（LVESD）、射血分数（EF）及血浆BNP水平的变化，并比较对房颤的疗效。结果：观察组治疗后24小时平均心室率、房颤发作持续时间、LVEDD、LVESD均降低，与对照组比较无差异（P＞0.05）；但观察组EF升高及BNP降低，均优于对照组，差异有统计学意义（P＜0.01），而两组对房颤的疗效无差异（P＞0.05）。结论：定心颗粒可以降低心室率、房颤发作持续时间，改善房颤疗效，与胺碘酮效果相似；定心颗粒可进一步改善阵发性房颤并慢性心衰患者的EF及BNP水平，从而改善心功能。

目的观察通心络胶囊对高血压合并颈动脉内膜增厚患者C反应蛋白的影响。方法选择80例高血压合并颈动脉内膜增厚患者并随机分为治疗组和对照组各40例,对照组予常规治疗,治疗组在常规治疗的基础上加服通心络胶囊,疗程6个月,分别于治疗前和治疗6个月后检测IMT和C反应蛋白。结果2组治疗后IMT较治疗前均降低,且治疗组疗效优于对照组。对照组治疗后CRP未见明显下降,而治疗组CRP下降明显,与对照组比较有显著性差异(P<0.05)。结论通心络胶囊可有效降低高血压合并颈动脉内膜增厚患者C反应蛋白和抑制IMT增厚。

目的:评价通心络胶囊对原发性高血压患者危险因素及靶器官损害的影响。方法:选择100例高血压患者进行常规治疗与常规治疗加通心络胶囊治疗的临床对比观察,6个月后对患者血压、血脂、肌酐、ABI、左室壁厚度及颈动脉内膜中层厚度(IMT)的作用和临床治疗效果进行评价。结果:2组患者血压、左室壁厚度I、MT或颈动脉斑块明显减轻,与治疗前比较有显著性差异(P均<0.05);通心络组BMI、血脂中总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)均有显著改善(P均<0.05),而对照组未见明显变化;2组患者肾功能指标与基线相比均无明显变化。结论:通心络胶囊能明显降低IMT或斑块,逆转左室肥厚,同时还能控制血脂、BMI等危险因素。

<正>冠心病心绞痛属中医“胸痹”、“心痛”等范畴,是临床上较为常见的一种疾病,其发生发展与动脉粥样硬化有很大关系,而其中炎症反应在动脉粥样硬化的发生发展和粥样斑块的不稳定性过程中起着重要作用。目前认为C-反应蛋白(CRP)对诊断冠心病,判断其预后,预测心血管事件危险等方面均有重要价值。笔者采用管昌益博士经验方心痛安颗粒治疗冠心病心绞痛取得较好疗效,并观察了该药对CRP的影响,现报道如下。