Noninvasive, accurate, and simultaneous grading of liver fibrosis, inflammation, and steatosis is valuable for reversing the progression and improving the prognosis quality of chronic liver diseases (CLDs). In this study, we established an artificial intelligence framework for simultaneous grading diagnosis of these three pathological types through fusing multimodal tissue characterization parameters dug by quantitative ultrasound methods derived from ultrasound radiofrequency signals, B-mode images, shear wave elastography images, and clinical ultrasound systems, using the liver biopsy results as the classification criteria. One hundred forty-two patients diagnosed with CLD were enrolled in this study. The results show that for the classification of fibrosis grade ≥ F1, ≥ F2, ≥ F3, and F4, the highest AUCs were respectively 0.69, 0.82, 0.84, and 0.88 with single clinical indicator alone, and were 0.81, 0.83, 0.89, and 0.91 with the proposed method. For the classification of inflammation grade ≥ A2 and A3, the highest AUCs were respectively 0.66 and 0.76 with single clinical indicator alone and were 0.80 and 0.93 with the proposed method. For the classification of steatosis grade ≥ S1 and ≥ S2, the highest AUCs were respectively 0.71 and 0.90 with single clinical indicator alone and were 0.75 and 0.92 with the proposed method. The proposed method can effectively improve the grading diagnosis performance compared with the present clinical indicators and has potential applications for noninvasive, accurate, and simultaneous diagnosis of CLDs.

Liver fibrosis, inflammation and steatosis are three typical pathological forms of chronic liver diseases (CLDs) and affect lots of people worldwide. The early diagnosis and accurate grading of these three diseases are decisive for controlling the development of the diseases, promoting the reversal of the disease course and improving the prognosis of patients with CLDs. This study proposes an intelligent grading framework for these three diseases based on a multi-parametric quantitative ultrasound (QUS) method to extract both explicable handcrafted and high-dimensional deep features from multimodal ultrasound data, including B-mode images, shear wave elasticity (SWE) images and radio-frequency and envelope signals of transient elastography (TE). The handcrafted and deep features are fused and used as inputs of an artificial neural network (ANN) to grade liver fibrosis, inflammation and steatosis simultaneously. With accuracy (ACC), sensitivity (SEN), specificity (SPE) and area under the receiver operating characteristic curve (AUC) as the evaluation indexes, the proposed method performs well with all the evaluation indexes for all the three diseases higher than 0.82 and those for liver fibrosis higher than 0.84. The results show that the proposed method may be a promising and competitive tool for the intelligent diagnosis of the three typical pathological forms of CLDs.

Objective To develop a non-invasive,accurate,convenient,and widely applicable intelligent diagnostic system to diagnose simultaneously liver fibrosis,inflammation,and steatosis of chronic liver disease(CLD).Methods This study is based on multimodal ultrasound imaging data from CLD patients,including two-dimensional B-mode ultrasound images,two-dimensional shear wave elastography,transient elastography data,and the corresponding original radio-frequency data.Quantitative ultrasound methods were used to extract multimodal features from these multimodal data,and the results of ultrasound-guided liver biopsy were used as the gold standard.Support vector machine(SVM)was used to construct an intelligent grading diagnosis system for CLD in a binary-classification manner.Results The proposed method achieves high the receiver operating characteristic(ROC)area under the curve(AUC)of 0.81,0.80,0.89,0.87 for the classification of fibrosis grade≥F1,≥F2,≥F3≥F4,and 0.80,0.93,0.93 for inflammation≥A2,≥A3,≥A4,and 0.75,0.92 for steatosis≥S1,≥S2.Conclusion The results indicated that the proposed method showed potential expected to be promoted to clinical applications.

目的 总结肝细胞癌(HCC)心脏转移的超声表现特征,并分析其预后.方法 2013年1月～2019年5月我院收治的19例HCC心脏转移患者,回顾分析患者心脏超声表现,总结其特征,并随访其预后.结果 16例(84％)在肝癌相邻的肝静脉内可见实性回声,并延续至下腔静脉和右心房,3例(16％)肝癌相邻下腔静脉内可见实性回声,并延续至右心房;13例(68％)为混合回声,6例(32％)为低回声;15例(79％)边界清晰,16例(84％)形态不规则;19例(100％)右心房癌栓内未见血流信号;12例(63％)右心房癌栓随心动周期活动,活动规律与心动周期无关,7例(37％)右心房癌栓随心动周期活动不明显;3例(16％)累及右室流入道;本组患者发现右心房肿瘤转移后生存时间为25～412天,其中2例患者出现急性肺栓塞.结论 肝静脉-下腔静脉-右心房或下腔静脉-右心房连续性癌栓是本病最重要的超声表现,本病患者生存时间短,可并发急性肺栓塞而死亡.

article: Evaluation of ultrasonic indexes and exercise endurance application of diuretic mixture combined with metoprolol in the treatment of senile chronic heart failure - Minerva Surgery 2021 Jun 23 - Minerva Medica - Journals

目的 探讨获得性免疫缺陷综合征(AIDS)合并马尔尼菲蓝状菌患者淋巴结的超声特征.方法 回顾性分析我院6例AIDS合并马尔尼菲蓝状菌患者淋巴结的超声特征.超声观察指标包括淋巴结大小、长短比、形态、边界、皮髓质回声、皮髓质分界,淋巴结门,血流分布及类型,以及有无钙化、液化、淋巴结融合情况.以病理结果和临床表现作为诊断本病标准.结果 6例(100％)出现淋巴结内部弥漫性等回声改变;5例(83％)淋巴门结构完全消失;血流分布无显著特征性,表现为门型、中央型、边缘型、混合型及无明显血流信号.结论 AIDS合并马尔尼菲蓝状菌患者淋巴结内部回声、淋巴门有相对特殊超声特征,结合病史可为临床诊断提供一定的参考依据.

目的 探讨门静脉海绵样变(CTPV)及其相关并发症的超声表现特征,并分析了超声漏诊的原因.方法 2017年6月～2020年6月首都医科大学附属北京地坛医院诊治的101例CTPV患者,经CT和MRI增强扫描诊断,接受腹部超声检查.总结CTPV及其相关并发症超声图像表现特征,并分析超声漏诊的原因,提出解决策略.结果 在本组101例CTPV患者中,超声诊断82例(82.2％),漏诊19例(17.8％);在超声诊断病例中,82例(100.0％)患者门静脉主干及其分支周围出现广泛或局部蜂窝状粗细不等的血管结构,70例(85.4％)出现门静脉管壁增厚,76例(92.7％)在迂曲扩张的蜂窝状血管结构内部呈红蓝相间的丰富的血流信号,脉冲多普勒测得门静脉样低速血流频谱,10例(12.2％)门脉周围迂曲扩张蜂窝状血管压迫胆管,导致胆管扩张,8例(9.6％)出现胆囊增大,6例(7.4％)出现胆囊结石,5例(6.1％)出现胆管结石,5例(6.1％)出现门体分流.结论 超声是诊断CTPV的首选影像学方法,超声漏诊的原因主要为海绵样变血管腔细、病变范围小,腹部胀气,假性胆管肿瘤征,肋间隙或胸骨下角窄.利用腹腔积液和胆囊等声窗扫查肝脏,采用超声造影技术或结合其他影像学技术检查可减少漏诊.

目的 探讨超声引导下置管引流治疗艾滋病合并巨大肝脓肿的临床应用价值.方法 回顾性分析超声引导下置管引流治疗20例艾滋病合并巨大肝脓肿患者的临床资料.结果 ①脓肿直径10.1～21.6 cm,平均(12.4±2.8) cm.②置管1周后炎症指标明显下降,2周后肝功能明显好转,脓肿缩小.③置管引流后治愈者16例(80％),引流后再次行外科手术治疗者4例(20％).④置管引流时间5～77 d,中位数为19 d,住院时间12～90 d,中位数为29 d.⑤20例患者术后均未发生并发症及未发生医护职业暴露.结论 超声引导下置管引流治疗艾滋病合并巨大肝脓肿安全、有效、损伤小、患者易耐受.

BACKGROUND:Tuberculosis is one of the main infectious diseases threatening human health, especially in HIV co-infected patients. Xpert® MTB/RIF assay amplifies the rpoB gene of MTB was recommended by the World Health Organization as the initial diagnostic test in cases of suspected infections with Mycobacterium tuberculosis (MTB) or HIV-coinfected TB.METHODS:A 44-year-old male HIV-positive patient co-infected with MTB presented with low-grade fever for 3 months. Rifampicin (RIF) resistance was detected in the celiac pus but not in the pleural effusion using Xpert® MTB/RIF assay. The same samples were then sequenced by next-generation sequencing (NGS) and in-house PCR for rpoB gene.RESULTS:The results of NGS and in-house PCR, however, were paradoxical in the same samples with low or no mutation sequences of RIF resistance. The patient's tuberculosis (TB) therapy was optimized based on first-line anti-TB drugs and antiretroviral treatment. The patient improved with this therapy.CONCLUSIONS:Even with high specificity, false positive results remain possible and RIF resistance detection by Xpert must be considered for clinical interpretation.

目的:探讨峰值应变离散度(PSD)评价肝硬化患者左心室收缩同步性的临床应用价值.方法:入选肝硬化患者60例(根据肝硬化Child-Pugh分级,其中Child-Pugh A级患者16例,Child-Pugh B级患者29例,Child-PughC级患者15例),健康对照组60例.在静息状态下超声心动图测量左心功能及形态参数如下:左心室峰值应变离散度(PSD)、左心室长轴整体应变峰值(GLS)、左心室射血分数(EF)、左心室舒张末期内径(LVDd)、左心室收缩末期内径(LVDs)、左房内径(前后径、上下径、左右径)、室间隔厚度等.比较肝硬化组与对照组间以及肝硬化组内不同分级间PSD的差异,并分析PSD的相关性因素.结果:(1)与对照组相比,静息状态下肝硬化组的PSD增加(P＜0.05),且以Child-PughC级增加最为明显(P＜0.05);(2)肝硬化组PSD与左房前后径、室间隔厚度相关(r=0.28,P＜0.05;r=0.26,P＜0.05).结论:肝硬化患者左室峰值应变离散度增加,Child-PughC级患者增加更显著,PSD可以作为评价肝硬化患者左心室收缩同步性的指标.

目的 应用二维斑点追踪超声心动图(2 dimension speckle tracking echocardiography,2D-STE)分析肝硬化左室整体纵向应变在不同Child-Pugh分级之间的差异,并探讨肝硬化患者左室收缩功能、Child-Pugh分级与二维剪切波弹性成像(2 dimension shear wave elastography,2D-SWE)测量肝脏杨氏模量之间的相关性.方法 选取肝硬化患者60例,根据Child-Paugh分级,分为Child A、B、C级,各20例,健康对照组60例,应用2D-STE分析两组左心室长轴收缩期整体应变峰值GLS:包括三腔心GLS、四腔心GLS、二腔心GLS及平均GLS,并进行2D-SWE测量肝硬化组肝脏杨氏模量.结果 (1)肝硬化组三腔心GLS、四腔心GLS及平均GLS较对照组减低(P＜0.05),且以Child C级减低最为明显.(2)肝硬化患者左室收缩功能减低与肝脏硬度呈正相关(P＜0.05,OR值1.02).结论 肝硬化左室心肌收缩功能减低,且以Child C级减低最为明显;同时肝脏硬度越高出现左室心肌收缩功能减低的风险就越大.

目的 探讨获得性免疫缺陷综合征(AIDS)患者超声引导下介入手术中医务人员职业防护方法.方法 回顾性分析经超声引导下介入手术的158例AIDS患者的临床资料、手术方式及防护措施.结果 158例患者共行超声引导下介入手术204次,均成功取得病变组织或达到临床治疗效果,未发生严重并发症,无死亡病例.医务人员发生1例粘膜暴露,暴露后按规则预防,医务人员未发生人类免疫缺陷病毒(HIV)感染.结论 医务人员为AIDS患者实施超声引导下介入手术安全性高.医务人员做好职业防护,严格遵守操作规范,术中精细操作,可避免发生职业暴露.

目的 应用超声三维斑点追踪技术(3-dimensional speckle tracking imaging,3D-STE)分析不同程度肝硬化患者左室心肌整体收缩功能.方法 以2017年1月至2019年1月于首都医科大学附属北京地坛医院住院的63例肝硬化患者为肝硬化组,根据患者Child-Pugh评分将患者分为Child-Pugh A级组、Child-Pugh B级组和Child-Pugh C级组,另选取63例同期健康体检者为健康对照组.通过收集临床一般资料,获得常规超声心动图参数,包括左房前后径、左房左右径、左房上下径、左室舒张末内径及左室射血分数.应用3D-STE分析两组患者左室心肌整体纵向应变(global longitudinal strain,GLS)、整体环向应变(global circumferential strain,GCS)、整体径向应变(global radial strain,GRS)及整体面积应变(global area strain,GAS).结果 63例肝硬化患者中Child-Pugh A级22例,Child-Pugh B级21例,Child-Pugh C级20例.肝硬化组患者左房前后径、左房左右径、左房上下径、左室舒张末内径分别为(38.28±3.93)mm、(38.96±4.83)mm、(52.90±6.81)mm和(48.32±5.00)mm,健康对照组分别为(32.43±3.22)mm、(33.44±4.26)mm、(45.30±3.68)mm和(44.58±2.81)mm,肝硬化组显著高于健康对照组(P均<0.001).两组患者左室射血分数差异无统计学意义[(67.78±5.69)％vs(70.20±5.64)％,t=-1.62,P=0.111].肝硬化组患者GCS、GAS、GRS分别为(-15.91±3.33)％、(-29.05±4.84)％和(-45.57±10.29)％,健康对照组分别为(-18.69±2.69)％和(-32.15±4.52)％、(-53.00±11.17)％,肝硬化组显著低于健康对照组(P均<0.05),以Child-Pugh C级患者减低最为明显(P<0.05).结论 肝硬化患者左室心肌整体收缩功能下降且随肝功能降低而下降;3D-STE能够为临床评估肝硬化患者左室收缩功能提供可靠的参考依据.

目的 应用速度向量成像技术(VVI)寻找妊娠期肝内胆汁淤积症(ICP)孕妇胎儿局部心功能异常的影像学指标,为ICP孕妇胎儿围产期管理提供依据.方法 以于我院超声科检查发现的ICP孕妇胎儿为研究对象,依据母体血清总胆汁酸(TBA)水平将ICP孕妇分为两组,TBA≥10～40μmol/L为ICP轻度组,入组26例;TBA≥40μmol/L为ICP重度组,入组26例;选择同孕周正常孕妇胎儿为健康对照组,入组52例.对胎儿行超声心动图检查,留存动态四腔心声像图,并将图像导入VVI软件脱机分析,获得双心室VVI参数,包括收缩期峰值速度(Vs)、舒张期峰值速度(Vd)、收缩期峰值应变(S)、收缩期峰值应变率(SRs)、舒张期峰值应变率(SRd),并计算三组胎儿射血分数(EF)、短轴缩短率(FS),分析各项指标的组间差异.结果 (1)三组胎儿EF、FS均在正常范围内,且组间无差异(P均＞0.05);(2) ICP重度组胎儿右室各节段SRs、SRd、S及Vd较ICP轻度组、对照组减低(P均＜0.01).结论 SRs、SRd、S及Vd可以作为早期提示重度ICP孕妇胎儿右心局部功能异常的影像学指标.

目的:探讨速度向量成像技术(VVI)监测妊娠期肝内胆汁淤积症(ICP)孕妇胎儿左右心纵向整体心功能的临床价值.方法:以2016年11月至2017年11月,于首都医科大学附属北京地坛医院超声科检查发现的ICP胎儿为研究对象.母体血清总胆汁酸浓度10≤TBA＜ 40μmol/L为ICP轻度组,入组28例;TBA ≥40 μmol/L为ICP重度组,入组28例;选择同孕周的正常孕妇胎儿,为正常对照组,入组56例.对所有入组胎儿行超声心动图检查,留存动态四腔心声像图,将图像导入VVI处理软件脱机分析,获得左右心室VVI参数,包括收缩期峰值速度(Vs)、舒张期峰值速度(Vd)、收缩期峰值应变(S)、收缩期峰值应变率(SRs)、舒张期峰值应变率(SRd).结果:ICP重度组胎儿左心室整体SRs、SRd及S较ICP轻度组和对照组减低(P＜0.01),但左心室整体SRs、SRd及S于ICP轻度组和对照组间,差异无统计学意义(P ＞0.05);ICP重度组胎儿右室整体Vd较ICP轻度组、对照组减低(P＜0.01),但于ICP轻度组和对照组间,差异无统计学意义(P ＞0.05);ICP重度组胎儿右心室整体SRs、SRd及S较ICP轻度组和对照组减低(P＜0.01),但于ICP轻度组和对照组间,差异无统计学意义(P＞0.05).结论:母体重度胆汁酸增高损害胎儿左心及右心整体收缩及舒张功能;母体轻度胆汁酸增高对胎儿左右心整体心功能无明确影响.

目的:寻找提示妊娠期肝内胆汁淤积症(ICP)胎儿肺损害的产前超声指标及与围产儿肺损害事件的相关性.方法:分析2016年11月至2017年11月,于北京地坛医院超声科检查发现的36例ICP胎儿超声及临床资料,孕周31 ～33周“.将研究对象分为两组,10≤TBA＜ 40μmol/L为轻度ICP组,入组18例;TBA≥40μmol/L为重度ICP组,入组18例;选择同孕周的正常胎儿为对照组,入组36例.观察并测量左(右)肺动脉起始段(PA1)、左(右)肺动脉中间段(PA2)、肺门处肺动脉(PA3)、肺内动脉第一级分支起始部(PA4)多普勒指标,测量参数包括加速时间(ACT)、射血时间(ET)、计算ACT/ET、收缩期峰值流速(PSV)、舒张末期流速(EDV)、舒张早期反向峰值速度(PEDRF)、搏动指数(PI)、阻力指数(RI).分析三组胎儿间各项指标间的差异及与围产儿肺损害事件的相关性.结果:重度ICP组肺损害事件发生率(27.8％)明显高于轻度ICP组(5.6％)和正常组(5.6％),差异有统计学意义(P＜0.001).②重度ICP组PA1 ～4段ACT均低于轻度ICP组和正常组,差异均有统计学意义(P均＜0.01);PA1～4段ACT减低与围产儿肺损害事件正相关,相关系数为(r=0.545,P=0.019)、(r=0.636,P =0.003)、(r=0.500,P=0.004)、(r=0.701,P=0.000).③重度ICP组PA1 ～4段ACT/ET均低于轻度ICP组和正常组,差异均有统计学意义(P均＜0.01);PA1 ～4段ACT/ET减低与围产儿肺损害事件正相关,相关系数为(r =0.599,P=0.031)、(r=0.565,P=0.012)、(r=0.500,P=0.042)、(r=0.685,P=0.001).④PA1 ～4段ET、PEDRF、PSV、EDV、RI、PI于三组间比较,差异均无统计学意义(P均＞0.05).结论:PA1-4段ACT、ACT/ET减低提示ICP胎儿肺损害,围产儿可能发生肺损害事件.

Objective To investigate the efficacy and safety of precise treatment guided by ultrasound for acquired immunodeficiency syndrome (AIDS) patients with liver abscess. Methods Total of 44 AIDS patients with liver abscesses (58 lesions) from January 2009 to April 2016 in our hospital were taken as the research objects, who were divided into percutaneous aspiration (PA) group and percutaneous catheter drainage (PCD) group according the size. The periods of body temperature returned to normal, closure of abscess, cure rate of a puncture, total cure rate and complications were compared between the two groups, respectively. Results There were 44 abscesses treated with PCD and 14 abscesses were treated with PA. The closure period of abscess in PCD group was significantly longer than that in PA group [(18.18 ± 8.73) d vs. (9.14 ± 3.96) d; t = 5.353, P < 0.001)]. The cure rate of a puncture in PCD group was significantly higher than that in PA group (44/44 vs. 8/14, P <0.001). Complications (0/44 vs. 1/14, P = 0.241) and period of body temperature returned to normal [(1.60 ± 0.52) d vs. (1.36 ± 0.50) d; t = 1.543, P = 0.128)] had no significant difference between the two groups, and the total cure rate of each group was 100%. One case with abscesses occured bleeding in PA group. No medical staff was exposed to infection. Conclusions Operation of precise treatment guided by ultrasound for AIDS patients with liver abscess was simple, with lower risk, higher cure rate and less complications.

目的 探讨艾滋病合并特殊感染及肿瘤的超声声像图及超声造影特征,分析其临床意义.方法 回顾性分析收治的231例艾滋病合并感染及肿瘤的超声声像图改变及超声造影表现.结果 感染150例:包括肝脓肿35例(23.33%)、化脓性炎14例(9.33%)、淋巴结核97例(64.67%)、马尔尼菲青霉菌4例(2.7%);恶性肿瘤81例:包括淋巴瘤42例(51.85%)、卡波西肉瘤16例(19.75%)、宫颈癌23例(28.40%).超声声像图及超声造影都有相应的改变.所有病例均在超声引导下进行组织活检、细针抽吸或置管引流后细菌培养,均有病理结果证实.结论 彩色多普勒超声及造影检查对艾滋病合并特殊感染及肿瘤的诊断有相应的影像学表现,给临床诊断提供重要信息,可以作为首选的影像学检查方法.

目的:对比分析二维超声指标在中孕期胎儿主动脉缩窄方面的应用价值,为产前诊断和围产期管理提供依据.方法:回顾分析2013年1月至2015年12月,于北京安贞医院胎儿心脏病母胎医学会诊中心,经产前超声心动图检查提示可疑主动脉缩窄的43例胎儿影像数据资料.43例主动脉缩窄胎儿临床资料完整,孕妇年龄21 ～ 40岁,平均(30.0±4.1)岁,孕周20 ～ 28周,平均(23.5±4.1)周.以出生后超声心动图证实为金指标,43例胎儿中15例经出生后或尸检证实为主动脉缩窄,确定为A组;28例经出生后或尸检证实为正常胎儿,确定为B组.以主动脉峡部Z-分数(Z-AoI)、主肺动脉内径/升主动脉内径(MPAd/AAOd)、主动脉峡部内径/动脉导管内径(AOId/ DAd)、三尖瓣环横径/二尖瓣环横径(TVd/MVd)为指标,分析其提示中孕期胎儿主动脉缩窄的灵敏度、特异度以及与金标准的一致性(Kappa值);计算胎儿主动脉瓣环径(AOd)、升主动脉内径(AAOd)、主动脉峡部内径(AOId)作为超声指标提示中孕期胎儿主动脉缩窄的cot-off值以及该cut-off值的灵敏度、特异度和Kappa值.结果:①以MPAd/AAOd≥1.6,AOId/DAd＜0.74,TVd/MVd＞ 1.5,Z-AoI＜-2为界值,提示主动脉缩窄的灵敏度分别为76.0％、82.9％、20.0％、80.1％,特异度分别为80.3％、80.0％、80.0％、91.4％,Kappa值分别为0.693、0.740、0.246、0.789;②制作ROC曲线,显示AOd＜ 3.45mm、AAOd＜ 3.55mm、AOId＜ 1.95mm为cut-off值,提示主动脉缩窄的灵敏度分别为92.9％、65.0％、86.7％;特异度分别为98.0％,73.0％,86.4％;经过一致性检验,三项指标的Kappa值分别为0.901,0.599,0.740.结论:①本研究的各项二维超声诊断指标中,主动脉瓣环内径在中孕期提示胎儿主动脉缩窄有非常重要的临床价值,与出生后超声心动图检查或尸检金标准的一致性最高;②主肺动脉内径/升主动脉内径、主动脉峡部内径/动脉导管内径、主动脉峡部Z-分数、主动脉峡部内径是提示中孕期胎儿主动脉缩窄的重要参考指标,与金标准有较高的一致性;③三尖瓣环横径/二尖瓣环横径、升主动脉内径与金标准的一致性,差异无统计学意义,不建议作为提示主动脉缩窄的超声指标.

Objective To evaluate the standard specification in liver biopsy guided by the color Doppler sonography through comparing the rate of complications between the two periods (January 2009 to March 2012 and April 2012 to June 2015).MethodsMedical records of all patients undergoing percutaneous liver biopsy guided by color Doppler sonography from January 2009 to June 2015 in Beijing Ditan Hospital, Capital Medical University were reviewed retrospectively. Patients were divided into treatment group (from April 2012 to June 2015) and control group (from January 2009 to March 2012) based on whether the standard specification was applied when patients undergoing liver biopsy guided by color Doppler sonography. The rates of complications were compared and further furtherly analyzed between the two groups.ResultsTotal of 5107 cases were given liver biopsy guided by the color Doppler sonography, among whom 2585 cases were in treatment group and 2522 cases were in control group. The total complication rate was 4.8 % (245/5107). In treatment group, bleeding was identiifed in 6 patients (0.23%), including one case (0.04%) with free intraperitoneal hemorrhage and 5 cases (0.19%) with subcapsular hematoma. Adjacent organ (kidney) injury was identiifed in 1 case (0.04%). Total of 86 patients (3.32%) occured the symptoms of pain. In control group, bleeding was identiifed in 22 cases (0.97%), including 2 cases (0.08%) with free&nbsp;hemorrhage, 18 cases (0.71%) with subcapsular hematoma, 1 case (0.04%) with hemobilia, 1 case (0.04%) with delayed bleeding and 130 patients (5.15%) occured the symptoms of pain. There were significant differences in complication rate (3.6% vs. 6.0%), bleeding rate (0.23% vs. 0.87%),incidence rate of hepatic capsular hematoma (0.19% vs. 0.71%) and rate of pain (3.32% vs. 5.15%) between treatment group and control group, respectively (P = 0.001, 0.002, 0.006, 0.001).ConclusionThe complication rate of liver biopsy guided by color Doppler sonography could be reduced by establishing reasonable standard speciifcation.