Objective:To explore the compatibitity change of different injection in infusion tabe. Methods:Using compatibility test and literatures to analysis. Results: While experimenting on polyene phosphatidylcholine injection and diammonium glycyrrhizinate injection, neither liquid nor diluent had changes in the appearance of the characters. Conclusion: The new drugs that have not yet been included in the injection of changes in the key, should be paid more attention to observation when it is used. If abnormal occurrence is appeared, it should be handled properly in time. The behavior will prevent the reaction products from producing adverse effect in body.

Objective:To find out the applications of the drugs increasing the white cells in our hospital and to analyze the cost-benefit for the most frequently used ones.Methods: DDDs,Daily costs and gross earnings for these drugs from beginning to the end of 2006 were statistically analyzed.Results: The gross earnings were 587 514.72 yuan for oral preparations,and 44 672.00 yuan for injectable ones that increase the white cells.The first three of DDDs were Leucogen tablets,Fufangzaofan pills and Diyushengbai tablets.Daily costs of rhG-CSF was 69.80 yuan,which was the most expensive,whereas batyl alcohol,the cheapest one,was only 0.09 yuan daily.Conclusion: The oral preparations constitute the most part of the drugs that increase the white cells in our hospital.The DDDs is closely related to the cost-benefit ratio,which means that the applicaions of the drugs which may increase the white cells are reasonable in our hospital.

康莱特注射液的主要成分为薏苡仁油,具有明显的抑瘤作用、免疫功能增强作用和镇痛作用。收集和查找文献资料,从药理作用、临床研究、药物不良反应等几个方面评价康莱特注射液。为其临床应用和进一步研发提供参考。

抗纤丸是天津市传染病医院研制的中药蜜丸剂,由当归、川芎、赤芍、黄芩等12味中药制成,具有活血化瘀、扶正祛邪,抗纤维化之功效,在临床应用近30年,主要用于治疗慢性肝炎、肝硬化.目前该制剂尚没有专属性的质量控制方法.黄芩具有抗氧化活性,具有广谱的抗菌和抗病毒作用,有效成分主要有黄芩苷、黄芩苷元和汉黄芩素等.因此本实验采用HPLC法检测抗纤丸中黄芩苷,为制定该制剂专属性的质量控制标准提供实验依据.

OBJECTIVE To establish an HPLC-DAD method to determine the content of paeoniflorin,ferulic acid and baicalin in Kangxian pills.METHODS The sample was determined by RP-HPLC-DAD with a Diamonsil C18 column,using methanol-1% phosphoric acid solution as a mobile phase,detecting wavelength at 230 nm,316 nm,280 nm and the column temperature being 35 ℃.RESULTS The three effective components could be detected by this method.A good linearity of paeoniflorin,ferulic acid and baicalin was in the range of 0.20-0.60 μg,0.025-0.075 μg,1.25-3.75 μg;the average recoveries were 100.87%,100.31%,101.05%.CONCLUSION The method is simple,accurate and reproducible.It can be used to control the quality of Kangxian pills.

目的:提高合理用药咨询的服务质量.方法:收集并整理本院2007年8月-2007年12月门诊中药合理用药咨询情况,对咨询类型与咨询内容进行分析.结果:用药问题占总咨询量的17.47%,肝脏疾病患者用药是传染病医院临床药学工作的重点.结论:开展专业化的门诊药物咨询是临床药学工作的重要内容,有助于加强医师、患者和临床药师之间的沟通,提高患者用药依从性,促进合理用药.

AIM: To establish the methods of quality control of Kangxian Pills (Redix Astragali,Radix Angelicale Sinensis,Rhizoma Chuanxiong,Radix Scutellariae,Fructus Schisandrae Chinensis,etc.). METHODS: Radix Angelicae sinensis;Rhizoma Chuanxiong;Radix Astragali;Radix Scutellariae were identified with TLC and the content of deoxyschizandrin and schisandrin B in the Kangxian Pills were determined by HPLC The separation was performed on Diamonsil~(TM) C_(18)(4.6 mm×250 mm,5 μm)analytical column with a mobile phase consisted of methanol and water(78(∶)22) at the flow rate of 1.0 mL/min.The UV detection wavelength was set at 254 nm first and was altered to 220 nm after 17 min. RESULTS: The same color spots in the TLC graphs of sample existed at the corresponding position compared with the reference solution.The linear range of deoxyschizandrin was within 0.39-(1.95) μg(r=0.999 9).The average recovery was 98.8%,RSD was 1.7%.The linear range of schisandrin B was within 0.09-0.45 μg(r=0.999 9).The average recorery was 99.1%,RSD was 1.7%. CONCLUSION: The methods are simple and have good reproducibility.

目的:建立抗纤丸中当归、川芎、五味子、黄芪、黄芩的薄层鉴别方法,为制定其质量标准提供依据.方法:薄层色谱法.结果:供试品色谱中,在与对照品及对照药材色谱相应的位置上,显相同颜色的斑点.结论:实验方法简便、重复性好.阴性对照无干扰.可为该制剂的质量控制的方法提供参考.

目的:建立健肝降脂丸的薄层鉴别方法,并进行临床研究观察。方法:采用薄层色谱法分别以苯-乙酸乙酯(19∶1),甲苯-乙酸乙酯-甲酸(15∶2∶1)为展开剂,对健肝降脂丸中丹参和何首乌进行定性实验。结果:分离良好,斑点清晰。结论:方法简便可靠,重现性好,适合用于日常的质量控制中应用,且临床疗效好,未发现明显不良反应。

探讨影响蜜丸硬度的因素及质量控制,力求采用新技术、新工艺,开展其稳定性方面的研究,提高蜜丸剂的有效性和安全性,突出中药蜜丸剂释药多缓慢持久、适于慢性病的调治的特点,完善和提高蜜丸制剂的质量。

Object: To establish an HPLC method for determination of baicalin in Kangxian pills.Methods: The separation was performed on a Phenomenex C_(18) column with methanol-water-phosphoric acid(47∶53∶0.2) as mobile phase.The flow rate was 1.0 ml/min and the detection wavelength was set at 280 nm.Results: The linearity was obtained within a range of 0.1~1.0 μg(r=0.999 5).The average recovery was 99.82% and RSD of 1.76%(n=5).Conclusion: The method is easy and reproducible and can be used for quality control of Kangxian pills.

(Objective) To establish the quality criteria of Yi-shen Ruan-gan (nourishing kidney and softening liver) mixture. (Methods) The qualitative idendificatioin of the the paeoniae radix was carried out by thin layer chromatography. (Results) The colour spectrum of experimental medicine showed same colour spot and was better distinct than that of control product and control medical material. (Conclusions) The method is sensitive, accurate and strongly specific and may be used to carry out the qualitative identification and quality control.

抗纤丸是本院制剂室生产的中药蜜丸剂,临床应用已20余年,抗纤丸具有活血化瘀、扶正祛邪和抗纤维化作用,主要治疗慢性肝炎和肝硬化。通过查阅文献,分析总结了抗纤丸中药成分的药理作用。

中药标本室(柜)是经营中药材及中药饮片的药品批发企业必须具备的条件之一,在药品使用单位中并无统一要求.近年来,不少医院从完善药剂科功能出发根据自身条件及特点,将各医院常用中药的原药材、饮片加以收集整理贴标签陈列,建立了中药标本室.

目的:建立抗腮糖浆的质检标准.方法:采用薄层色谱法对抗腮糖浆中板蓝根进行定性鉴别.结果:供试品色谱在与对照品色谱相应的位置上显相同颜色的斑点.结论:该法可用于抗腮糖浆的质量控制.

目的:建立抗纤丸的质量控制标准.方法:采用薄层色谱法对抗纤丸中黄芩进行定性鉴别.结果:供试品色谱在与对照品色谱相应的位置上显相同颜色的斑点.结论:该法可用于抗纤丸的质量控制.

[目的]观察严重急性呼吸综合征(SARS)的临床特征及中西医结合治疗疗效.[方法]在西医对症治疗、抗菌、抗病毒、吸氧和辅助治疗基础上,根据患者全部症状、体征、舌苔、脉象所出现的频率进行辨证,在早期和中期以白虎加苍术汤加味或三仁汤加味,恢复期以清暑益气汤加味治疗.[结果]41例患者中39例(95.10%)痊愈出院,1例(2.44%)恢复期,1例(2.44%)死亡.其中服用中药患者发热、憋气、胸闷等症状改善均明显好于单纯西药治疗者,同时胸片表明服用中药可促进炎症吸收,中药并可防止激素减量后的反跳.[结论]中西医结合治疗SARS疗效较好,值得进一步深入研究.