Purpose: Assess the comparative accuracy and reliability of postoperative toric intraocular lens (TIOL) alignment measurement methods: Casia2 and Adobe Photoshop with digital slit lamp images (PS method).Methods: In a study of 41 subjects with 58 eyes postimplantation of TIOL, we independently measured TIOL alignment with Casia2 and PS methods. The intraclass correlation coefficient (ICC1,1) was employed to assess the repeatability of the Casia2 method. While ICC2,1 for absolute agreement and Bland-Altman analysis were utilized to determine the interdevice agreement between the two methods, the regression analysis was conducted to identify any proportional bias.Results: Casia2 demonstrated excellent intradevice repeatability with an ICC1,1 of 0.998. The absolute agreement between Casia2 and PS was very high with an ICC2,1 of 0.999. The average discrepancy between the two measurement methods was -0.828 degrees, with a 95% confidence interval (CI) ranging from -1.623 degrees to -0.032 degrees. The 95% limits of agreement (LoA) were between -6.761 degrees and 5.105 degrees, indicating a strong concordance in TIOL alignment measurements. Casia2 was capable of accurately measuring the TIOL axis alignment under conditions of pupil diameters (PDs) of 4 mm or greater.Conclusion: Casia2 and PS demonstrated significant concordance in measuring postoperative TIOL alignment, with Casia2 offering a more straightforward and accessible alternative, particularly beneficial for patients with suboptimal pupil dilation.

Purpose: Assess the comparative accuracy and reliability of postoperative toric intraocular lens (TIOL) alignment measurement methods: Casia2 and Adobe Photoshop with digital slit lamp images (PS method). Methods: In a study of 41 subjects with 58 eyes postimplantation of TIOL, we independently measured TIOL alignment with Casia2 and PS methods. The intraclass correlation coefficient (ICC1,1) was employed to assess the repeatability of the Casia2 method. While ICC2,1 for absolute agreement and Bland-Altman analysis were utilized to determine the interdevice agreement between the two methods, the regression analysis was conducted to identify any proportional bias. Results: Casia2 demonstrated excellent intradevice repeatability with an ICC1,1 of 0.998. The absolute agreement between Casia2 and PS was very high with an ICC2,1 of 0.999. The average discrepancy between the two measurement methods was -0.828°, with a 95% confidence interval (CI) ranging from -1.623° to -0.032°. The 95% limits of agreement (LoA) were between -6.761° and 5.105°, indicating a strong concordance in TIOL alignment measurements. Casia2 was capable of accurately measuring the TIOL axis alignment under conditions of pupil diameters (PDs) of 4 mm or greater. Conclusion: Casia2 and PS demonstrated significant concordance in measuring postoperative TIOL alignment, with Casia2 offering a more straightforward and accessible alternative, particularly beneficial for patients with suboptimal pupil dilation.

目的 评价康柏西普联合黄斑局部/格栅样激光光凝治疗糖尿病性黄斑水肿(DME)的有效性及安全性.方法 检索CNKI、万方、VIP、CBM、Cochrane Library、Embase、Pubmed、ClinicalTrials.gov数据库中有关康柏西普、激光光凝术治疗DME随机对照文献,检索时间自建库起至2022年2月.使用RevMan 5.4统计软件进行Meta分析.结果 纳入12篇文献,包括2208例患者、2322只DME患眼.康柏西普联合黄斑局部/格栅样激光光凝治疗的有效率明细优于单用激光光凝治疗(P<0.01),而不良事件差异无统计学意义(P>0.05).结论 康柏西普联合黄斑局部/格栅样激光光凝治疗DME疗效优于单用激光光凝治疗.

Background Kimura’s disease is a rare, benign, chronic inflammatory disease that presents as painless, solid masses mainly affecting the deep subcutaneous areas of the head and neck, especially the salivary glands, parotid glands and nearby lymph nodes. It is characterized by elevated peripheral blood eosinophil and Immunoglobulin E (IgE) levels. Case presentation A 31-year-old Asian male presented with an orbital space-occupying lesion lasting for 1.5 years. Ten years prior, surgical excision of bilateral fossa cubitalis and groin masses was performed, and the pathological examination showed "lymphoproliferative disease". One year later, masses reappeared near the surgical sites; they grew slowly and shrank after glucocorticoid treatment . At this point, admission examinations showed in the peripheral blood an eosinophil proportion of 13.4%, a total IgE level of 26,900.00 IU/mL, prurigo present on the whole body, and multiple palpable masses near the bilateral fossa cubitalis and groin. The left eyeball was exophthalmic. The left elbow mass was excised, and the pathological examination confirmed Kimura’s disease. Oral glucocorticoid therapy is taken and tapering regularly. The eosinophil count returned to normal, the IgE level gradually decreased, the orbital space-occupying lesion and elbow and groin masses shrank significantly, and the whole-body skin prurigo disappeared. Currently, the patient has been in a stable condition for eighteen months. Conclusion Our case provides a novel insight that Kimura’s disease should be involved in the differential diagnosis of inflammatory lesion mass of orbit and also supports systemic regular glucocorticoid as a valuable therapy of such condition, but close follow-up and long-term observation are crucial.

目的 了解深圳市龙岗区青少年屈光状态及眼生物参数变化的变化.方法 选取深圳市龙岗区4所九年一贯制学校的四年级和初一年级进行抽样,2018年完成第一轮调查,2020年对同一调查对象进行随访.采用对数视力表、电脑验光仪及索维生物测量检测视力、等效球镜及眼生物学参数,仅纳入右眼数据进行分析.结果 与2018年比较,2020年男生、女生等效球镜和眼轴参数增加(P<0.01).2018年初一学生等效球镜、眼轴、角膜曲率及前房深度大于四年级学生;2020年两个年级学生的上述参数均高于2018年(P<0.05或0.01).2018年公立学校学生的等效球镜及眼轴均大于私立学校学生,2020年两类学校学生等效球镜及眼轴均增加(P<0.01).与2018年比较,2020年两类学校学生的角膜曲率及前房深度均有变化(P<0.01).2020年四年级学生近视率从50.2％上升至62.1％,初一学生近视率从71.0％上升至83.9％(P<0.01).2020年女生近视率高于男生,初一学生近视率高于四年级,公立学校高于私立学校(P<0.05).初一学生近视戴镜率高于四年级,公立学校学生高于私立学校(P<0.05).结论 深圳市龙岗区青少年等效球镜、眼生物学参数随年龄增长而改变,近视率也相应增加.

目的:观察中西药合用治疗出血性玻璃体浑浊的效果.方法:30例随机分为两组各15例,两组均用西药治疗,观察组加用丹参注射液治疗.结果:观察组总有效率高于对照组(P＜0.05).观察组治疗后视力高于对照组(P＜0.05),而眼压明显低于对照组(P＜0.05).观察组眼底出血、视力下降、视物模糊等不良反应发生率低于对照组(P＜0.05).结论:中西药合用治疗出血性玻璃体浑浊效果较好.

目的:对合理使用抗VEGF药物辅助治疗糖尿病视网膜病变(PDR)的治疗效果进行评价.方法:选取2017年1月—2019年12月在我院住院治疗的30例PDR患者作为研究对象,以随机分组的方式分为实验组和常规组,每组15例(患眼15眼).实验组采用视网膜激光辅以抗VEGF药物(康柏西普)进行治疗,常规组采用视网膜激光进行治疗,分析两组疗效.结果:实验组视网膜水肿恢复时间、渗出吸收时间以及眼底出血吸收时间均短于常规组;BCVA水平以及CMT水平均低于常规组;并发症发生率比常规组低;两组差异具有统计学意义(P<0.05).结论:康柏西普辅助治疗糖尿病视网膜病变能有效改善病情,值得推广.

目的 探讨玻璃体腔注射康柏西普对老年性湿性黄斑病变患者视力及并发症的影响.方法 选取本院2018年5月-2019年3月收治的86例(86眼)老年性湿性黄斑病变患者,采取随机数字表法将其分为对照组和试验组,各43例,对照组采用玻璃体腔注射曲安奈德治疗,试验组给予玻璃体腔注射康柏西普治疗,分析比较两组视力及并发症情况.结果 试验组视力高于对照组且黄斑中心凹视网膜厚度小于对照组,差异具有统计学意义(P＜0.05);试验组并发症总发生率低于对照组,差异具有统计学意义(P＜0.05).结论 玻璃体腔注射康柏西普对老年性湿性黄斑病变患者的视力具有一定的改善作用、有效降低并发症发生率.

目的 观察儿童弱视患者给予综合治疗的疗效.方法 选取我院近期接收的50例弱视患儿,根据其视力评估结果,给予综合治疗方案,观察其临床疗效.结果 弱视综合治疗的效果与患儿的弱视类型、治疗年龄密切相关.其中,屈光不正性弱视患儿的疗效最好,年龄越小的患儿,其疗效越好,P<0.05.结论 在儿童弱视的治疗中,综合治疗的疗效显著,但该症宜早发现、早诊断、早治疗,以保证患儿的视功能恢复效果.

目的 收集一个常染色体显性遗传的青少年开角型青光眼(JOAG)家系,分析该家系的临床特征和分子遗传学特点.方法 收集一个JOAG家系的临床资料,包括详细的既往病史、生长发育史、生育史等,并进行全面的眼部和全身检查,包括视功能、眼压、眼前节和眼后节检查等.采集家系患者和正常成员的外周静脉血提取基因组DNA,筛选疾病相关基因序列改变,定位致病突变后,通过生物信息学的方法准确鉴定碱基突变和结构性变异,综合考虑家系资料、测序数据和现有多态性数据,设计分析方法,对所有变异进行筛查,从而确定致病变异,并分析其与患者临床特征的关系.结果 该家系呈常染色体显性遗传模式,患者表现为眼压升高,房角异常,发病年龄均低于40岁,且无其它疾病表征.分子遗传学分析上,经筛选MYOC、CYP1B1和WDR36等青光眼相关候选基因,仅发现一些单核苷酸多态性(SNP)位点.但携带有MYOC基因的SNP位点T353I的JOAG患者发病年龄早,且病情发展的更快、更重.结论 该JOAG家系中发现MYOC基因的单核苷酸多态性位点T353I与JOAG易感性相关,这是中国人所特有的一种多态性序列改变,与JOAG的严重程度有关,有助于MYOC基因型与临床表型关系的研究.

Objective To investigate the clincal characteristics and treatment of infective endophthalmitis after cataract surgery. Methods Total of 20 patients (20 eyes) with infective endophthalmitis after cataract surgery were selected from January 2012 to January 2016 in People's Hospital of Longgang District and Shenzhen Eye Hospital. All the 20 cases were accepted with insurface anesthesia of vancomycin intravitreal injection, 6 severe cases accepted vitreous body surgery with conventional closed three channel 23 G vitreous body resection surgery combined with silicone oil tamponade. Silicone oil removal was performed at 3-6 months after operation. The degree of eye pain, corneal opacity, anterior chamber purulent exudate, vitreous seepage, the improvement of symptoms such as eye condition, routine blood test of were investigated on patients with 1 week after vitrectomy (second operation) and 1 week after silicone oil (third operation), and investigated the best corrected visual acuity of patients. Results After the second operation, pain of 20 patients was relieved, keratopnea disappeared, preatrial purulent exudate disappeared, glass body was transparent; the eyes were visible at the base of the nipple, the pale was red, the retina was flat, and the center of the macula was visible. Patients following up for 3-6 months after the third operation were nonrecurrent. Compared with the second operation, the differences of the best orthodontic vision of 1 week after the second operation and 1 week after the third operation were all statistically significant (t = 76.0, P =0.019; t = 53.74, P = 0.027). Conclusions Patients with infectious endophthalmitis after cataract intraoperative and postoperative should choose vancomycin in combination with other antibacterial drugs to anti-infection, and vancomycin injection drug in vitreous surgery, vitrectomy and silicone oil filling should be adopted for severe cases, symptoms of patients after operation improved significantly, and eyesight had significantly improved.

目的 探究机械性眼外伤致伤原因以及对预后的影响因素分析.方法 选取深圳市龙岗区人民医院2015年6月-2016年6月收治的90例机械性眼外伤致伤患者作为研究对象,对这些患者的基本信息、眼外伤致伤原因、伤后就诊时间以及治疗方法等信息进行全面细致的统计和分析.结果 在这些患者中致伤原因主要为钝器伤,占总数的72.22％;其次为锐器伤和爆炸伤,分别占总数的17.78％和10.00％.患者视力预后的主要影响因素为就诊时间、致伤的原因以及是否进行手术治疗.结论 机械性眼外伤致伤的原因主要包括钝器伤、锐器伤和爆炸伤,结合预后的影响因素采取有效的措施有效的提高预后的效果.

OBJECTIVE To investigate the clinical effect of surgery in different time of patients with open-globe injury.METHODS From March of 2015 to March of 2016,124 cases with open-globe trauma admitted in our hospital were included and assigned into early surgery group (n=60) that accepted surgery 2-4 days after injury and conventional surgery group (n=64) that underwent procedure 7-14 days after trauma.Then results in terms of treatment efficacy and complications were compared between two groups after surgical treatment.RESULTS Functional recovery rate and the total cure rate of early surgery group were 90％ and 96.67％,and they were significantly higher than counterparts of the conventional surgery group which were 59.38％ and 81.25％ (P＜0.05).The anatomical recovery rate and unhealed rate in early surgery group (6.67％,3.33％) showed no statistical difference in contrast to conventional surgery group (21.88％,18.75％).In early surgery group,58 cases (96.67％) saved their eyeballs,while in conventional surgery group 60 cases (93.75％) retain the eye which meant no difference between the two groups (P＞0.05).After surgery,occurrence rates of silicone oil,retinal detachment,vitreous re-bleeding,secondary glaucoma,TPVR (trauma proliferative vitreoretinopathy) in early surgery group were significantly lower than in conventional surgery group (P＜0.05).CONCLUSIONS Early surgical treatment of open-globe injury effectively improved the treatment effect,reduced the incidence of related complications,improved the prognosis of patients,therefore it was the best option for open-globe injury cases.

目的 观察小切口白内障囊外摘除术联合后房型人工晶体植入术治疗糖尿病代谢性白内障的临床效果.方法 160例(160眼)糖尿病代谢性白内障患者,采取数字随机法分成观察组和对照组,各80例(80眼).观察组采取小切口白内障囊外摘除术联合后房型人工晶体植入术治疗,对照组采取常规白内障囊外摘除术联合后房型人工晶体植入术治疗,比较两组临床效果.结果 观察组患者术后7 d、1个月、3个月的视力恢复水平优于对照组,差异均有统计学意义(P<0.05).观察组患者术后7 d、1个月、3个月的角膜散光水平低于对照组,差异均有统计学意义(P<0.05).观察组并发症发生率为10.00%,对照组为36.25%,观察组患者并发症发生率低于对照组,差异有统计学意义(P<0.05).结论 小切口白内障囊外摘除术联合后房型人工晶体植入术治疗糖尿病代谢性白内障的临床效果显著,较传统手术方法更好,对患者有利,具有推广价值.

OBJECTIVE:To evaluate the effect of annular electrode lacrimal duct reconstruction in improving the safety and efficacy of nasolacrimal duct stent implantation for treatment of nasolacrimal duct obstruction.METHODS:This randomized clinical trial was performed to compare the efficacy, success rate of intubation, time used for stent implantation, intraoperative pain, and extubation-assciated complications between nasolacrimal stent implantation with and without annular electrode lacrimal duct reconstruction.RESULTS:A total of 119 eligible patients were enrolled in this trial. The total curative rate at 6 months of follow up after extubation was 70.9% (83/117) in these patients, and was significnatly higher in pateinets with lacrimal duct reconstruction than in those without [80.6% (54/67) vs 58.0% (29/50); χ(2)=7.093, P<0.05]. The total success rate of stent implantation was 98.3% (117/119) in all the patients initially enrolled, and two patients experienced failure of stent implantation and were excluded; the success rate was signfiicantly higher in patients initially enrolled in the lacrimal duct reconstruction group (χ(2)=6.282, P<0.05). The median time required for intubation was shorter in lacrimal duct reconstruction group (12 s vs 33 s; Z=-36.722, P<0.05). The intendity of intraoperative pain was comparable between the two groups (t=0.833, P=0.405). The total rate of puncta injury was 43.6% (51/117) in these patients and similar between the two groups (χ(2)=1.459, P=0.227). The total rate of extubation difficulty was 9.4% (11/117) in all the patients, and was lower in lacrimal duct reconstruction group [4.5% (3/67) vs 16% (8/50); χ(2)=4.463, P<0.05]. Stent breakage in extubation occurred in 4.3% (11/117) of the patients with similar rates between the two groups (χ(2)=2.964, P=0.085). Spearman bivariate correlation analysis showed that the time required for intubation was inversely correlated with the treatment efficacy (r=-0.584, P<0.05) and positively with the occurrence of extubation difficulty (r=0.491, P<0.05); extubation difficulty was inversely correlated with the curative effect (r=-0.511, P<0.05).CONCLUSION:Annular electrode nasolacrimal duct reconstruction can increase the safety and efficacy of nasolacrimal duct stent implantation for treatment of nasolacrimal duct obstruction.

目的：探讨鼻泪管阻塞模型理想的制作方法，以及动物模型鼻泪管阻塞的判断方法等。方法10只新西兰大白兔随机分成3组，金葡组4只8眼行鼻泪管损伤后接种金黄色葡萄球菌，结扎组4只8眼行鼻泪管损伤后缝线结扎，另一组2只4眼作为对照组，行鼻泪管损伤后不做进一步处理。观察损伤后3、7、14 d的临床表现及14 d时的泪道冲洗结果，泪囊造影情况，比较这些制作鼻泪管阻塞模型方法的成功率、临床表现等。结果结扎组鼻泪管阻塞成功率为100％（8／8），金葡组成功率为25％（2／8），对照组为0（0／4）。金葡组与结扎组、金葡组与对照组、结扎组与对照组比较，成功率的差异均有统计学意义（ P＜0.05）。泪道阻塞眼均有溢泪，泪道冲洗不通，泪囊造影示泪囊显影，鼻泪管不显影，但分泌物较少，金葡组早期分泌物较多。结论兔可作为鼻泪管阻塞模型较理想的实验动物，结扎法是制作兔鼻泪管阻塞模型的较理想的方法。

糖尿病视网膜病变是常见的严重糖尿病眼病,常造成视力减退或失明.该病严重影响着全球成千上万人的生活质量.糖尿病视网膜病变分为增殖性糖尿病视网膜病变与非增殖性糖尿病视网膜病变.糖尿病视网膜病变是糖尿病患者致盲的一个潜在因素,其诊断和治疗集中在疾病后期的血管畸形.本文就糖尿病视网膜病变的病因诊断和治疗的研究进展做一综述,可为基础与临床的深入研究和诊治提供借鉴与参考.

目的：探究甲基强的松龙对外伤性视神经病变视网膜厚度和视网膜神经节细胞的影响。方法从2012年1月到2014年8月在我们两院进行治疗的外伤性视神经病变患者中随机选择60例作为研究对象，按照入院的先后顺序平均分为治疗组和对照组。治疗组患者采用大剂量甲基强的松龙进行冲击治疗，同时配合高渗剂、神经营养药及血管扩张剂等进行治疗。对照组则应用常规剂量地塞米松进行治疗，辅助治疗同治疗组。在治疗前及治疗后第七、十四、二十一天分别检测两组患者的闪光及图形视觉诱发电位（ VEP）、视乳头周围视网膜神经纤维层（ pRN－FL）平均厚度和黄斑区视网膜神经节细胞复合体（ mGCC）整体平均厚度，并对两组数据的变化情况进行观察和比较。结果在治疗期间对两组患者的各项指标进行检测后发现，随着时间的变化，每组患者治疗前后的VEP波幅值、pRNFL厚度、mGCC 平均厚度出现一定程度的变化，差异有统计学意义（P＜0．05）。但治疗组与对照组比较，各项指标差异没有统计学意义（P＞0．05）。结论使用甲基强的松龙对外伤性视神经病变进行冲击治疗，没有得到优于对照组的治疗效果。因此在实际治疗过程中，不建议将大剂量甲基强的松龙冲击治疗作为 TON 的标准治疗方法。

AIM:To compare the curative effects between laser multi-point scanning and single-point multiple scanning for the treatment of non-proliferative diabetic retinopathy. METHODS:Fifty patients with non-proliferative diabetic retinopathy from January 2010 to January 2014 in our hospital were selected for the study, and were divided into two groups, the control group and the observation group, using a random number table. Twenty-five patients(43 eyes)in the observation group completed panretinal photocoagulation(PRP)therapy once by 577nm laser multi-point scanning. Twenty-five patients(41 eyes)in the control group completed PRP therapy by the single-point multiple scanning. The differences of average threshold sensitivity of visual field, F-ERG a/b wave amplitude, the clinical effective rates, the laser energy, the number of laser spot and the energy density between the two groups at various time points were compared.RESULTS:At 1d after the treatments, average threshold sensitivity of visual field was lower than those at 1d before treament, and the difference was statistically significant(t=2.421, P=0.017). The differences of average threshold sensitivity between the two groups at 1d before treatments, at 1d, 1, 2, 6, 12mo after treatments, were not statistically significant(P>0.05). The F-ERG a wave amplitude of both groups at 1d after treatments were lower than those of 1d before treatments, and the difference was statistically significant(t=2.319, P=0.025). There were no differences of the F-ERG b wave amplitude between both groups at 1d before treatments and at 1d, 1, 2, 6, 12mo after treatments(P>0.05). The F-ERG b wave amplitude of both groups at 1d after treatments were lower than those at 1d before treatments, and the difference was statistically significant(t=2.276, P=0.031). There were no differences between the two groups in terms of clinical effective rates and the number of laser spot(P>0.05). Laser energy used in the observation group was higher than that in the control group, the energy density was lower than that in the control group. The differences on the two items were statistically significant(P <0.05).CONCLUSION:There is no significant difference on clinical efficacy between laser multi-point scanning and single-point multiple scanning of PRP therapy. But the energy density of multi-point scanning mode is lower, and the damage made by this mode is less.

AIM: To explore the role that hepatocyte growth factor (HGF) plays in proliferative vitreoretinopathy (PVR) after retinal detachment( RD).METHODS: The contents of HGF in subretinal fluid (SRF) in 49 cases with RD were measured with enzyme-linked immunosorbent assay.RESULTS: With the worsening of PVR and vitreous opacity and prolonging of disease course, the contents of HGF increased, P<0.05 was considered statistically significant.CONCLUSION: The change of HGF in SRF had a close relationship with the occurrence and development of PVR after RD.