Objective:To explore the application effect of massive open online course (MOOC) combined with peer mutual assistance in cardiopulmonary resuscitation teaching.Methods:A total of 140 students in the same class of Batch 2015 were divided into the experimental group and the control group. In the teaching of cardiopulmonary resuscitation, the experimental group was based on the MOOC teaching platform, watched videos and topic tests before class, and used the peer mutual assistance in class. While the control group adopted traditional classroom teaching mode. The teaching effect of the two groups were evaluated by comparing the operation assessment scores and questionnaire survey of students' satisfaction with teaching. SPSS 22.0 was used for t-test and Chi-square test. Results:The operating assessment score of the experimental group was (82.20±2.31), and the operating assessment score of the control group was (75.80±1.72). The difference was statistically significant ( t=3.27, P<0.05). The questionnaire survey showed that the course satisfaction and learning motivation of the experimental group were better than those of the control group. In learning burden, the two groups had similar results ( P=0.739). Conclusion:MOOC combined with peer mutual assistance in cardiopulmonary resuscitation teaching can help students better master skills, improve students' course satisfaction and learning motivation, without increasing their learning burden.

目的 探析清气凉营汤对脓毒症(Sepsis)患者HMGBL、sRAGE及免疫功能的影响.方法 收集本院2019年8月至2020年2月急诊留观室、ICU收治的Sepsis患者60例,单盲试验原则,数字标注法随机分组,对照组30例,采用西医标准治疗方案,清气凉营组30例,在标准方案基础上联合清气凉营汤用药.比较两组治疗前、治疗7d血清HMGB1与血浆sRAGE水平、CD4+、CD8+水平及急性生理学及慢性健康状况评分系统(APACHE Ⅱ)评分,记录28 d病死率.结果 两组治疗7d后APACHE Ⅱ评分、血清HMGB1与血浆sRAGE水平显著低于治疗前(P＜0.05);且清气凉营组治疗7d后APACHE Ⅱ评分、血清HMGB1与血浆sRAGE水平改善幅度显著优于对照组(P＜0.05).两组治疗7d后CD4+、CD8+均明显高于治疗前(P＜0.05),且清气凉营组改善幅度显著优于对照组(P＜0.05).清气凉营组患者治疗28 d死亡率显著低于对照组(P＜0.05).结论 清气凉营汤治疗脓毒症效果良好,能降低患者HMGB1、sRAGE水平,抑制炎症因子过表达,调节机体免疫功能,促进自身免疫系统恢复稳态,减低病死风险.

目的 探讨岭南地区H3N2流感病毒感染患者的临床特点.方法 对221例H3N2流感病毒感染患者的临床特征进行回顾,采用描述性统计方法对其发病特征进行分析.结果 221例甲型H3N2流感病毒感染以21岁～30岁的青壮年人群为主,发病季节高峰在夏季(6月-8月)为多,均以发热为主,流感样症状较明显,阳性体征以不同程度的咽部充血及扁桃体肿大为主,血常规检查白细胞多数在正常范围.结论 岭南地区H3N2流感病毒感染表现出普通流行性感冒的症状和特点,应加强病原学检测及监测,规范抗病毒治疗.

目的:旨在探讨岭南地区甲型H3N2流感病毒感染病例中医证候分型,为中医诊治提供依据.方法:收集病源学诊断的甲型H3 N2流感病毒感染病例患者的中医证候要素资料,并将所有中医四诊信息进行聚类分析,提炼出其基本证候,参照中医辨证分型标准赋予适当证型名称,分析其中医证候分布情况.结果:共纳入岭南地区221例甲型H3N2流感病毒感染的患者,经聚类分析,其中医证型分别是:外感风寒化热挟湿证42例,外感风热挟湿证92例,外感风热证87例.结论:岭南地区H3 N2流感病毒感染病例多兼挟湿邪为患,与岭南多湿的特点一致.

OBJECTIVE To investigate the viral etiology of influenza in patients with confirmed pathogens and its correlation with systemic inflammatory response syndrome (SIRS) .METHODS From Feb .2009 to Sept .2011 , 531 virus-positive cases with influenza were received in the Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine . This paper investigated the patients for clinical epidemiology and analyzed the relanvance between SIRS patients and etiology .RESULTS Positive diagnoses were achieved:221 cases (41 .62% ) were infected with seasonal influenza A virus ,135 cases (25 .42% ) with the new H1N1 influenza A virus ,152 cases (28 .63% ) with influenza B virus .In the patients with seasonal influenza A virus ,the new H1N1 influenza A virus and influenza B virus ,the incidence of SIRS were respectively 29 .4% ,22 .9% and 29 .4% .And there was no significance between the groups (P>0 .05) .CONCLUSIONS Most of the influenza patients are mainly infected with seasonal influenza A virus ,the new H1N1 influenza A virus and influenza B virus ,and more than 20% of them have SIRS .More study is needed to elucidate the occurrence and characteristics of SIRS among influenza patients .

罗翌教授论治失眠认为其病机以肝脾肾虚为本,痰湿瘀热为标;在治疗上以经方为基础,灵活运用复法复方加减,同时配合腹针治疗,取得良好疗效.

目的 旨在探讨病毒病原学明确的流感样病例患者的中医证候分型.方法 对流感样病例患者进行了病原学检测,分析其病原学分布特点,并对病原学明确的患者进行中医证候要素资料的收集,并将所有中医四诊信息进行聚类分析,提炼出流感样疾病的基本证候,参照中医辨证分型标准赋予适当证型名称,分析其中医证候分布情况.结果 在531例病毒病原学结果中,普通甲型流感病毒感染221例(41.62％),新型H1N1甲型流感病毒感染135例(25.42％),乙型流感病毒感染152例(28.63％),其他感染23例(4.33％).531例病毒病原学证实的流感样病例经聚类分析得出4个证型:外感风邪证94例,外感风寒化热证80例,外感风热证125例,外感风热夹湿证232例.结论 岭南流感样病例中,以感染甲、乙型流感病毒为主,岭南流感样病例证候以风热夹湿证最为多见,与岭南多湿的特点一致.

目的:观察中药沐足治疗外感发热的临床疗效。方法:将293例患者随机分为治疗组和对照组A组、对照组B组,治疗组采用中药粉剂沐足治疗,对照组A组采用柴胡针治疗,对照组B组采用赖氨匹林治疗。观察各组临床疗效及体温曲线下面积、不良反应。结果:总有效率治疗组为77.0%,对照组A组为78.6%,对照组B组为87.4%,各组比较,差异有显著性意义(P<0.05)。治疗组与对照组A组比较,差异无显著性意义(P>0.05);与对照组B组比较,差异有显著性意义(P<0.05)。1h时体温曲线下面积治疗组与对照组A组比较,差异无显著性意义(P>0.05),治疗组与对照组B组比较,差异有显著性意义(P<0.05)。2h时各组比较,差异均无显著性意义(P>0.05)。4h时治疗组与对照组A组、对照组B组比较,差异均有显著性意义(P<0.05)。提示治疗组能达到良好的退热效果,其退热效果与对照组A组柴胡针肌肉注射效果相当,比对照组B组赖氨匹林静脉注射短期效果稍差,但退热时间较赖氨匹林长。结论:中药沐足治疗外感发热疗效肯定。

Objective: To investigate the syndrome patterns of Traditional Chinese Medicine in cases of influenza with definite viral etiology.Methods: Through detection etiology of the influenza cases,analysis of the distribution characteristics,collectting syndrome elements of the patients with definite viral etiology and cluster analysis of the four diagnostic information,we refined the basic syndrome patterns of influenza,gave them appropriate names and then syndromes distribution was carried out.Results: In the 531 cases of influenza illness,ordinary flu A virus occured in 135 cases(41.62%).The new type HINI flu A virus accounted for 135 cases(25.42%).Flu B virus accounted for 152 cases(28.63%) and the other flu viruses accounted for 23 cases(4.33%).As for TCM syndrome patterns,4 types of syndromes were presented: the exogenous wind syndrome accounted for 94 cases,the syndrome of heat transformed from wind cold accounted for 80 cases,the syndrome of superficies attacked by wind-heat accounted for 125 cases,the syndrome of superficies attacked by wind-heat with dampness accounted for 232 cases.Conclusion: In the caese of influenza illnesses in Lingnan area,flu A virus and B virus play the most important part.The syndrome of superficies attack by wind-heat with dampness takes the largest amount which is consistent with dampness—the characteristic of Lingnan area.

Objective:To observe the therapeutic effect of Yan's Yixin Prescription(YHP) for angina pectoris(AP) in coronary heart disease patients complicated with diabetes mellitus.Methods:Forty-five qualified patients were randomized into control group and treatment group.The two groups were given routine western medicine,and the treatment group received YHP additionally.Before and after treatment,we observed the changes of symptoms,blood glucose content,and electrocardiogram as well as the frequency,degree and duration of angina pectoris attack,and the dosage of glycerol trinitrate.Results:The total effective rate was 91.7% in the treatment group and 66.7% in the control group,the difference being significant between the two groups(P 0.05).Fasting blood glucose(FBG) and 2-hour preprandial blood glucose levels were decreased in both groups after treatment(P 0.05 compared with those before treatment),and the difference of FBG was significant between the two groups(P 0.05).The frequency and duration of AP attack were decreased in both groups after treatment(P 0.05 compared with those before treatment),and the difference was significant between the two groups(P 0.05).Conclusion:YHP exerts certain effect for the treatment of AP in coronary heart disease patients complicated with diabetes mellitus,which is worth of further research and clinical expansion.

温胆汤是治疗痰热饮证的常用方剂,本文通过对温胆汤的源流、组成、类方比较,归纳其加减特点和用药症状,结合岭南地区的发病特点,提出温胆汤在临床的运用体会,旨在指导临床.

目的观察益心方对冠心病患者血脂及超敏C反应蛋白(hs-CRP)的影响。方法将62例冠心病患者随机分为两组各31例,对照组给予常规西药治疗,治疗组在常规西药治疗基础上给予益心方口服,每日1剂,疗程均为4周。观察治疗前后两组患者血清胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和hs-CRP浓度变化。结果治疗组治疗后TC、TG、LDL-C、hs-CRP显著低于治疗前水平(P<0.05),HDL-C升高(P<0.05),与对照组治疗后比较也有统计学意义(P<0.05)。而对照组各指标治疗前后比较差异无统计学意义(P>0.05)。结论益心方通过降低血脂、抗炎等机制对预防冠心病早期动脉粥样硬化起着重要作用。

目的:观察邓老冠心方治疗冠心病患者的临床疗效及其对气虚证症状积分的影响。方法:将40例患者随机分为2组各20例,对照组常规给予阿斯匹林、β受体阻滞剂、钙通道阻滞剂或长效硝酸酯类药物治疗;治疗组在对照组治疗基础上联合邓老冠心方(组成:橘红、法半夏、茯苓、甘草、枳壳、竹茹、党参、丹参、莶草等)治疗。观察2组临床疗效及气虚证症状积分。结果:总有效率治疗组为85%,对照组为75%,2组比较,差异无显著性意义(P>0.05)。治疗1疗程后2组气虚证症状积分与治疗前比较,差异均有显著性意义(P<0.05);2组治疗后气虚证症状积分比较,差异有显著性意义(P<0.05)。结论:邓老冠心方对冠心病患者有较好的临床缓解作用,并能改善患者气虚证症状积分。

目的:观察中医综合疗法治疗慢性阻塞性肺疾病(COPD)急性加重期呼吸衰竭的有效性。方法:将符合纳入标准COPD急性加重期呼吸衰竭患者90例,随机分为治疗组,对照组各45例。对照组予无创正压通气合西医常规方法治疗,治疗组加用中医综合疗法。结果:治疗组总体疗效优于对照组、主要症状和体征(咳嗽、喘息、痰量、紫绀、肺部罗音)、肺功能改善情况、血气分析变化、呼吸机相关性肺炎(VAP)的发生率、气管插管率、死亡率皆低于对照组与对照组相比具有显著性差异。结论:中医综合疗法可提高通气效率,控制肺部感染,减少机械通气时间,显著减少无创通气的副作用,并可降低并发症的发生。在干预呼吸机相关性肺炎发生,改善呼吸肌疲劳,缩短上机时间等方面有优越性。

Objective:To observe the clinic therapeutic effect that Xinxiang powder treat the people with damp and heat evil in exterior syndrome,and evaluating its safety.Method:Adopting the randomization comparison single-blind method to divide the 120 patients who are diagnosed as viral upper respiratory infection into two groups which named Xinxiang powder(treat group),Banlangen powder(comparison group one).Observing the results of treatment effect on those who are diagnosed as damp and heat evil in exterior symdrome in TCM,at the same time evaluating the safety of the Xinxiang powder.Result:The average time that Xinxiang powder group,banlangen group begin to bring down a fever degree is separately 2.588 and 3.290 hours.The average time that body temperature dropped to normal for the first time is respectively 7.396 and 17.145 hours,the average time that the two groups totally bring down a fever degree is respectively 9.108,9.883 hours.The Xinxiang powder group was obviously shorter than the Banlangen powder group,and compared with comparison group had statistics meanings(P0.05).It suggested that the therapy effect which Xinxiang powder group to bring down a fever degree is superior to Banlangen powder group.17 patients' temperature totally came down to normal in treat group after treatment,compared with 7 patients in the comparison group,had statistics meanings(P0.05).The cure rate and the total effective rate in two groups were 21.7%,6.7%,and 83.3%,68.3%.The comparison between the proportions of the treat group and the comparison groups had significant difference,so it showed that treat group had better therapeutic effect to the comparison groups.During the study,no serious side effect of Xinxiang powder had been found.It proved that Xinxiang powder was safety.Conclusion:Clinical Study indicates xinxiang powder has a perfect effect on antipyretic to treat Acute Viral upper respiratory infection with the damp and heat evil in exterior syndrome in traditional Chinese medicine.It can decrease the fever steadily and meliorate the syndromes of Acute Viral upper respiratory infection such as sore throat,headache,muscular pain,hypodynamia,etc.And Xingxiang powder is convenient for being taken,safety and without side effect,it can be a characteristic prepared Chinese medicine to treat the Acute Viral upper respiratory infection with Disorder due to Dampness in traditional Chinese medicine.