Objective:To study the efficacy and safety of natural calcined bone repair material(NCBM)in repairing bone defect af-ter tooth extraction.Methods:A randemized,double-blinded,parallel,positive control(Bio-Oss)and multi-center clinical trial was employed.Imaging examination was used as the main efficacy evaluation index,surgical wound healing,rejection reaction,bone me-tabolic changes,bone infection signs were the subordinate efficacy evaluation indexes,the incidence of adverse reactions was observed for safety evaluation.Results:280 cases were included,269 cases completed the trial.In NCBMand Bio-Oss group the effective rate of imaging examination was 93.08% and 93.70%(P >0.05)respectively.The wound healing time of the 2 groups was less than 7 days,no rejection reaction,bone metabolic change and bone infection sign were observed.The incidence of adverse events in NCBM and the Bio-Oss group was 0.72% and 2.14%(P >0.05)respectively.Conclusion:The efficacy and safety between natural cal-cined bone repair material is not inferior to Bio-Oss in repairing bone defect after tooth extraction.

OBJECTIVE:To probe into the practice and experience of the pharmaceutical service on the patients with oral and maxillofacial space infection by the clinical pharmacists in Stomatological Hospital of the Fourth Military Medical University , and to provide reference for the clinical pharmacists .METHODS:The typical cases of clinic and relevant medical knowledge were applied into the analysis by the clinical pharmacists , the pharmaceutical service were conducted in respect of the formulation of therapeutic scheme of physician , administration of nurse , drug use of patients and the monitoring of adverse reactions after the drug was administered etc .RESULTS: The pharmacists participated in the pharmaceutical treatment of patients with oral and maxillofacial space infection , provided guidance for the rational drug use of physician , proper administration of nurse and rational drug use of patients and monitored the adverse drug reactions , so as to ensure the security of drug use in clinic .CONCLUSIONS: The clinic pharmacists should go into the clinical front line to provide the pharmaceutical service , make full use of their pharmacy specialty , improve the level of rational drug use in clinic and ensure the medication safety in patients .

The original teaching of clinical pharmacy for stomatology course did not let students aware of the importance of drugs in the treatment of oral diseases. The original teaching framework was rearranged:decentralizing knowledge of oral diseased related clinical pharmacy into several mod-ules;setting general knowledge into the oral basic medical module;adding the practice of visiting the pharmacy and manufacturing laboratory. Teaching process was closely combined with clinics and was integrated with disease-centered oral medicine curriculum integration system. Students responded that the teaching effect was better. The rearranged teaching method can enhance students' attention on drug treatment for oral diseases,improve their ability of clinical medication and promote the teaching quality.

To combine the theory teaching and clinical practice medicine knowledge effectively through adding noviciate in Clinical Pharmacy of Stomatology ,enhance the ability of using oral clinical medica-tion ,make up for the inadequacy of domestic existing oral teaching curriculum model .

口腔临床药物学是现代药学与口腔临床医学相结合的产物,对于口腔专业学生来说是十分必要且重要的一门学科.口腔临床药物学课程的设置就是为了帮助学生在临床上能够做到合理正确地使用药物.这门课程的设计需要理论与实践相互结合,对于教师来说,既要给学生传授基础知识和基本技能,还要培养学生在实践中应用知识的能力.人民出版社出版的《口腔临床药物学》(第4版)教材中,第十七章到第十九章是在前面章节不同类型药物的理论学习基础上,介绍针对口腔不同疾病包括牙体牙髓病、牙周病及口腔黏膜病的临床用药[1].如果说前面章节的学习是让口腔医学专业的学生了解一些常用药物的基本知识,那么后面3章则是教会学生将知识用于临床实践.

Objective To study the effect of the ardipusilloside(ADS) on proliferation of the human glioma U373MG cells and its mechanism.Methods The cultured U373MG cells were randomly divided into two groups: dimethyl sulphoxide control group(control group) and ADS treatment group(ADS group).MTT assay was performed to measure the effect of the different concentrations of ADS on the proliferation of U373MG cells.The apoptosis of U373MG cells was detected by flowcytometry.The Caspase-3 and p-Caspase-3 were determined by immunocytochemistry.Results ADS significantly inhibited the viability of U373MG cells in a dose-and time-dependent manner.Flow cytometry results showed that U373MG cell apoptosis rate was significantly increased with the increase of concentration and incubation time,the immunocytochemical results showed that Caspase-3 and p-Caspase-3 were highly expressed in U373MG cells after the treatment with ADS(P0.05).Conclusion ADS can inhibit the proliferation of U373MG cells and effectively induce the apoptosis of U373MG cells according to the activation of Caspase-3 and p-Caspase-3.

在高等教育改革大背景下,全面提升我国高等医学教育教学质量势在必行。本文提出了在《口腔临床药物学》教学工作中引入"以口腔疾病为中心"的课程讲授及"以问题为中心"的教学方法等,期望有助于学生的系统学习,提高口腔医学教育的质量,适应教育改革的总体形势。

多媒体教学现已成为现代教育的主流,但应用多媒体的弊端也随之显露出来。提出了高校在使用多媒体教学时改进课件质量、加强互动沟通、掌握教学进度、与传统教学方式结合等方面的具体措施,以提高高校多媒体教学的质量。

目的:根据《口腔临床药物学》课程特点,结合第四军医大学教学评估工作,对该门课程教学内容、方法等进行尝试性改革,并取得了明显成效。结果表明,在遵守课程标准的基础上,大胆对原有教学模式改革,可调动教员、学员的积极性与主动性,提高教学质量。