Background: The pathogenesis of multiple sclerosis (MS) may be closely related to immune regulation and inflammatory cytokines induced by specific flora. Repairing the intestinal flora may alter the immune response in MS patients, thus opening up novel approaches for the treatment of MS. Objective: We aimed to test the therapeutic effect of fecal microbiota transplantation (FMT) on experimental autoimmune encephalomyelitis (EAE) and the characteristics of intestinal microbiota composition changes, explore the potential mechanisms of FMT treatment. Methods: EAE animals were treated with FMT, with the therapeutic effects were evaluated by observing neurological scores and measuring serum levels of cortisol, IL-17, and TLR-2. Fecal microbiome 16S rRNA sequencing was used to profile changes in microbiota composition, and adrenalectomy pretreatment was used to test whether FMT effects were dependent on HPA axis function. Results: FMT improved neurological function and reduced serum IL-17 to levels that were close to the control group. FMT reestablished intestinal homeostasis by altering the structure of the intestinal flora, increasing the abundance of beneficial flora, and regulating intestinal metabolites. We found that the therapeutic effects of FMT depended partly on the efferent function of the HPA axis; surgical disruption of the HPA axis altered the abundance and diversity of the intestinal flora. Conclusion: FMT showed a neuroprotective effect on EAE by increasing the abundance of the beneficial flora, rebuilding intestinal homeostasis, reducing IL-17 and cortisol serum levels, and promoting serum TLR-2; the therapeutic effect of FMT on EAE is partly dependent on the HPA axis.

Objective To analyze the initial symptom and the cause of the misdiagnosis of Wilson's Disease (WD) so as to enhance awareness of this condition and reduce diagnostic errors. Methods The clinical data of 179 patients with the confirmed diagnosis of WD who were hospitalized in the First Affiliated Hospital of Guangdong Pharmaceutical University from October 2014 to September 2021 were analyzed. Those patients who had attended two or more hospitals, had been misdiagnosed as other diseases, or failed to get a clear diagnosis for 3 months and over before hospitalization were included in the group of clinical misdiagnosis or the group without a definite diagnosis. Results One hundred twenty-nine cases (72.1%) were misdiagnosed, 39 cases (21.8%) failed to be diagnosed as a specific disease, and only 11 cases (6.2%) had been diagnosed as WD within 3 months at the early stage of the disease. WD was easily masqueraded as a variety of diseases, including all types of hepatitis, cirrhosis, splenomegaly, hepatomegaly, encephalitis, encephalopathy, peripheral neuropathy, psychosis, osteoarthrosis, nephrosis, anemia, and other illnesses. Conclusion Wilson's Disease is prone to long-term misdiagnosis or unclear diagnosis. Early diagnosis and treatment are the most important determinations of the prognosis. Therefore, when facing patients with doubtful WD, it is valued to perform Kayser–Fleischer ring, copper metabolism, imaging examination, genetic tests, and radioactive copper test if necessary.

Objective: To study the polymorphism distribution of estrogen receptor (ER) α gene and the correlation between different types of polymorphism in multiple sclerosis (MS) and neuromyelitis optica (NMO) patients. Methods: Forty-six cases of MS and NMO diagnosed from June 2018 to December 2019 were collected. Peripheral venous blood samples were collected. The patient’s gender, age of onset, course of disease, and other clinical data were recorded. Fifty-eight healthy volunteers of the same age and sex were selected. By means of Pvu II and Xba I restriction fragment length polymorphism enzyme recognition sites of ER α gene, polymerase chain reaction-restriction fragment length polymorphism analysis was conducted. Results: There was no significant difference in the frequency distribution of ER α gene’s PP, Pp, and pp genotype between MS and NMO case group and control group (P = .598). Frequency distribution of ER α gene’s XX, Xx, and xx was statistically significant between MS and NMO case group and control group (P = .021). Among them, distribution of Xx and Xx gene frequency between patient group and the control group was statistically significant (P = .001, OR = 4.622, 95% CI: 1.803–11.852). There was no significant correlation between ER α genotypes and the onset age in patient group (P > .05). The difference was statistically significant in disease duration of XX and Xx genotype (P = .006). The comparison of Xx and xx genotype frequency distribution in gender exists a difference(P = .047, OR = 7.500, 95% CI: 1.023–54.996). Conclusions: Xba I gene polymorphisms in the ER α gene have correlation with MS and NMO. Xba I gene could be a risk factor of MS and NMO pathogenesis, especially the women with Xx genotype are more vulnerable. Xba I gene polymorphisms in the ER α gene may impact the disease duration of MS and NMO, or rather, the disease duration of Xx genotype persists longer than Xx genotype. Pvu II gene polymorphisms in the ER α gene has no correlation with MS and NMO.

Background:Hepatolenticular degeneration (HLD), also known as Wilson disease (WD), is a rare autosomal-recessive hereditary disease, which is often missed and misdiagnosed because of its various clinical manifestations. And WD is even more rare with giant subarachnoid cysts. In this report, we will provide a case of WD with an intracranial arachnoid cyst (IAC). Case description:A 27-year-old woman was hospitalized in a traditional Chinese medicine hospital in Guangzhou with the first manifestation of a "slight involuntary tremor of her left upper limb". There was no improvement after acupuncture treatment, and then she was transferred to another large general hospital in Guangzhou. MRI examination of the head showed "left frontal, parietal and temporal giant subarachnoid cyst" and the patient underwent "left frontotemporal arachnoid cyst celiac shunt operation." After the operation, the patient's left limb shaking remained unchanged. Subsequently, the patient was referred to another big hospital in Guangzhou, considered "Parkinson's disease," and given "Medopa, Antan" and other treatments. However, the patient's limb shaking continued to increase and gradually developed to the extremities. At last, the patient was referred to our hospital, combined with the medical history, neurological signs, and auxiliary examination results, improve the examination of corneal K-F ring, blood ceruloplasmin, gene screening, and other tests; the diagnosis was confirmed as hepatolenticular degeneration. Conclusion:After expelling copper and symptomatic treatment, the condition is improved.

目的 探讨翻转课堂混合式教学模式在神经内科住院医师规范化培训中的教学效果,为提高住培学生学习效果及兴趣寻求更为优越的教育模式.方法 对12名住培学生按照神经内科住院医师规范化培训要求进行《神经病学》理论授课,绪论至第九章部分采用传统授课方法,第十至第十八章部分以翻转课堂的混合式教学形式进行.比较翻转课堂的混合式教学前后学生评判性思维及自主学习能力改变情况、传统教学与翻转课堂混合式教学两种模式的满意度调查情况.结果 学生在接受翻转课堂的混合式教学后,评判性思维及自主学习能力均得到明显提高;翻转课堂混合式教学模式对提高学习积极性、增强理论知识感性认识、加深对知识的理解和记忆、缩短理论与临床实际的差距、增强分析临床问题的能力、有效利用学校资源、提高自学能力、锻炼归纳总结及表达的能力、培养评判性思维能力等方面均明显优于传统教学模式.结论 翻转课堂混合式教学模式应用于神经内科住院医师规范化培训能增强住培学生评判性思维及自主学习能力,增加教学满意度,提高神经内科住培学生学习效果及学习兴趣.

目的 探讨卒中后抑郁应用舍曲林治疗的效果及对患者脑源性神经营养因子(BDNF)的影响.方法 选取2018年1月至2020年10月在广东药科大学附属第一医院神经内科及连南瑶族自治县人民医院脑科接受治疗的40例卒中后抑郁患者作为研究对象,根据随机数字表法分为观察组与对照组,各20例.对照组给予氯丙咪嗪治疗,观察组采用盐酸舍曲林治疗,比较两组治疗效果.结果 观察组治疗后汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分低于对照组,血清BDNF、5-羟色胺(5-HT)水平高于对照组,且观察组治疗有效率高于对照组,不良反应发生率低于对照组,差异有统计学意义(P<0.05).结论 舍曲林应用于卒中后抑郁患者,可有效减轻焦虑抑郁情绪,改善BDNF、5-HT水平,提高治疗效果,且安全性高.

目的 探究经纤维支气管镜肺泡灌洗痰热清注射液治疗重症肺炎的可行性.方法 选择2018年10月至2019年11月我院收治的72例重症肺炎患者进行研究,根据治疗方案不同进行分组,其中,对照组(n=36)采用常规西医方案治疗,试验组(n=36)在对照组的基础上经纤维支气管镜肺泡灌洗痰热清注射液,比较两组治疗效果及安全性.结果 试验组患者治疗总有效率94.44％,较对照组的75.0％明显升高(P<0.05).试验组患者出现肺部感染控制窗时间、住院时间显著短于对照组(P<0.05).试验组不良反应发生率5.56％,与对照组的2.78％相比,差异无统计学意义(P>0.05).结论 经纤维支气管镜肺泡灌洗痰热清注射液治疗重症肺炎能够显著提高治疗效果,缩短病程,且其安全性良好.

硬膜外动静脉瘘(dural arteriovenous fistula,DAVF)与脑静脉血栓形成(intracranial venous sinus thrombosis,IVST)发病率低[1-21,在临床工作中漏诊率和误诊率较高.DAVF合并IVST时病情更严重,风险更高,治疗难度更大,预后差.一经发现应及时治疗,否则会导致严重不良后果.本文通过对1例IVST合并DAVF的病例诊治过程进行报道,结合相关文献分析,提高对该疾病的认识.

目的 探讨高压氧(HBO)治疗是否能提高传统抗抑郁药物对卒中后抑郁(PSD)的疗效及缩短起效时间并探讨其可能机制.方法 选取2017年1月至2019年6月在我院神经内科住院及门诊就诊的PSD患者60例,随机分成HBO治疗组和舍曲林治疗组.HBO治疗组28例,予以高压氧联合舍曲林治疗;高压氧治疗每日1次,每周5次,10次为1疗程,连续治疗2疗程,共观察4周;同时患者口服舍曲林(左洛复)50 mg/d,共观察4周.舍曲林治疗组32例,仅给予舍曲林50 mg/d,连续治疗观察4周.所有PSD患者在治疗前及治疗后第7、14、21、28天分别进行HAMD评分,同时采集静脉血,ELISA检测血清BDNF及mTOR表达.结果 HBO治疗组在治疗第7天即能明显改善PSD患者HAMD评分,而舍曲林治疗组则无明显改善;在治疗第14、21、28天,HBO治疗组HAMD评分治疗前后改变差值均明显高于舍曲林治疗组.在治疗第7天,HBO治疗组与舍曲林治疗组治疗后血清BDNF的改变并无明显差异,而在第14天,HBO治疗组BDNF治疗前后改变差值明显高于舍曲林治疗组.HBO治疗组在治疗第7、14天,mTOR水平较治疗前明显升高,而舍曲林治疗组则无明显改善.结论 HBO联合舍曲林能缩短舍曲林对PSD患者的起效时间,提高疗效;HBO联合舍曲林具有快速提高血清mTOR水平作用,可能是HBO介导快速协同抗抑郁作用的机制之一.

目的 探讨亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与连南瑶族自治县瑶族人群H型高血压的相关性,以期为该地区H型高血压的预防和治疗提供理论依据.方法 选取2018年1月至2019年6月在连南瑶族自治县人民医院门诊及住院患者以及体检中心健康自愿者,且以三代均居住在连南瑶族自治县境内瑶族人群共363人为研究对象,根据血压及血浆同型半胱氨酸(Hcy)水平,将其分为正常对照组(124人)、非H型高血压组(136人)、H型高血压组(103例).采用聚合酶链反应-限制性酶切片断长度多态性(PCR-RFLP)法对正常对照组、非H型高血压组、H型高血压组人群进行MTHFR基因C677T多态性检测,对H型高血压发生相关危险因素进行Logistic回归分析.结果 经PCR-RFLP检测发现,3组MTHFR C677T隐性模型CC+ CT、TT基因型分布频率比较差异有统计学意义(P＜0.05).H型高血压组MTHFR C677T的CC、CT和TT基因型Hcy水平分别为(15.52±2.47)、(18.24±2.61)和(21.06±2.87)μmol/L,差异有统计学意义(F=39.400,P＜0.001),其中TT基因型Hcy含量高于CC、CT基因型,CT基因型Hcy含量高于CC基因型(P＜0.05).Logistic回归分析结果显示,MTHFR C677T TT基因型是连南瑶族自治县瑶族人群H型高血压发病的危险因素(OR 2.210、95％ CI 1.103～4.428).结论 连南瑶族自治县瑶族人群MTHFR C677T TT基因型是发生H型高血压的危险因素.

Introduction Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies of gastrointestinal tract in the world, and the long-term prognosis for ESCC patients still remains dismal due to the lack of effective early diagnosis biomarkers. Materials and methods Western blot and immunochemistry were used to determine the expression of PRR11 in 201 clinicopathologically characterized ESCC specimens. The effects of PRR11 on stem cell-like traits and tumorigenicity were examined by tumor sphere formation assay and SP assays in vitro and by a tumorigenesis model in vivo. The mechanism by which PRR11 mediated Wnt/β-catenin signaling was explored using luciferase reporter, immuno-chemistry, and real time-PCR (RT-PCR) assays. Results We found that PRR11 was markedly upregulated, at the level of both transcription and translation, in ESCC cell lines as compared with normal esophageal epithelial cells (NECCs). Immunohistochemical analysis showed that 69.2% paraffin-embedded archival ESCC specimens exhibited high levels of PRR11 expression, and multivariate analysis revealed that PRR11 upregulation might be an independent prognostic indicator for the survival of patients with ESCC. Furthermore, overexpression of PRR11 dramatically enhanced, whereas inhibition of PRR11 reduced the capability of cancer stem cell (CSC)-like phenotypes and tumorigenicity of ESCC cells both in vitro and in vivo. Mechanically, we demonstrated PRR11-enhanced tumorigenicity of ESCC cells via activating Wnt/β-catenin signaling, and PRR11 expression is found to be significantly correlated with β-catenin nuclear location in ESCC. Conclusion Our findings suggest that the PRR11 might represent a novel and valuable prognostic marker for ESCC progression and play a role during the development and progression of this malignancy.

BACKGROUND:Cerebral venous sinus thrombosis (CVST) is always confused with dural arteriovenous fistula (DAVF) in clinical practice; however, both of them are very rare cerebral vascular diseases. In this report, we provide one case of DAVF combined with CVST.CASE DESCRIPTION:A 75-year-old woman complained of headache with nausea and vomiting for 4 days. Magnetic resonance venography revealed filling defect in the torcular, left transverse, and sigmoid sinus, which strongly suggested sinus thrombosis. The patient underwent anticoagulation treatment for 9 days. However, the manifestation was not alleviated, magnetic resonance imaging detected the lesion was enlarged, and the midline shifted to the left. Digital subtraction angiography examination detected that one fistula classified as Borden type IA was fed by the left superficial temporal artery and drained into the left transverse and sigmoid sinus. Endovascular embolization with ethylene vinyl alcohol was conducted.CONCLUSIONS:Follow-up at 6 months indicated that the patient recovered without any sequelae.

目的 比较部分脾动脉栓塞术(partial splenic embolization,PSE)与脾切除术治疗肝豆状核变性(hepatolenticular degeneration,HLD)合并脾功能亢进(脾亢)的疗效.方法 收集广东药科大学附属第一医院2006年3月至2016年12月收治的22例HLD合并脾亢行PSE和脾切除术病例,PSE组10例,脾切除术组12例,随访2年,收集患者的一般信息、血常规、肝功能、凝血指标、术后主要并发症和随访情况.结果 PSE与脾切除术均可使白细胞和血小板升高,两组术后白细胞、血小板对比差异有统计学意义(P<0.05).PSE组与脾切除术组术后红细胞和血红蛋白对比,仅术后第7天时差异有统计学意义(P<0.05).PSE组术后1年与术前的丙氨酸氨基转移酶对比下降(P=0.007);两组术后1年的总胆红素与术前对比明显下降(PPSE=0.035,P脾切=0.0001).但白蛋白前后无明显变化(P>0.05).两组术后1年的PT均较术前缩短改善(P<0.05);脾切除术组术后APTT与术前对比均缩短(P<0.05).两组术后主要并发症都是发热和腹胀、腹痛,PSE组并发症较轻.两组术后神经系统症状均未加重.结论 PSE和脾切除术均可有效改善HLD合并脾亢所致的血细胞三系减低、肝功能和凝血指标.虽PSE部分疗效不如脾切除术显著,但PSE具有相对安全、创伤小,术后并发症较轻,手术指征要求低,可重复治疗的优势,值得临床推广应用.

目的 研究淫羊藿苷(ICA)治疗实验性自身免疫性脑脊髓炎(EAE)对环磷腺苷效应元件结合蛋白(CREB)的影响,并探讨ICA治疗的作用机制.方法 复制C57BL/6小鼠EAE模型,并将其分为3组,每组6只.模型对照组:予生理盐水3 ml/d灌胃;ICA组:予以ICA 300 mg/(kg·d)灌胃;ICA+H89组:予以ICA 300 mg/(kg·d)灌胃并予以蛋白激酶A(PKA)特异性阻断剂H895 mg/(kg·d)腹腔注射;另取6只未经模型复制的C57BL/6小鼠同等条件下饲养作为正常对照组,予生理盐水3 ml/d灌胃.EAE小鼠在发病达高峰时开始给药,1次/d,连续给药5 d.每日进行神经损害评分,至给药结束后次日.给药结束后次日进行神经损害评分后处死小鼠,立即采集脊髓颈膨大部分进行Western blotting检测,检测CREB的表达.结果 ICA组小鼠神经损害表现明显改善,与治疗前比较差异有统计学意义(P<0.05),而ICA+H89组小鼠及模型对照组小鼠神经损害评分均无改善,治疗前后比较差异无统计学意义(P>0.05).模型对照组脊髓组织中CREB的表达较正常对照组降低(P<0.05).ICA组治疗后CREB的表达与模型对照组比较,差异有统计学意义(P<0.05),ICA组CREB的表达升高.但同时给予ICA与H89治疗的小鼠并不能提高脊髓组织中CREB的表达,与模型组比较差异无统计学意义(P>0.05).结论 ICA可能是通过PKA途径提高中枢神经系统中CREB的表达,从而发挥对EAE的治疗作用.

The slow onset of traditional antidepressants has become an urgent clinical issue, researchers are constantly exploring new antidepressants with prompt action. Previous studies have found that zinc levels were decreased in serum and brain of depressed patients or animal models. Zinc treatment can improve depressive symptoms and enhance the antidepressant effects of monoamine antidepressants. However, its mechanism of action is still unclear. This present study aims to investigate whether the zinc can enhance the rapid action of traditional antidepressant imipramine and to explore the potential mechanisms of action through the rapid antidepressant targets CREB (cAMP-response element binding protein) and mTOR (mammalian target of the rapamycin). Drug treatment included intraperitoneal injection of imipramine or zinc alone and imipramine plus zinc. Zinc had a rapid enhanced antidepressive effect on the imipramine and achieved a rapid antidepressant effect similar to ketamine. Combination of zinc with imipramine rapidly enhanced the phosphorylation of mTOR Ser2448 and CREB Ser133, and increased the expression of mTOR and CREB, which were dependent on the activation of PKA. In conclusion, combination therapy with zinc and monoamine antidepressants may overcome the problem of slow-onset action of traditional antidepressants in clinical uses.

Background: Glioma is the most lethal primary brain tumor, the survival rate still isn't improved in the past decades. It's essential to study the regulatory mechanism of glioma progression, hoping to find new therapy targets or methods. The family of tripartite motif (TRIM) containing proteins are E3 ubiquitination ligases, which play critical role in various tumor progression. Methods: Cell proliferation and invasion were analyzed by colony formation assay, soft agar growth assay, BrdU incorporation assay and transwell invasion assay. Luciferase reporter analysis was used to analyze NF-kappa B pathway activity. Results: We found TRIM31 was upregulated in glioma cells and tissues, its overexpression significantly promoted glioma cell proliferation and invasion, while its knockdown significantly inhibited glioma cell proliferation and invasion. Mechanism analysis found TRIM31 promoted NF-kappa B pathway activity and increased its targets expression. NF-kappa B inhibition reversed the phenotype caused by TRIM31, confirming TRIM31 promoted glioma progression through activating NF-kappa B pathway. Using clinical specimens found TRIM31 expression was positively correlative with NF-kappa B activity. Conclusion: This study found TRIM31 promoted glioma proliferation and invasion through activating NF-kappa B activity.

目的 探讨早期母婴分离导致大鼠成年后抑郁的机制及早期应激对成年后海马Gabra6亚基表达的影响.方法 将8只Sprague Dawley孕鼠分娩的64只新生鼠随机分为母婴分离(MS)组和对照组.MS组幼鼠出生后第2～15天进行母婴分离,每天固定分离6 h.之后对其进行体重评估,行为学检测包括糖水偏爱、新环境进食抑制、强迫游泳实验,膜片钳实验检测自发动作电位,Western blot实验检测Gabra6蛋白表达.结果 与对照组比较,MS组成年后的体重和糖水偏爱度差异无统计学意义(P>0.05),而在新环境进食抑制的进食潜伏期和强迫游泳不动时间均明显延长(P<0.05).电生理实验显示MS组海马CA1区锥体神经元的自发动作电位发放频率降低(P<0.05).Western blot实验显示,MS组海马的Gabra6蛋白表达降低(P<0.05).结论 生命早期的不良应激可导致成年后出现抑郁样症状,海马区域Gabra6表达的异常可能参与了这一过程.

目的 采用实时荧光定量PCR (qRT-PCR)法探索全反式维甲酸(ATRA)对兔颈动脉粥样硬化斑块组织炎症因子表达的影响.方法 选取24只纯种雄性新西兰白兔随机分为对照组、模型组、ATRA组.对照组给予基础饲料、其余两组给予高脂饲料,共饲养12周.饲养4周后,ATRA组ig 5 mg/kg的ATRA,模型组和对照组ig等量溶剂,每天1次,至12周末处死各组动物.取颈动脉粥样硬化斑块组织,进行HE染色,显微镜下观察管壁结构;提取组织RNA,qRT-PCR法测定组织中转化生长因子-β1(TGF-β1)、白细胞介素-10(IL-10)、基质金属蛋白酶-2(MMP-2)和基质金属蛋白酶-9(MMP-9)mRNA的相对表达量.结果 模型组可见典型的AS斑块,可见薄层的纤维帽及大的脂质核心,以及大量炎症细胞浸润,内弹力纤维膜断裂;ATRA组内皮细胞形态基本完整,可见少量炎性细胞浸润.与对照组比较,模型组中TGF-β1和IL-10 mRNA的相对表达量明显降低(P＜0.05),而MMP-2和MMP-9 mRNA的相对表达量明显升高(P＜0.05);与模型组比较,ATRA组的TGF-β1和IL-10 mRNA的相对表达量明显升高(P＜0.05),MMP-2和MMP-9 mRNA的相对表达量明显降低(P＜0.05).结论 ATRA可通过调节炎症因子的表达抗动脉粥样硬化.

Objective: To observe whether baicalein have therapeutic value on diabetes mellitus (DM) with cerebral small vessel disease (CSVD) so as to explore the pathogenesis and therapy of the cognitive ability and behavioral function disorder caused by chronic cerebral ischemia and hypoxia. Methods: A total of thirty male SD rats were randomly divided into normal control group, model group and treatment group, 10 rats in each group. After the stable models of DM with CSVD were established, cognitive function scores of all rats were evaluated byMorris water maze test, and the levels of acetylcholine (Ach) and acetylcholinesterase (AchE) in brain were assessed to evaluate the protective effects of baicalein. Results: Morris water maze test showed that learning and memory function had been significantly impaired in rats of DM with CSVD since the 7th day of modeling. Spatial probe test founded that the times of crossing platform in the model group were significantly lower than those in the normal control group (P＜0.05). Compared with the normal control group, the Ach level in the brain homogenate of the model group reduced significantly (P＜0.05), while the AchE level increased significantly (P＜0.05). Compared with the model group, the Ach level in the brain homogenate of the treatment group increased significantly (P＜0.05). The HE staining sections illustrated a large number of active neurons were found in the control group, but loose spongiform degeneration of brain tissue, apoptosis and necrosis of neurons and karyopyknosis were detected in the model group. However, it showed that the learning and memory abilities in the treatment group had improved, while the brain tissue also had been protected. Conclusion: Baicalein has a protective effect on cognitive impairment in diabetes mellitus with cerebral small vessel disease, and it may be a new targeted therapy for this disease.

目的 了解广东省清远市连南瑶族自治县农村居民高血压患病情况,以及居民对高血压相关知识的知晓率,为农村居民高血压的预防干预提供科学依据.方法 采用多阶段随机抽样的方法对连南瑶族自治县6个乡镇抽取的742名40~89岁常住居民进行问卷调查和血压测量.结果 所调查的742名居民中,共有高血压患者271例,高血压患病率为36.52%,标化患病率为35.96%.瑶族居民高血压患病率为39.42%,标准化患病率为39.13%;汉族居民高血压患病率为32.82%,标准化患病率为32.79%.瑶族与汉族居民高血压患病率比较无统计学差异(P>0.05).瑶族居民对"饮酒会使血压增高"及"饮食偏咸会使血压增高"这2项知晓率明显低于汉族,具有统计学差异(P=0.008,P=0.037);瑶族与汉族居民对其余8项高血压相关知识知晓率比较均无统计学差异(P>0.05).结论 连南地区农村居民高血压患病率较高,对高血压知识知晓率较低,居民的健康意识较为薄弱,有待进一步加强该地区高血压的宣教.