目的:讨论健康教育在社区管理高血压患者中实施的重要性.方法:选择85例高血压患者,随机分成对照组(不积极参加健康教育活动)42例与研究组(积极参加健康教育活动)43例,对比两组干预结局.结果:研究组健康知识掌握度高于对照组;研究组不良行为率低于对照组;差异均有统计学意义(P<0.05).结论:通过有效的健康教育,可以提高高血压患者的健康知识,改变生活方式,提升自我管理水平,值得应用推广.

宫颈癌是女性生殖系统最常见的恶性肿瘤,全球年新发病例约53万,我国发病率逐年增加,年新发病例高达13万[1],山西省是宫颈癌高发区[2].研究表明宫颈癌的癌前病变期较长、可逆,尽早展开宫颈癌筛查及采取有关措施,对于预防宫颈癌意义重大[3].本研究希望通过人乳头瘤病毒(HPV)联合薄层液基细胞学检查(TCT)效能比较,掌握山西省HPV感染亚型及TCT细部变化分布特征,为全面优化宫颈癌防控策略和资源配置提供科学参考.

目的 通过对太原市901例大学生性行为现状进行调查,探究影响其性行为的相关因素,为开展高校性健康教育提供依据.方法 于201 8年5～7月山西省大学城10所高校,随机选取2所高校,每所高校随机抽取5个学生,进行自填式匿名问卷调查,回收有效问卷901份,采用SPSS19.0分析.结果 901例大学生性行为的发生率为11.32％ (102/901),有59.80％ (61/102)学生在性行为中每次使用安全套,其中27.45％ (28/102)有≥2个性伴侣,仅有26.86％ (242/901)的学生接受过学校性教育课程.Logistic回归分析显示,大三年级比大一年级学生发生性行为的可能性更高(OR=2.99,P＜0.01),非医学类院校学生比医学院校学生不易发生性行为(OR=0.35,P=0.001).多性伴侣发生的危险因素有男性(OR=2.61)、郊区/县城生源地(OR=2.08)、单亲家庭(OR=4.34)、正处恋爱期状态(OR=2.25)和月生活费在800～ 999元(OR=2.25).无安全措施性行为的危险因素是男性(OR=2.83)、郊区/县城生源地(OR=2.35)、单亲家庭(OR=4.14)、正处恋爱期状态(OR=2.51).结论 被调查学生性观念较为开放,高危性性行为较多,高校应加强相关干预措施.

目的 掌握山西省淋病流行特征,定量预测发病趋势,为进一步优化控制策略提供科学依据.方法 采用时间序列描述性流行病学研究方法对山西省2005—2018年淋病流行特征进行分析,并运用自回归移动平均模型(ARIMA模型)对未来3年发病趋势进行预测.结果 2005—2018年山西省淋病发病率发展总体呈现下降态势.根据月发病数构建ARIMA(0,1,1)×(1,1,0)12模型进行预测,结果显示2019—2021年山西省淋病发病水平呈现逐年下降趋势.结论 山西省淋病防治工作进展良好,应继续推进防治策略强度,ARIMA模型能较为精确地预测淋病发病趋势.

梅毒是苍白密螺旋体苍白亚种引起的一种慢性、系统性的性传播疾病,是我国法定报告的乙类传染性.监测显示,近年来梅毒流行已成为全球和我国重要的公共卫生和社会问题[1]. 山西省从1982年首次报告梅毒病例以后,梅毒报告病例数逐年增加,疫情呈上升趋势[2].及时、准确、科学地开展监测数据分析,全面掌握疾病流行特征和流行危险因素,对疾病预防控制工作至关重要[3].本研究基于2011—2017年山西省梅毒疫情监测数据, 利用Logistic回归方法探索分析山西省梅毒分型谱流行新特征和流行危险因素,进一步明确梅毒防控工作重点和要点,为制定梅毒的合理防控措施和疫情的有效控制提供参考.

梅毒是苍白密螺旋体苍白亚种引起的一种慢性、系统性的性传播疾病,若发生流行不仅危害患者和下一代身心健康甚至危及生命,且容易引发成为公共卫生问题.及时、准确开展监测数据分析,全面掌握疾病流行特征,对疾病预防控制工作至关重要. 山西省从1982年首次报告梅毒病例, 截止2010年疫情汇总分析显示, 期间梅毒报告病例数逐年增加,疫情呈上升趋势,2010年以后整体疫情特点和流行特征尚不明确. 本研究基于2011-2017年山西省梅毒疫情监测数据,探索山西省梅毒疫情流行新特征和趋势,发现进一步梅毒防控工作重点,为制定梅毒的合理防控措施和疫情的有效控制提供参考.

目的 评估抗病毒治疗(ART)成人艾滋病病例的效果,分析其主要影响因素.方法 采用回顾性队列研究方法,选择山西南部4市2004年6月底至2012年12月底纳入国家免费抗病毒治疗系统的病例,收集资料补充调查,使用SPSS19.0进行统计分析.结果 1887例抗病毒治疗病例,存活率为83.1％,死亡率为13.5％,停药率为1.4％,转诊率为1.2％,失访率为0.8％;治疗后第0.5、1、2、3、4、5、6、7和8年累计生存率分别为0.91、0.89、0.88、0.86、0.85、0.82、0.80、0.79和0.79;CD4+T淋巴细胞从ART前的143.5个/μL平均增加205.3个/μL,治疗前后＜100个/μL的比例由41.4％下降至7.8％、＞ 350个/μL的比例由0.9％上升至46.7％.病毒载量治疗前＜LDL占18.2％,治疗后提高到89.1％;Cox比例风险回归模型多因素分析发现,ART前CD4+T淋巴细胞计数、ART时年龄、ART前BMI 3个变量的分组与生存时间差异分别有统计学意义.死亡危险比(HR)分别为4.05、3.68、3.44.结论 抗病毒治疗取得了较好的治疗效果.

Objective To explore factors influencing mortality rate of HIV/AIDS and to improve the effectiveness of antiretroviral therapy (ART).Methods By means of retrospective cohort study and the AIDS control information system,HIV/AIDS case reports and antiviral treatment information of 4 cities in southern Shanxi province up to end of December 2012 were selected,to calculate the mortality rate and treatment coverage based on further data collected,along with analysis using the Cox proportional hazards survival regression.Results 4 040 cases confirmed of HIV/AIDS were included in this study.The average age was (36.0± 12.9) years,with 65.3％ being male,56.5％ being married,735％ having junior high school education or lower,58.4％ being peasants,54.3％ with sexually transmitted infection (40.1％ were heterosexual,14.2％ were homosexual),and 38.9％ were infected via blood transmission (20.2％ were former plasma donors,16.2％ blood transfusion or products recipients,2.4％ were injection drug users).Overall mortality decreased from 40.2 per 100 person/year in 2004 to 6.3 per 100 person/year in 2012,with treatment coverage concomitantly increasing from almost 14.8％ to 63.4％.Cox proportional hazards survival regression was used on 4 040 qualified cases,demonstrating the top mortality risk factor was without antiretroviral therapy (RR=14.9,95％CI:12.7-17.4).Cox proportional hazards survival regression was made on 1 938 cases of antiviral treatment,demonstrating that the mortality risk of underweight or obese before treatment was higher than those of normal and overweight cases (RR=2.7,95％CI:1.6-4.5),and the mortality of those having a CD4+ T-lymphocyte count ≤50 cells per μl before treatment was more than 50 cases (RR=2.6,95％CI:1.5-4.5) ;Cox proportional hazards survival regression was made on 2 102 cases of untreated cases,demonstrating the mortality risk of those initially diagnosed as AIDS was higher than those initially diagnosed as HIV(RR=3.4,95％CI:2.9-4.0).Conclusion The ART could successfully make lower HIV/AIDS mortality rate,indicating effective ART can further decrease mortality.

目的探索艾滋病病毒（HIV）感染者/艾滋病（AIDS）病人（简称HIV/AIDS病人）的病死率和影响因素,以及提高抗病毒治疗（ART）效果的方法。方法采用回顾性队列研究方法。通过艾滋病综合防治信息系统,选择山西省截止到2013年12月底报告的HIV/AIDS病例和ART信息,收集资料补充调查,计算病死率和治疗比例,用Cox比例风险回归模型进行分析。结果共收集HIV/AIDS确诊病例4861例,年龄平均（36.7±13.0）岁,男性占67.9%,农民占55.0%,性传播占61.4%。从2004年到2013年ART的比例由14.9%上升到62.3%,同期HIV/AIDS病例的病死率从40.7/100人年降低到5.0/100人年。对4861例HIV/AIDS病例Cox回归分析显示,最主要死亡风险是未进行ART[危险比（HR）=4.8]和未进行CD+4T淋巴细胞检测（HR=5.9）;对2400例ART病例Cox回归分析显示,治疗前体质指数（BMI）过低和肥胖病例的死亡风险高于正常和超重病例（HR=2.4）、治疗前CD+4T淋巴细胞≤50个/μL病例的死亡风险高于＞50个/μL病例（HR=2.3）。结论ART显著降低了HIV/AIDS病人的病死率,提示强化ART工作可进一步降低病死率。

OBJECTIVE:To explore factors influencing mortality rate of HIV/AIDS and to improve the effectiveness of antiretroviral therapy (ART). METHODS:By means of retrospective cohort study and the AIDS control information system, HIV/AIDS case reports and antiviral treatment information of 4 cities in southern Shanxi province up to end of December 2012 were selected, to calculate the mortality rate and treatment coverage based on further data collected, along with analysis using the Cox proportional hazards survival regression. RESULTS:4 040 cases confirmed of HIV/AIDS were included in this study. The average age was (36.0 ± 12.9) years, with 65.3% being male, 56.5% being married, 73.5% having junior high school education or lower, 58.4% being peasants, 54.3% with sexually transmitted infection (40.1% were heterosexual, 14.2% were homosexual), and 38.9% were infected via blood transmission (20.2% were former plasma donors, 16.2% blood transfusion or products recipients, 2.4% were injection drug users). Overall mortality decreased from 40.2 per 100 person/year in 2004 to 6.3 per 100 person/year in 2012, with treatment coverage concomitantly increasing from almost 14.8% to 63.4%. Cox proportional hazards survival regression was used on 4 040 qualified cases, demonstrating the top mortality risk factor was without antiretroviral therapy (RR = 14.9, 95% CI: 12.7-17.4). Cox proportional hazards survival regression was made on 1 938 cases of antiviral treatment, demonstrating that the mortality risk of underweight or obese before treatment was higher than those of normal and overweight cases (RR = 2.7, 95% CI: 1.6-4.5), and the mortality of those having a CD4(+) T-lymphocyte count ≤ 50 cells per µl before treatment was more than 50 cases (RR = 2.6, 95% CI: 1.5-4.5); Cox proportional hazards survival regression was made on 2 102 cases of untreated cases, demonstrating the mortality risk of those initially diagnosed as AIDS was higher than those initially diagnosed as HIV (RR = 3.4, 95% CI: 2.9-4.0). CONCLUSION:The ART could successfully make lower HIV/AIDS mortality rate, indicating effective ART can further decrease mortality.

根据山西省卫生和计划生育委员会的要求，山西省疾病预防控制中心于2015年2月初，组织相关专家，依据传染病监测数据资料，对我省几个重点传染病进行了分析研判。研判所用2014年传染病监测数据是按照审核日期统计的结果，当时正在进行传染病报告卡的排重工作，排重工作结束之后，有些传染病报告病例数可能发生微弱变动，但不会对分析研判结果产生影响。

艾滋病免费抗病毒治疗是艾滋病防治工作重要组成部分，也是国家对艾滋病患者实施的“四免一关怀”策略的重要内容之一。山西省自2004年开展国家免费艾滋病抗病毒治疗工作，取得了良好的治疗效果[1-3]。为评估艾滋病免费抗病毒治疗效果，现将山西省部分市艾滋病免费抗病毒治疗情况进行效果分析。

Objective To evaluate the effectiveness of free antiretroviral therapy(ART) in adults and the factors influence ART outcome. Methods A retrospective cohort study was conducted Shanxi province. All qualified ART recipients were enrolled in the national free ART program from June 2004 to December 2012. Statistical analysis was conducted by SPSS software (version 19.0), use the t test and chi-square test, with Cox regression model for survival analysis. Results One thousand eight hundred and eighty-seven cases were included in the study. The rates for participants, who survived, who were deceased for acquired immune deficiency syndrome (AIDS) related diseases, who withdrawal from the treatment, who transferred to other hospital and who lost for follow-up were 83.1%, 13.5%, 1.4%, 1.2% and 0.8%, respectively. The cumulative survival rates were 0.91, 0.89, 0.88, 0.86, 0.85, 0.82, 0.80, 0.79 and 0.79 at 0.5, 1.0, 2.0, 3.0, 4.0, 5.0, 6.0, 7.0 and 8.0 years after treatment initiation, respectively. The medians of CD4+T cell count were 143.5 cells/μL prior to treatment and 205.3 cells/μL post treatment. 18.2% of ART recipients had their viral loads below detection limit before therapy and this percentage increased to 89.1% after therapy. In the multivariate Cox proportional hazard model, CD4+T cell count and BMI before treatment initiation, and the age start therapy were significantly associated with survival time. The Hazard ratio was 4.05, 3.44 and 3.68, respectively. Record the count of CD4+T lymphocyte after antiretroviral treatment, the difference of CD4+T lymphocyte count between before antiretroviral treatment and after, 3 covariates had been produced by the viral load program generates after antiretroviral treatment , 15 variables had been proved to be statistically and professional significance before antiretroviral treatment. Analysis above all variables based on multi factor time-dependent Cox regression model. There were statistical differences between the count of CD4+T lymphocyte after antiretroviral treatment and the survival time (HR=30.28). Conclusion The ART treatment has been successfully implemented with the significant improvement on immune system and containment of viral replication.

目的 评估山西省艾滋病免费抗病毒治疗(ART)的效果.方法 选择2004年6月底至2013年12月底纳入国家免费抗病毒治疗的病例,采用回顾性队列研究方法,通过治疗前后死亡率、CD4+T淋巴细胞(简称CD4细胞)、病毒载量的变化进行评估.结果 共调查2377例艾滋病病例,平均年龄38.8岁、男性占66.0％、农民占59.3％、传播途径以异性性传播为主(43.1％).共有17种抗病毒治疗用药方案,使用其中6种初始治疗用药方案的病例占97.7％.治疗前CD4细胞数平均为158个/μL,治疗后平均为345.1个/μL,治疗前后平均增加187.1个/μL(P=0.000).病毒载量治疗前＜最低检测限(LDL)占18.3％、几何均数4.0×104拷贝/mL,治疗后＜LDL占85.0％、几何均数2.2×103拷贝/mL.治疗前后CD4细胞和病毒载量数值差异和构成比有统计学意义.死亡病例和存活病例的CD4细胞计数在治疗前、治疗后、治疗前后增长值均有明显差异.治疗后第6、12、24、36、48、60、72、84、96、108个月死亡率(CDR; 1/100人年)分别为13.8、9.0、2.6、1.8、1.9、2.9、2.9、1.5、3.9、4.6.结论 治疗后死亡率下降、CD4细胞增加和病毒载量下降明显,抗病毒治疗取得了较好的效果.

Objective To analyze the survival time and factors of deaths who patients received highly active antiretroviral therapy( HAART) and to provide information for reduction of AIDS death rate. Methods The data of patient's death who received HAART in Shanxi Province were collected by China Information System for Diseases Control and Prevention from 2004 to 2013,and were analyzed by SPSS 18. 0 software. Results 315 patient's death were retrieved. The average age was 43. 73 ± 12. 65 years old. The ratio of male to female was 1. 7 ∶ 1. 69. 21% of patients were married or cohabited. 58. 10% of patients were infected with HIV through blood transmission. 73. 33% of them died of AIDS related disease. 64. 13% of patients had entered the AIDS clinical WHO stage Ⅲ or Ⅳ for receiving treatment. The median of baseline CD4+cell counts was 44 counts / μL and the median of the interval between the time of HIV confirmation and HAART treatment was 218 days. Factors affecting death patients survival time were AIDS clinical staging of WHO,baseline CD4+cell counts and the infection routes. Conclusions The lower baseline CD4+cell counts and the higher WHO stages are the main factors related to death of AIDS patients received HARRT.

山西省自2004年6月开展艾滋病高效抗逆转录病毒治疗（ highly active anti-retroviral therapy ，HAART），截至2013年12月底，全省累计接受免费抗病毒治疗患者2392例。本研究对2004—2013年接受国家免费抗病毒治疗的患者进行了生存时间及影响因素分析，以了解山西省接受艾滋病抗病毒治疗患者的生存状况，并为进一步提高山西省艾滋病抗病毒治疗工作的质量提供依据。

山西省平定县自2007年发现首例艾滋病病毒感染者以来，报告的 HIV／AIDS （艾滋病病毒感染者／艾滋病患者）数量逐年增多，为控制艾滋病流行，减少艾滋病发病率和病死率提供科学依据。现将平定县2007-2013年艾滋病疫情资料进行流行病学分析。

山西省性病疫情自2000年以来,病例报告呈逐年上升态势.特别是梅毒病例报告增加迅速,为了解梅毒报告病例的流行特征,现将山西省2000-2010年梅毒报告病例进行流行病学分析. 1 资料与方法 梅毒病例资料来源于《疾病监测信息报告管理系统》,以Excel软件建立数据库并进行分析.

梅毒(Syphilis)是由梅毒螺旋体引起的一种慢性全身性疾病,是经典性病之一.相信大家对这个疾病都不会陌生,它主要通过性途径传播,在发展过程中可以侵及人体任何器官和组织,产生功能障碍,组织破坏甚至死亡;亦可潜伏多年甚至终身不露丝毫痕迹;有自愈倾向,但易复发.在我国古代,梅毒被称为“花柳病”,作为一种最古老的性传播疾病,早在几百年前的医学著作上就有关于梅毒的症状及治疗等记载.梅毒对于人类身体健康的威胁不可小视.

山西省于2004年6月开展国家免费艾滋病,即获得性免疫缺陷综合征(AIDS)抗病毒治疗工作,并取得了良好的社会效果.为评估艾滋病免费抗病毒治疗效果,本文从抗病毒治疗药物不良反应方面对其进行评估分析,为综合评价治疗效果提供依据.