从济川煎的方名溯源、《景岳全书》本草原文窥探、当归与肉苁蓉的君药之争及历代功效论述考辨入手,探讨济川煎的方药释义.认为济川煎方名原义为增液行舟,当归为君养血润燥,肉苁蓉为臣润下通便,综合分析其功效并非温肾助阳而是侧重于养血润燥通便,主治为阴血亏虚之便秘,并通过古籍文献等例证效验.

Objective:To explore the current status and influencing factors of self-care ability in patients with cystostomy and ileal conduit.Methods:Using the convenient sampling method, a total of 160 patients with cystostomy and ileal conduit who visited the Urostomy Clinic of Peking University First Hospital from October 2021 to March 2022 were selected as the research objects. Patients were surveyed using a general information survey questionnaire, Social Support Rating Scale (SSRS) and Urostomy Education Scale. Spearman correlation analysis was used to explore the correlation between social support and self-care in patients with cystostomy and ileal conduit, and multiple linear regression analysis was used to explore the influencing factors of self-care ability in patients with cystostomy and ileal conduit. A total of 160 questionnaires were sent out, and 157 were effectively collected, with an effective recovery rate of 98.13% (157/160) .Results:The total score of Urostomy Education Scale of 157 patients with cystostomy and ileal conduit was [20.00 (4.00, 21.00) ]. The results of multiple linear regression analysis showed that marital status, comorbidities, stoma and peristomal complications, frequency of follow up in urostomy clinic and objective support were the influenting factors for self-care of patients with cystostomy and ileal conduit ( P<0.05) . Conclusions:Self-care of patients with cystostomy and ileal conduit is related to many factors. Medical staff should strengthen the intervention and management of patients with cystostomy and ileal conduit from multiple aspects such as individual and social function, so as to improve their self-care ability.

Psychocardiology is an interdisciplinary disease concept developed from the “biopsychosocial model” in recent years. One of the important theories proposed in the Inner Canon of Huangdi is that “the heart governs mental activities”, which can be used to guide the treatment of psychocardiological diseases. We summarized the connotation of “the heart governing mental activities”, discussed the connection and differences between the specific theory and psychocardiological diseases, and provided a comprehensive analysis of the current status of traditional Chinese medicine treatment and research on psychocardiological diseases based on “the heart governing mental activities” in order to provide reference for clinical practice.

结肠黑变病(MC)的发生与进展和服用含蒽醌类中药可能存在一定的相关性.本文简述中西医对MC的认识,并从与服用蒽醌类中药相关的MC临床病例研究和蒽醌类中药对MC最新机制研究两方面进行总结,探讨含蒽醌类中药对MC可能产生的影响并提出安全应用该类药物的建议,对蒽醌类中药相关的研究方向提出展望.

文章从"胃不和则卧不安"理论入手,认为血管痉挛性心绞痛病机以"阳微阴弦"为核心,以中焦升降失司、上焦心阳不振、湿饮瘀浊痹阻为要点,具有本虚标实的特征;其辨治应着眼于振上焦心阳、蠲湿饮瘀浊、和中焦升降及缓心脉挛急4个层次.文章浅析血管痉挛性心绞痛的辨治思路,以期对张伯礼教授在该病诊疗中展现出的临证思维有所体悟.

冠脉痉挛是引起多种临床心血管疾病的病理生理状态,多以胸闷、胸痛等症为主,临床较为常见,但目前精准诊断较为困难,机制尚不明确.张伯礼教授临证经验丰富,指出临床上冠脉痉挛患者以心阳不足为本,血瘀为基,多病理因素(痰湿、气滞、肝郁等)兼夹致病,宽胸温阳当为第一要义.在辨治冠脉痉挛所致胸痹时当首辨标本虚实,分清轻重缓急,谨守病机,标本兼顾,随证化裁.

目的 研究丹参素对中波紫外线(UVB)照射后人角质成细胞(HaCaT细胞)损伤的保护作用及其可能机制.方法 将人角质形成细胞HaCaT细胞分为5组:空白组、UVB组和低、中、高3个浓度实验组.空白组细胞不做任何处理,UVB组用30 mJ·cm-2 UVB处理,实验组用低、中、高3个浓度(1,10,100nmol·L-1)丹参素预处理24后,再用30 mJ·cm-2 UVB处理.用比色法测定干预后HaCaT细胞活力和LDH释放量;用氧化敏感荧光探针检测细胞中活力氧簇(ROS)水平;用免疫印迹实验检测凋亡相关蛋白表达水平.结果 空白组、UVB组和低、中、高3个浓度实验组的细胞活力分别为(100.00±0.00)％,(71.30±3.78)％,(84.83±4.95)％,(90.62±11.07)％和(91.90±14.74)％;这5组的LDH释放量分别为0.72±0.04,1.10±0.05,0.88 ±0.06,0.90±0.03和0.87±0.08;这5组的ROS水平分别为54.43±0.22,86.67±3.35,76.75±2.06,76.36±2.34和73.30±2.16,UVB组与空白组相比,细胞活力明显下降,而LDH释放量与ROS水平均明显增加,差异均有统计学意义(均P＜0.01);低、中、高3个浓度实验组与UVB组比较,细胞活力明显升高,而LDH释放量与ROS水平均明显降低,差异均有统计学意义(P＜0.05,或P＜0.01).这5组的蛋白表达水平(Bcl2与Bax蛋白表达量比值)分别为0.52±0.06,0.24±0.02,0.35±0.04,0.27±0.01和0.22±0.02,UVB组与空白组相比,差异均有统计学意义(P＜0.01);低、中2个浓度实验组与UVB组相比,差异均有统计学意义(均P ＜0.05).结论 丹参素可以抑制UVB诱导的细胞凋亡.

目的：探讨负压封闭引流技术配合点状植皮在治疗糖尿病足中的效果。方法：选取糖尿病性足坏疽患者58例，应用负压封闭引流技术配合点状植皮术治疗，观察创面愈合率和创面愈合时间等指标。结果：58例创面愈合时间12~83 d，平均32.4 d；临床痊愈49例，显效3例，有效4例，无效3例，创面愈合率88.4%，总有效率为94.8%。结论：负压封闭引流技术配合点状植皮术治疗糖尿病性足，对坏疽创面有良好的促愈作用。

丹参是唇形科鼠尾草属多年生草本植物丹参（Salviae miltiorrhizae Bunge）的干燥根和根茎，具有活血祛瘀、通经止痛、清心除烦、凉血消痈之功效[1]，始载于《神农本草经》，被列为本草上品。用现代科学方法研究丹参的成分、作用始于20世纪30年代，数十年来，经过化学、药学及药理学和临床医学工作者的共同努力，证实丹参具有抗炎、抗氧化、改善微循环等多种功效。近年来，随着临床和实验室研究的深入开展，使丹参在皮肤科领域的运用范围不断扩大，现结合有关文献就丹参多种有效成分、丹参制剂在皮肤科的应用综述如下。

[目的]考察不同血清含量以及培养不同时间对人永生化角质形成细胞(HaCaT)细胞的生长及迁移特性的影响,为HaCaT细胞划痕实验条件优化提供实验数据支撑.[方法]培养HaCaT细胞,按10％血清浓度全培基(全培基阳性对照组)、2％低浓度血清培基(低血清培基组)及无血清培基(对照组)分组,通过进行细胞划痕实验,CCK-8细胞活力检测、Brdu细胞增殖实验,分析HaCaT生长特性.[结果]在24 h内,低血清培基组HaCaT细胞与全培基组相比,细胞增殖能力无明显差异,细胞活力有增高的趋势.细胞孵育48 h后,全培基组细胞增殖能力及活力明显升高.24～48 h,全培基组细胞增殖能力及细胞活力的提升速度明显高于低血清培基组.[结论]培养基中血清含量对HaCaT细胞生长特性及迁移能力具有重要影响,培养24 h内低血清培养条件有利于划痕实验的观察与测定.

In recent years, through a large number of clinical practice has proved that Salvia Miltiorrhiza is the medicine of the skin healing, wound healing, and to promote wound healing. With the application range of Salvia Miltiorrhiza expanding, promote wound healing mechanism has a more in-depth study. The author summarize the scholars at domestic and foreign in recent ten years in Salvia Militiorrhiza and its pharmacological active ingredients promote wound tissue repair mechanism research progress, from promote microcirculation, immune regulation,inhibiting regeneration, reduce tissue ischemia-reperfusion injury and promote wound tissue regeneration, inhibiting inflammatory reaction and apoptosis and its relationship with growth factors and other aspects as follows.