Purinergic signalling adenosine and its A1 receptors have been demonstrated to get involved in the mechanism of acupuncture (needling therapy) analgesia. However, whether purinergic signalling would be responsible for the local analgesic effect of moxibustion therapy, the predominant member in acupuncture family procedures also could trigger analgesic effect on pain diseases, it still remains unclear. In this study, we applied moxibustion to generate analgesic effect on complete Freund's adjuvant (CFA)-induced inflammatory pain rats and detected the purine released from moxibustioned-acupoint by high-performance liquid chromatography (HPLC) approach. Intramuscular injection of ARL67156 into the acupoint Zusanli (ST36) to inhibit the breakdown of ATP showed the analgesic effect of moxibustion was increased while intramuscular injection of ATPase to speed up ATP hydrolysis caused a reduced moxibustion-induced analgesia. These data implied that purinergic ATP at the location of ST36 acupoint is a potentially beneficial factor for moxibustion-induced analgesia.

介绍李培教授治疗慢性疲劳综合征的经验.李培教授立足于现代医学对慢性疲劳综合征的认识,并结合四川地域特征,总结多年临床经验,认为脾虚挟湿是其主要病机,治以健脾化湿为主,以清暑益气汤加减,疗效确切,值得临床推广.并附验案1则,以资佐证.

目的 通过观察不同灸法足三里穴位局部的温度曲线变化,探讨不同灸法穴位局部的温热效应特征.方法 对31名健康志愿者序贯施予隔附饼灸、悬灸和隔姜灸3种不同灸法,使用温度记录仪动态监测施灸过程中足三里穴局部皮肤的温度曲线,并分析其变化特征.结果 3种施灸方法比较,灸前温度,3种灸法无显著差异(P＞0.05);最高温度、终末温度显示出差异:隔姜灸高于悬灸(P＜0.05),隔附子饼灸高于悬灸(P＜0.05),隔姜灸高于隔附子饼灸(P＜0.05);终末温度:悬灸高于隔姜灸、隔附子饼灸(P＜0.05),隔姜灸与隔附子饼灸无显著性差异(P＞0.05).结论 不同施灸方法具有各自不同的温度曲线特点:悬灸呈现出小波平缓的温度曲线特点,隔物灸则呈现出大波浪式递增的温度曲线特点.从皮肤安全性考虑,悬灸大于隔附子饼灸,隔附子饼灸大于隔姜灸.从温热角度出发,如果医生不以发泡为目的灸法则推荐选用悬灸和隔附子饼灸.

OBJECTIVE:To observe different effects of moxibustion on extracellular potassium ion in acupoint under physiological and pathological status and provide experimental evidence for exploring action mechanism of moxibustion on acupoint local. METHODS:Forty female SD rats were randomly divided into a blank group, a blank-moxibustion group, a model group and a model-moxibustion group, 10 cases in each one. The complete Freund's adjuvant(CFA) was adopted to establish model of adjuvant arthritis (AA) in the model group and model-moxibustion group. No treatment was given in the blank group and model group while moxibustion was applied at "Zusan-li" (ST 36) for 30 min in the blank-moxibustion group and model-moxibustion group. The tissue fluid in "Zusanli" (ST 36) was collected with microdialysis and real-time analyzed by electrolytic analyzer. The change of concentration of potassium ion in "Zusanli" (ST 36) was observed. RESULTS:(1) Under physiological status, the concentration of extracellular potassium ion in the blank group was not changed within 150 min (P > 0.05); before the moxibustion, the concentration of extracellular potassium ion in the blank-moxibustion group was (1.21 +/- 0.31) mmol/L, and after treatment it was gradually increased and reached its peak at (2.38 +/- 0.42) mmol/L after 60 min (P < 0.05), then it was reduced. 150 min after the treatment, concentration of potassium ion was slightly higher than that before moxibustion as well as that in the blank group. The concentration in the blank-moxibustion group at 60 min was statistically significant compared with that in the blank group (P < 0.05). (2) Under pathological status, the concentration of extracellular potassium ion in the model group was not changed within 150 min, differences of which at each time point was not statistically significant (all P > 0.05). Before the moxibustion, the concentration of extracellular potassium ion was (1.09 +/- 0.12) mmol/L in the model-moxibustion group, and it was immediately increased to (1.96 +/- 0.18) mmol/L after moxibustion. 60 min and 90 min after the moxibustion, it still maintained a higher level, which was (1.87 +/- 0.29) mmol/L and (1.59 +/- 0.16) mmol/L respectively (both P < 0.05). The differences of each time point after moxibustion in the model-moxibustion group were statistically significant compared with those in the model group (all P < 0.05). CONCLUSION:The moxibustion could increase the concentration of potassium ion in rat's acupoint local under physiological status but time of effect is short; with moxibustion at "Zusanli" (ST 36) under pathological status, the concentration of local potassium ion is obviously increased and maintains for a long time.

腱鞘囊肿是发生于关节囊或腱鞘附近的一种内含胶冻状黏液的良性肿块,多为单房性,也可为多房性.发病原因不明.中医认为本病症为聚筋或筋瘤,系外伤筋膜,邪气所居,郁滞运化不畅,水液积聚于骨节经络而成.本病最常发生于腕部背侧,多见于青年和中年,女性多于男性.大多逐渐发生或偶尔发生,生长缓慢.极少数病例囊肿可自行吸收,但时间长.针灸疗法对该病有很好的临床疗效,现将临床治疗该病常用的几种针灸疗法总结如下.

急性腰痛是临床常见病、多发病之一,针灸疗法以其安全、速效、价廉、无副作用等优势,在急性腰痛的临床治疗上发挥着不可替代的重要作用.本文通过综述近年来针灸在治疗急性腰痛的有关文献,从而系统的从九个方面回顾临床常用的针灸及其相关疗法,同时也为以后的临床及科学研究进行必要的探索.

Acupoint has been regarded as both crucial and initiate step for generating clinic efficacy by moxibustion therapy.So the local acupoint would to be an important target to uncover the mechanism of moxibustion.This review mainly focus on discussing the biological mechanism of changed temperature,blood flow,molecular events,immunity,transient receptor potential,and purinergic signaling at the moxibustioned site caused by moxibustion stimulation.

<正>腧穴是脏腑经络气血输注于体表的特殊部位,也是疾病的反应点和针灸等治法的刺激点。腧穴配伍是指按一定原则将两个及以上的腧穴有机地组合起来,成为一个穴位配方,用以治疗和预防疾病。现将腧穴配伍的研究进展综述如下。1腧穴配伍方式研究有学者考究《难经.七十五难》中的"泻南补北"法,在总结历代文献的基础上归纳其病机并按照脏、经、

Objective:To study the effects of moxibustion at acupoint on the expression of Eraf gene in adjuvant arthritis(AA) rats.Methods:SD rats were randomly divided into control group,model group,aconite moxibustion group.7 days after AA model established,aconite moxibustion were performed for five Zhuang.2 hours after treatment,the moxibustioned tissue(0.5 cm×0.5 cm) were took immediately in which the expression Eraf was detected by real-time quantitative PCR.Results:The expression of Eraf was significantly down-expressed in model group(vs.control group,P0.05).Aconite moxibustion could increase the expression of Cox7a2(vs.model group,both P0.05).Conclusion:Eraf gene could be significantly up-expressed by moxibustion at Zusanli(ST36) acupoint.

"若要安，三里常不干"是概括足三里治疗效应的经典论述。本文结合近年来国、内外针灸作用原理穴位局部探索方面的成果及皮肤免疫系统的理论认识，提出从足三里艾灸--穴位局部-皮肤免疫系统激活反应环节深入研究足三里艾灸作用原理，以冀为艾灸-皮肤-神经免疫网络调节机理新方向的研究奠定基础。