目的 对比军体训练前后人体成分和功能性动作模式筛查(functional movement screen,FMS)评分各项目差异及相关性分析,探讨军体训练对新训学员人体成分和FMS评分的影响.方法 随机选取新训学员共121名,进行2个月特色军体训练,分别于军体训练前后采用生物电阻抗分析仪测量其人体成分并评估其FMS评分.结果 121名学员军体训练前后体质量、体质量指数(body mass index,BMI)、体脂肪、肌肉含量、去脂体质量、骨骼肌含量、身体总水分、蛋白质、无机盐以及各部位肌肉、脂肪含量差异均有统计学意义;FMS评分总分及6个分项深蹲、直线弓箭步、肩部灵活性、主动直腿抬高、躯干稳定俯卧撑、旋转稳定得分前后差异有统计学意义;FMS总分与6项人体成分有相关性.结论 军体训练整体改善了学员的人体成分情况,提高了FMS各项评分.FMS评分总分与学员多项人体成分有相关性.

Objective To explore the influence of percutaneous coronary intervention (PCI) on the syndromes in patients with coronary heart disease (CHD) and blood stasis syndrome, and to investigate its improvement in blood stasis syndrome.Methods The influence of factors such as age, sex, number of coronary artery lesions and degree of lesion stenosis on blood stasis syndrome were observed before and after PCI.The relationship between electrocardiogram (ECG) changes and the blood stasis syndrome scores was analyzed.The difference of blood stasis syndrome scores were observed in patients with CHD and blood stasis syndrome before and after PCI.Results The syndrome score was positively correlated with age, the number of coronary artery lesions and the degree of stenosis.Patients with clinical symptoms or abnormal electrocardiogram had the higher the score of blood stasis syndrome.PCI could alleviate the patient's clinical symptoms, reduce the degree of stenosis, reduce the number of lesions, and improve the abnormal electrocardiogram.Conclusion PCI can improve the clinical symptoms and abnormal electrocardiogram in patients with CHD and blood stasis syndrome rapidly, and reduce the score of blood stasis syndrome.

Objective:To investigate the incidence and risk factors of breast cancer-related lymphedema (BCRL) after surgery in women.Methods:A total of 246 female patients were selected with unilateral and single-focus breast cancer. The relevant medical history data were consulted, and the medical records of scientific research were completed, including general data of the patients (age, weight, payment method, culture level, complication, etc.), the tumor data (pathological type, stage, postoperative hormone receptor, the Her-2, number of lymph node dissection, number of positive lymph nodes, etc.) and the treatment data (surgery way, axillary lymph node processing way, whether to accept radiation therapy, whether to accept postoperative chemotherapy, chemotherapy program, chemotherapy cycles, whether to accept endocrine therapy, endocrine medication and medication time, etc.), establishing the clinical data bases of BCRL. BCRL evaluation was completed by means of the follow-up cases, and its severity was judged by the perception of self-symptoms in bilateral palms, forearms, upper arms and other parts in patients, by using the Norman Chinese version questionnaire. The clinical data were retrospectively analyzed, combined with the statistical factors associated with BCRL, onset age, preoperative BMI, follow-up BMI, operation method, operative side, number of lymph nodes dissected, positive lymph nodes, hypertension, diabetes, chemotherapy, radiotherapy and endocrine therapy, etc..Chi-square test was used for univariate analysis, and logistic regression analysis method was used for multiple factors analysis.Results:Forty-seven cases were diagnosed with BCRL, 199 cases were't diagnosed with BCRL and the incidence of BCRL at 1-3 years after surgery was 19.11%. All the cases were clearly diagnosed by pathology, including 136 cases with ER positive, 113 cases with PR positive and 161 cases with Her-2 positive. Only 31 cases in the whole group received breast-conserving surgery. In the univariate analysis of the influencing factors of BCRL, there were 9 factors including BMI, hypertension, postoperative chemotherapy, postoperative radiotherapy, postoperative endocrine therapy, number of lymph node dissection, positive lymph nodes and age of diagnosis, which were statistically significant differences between the edema group and the non-edema group. Multivariate analysis showed that hypertension (OR=11.868), postoperative chemotherapy (OR=6.669), radiotherapy (OR=3.408) and positive lymph nodes (OR=3.838) were risk factors for BCRL.Conclusion:BCRL is one of the serious complications after breast cancer surgery, for patients with hypertension, positive lymph nodes, receiving postoperative chemotherapy and radiotherapy, the health education and preventive measures should be actively carried out to avoid the occurrence of lymphedema.

目的 通过对比海军某部2014年新兵入伍4个月前后中医体质变化情况,分析军事基础训练对新兵中医体质变化的影响.方法 对新兵入伍4个月前后进行两次流行病学调查,根据《中医体质分类与判定》标准,采用最大值法对数据进行对比分析.结果 气虚质(x2=6.277,P＜0.05)、气郁质(x2=8.103,P＜0.05)前后数量差异有统计学意义;平和质(χ2=26.625,P＜0.01)、阳虚质(x2=6.277,P＜0.01)、特禀质(x2=14.160,P＜0.01)数量差异有显著性意义.结论 军事基础训练对新兵中医体质有影响.

Objective Observe the influence of the resection of the tumor in situ liver on general state and the im-mune function in mice.Methods Do the resection of the tumor in situ liver in mice to observe the operation of sponta-neous activity of mice after different time node,ability of lymphocyte proliferation and the influence of CD4+/CD8+ ra-tio and other indexes.Results Compared with the normal mice,spontaneous activity in mice reduce on the first postop-erative day,with statistical significance(P <0.05);Compared with the normal mice,the reproductive capacity of lym-phocytes in mice reduce on the first and third day,with statistical significance(P <0.05);Compared with the first post-operative day mice,CD4+/CD8+ lymphocytes in mice increase on the seventh postoperative day and the normal mice, with?statistical significance(P <0.01).Conclusion Resection of the tumor in situ liver caused greater stress injury and immunosuppression in mice.Mice are similar to human perioperative after surgery,also need a certain amount of time gradually returned to normal state.

新兵高强度训练并随之引发的下腰痛高复发率,是长期困扰基层训练的一大难题.在研究、跟踪下腰痛运动康复新理念、新技术、新方法的基础上,提出从下腰痛常识教育、腰部运动管理、日常保健教育、心理教育四个方面介绍综合预防训练性下腰痛的实践做法,以期达到减少腰痛患病率、促进下腰痛快速康复、提高士兵体能、增强战斗力的战略目的.

Objective To campare the clinical efficacy of wrist-ankle acupuncture versus physical therapy in treating lumbar intervertebral disc herniation (LIDH).Method Fifty LIDH patients were randomized into a treatment group of 20 cases and a control group of 30 cases. The treatment group was intervened by wrist-ankle acupuncture, while the control group was by traction and interference electrotherapy. The short-form McGill Pain Questionnaire (SF-MPQ) and lumbar pain scoring system by Japanese Orthopedic Association (JOA) were compared before and after intervention.Result The SF-MPQ and JOA scores were significantly changed respectively after 5-day, 10-day, 15-day treatment as well as at the follow-up study in both groups (P<0.01). There were no significant differences between the two groups in comparing the SF-MPQ and JOA scores respectively after 5-day, 10-day, 15-day treatment as well as at the follow-up study (P>0.05).Conclusion Wrist-ankle acupuncture and physical therapy both are effective in treating LIDH, as they both can release the pain.

目的:检验构建的蜂毒素改造物是否达到减轻溶血副作用、保留或增强抗肿瘤活性的目的.方法:比较蜂毒素改造物与蜂毒素的体外溶血作用及急性毒性作用;MTT法检测其对H2肝癌细胞的增殖抑制作用;观察蜂毒素改造物瘤内注射对荷肝癌小鼠的抗肿瘤作用.结果:蜂毒素改造物致溶血浓度约为蜂毒素的2.2倍,LD50约为蜂毒素的4倍;蜂毒素改造物对H22肝癌细胞具有增殖抑制作用,呈浓度依赖性;蜂毒素改造物瘤内注射3d后,荷瘤鼠肿瘤增长速度减缓(P＜0.05),中位生存时间长于蜂毒素及生理盐水组,但差异无统计学意义(P＞0.05).结论:对蜂毒素分子一级结构进行适当修饰和改造,理论上和实践上均具有可行性,能达到降低蜂毒素溶血副作用、继续保留其抗肿瘤活性的目的.

目的:探讨癌因性疲乏的中医证候分布特点及规律.方法:参照《中药新药临床研究指导原则-中医证候指导原则》及《中医内科学》虚劳病中出现的疲乏证候,制定癌因性疲乏基本证候群,以消化道肿瘤的稳定期及无瘤幸存者为例,调查其证候分布及自述症状表现.结果:共调查142例患者,癌因性疲乏患者最常出现的疲乏伴随症状有出汗,睡眠差,脘腹胀,气短,食欲差,头晕,大便异常.证候分布依次为(阳)气虚,脾气虚,(阴)血虚,肺气虚,肾气虚,肝郁气滞,肾阳/阴虚,温(热)困脾,心气虚.结论:癌因性疲乏证候分布以虚证为主,虚证中以气虚类证为主,兼有湿阻及气滞证.

Objective To investigate life satisfaction of the second batch of pre-selected medical non-commissioned officer trainees in one military college, so as to collect the epidemiological survey data for promoting and safeguarding its education.Methods Participants were involved in a cross-sectional study.They completed questionnaires which were based on the standard of“Multidimensional Students Life Satisfaction Scale”( MSLSS) . Conclusion The effort in promoting these trainees'education done by this military college proves to be effective by our investigation and analysis.Moreover, the research will provide scientific evidences for the formulation of a more practical training project.

Hepatocellular carcinoma (HCC) is a highly malignant disease, and its outcome of routine therapies is poor. Comprehensive treatment including gene therapy is an important way to improve patients' prognosis and survival. In this study, we successfully constructed a triple-controlled cancer-selective oncolytic adenovirus, QG511-HA-Melittin, carrying melittin gene, in which the hybrid promoter, hypoxia-response element (HRE)-AFP promoter, was used to control viral E1a expression targeting AFP-positive cancer cells in hypoxia microenviroment, and the E1b-55 kDa gene was deleted in cancer cells with p53-deficiency. The cytological experiments found that the viral replication of QG511-HA-Melittin was increased to 12800-folds in Hep3B cells within 48 h, and 130-folds in SMMC-7721, but the virus did not replicate in L-02 cells. QG511-HA-Melittin had a strong inhibition effect on AFP-positive HCC cell proliferation, such as Hep3B and HepG2, whereas, there was low or no inhibition effect of QG511-HA-Melittin on AFP-negative cancer cells SMMC-7721 and normal cells L-02. In the in vivo experiment, compared with the blank control group, QG511-HA-Melittin can significantly inhibit the growth of HCC xenografts (P<0.05). The survival of mice in QG511-HA-Melittin group was much longer than that of the blank control group. Both in vitro and in vivo experiments manifested that QG511-HA-Melittin exerts an inhibitory effect on HCC cells, which may provide a new strategy for HCC biotherapy.

目的 观察原发性肝癌患者手术前后舌象特征变化,探讨肝癌围手术期患者证候特征.方法 收集103例拟行手术的原发性肝癌患者,于术前1天及术后1、3、5天上午6:30-8:00观察患者舌象,填写中医舌象调查表,用数码照相机留取舌体图片,采用中医舌诊综合信息处理系统分析舌质及舌苔颜色平均RGB各分量值.结果 定性及定量结果均提示,术前患者以青紫舌为主,术后1天以红舌为主,术后3、5天青紫舌占居首位(P＜0.05);术后舌质颜色R分量值升高,以术后第1天最明显,术后3、5天舌质颜色R分量值逐渐下降(P＜0.05).术后3、5天较术前1天舌苔R、G、B各分量值逐渐下降(P＜0.05).术后舌形胖大、齿痕、点刺舌有增多趋势(P＜0.05).手术前后皆以厚腻苔为主,且术后较术前比例逐渐上升(P＜0.05).术后1、3、5天较术前1天舌下络脉宽度明显降低(P＜0.05).结论 血瘀、水湿、气虚证舌象贯穿原发性肝癌患者围手术期,术后5天内阴虚内热舌象比例有所增加.

Objective: By observing the change in pulse manifestation characteristics before and after operation in patients with primary liver cancer,it is to provide data support that traditional Chinese medicine will be applied to perioperative patients with hepatocellular carcinoma. Methods: The pulse graph parameters with left and right hands Guan's pulse were collected by using SMART MX-1 I type pulse instrument 6∶ 30- 8∶ 00 in the morning of 1 days before operation,1,3,5 days after operation. The collected data was analyzed with SAS software. Results: The third days after operation patients' left hand pulse rate were faster than the first day before operation( P 0. 05). After operation patients' right hand pulse rate were faster than the first day before operation( P 0. 05),and the most obvious change was in the third day after operation. Conclusion: Xian( taut) and slippery pulse is throughout the perioperative patients with primary liver cancer. Pulse rate are accelerated after surgery,changing to rapid pulse.

[Objective] To understand Chinese scholars in different periods on the different understanding of tongue, for further development of research and provide a theoretical basis. [Method] Access to a large number of ancient books and literature, selection and tongue of related articles, extract and summa-rize the main points. [Result] The ancient understanding of TCM tongue is very knowledgeable, and by the subjective leading generation, does not have the scientific rigour;modern research of Chinese medicine tongue is mainly from the tongue and tongue color, tongue shape and other aspects, the objec-tive diagnosis and analysis system, the research methods of modern TCM tongue with scientific rigor modern Chinese Medicine; from the point of view, different degrees of col aterals and the width of the color purple tongue, sublingual y reflect the progress of the blood stasis degree and disease conditions, different diseases have different characteristics of the tongue. [Conclusion] Research on the development of modern tongue made certain contribution to TCM development.

Objective: To analyze influencing factors and the distribution of TCM constitutions, the depression of African students in China. Method: Foreign students in the Second Military Medical University were chosen to perform epidemiological investigation through Zung self-rating depression scale(SDS), TCM constitutions scale and background information scale. Result: Average scores of SDS were(45.33 ±1.26), 37.0% of the students were depressed; the influencing factors of the depression were peace constitution( β=-0.39), age(β=0.42), the time of staying in China( β=-0.26) and Qi stagnation constitution( β=0.24). Conclusion: Qi stagnation constitution and age are the main factors of African students forming the depression, peace constitution and the time of staying in China are against the formation of depression.

Objective To investigate the relationship between sleep quality and mental health status among the first group of military preliminary medical sergeant students and supply scientific advices to improve their sleep,promote and serve for their education.Methods A total of 528 military preliminary medical sergeant students were selected from a military university by a random sampling method and surveyed by a self-evaluation questionnaire including Pittsburgh sleep quality index(PSQI)and Symptom Checklist 90(SCL-90).Results 23.1% preliminary sergeants had sleep disorder.The top three PSQI factors were subjective sleep quality,daytime dysfunction and sleep duration.Male military students were better than female students in sleep quality and daytime dysfunction(P0.05).The students of different education backgrounds had significant differences in subjective sleep quality,sleep latency,sleep disturbances and daytime dysfunction scores(P0.05).Beside use of sleeping medication,all the other PSQI factors had strong correlation with the SCL-90 factors.Multiple linear regression analysis showed that factor depression,somatization,interpersonal sensitivity,schizophrenia,paranoid of SCL-90 had significant effect on PSQI scores.Conclusion The sleep quality of military preliminary medical sergeants needs to be improved.Sleep quality is highly correlated with mental health status.The school management should pay more attention to the sleep quality and take measures to ensure the sleep quality.

OBJECTIVE:To study the traditional Chinese medicine (TCM) syndrome distribution in patients with hepatitis B virus (HBV) infection in Qidong region of Jiangsu Province, China.METHODS:A cross-sectional survey was performed. Subjects from Qidong of Jiangsu Province of China were screened among the locally enrolled residents by detecting hepatitis B surface antigen (HBsAg) from May 2007 to May 2011 and were assigned to HBsAg-negative cohort or HBsAg-positive cohort. Then, the subjects were diagnosed according to alanine aminotransferase, alpha-fetoprotein and B ultrasound. The syndrome of the subjects was determined using a TCM questionnaire consisting of signs and symptoms.RESULTS:A total of 5 908 subjects were enrolled in this survey, among whom, 4 718 were diagnosed with HbsAg infection (positive result of HbsAg detection) and 1 147 were negative. 143 subjects were excluded for not receiving the blood examination. The final diagnoses of the subjects were non-HBV infection (n=1128), HBV carrier (n=4019), chronic hepatitis B (n=225), posthepatitic cirrhosis (n=263) or liver cancer (n=111). The TCM syndrome differentiation results showed that there were differences in syndrome distribution between HBV-infected and non-HBV-infected patients. The main syndromes of the HBV-infected patients were qi deficiency, qi stagnation, blood stasis and dampness heat, related to the Zang of liver and spleen. The distribution principles of TCM syndrome among patients of HBV carrier, chronic hepatitis B and cirrhosis were similar. Moreover, with the progression of the patients' condition, the scores of syndromes increased, and the number of accompanying syndromes increased as well. The main syndromes of patients with liver cancer were blood stasis and excess heat, which was slightly different from that of the other HBV-infected patients.CONCLUSION:The TCM syndrome distribution in patients of HBV infection in Qidong region of Jiangsu Province shows regularity. The disorder is mainly due to qi stagnation and blood stasis and is also related to deficiency of healthy qi, especially deficiency of spleen qi.

目的 研究中药和针灸治疗过敏性鼻炎的联合疗效.方法 采用前瞻性随机对照研究方法,随机将患者分为3组,分别为玉屏风散加减、针灸"鼻三针"以及玉屏风散联合"鼻三针"治疗,治疗前和治疗结束后的第一个月填写症候表,根据组内自身前后的症状积分以及三组间症状改善率的统计学分析,观察疗效.结果 中药组、针灸组及针药并治组的有效率分别为80%、87.19%和97.36%.各组患者治疗前症状积分与治疗后症状积分数的自身对照比较,差异均有统计学意义(P＜0.05);针药并治组的有效率与单纯针灸组和中药组比较差异具有统计学意义(P＜0.05).结论 玉屏风散和"鼻三针"针灸治疗治疗过敏性鼻炎疗效显著,能有效地改善患者的症状,而"鼻三针"配合玉屏风散的辨证论治治疗过敏性鼻炎具有协同作用.

OBJECTIVE To analyze the distribution of traditional Chinese medicine constitution types in elderly patients with insomnia. METHODS The epidemiological data were collected from communities in the Yangpu District, Shanghai via a cross-sectional field survey. The elderly participants were enrolled by using the Pittsburgh Sleep Quality Index (PSQI) scale and the TCM Constitution Questionnaire. RESULTS (1)The distribution of imbalanced constitutions between the elderly with insomnia and normal subjects showed statistical difference (P<0.01) and the elderly with insomnia tend to be of imbalanced constitutions. Among these unbalanced constitutions, deficient constitutions were more frequent than others in the elderly with insomnia, and yang-deficiency and qi-deficiency occurred mostly in unbalanced and simple constitutions. (2) Blood-stasis and qi-stagnation constitutions were more frequent in females than in males among the elderly with insomnia. Frequency of deficiency constitutions in the elderly increased as the age increases. (3) The frequency of composite constitutions was higher than that of simple constitutions in elderly patients with insomnia (74.8%), among which qi-deficiency was more likely to be composite with other constitutions. CONCLUSION Identification and classification of traditional Chinese medicine constitution types will provide further information for devising projects with systematic intervention for insomnia management.